{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T17:19:45Z","timestamp":1766510385946,"version":"3.48.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1004303"],"award-info":[{"award-number":["2018YFC1004303"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071606"],"award-info":[{"award-number":["82071606"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundamental Research Funds of Shandong University","award":["2023QNTD004"],"award-info":[{"award-number":["2023QNTD004"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Diabetol"],"DOI":"10.1007\/s00592-025-02546-8","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T05:27:45Z","timestamp":1750397265000},"page":"2047-2053","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondrial DNA variations and risk of incident gestational diabetes mellitus: a nested case-control study"],"prefix":"10.1007","volume":"62","author":[{"given":"Yuqing","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maoning","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanzhong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongsong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7407-9220","authenticated-orcid":false,"given":"Shigang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejun","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"2546_CR1","doi-asserted-by":"crossref","unstructured":"Nguyen CL et al (2018) Prevalence of Gestational Diabetes Mellitus in Eastern and Southeastern Asia: a Systematic Review and Meta-Analysis. J Diabetes Res 2018:6536974","DOI":"10.1155\/2018\/6536974"},{"issue":"1","key":"2546_CR2","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s11427-018-9377-y","volume":"62","author":"Z Wu","year":"2019","unstructured":"Wu Z, Jin T, Weng J (2019) A thorough analysis of diabetes research in China from 1995 to 2015: current scenario and future scope. Sci China Life Sci 62(1):46\u201362","journal-title":"Sci China Life Sci"},{"issue":"11","key":"2546_CR3","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.tem.2018.09.004","volume":"29","author":"EC Johns","year":"2018","unstructured":"Johns EC et al (2018) Gestational diabetes mellitus: mechanisms, treatment, and complications. Trends Endocrinol Metab 29(11):743\u2013754","journal-title":"Trends Endocrinol Metab"},{"issue":"3","key":"2546_CR4","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.ecl.2019.05.001","volume":"48","author":"ED Szmuilowicz","year":"2019","unstructured":"Szmuilowicz ED, Josefson JL, Metzger BE (2019) Gestational diabetes mellitus. Endocrinol Metab Clin North Am 48(3):479\u2013493","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"5","key":"2546_CR5","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1093\/humupd\/dmv024","volume":"21","author":"AB Otten","year":"2015","unstructured":"Otten AB, Smeets HJ (2015) Evolutionary defined role of the mitochondrial DNA in fertility, disease and ageing. Hum Reprod Update 21(5):671\u2013689","journal-title":"Hum Reprod Update"},{"issue":"5","key":"2546_CR6","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1016\/j.bbadis.2016.11.010","volume":"1863","author":"JS Bhatti","year":"2017","unstructured":"Bhatti JS, Bhatti GK, Reddy PH (2017) Mitochondrial dysfunction and oxidative stress in metabolic disORders\u2014a step towards mitochondria based therapeutic strategies. Biochim Biophys Acta Mol Basis Dis 1863(5):1066\u20131077","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"5806","key":"2546_CR7","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/290457a0","volume":"290","author":"S Anderson","year":"1981","unstructured":"Anderson S et al (1981) Sequence and organization of the human mitochondrial genome. Nature 290(5806):457\u2013465","journal-title":"Nature"},{"issue":"3","key":"2546_CR8","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3109\/09513590.2012.736556","volume":"29","author":"F Crovetto","year":"2013","unstructured":"Crovetto F et al (2013) A role fOR mitochondria in gestational diabetes mellitus? Gynecol Endocrinol 29(3):259\u2013262","journal-title":"Gynecol Endocrinol"},{"issue":"3","key":"2546_CR9","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.sjbs.2014.11.001","volume":"22","author":"IA Khan","year":"2015","unstructured":"Khan IA et al (2015) Screening of mitochondrial mutations and insertion-deletion polymorphism in gestational diabetes mellitus in the Asian Indian population. Saudi J Biol Sci 22(3):243\u2013248","journal-title":"Saudi J Biol Sci"},{"issue":"1","key":"2546_CR10","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.sjbs.2021.08.102","volume":"29","author":"KK Alharbi","year":"2022","unstructured":"Alharbi KK et al (2022) Screening of mitochondrial mutations in Saudi women diagnosed with gestational diabetes mellitus: a non-replicative case-control study. Saudi J Biol Sci 29(1):360\u2013365","journal-title":"Saudi J Biol Sci"},{"issue":"1","key":"2546_CR11","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0168-8227(99)00138-2","volume":"48","author":"Y Chen","year":"2000","unstructured":"Chen Y et al (2000) Mitochondrial gene mutations in gestational diabetes mellitus. Diabetes Res Clin Pract 48(1):29\u201335","journal-title":"Diabetes Res Clin Pract"},{"issue":"1","key":"2546_CR12","doi-asserted-by":"publisher","first-page":"56","DOI":"10.2337\/dc12-0741","volume":"36","author":"MH Black","year":"2013","unstructured":"Black MH et al (2013) The relative contribution of prepregnancy overweight and obesity, gestational weight gain, and IADPSG-defined gestational diabetes mellitus to fetal overgrowth. Diabetes Care 36(1):56\u201362","journal-title":"Diabetes Care"},{"issue":"2","key":"2546_CR13","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.mito.2010.09.013","volume":"11","author":"L Fan","year":"2011","unstructured":"Fan L, Yao YG (2011) MitoTool: a web server fOR the analysis and retrieval of human mitochondrial DNA sequence variations. Mitochondrion 11(2):351\u2013356","journal-title":"Mitochondrion"},{"key":"2546_CR14","doi-asserted-by":"crossref","unstructured":"Plows JF et al (2018) The pathophysiology of gestational diabetes mellitus. Int J Mol Sci 19(11)","DOI":"10.3390\/ijms19113342"},{"issue":"2","key":"2546_CR15","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/13779","volume":"23","author":"RM Andrews","year":"1999","unstructured":"Andrews RM et al (1999) Reanalysis and revision of the Cambridge reference sequence fOR human mitochondrial DNA. Nat Genet 23(2):147","journal-title":"Nat Genet"},{"issue":"1","key":"2546_CR16","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1113\/eph8802514","volume":"88","author":"P Fern\u00e1ndez-Silva","year":"2003","unstructured":"Fern\u00e1ndez-Silva P, Enriquez JA, Montoya J (2003) Replication and transcription of mammalian mitochondrial DNA. Exp Physiol 88(1):41\u201356","journal-title":"Exp Physiol"},{"issue":"9","key":"2546_CR17","doi-asserted-by":"publisher","first-page":"9123","DOI":"10.1007\/s11033-012-1784-8","volume":"39","author":"X Yang","year":"2012","unstructured":"Yang X et al (2012) Mitochondrial DNA polymorphisms are associated with the longevity in the Guangxi Bama population of China. Mol Biol Rep 39(9):9123\u20139131","journal-title":"Mol Biol Rep"},{"key":"2546_CR18","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.mito.2014.04.013","volume":"17","author":"O Guney","year":"2014","unstructured":"Guney O et al (2014) Mitochondrial DNA polymorphisms associated with longevity in the Turkish population. Mitochondrion 17:7\u201313","journal-title":"Mitochondrion"},{"key":"2546_CR19","doi-asserted-by":"publisher","first-page":"63","DOI":"10.2147\/TACG.S198593","volume":"12","author":"M Eaaswarkhanth","year":"2019","unstructured":"Eaaswarkhanth M et al (2019) Mitochondrial DNA D-loop sequencing reveals obesity variants in an Arab population. Appl Clin Genet 12:63\u201370","journal-title":"Appl Clin Genet"},{"issue":"6","key":"2546_CR20","first-page":"1521","volume":"24","author":"AM Czarnecka","year":"2010","unstructured":"Czarnecka AM et al (2010) Mitochondrial genotype and breast cancer predisposition. Oncol Rep 24(6):1521\u20131534","journal-title":"Oncol Rep"},{"issue":"4","key":"2546_CR21","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1309\/GQFCCJMH5KHNVX73","volume":"126","author":"F Navaglia","year":"2006","unstructured":"Navaglia F et al (2006) Mitochondrial DNA D-loop in pancreatic cancer: somatic mutations are epiphenomena while the germline 16519 T variant wORsens metabolism and outcome. Am J Clin Pathol 126(4):593\u2013601","journal-title":"Am J Clin Pathol"},{"issue":"2","key":"2546_CR22","doi-asserted-by":"publisher","first-page":"e30874","DOI":"10.1371\/journal.pone.0030874","volume":"7","author":"EE Mueller","year":"2012","unstructured":"Mueller EE et al (2012) Mitochondrial haplogroups and control region polymorphisms in age-related macular degeneration: a case-control study. PLoS One 7(2):e30874","journal-title":"PLoS ONE"},{"key":"2546_CR23","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.mito.2013.07.001","volume":"16","author":"SP Kabekkodu","year":"2014","unstructured":"Kabekkodu SP et al (2014) Mitochondrial DNA variation analysis in cervical cancer. Mitochondrion 16:73\u201382","journal-title":"Mitochondrion"},{"issue":"4","key":"2546_CR24","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1006\/bbrc.2001.5436","volume":"286","author":"S Umeda","year":"2001","unstructured":"Umeda S et al (2001) Both heavy strand replication origins are active in partially duplicated human mitochondrial DNAs. Biochem Biophys Res Commun 286(4):681\u2013687","journal-title":"Biochem Biophys Res Commun"},{"issue":"11","key":"2546_CR25","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1249\/MSS.0000000000002390","volume":"52","author":"HL Vellers","year":"2020","unstructured":"Vellers HL et al (2020) AssoCIation between mitochondrial DNA sequence variants and V\u02d9O2 max trainability. Med Sci Sports Exerc 52(11):2303\u20132309","journal-title":"Med Sci Sports Exerc"},{"issue":"5","key":"2546_CR26","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1016\/S0002-9440(10)61132-7","volume":"160","author":"V M\u00e1ximo","year":"2002","unstructured":"M\u00e1ximo V et al (2002) Mitochondrial DNA somatic mutations (point mutations and large deletions) and mitochondrial DNA variants in human thyroid pathology: a study with emphasis on H\u00fcrthle cell tumors. Am J Pathol 160(5):1857\u20131865","journal-title":"Am J Pathol"},{"issue":"8","key":"2546_CR27","doi-asserted-by":"publisher","first-page":"e0182509","DOI":"10.1371\/journal.pone.0182509","volume":"12","author":"F Troncoso","year":"2017","unstructured":"Troncoso F et al (2017) Gestational diabetes mellitus is associated with increased pro-migratORy activation of vascular endothelial growth factor receptor 2 and reduced expression of vascular endothelial growth factor receptor 1. PLoS One 12(8):e0182509","journal-title":"PLoS ONE"},{"issue":"4","key":"2546_CR28","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1007\/s00125-008-0933-z","volume":"51","author":"KS Park","year":"2008","unstructured":"Park KS et al (2008) A mitochondrial DNA variant at position 16189 is associated with type 2 diabetes mellitus in Asians. Diabetologia 51(4):602\u2013608","journal-title":"Diabetologia"},{"key":"2546_CR29","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.mito.2020.12.006","volume":"57","author":"X Deng","year":"2021","unstructured":"Deng X et al (2021) PolymORphisms and haplotype of mitochondrial DNA D-loop region are associated with polycystic ovary syndrome in a Chinese population. Mitochondrion 57:173\u2013181","journal-title":"Mitochondrion"},{"key":"2546_CR30","doi-asserted-by":"publisher","first-page":"2200","DOI":"10.3389\/fimmu.2019.02200","volume":"10","author":"J Russlies","year":"2019","unstructured":"Russlies J et al (2019) PolymORphisms in the mitochondrial genome are associated with bullous pemphigoid in Germans. Front Immunol 10:2200","journal-title":"Front Immunol"},{"issue":"1","key":"2546_CR31","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1002\/ajmg.a.30323","volume":"131A","author":"Q Wang","year":"2004","unstructured":"Wang Q et al (2004) Mitochondrial DNA control region sequence variation in migraine headache and Cyclic vomiting syndrome. Am J Med Genet Part A 131A(1):50\u201358","journal-title":"Am J Med Genet Part A"},{"issue":"1","key":"2546_CR32","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1146\/annurev.bi.64.070195.003353","volume":"64","author":"CB Newgard","year":"1995","unstructured":"Newgard CB, McGarry JD (1995) Metabolic coupling factors in pancreatic \u03b2-cell signal transduction. Annu Rev Biochem 64(1):689\u2013719","journal-title":"Annu Rev Biochem"},{"issue":"1","key":"2546_CR33","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1196\/annals.1338.007","volume":"1042","author":"T-K Lin","year":"2005","unstructured":"Lin T-K et al (2005) Increased oxidative damage with altered antioxidative status in type 2 diabetic patients harboring the 16189 T to C variant of mitochondrial DNA. Ann NY Acad Sci 1042(1):64\u201369","journal-title":"Annals NY Acad Sci"},{"issue":"4","key":"2546_CR34","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1073\/pnas.94.4.1166","volume":"94","author":"G Villani","year":"1997","unstructured":"Villani G, Attardi G (1997) In vivo control of respiration by cytochrome c oxidase in wild-type and mitochondrial DNA mutation-carrying human cells. Proc Natl Acad Sci USA 94(4):1166\u20131171","journal-title":"Proc Natl Acad Sci USA"},{"key":"2546_CR35","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1146\/annurev.bi.65.070196.003023","volume":"65","author":"RO Poyton","year":"1996","unstructured":"Poyton RO, McEwen JE (1996) Crosstalk between nuclear and mitochondrial genomes. Annu Rev Biochem 65:563\u2013607","journal-title":"Annu Rev Biochem"},{"issue":"3","key":"2546_CR36","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1093\/hmg\/ddg021","volume":"12","author":"R Ac\u00edn-P\u00e9rez","year":"2003","unstructured":"Ac\u00edn-P\u00e9rez R et al (2003) An intragenic suppressor in the cytochrome c oxidase I gene of mouse mitochondrial DNA. Hum Mol Genet 12(3):329\u2013339","journal-title":"Hum Mol Genet"},{"issue":"24","key":"2546_CR37","first-page":"4849","volume":"430","author":"S Cogliati","year":"2018","unstructured":"Cogliati S et al (2018) Regulation of mitochondrial electron transport chain assembly. J Mol Biol 2018 430(24):4849\u20134873","journal-title":"J Mol Biol 2018"},{"issue":"12","key":"2546_CR38","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s11892-020-01355-3","volume":"20","author":"CE Powe","year":"2020","unstructured":"Powe CE, Kwak SH (2020) Genetic studies of gestational diabetes and glucose metabolism in pregnancy. Curr Diab Rep 20(12):69","journal-title":"Curr Diab Rep"},{"key":"2546_CR39","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.mgene.2014.03.001","volume":"2","author":"IA Khan","year":"2014","unstructured":"Khan IA et al (2014) Investigation of Calpain 10 (rs2975760) gene polymorphism in Asian Indians with gestational diabetes mellitus. Meta Gene 2:299\u2013306","journal-title":"Meta Gene"},{"issue":"1","key":"2546_CR40","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.mito.2006.11.013","volume":"7","author":"N Raule","year":"2007","unstructured":"Raule N et al (2007) AssoCIation studies on human mitochondrial DNA: methodological aspects and results in the most common age-related diseases. Mitochondrion 7(1):29\u201338","journal-title":"Mitochondrion"},{"issue":"1","key":"2546_CR41","doi-asserted-by":"publisher","first-page":"16989","DOI":"10.1038\/s41598-017-17086-7","volume":"7","author":"W Jiang","year":"2017","unstructured":"Jiang W et al (2017) Mitochondrial DNA mutations associated with type 2 diabetes mellitus in Chinese Uyghur population. Sci Rep 7(1):16989","journal-title":"Sci Rep"}],"container-title":["Acta Diabetologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-025-02546-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00592-025-02546-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-025-02546-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T17:01:40Z","timestamp":1766509300000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00592-025-02546-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,20]]},"references-count":41,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2546"],"URL":"https:\/\/doi.org\/10.1007\/s00592-025-02546-8","relation":{},"ISSN":["1432-5233"],"issn-type":[{"type":"electronic","value":"1432-5233"}],"subject":[],"published":{"date-parts":[[2025,6,20]]},"assertion":[{"value":"24 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This study was performed in accordance with the principles of the Declaration of Helsinki. The Institutional Review Board of the School of Medicine, Nanjing University approved to conduct of this study. The ethical approval was received on the 24th of December 2018, and the approval number was [2018-2019].","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consents were obtained from all the subjects involved in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}