{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:48:04Z","timestamp":1790657284585,"version":"4.1.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Diabetol"],"DOI":"10.1007\/s00592-025-02555-7","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T06:35:29Z","timestamp":1751438129000},"page":"1585-1596","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy and safety of platelet-rich plasma versus conventional care in diabetic foot ulcers: a meta-analysis of randomized controlled trials"],"prefix":"10.1007","volume":"62","author":[{"given":"Hongyan","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1771-8790","authenticated-orcid":false,"given":"Xiaohong","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"2555_CR1","doi-asserted-by":"crossref","unstructured":"Armstrong DG, Tan TW, Boulton AJM, Bus SA (2023) Diabetic foot ulcers. Rev Jama 330:62\u201375","DOI":"10.1001\/jama.2023.10578"},{"key":"2555_CR2","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1177\/0141076816688346","volume":"110","author":"JZ Lim","year":"2017","unstructured":"Lim JZ, Ng NS, Thomas C (2017) Prevention and treatment of diabetic foot ulcers. J R Soc Med 110:104\u2013109","journal-title":"J R Soc Med"},{"issue":"Suppl 1","key":"2555_CR3","doi-asserted-by":"publisher","first-page":"e3272","DOI":"10.1002\/dmrr.3272","volume":"36","author":"M Monteiro-Soares","year":"2020","unstructured":"Monteiro-Soares M, Boyko EJ, Jeffcoate W et al (2020) Diabetic foot ulcer classifications: A critical review. Diabetes Metab Res Rev 36(Suppl 1):e3272","journal-title":"Diabetes Metab Res Rev"},{"key":"2555_CR4","doi-asserted-by":"publisher","first-page":"108690","DOI":"10.1016\/j.jdiacomp.2024.108690","volume":"38","author":"M Ruiz-Mu\u00f1oz","year":"2024","unstructured":"Ruiz-Mu\u00f1oz M, Martinez-Barrios FJ, Fernandez-Torres R, Lopezosa-Reca E, Marchena-Rodriguez A (2024) Autologous platelet-rich plasma (APRP) in diabetes foot disease: a meta-analysis. J Diabetes Complications 38:108690","journal-title":"J Diabetes Complications"},{"key":"2555_CR5","doi-asserted-by":"publisher","first-page":"e14856","DOI":"10.1111\/iwj.14856","volume":"21","author":"X Fang","year":"2024","unstructured":"Fang X, Wang X, Hou Y, Zhou L, Jiang Y, Wen X (2024) Effect of platelet-rich plasma on healing of lower extremity diabetic skin ulcers: A meta-analysis. Int Wound J 21:e14856","journal-title":"Int Wound J"},{"key":"2555_CR6","doi-asserted-by":"publisher","first-page":"1399924","DOI":"10.3389\/fendo.2024.1399924","volume":"15","author":"Z Fan","year":"2024","unstructured":"Fan Z, Huang J, Liu Y et al (2024) Multifactorial analysis of risk factors for foot ulcers in patients with neurovascular complications of diabetes. Front Endocrinol (Lausanne) 15:1399924","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2555_CR7","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1080\/14737167.2017.1305891","volume":"17","author":"I Petrakis","year":"2017","unstructured":"Petrakis I, Kyriopoulos IJ, Ginis A, Athanasakis K (2017) Losing a foot versus losing a dollar; a systematic review of cost studies in diabetic foot complications. Expert Rev Pharmacoecon Outcomes Res 17:165\u2013180","journal-title":"Expert Rev Pharmacoecon Outcomes Res"},{"key":"2555_CR8","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/nyas.13569","volume":"1411","author":"E Everett","year":"2018","unstructured":"Everett E, Mathioudakis N (2018) Update on management of diabetic foot ulcers.ann N. Y Acad Sci 1411:153\u2013165","journal-title":"Y Acad Sci"},{"key":"2555_CR9","first-page":"1684","volume":"11","author":"JM Raja","year":"2023","unstructured":"Raja JM, Maturana MA, Kayali S, Khouzam A, Efeovbokhan N (2023) Diabetic foot ulcer: A comprehensive review of pathophysiology and management modalities.world. J Clin Cases 11:1684\u20131693","journal-title":"J Clin Cases"},{"key":"2555_CR10","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1089\/wound.2015.0635","volume":"4","author":"RG Frykberg","year":"2015","unstructured":"Frykberg RG, Banks J (2015) Challenges in the treatment of chronic wounds.adv wound care. (New Rochelle) 4:560\u2013582","journal-title":"(New Rochelle)"},{"key":"2555_CR11","doi-asserted-by":"publisher","first-page":"36","DOI":"10.25270\/wnds\/2022.3642","volume":"33","author":"YA Orban","year":"2022","unstructured":"Orban YA, Soliman MA, Hegab YH, Alkilany MM (2022) Autologous platelet-rich plasma vs conventional dressing in the management of chronic diabetic foot. Ulcers Wounds 33:36\u201342","journal-title":"Ulcers Wounds"},{"key":"2555_CR12","doi-asserted-by":"crossref","unstructured":"Rajendran S, Thiyagarajan M, Singh B, Navrathan N (2021) A comparative study on effect of platelet rich plasma vs conventional dressing in healing rate of chronic diabetic ulcers. Biomedicine 41:849\u2013\u200954","DOI":"10.51248\/.v41i4.121"},{"key":"2555_CR13","doi-asserted-by":"publisher","first-page":"4551","DOI":"10.1016\/j.biomaterials.2007.06.037","volume":"28","author":"E Anitua","year":"2007","unstructured":"Anitua E, S\u00e1nchez M, Orive G, And\u00eda I (2007) The potential impact of the Preparation rich in growth factors (PRGF) in different medical fields. Biomaterials 28:4551\u20134560","journal-title":"Biomaterials"},{"key":"2555_CR14","doi-asserted-by":"crossref","unstructured":"Page MJ, McKenzie JE, Bossuyt PM et al (2021):The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.bmj 372","DOI":"10.1136\/bmj.n71"},{"key":"2555_CR15","doi-asserted-by":"publisher","first-page":"d5928","DOI":"10.1136\/bmj.d5928","volume":"343","author":"JP Higgins","year":"2011","unstructured":"Higgins JP, Altman DG, G\u00f8tzsche PC et al (2011) The Cochrane collaboration\u2019s tool for assessing risk of bias in randomised trials. BMJ 343:d5928","journal-title":"BMJ"},{"key":"2555_CR16","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1037\/1082-989X.11.2.193","volume":"11","author":"TB Huedo-Medina","year":"2006","unstructured":"Huedo-Medina TB, S\u00e1nchez-Meca J, Mar\u00edn-Mart\u00ednez F, Botella J (2006) Assessing heterogeneity in meta-analysis: Q statistic or I\u00b2. index?Psychological Methods 11:193","journal-title":"index?Psychological Methods"},{"key":"2555_CR17","first-page":"629","volume":"315","author":"M Egger","year":"1997","unstructured":"Egger M, Smith GD, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple. Graphical Test Bmj 315:629\u2013634","journal-title":"Graphical Test Bmj"},{"key":"2555_CR18","doi-asserted-by":"publisher","first-page":"16","DOI":"10.4103\/ejs.ejs_83_17","volume":"37","author":"E-SA Abd El-Mabood","year":"2018","unstructured":"Abd El-Mabood E-SA, Ali HE (2018) Platelet-rich plasma versus conventional dressing: does this really affect diabetic foot wound-healing outcomes?The. Egypt J Surg 37:16\u201326","journal-title":"Egypt J Surg"},{"key":"2555_CR19","doi-asserted-by":"crossref","unstructured":"Ahmed M, Reffat SA, Hassan A, Eskander F (2017) Platelet-rich plasma for the treatment of clean diabetic foot ulcers. Ann Vasc Surg 38:206\u2013\u200911","DOI":"10.1016\/j.avsg.2016.04.023"},{"key":"2555_CR20","first-page":"68","volume":"52","author":"VR Driver","year":"2006","unstructured":"Driver VR, Hanft J, Fylling CP, Beriou JM (2006) A prospective, randomized, controlled trial of autologous platelet-rich plasma gel for the treatment of diabetic foot ulcers. Ostomy Wound Manage 52:68","journal-title":"Ostomy Wound Manage"},{"key":"2555_CR21","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1007\/s00268-019-05316-0","volume":"44","author":"A Elsaid","year":"2020","unstructured":"Elsaid A, El-Said M, Emile S, Youssef M, Khafagy W, Elshobaky A (2020) Randomized controlled trial on autologous platelet\u2010rich plasma versus saline dressing in treatment of non\u2010healing diabetic foot ulcers. World J Surg 44:1294\u20131301","journal-title":"World J Surg"},{"key":"2555_CR22","first-page":"178","volume":"37","author":"AA Goda","year":"2018","unstructured":"Goda AA, Metwally M, Ewada A, Ewees H (2018) Platelet-rich plasma for the treatment of diabetic foot ulcer: a randomized, double-blind study.the Egyptian. J Surg 37:178\u2013184","journal-title":"J Surg"},{"key":"2555_CR23","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.avsg.2021.10.061","volume":"82","author":"EM Hossam","year":"2022","unstructured":"Hossam EM, Alserr AHK, Antonopoulos CN, Zaki A, Eldaly W (2022) Autologous platelet rich plasma promotes the healing of Non-Ischemic diabetic foot ulcers. Randomized Controlled Trial Annals Vascular Surg 82:165\u2013171","journal-title":"Randomized Controlled Trial Annals Vascular Surg"},{"key":"2555_CR24","doi-asserted-by":"publisher","first-page":"3815","DOI":"10.2147\/IJGM.S427401","volume":"16","author":"J Huang","year":"2023","unstructured":"Huang J, Sun J, Wang Q et al (2023) A novel wound therapy modality: autologous wound edge dotted Full-Thickness skin grafting improving diabetic foot ulcer healing. Int J Gen Med 16:3815\u20133827","journal-title":"Int J Gen Med"},{"key":"2555_CR25","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1111\/wrr.12294","volume":"23","author":"L Li","year":"2015","unstructured":"Li L, Chen D, Wang C et al (2015) Autologous platelet-rich gel for treatment of diabetic chronic refractory cutaneous ulcers: A prospective, randomized clinical trial. Wound Repair Regen 23:495\u2013505","journal-title":"Wound Repair Regen"},{"key":"2555_CR26","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.jss.2019.09.019","volume":"246","author":"X Liao","year":"2020","unstructured":"Liao X, Liang JX, Li SH et al (2020) Allogeneic Platelet-Rich plasma therapy as an effective and safe adjuvant method for chronic wounds. J Surg Res 246:284\u2013291","journal-title":"J Surg Res"},{"key":"2555_CR27","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.dsx.2021.03.005","volume":"15","author":"N Malekpour Alamdari","year":"2021","unstructured":"Malekpour Alamdari N, Shafiee A, Mirmohseni A, Besharat S (2021) Evaluation of the efficacy of platelet-rich plasma on healing of clean diabetic foot ulcers: A randomized clinical trial in Tehran. Iran Diabetes Metab Syndr 15:621\u2013626","journal-title":"Iran Diabetes Metab Syndr"},{"key":"2555_CR28","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1111\/j.1742-481X.2011.00797.x","volume":"8","author":"H Saad Setta","year":"2011","unstructured":"Saad Setta H, Elshahat A, Elsherbiny K, Massoud K, Safe I (2011) Platelet-rich plasma versus platelet-poor plasma in the management of chronic diabetic foot ulcers: a comparative study. Int Wound J 8:307\u2013312","journal-title":"Int Wound J"},{"key":"2555_CR29","doi-asserted-by":"publisher","first-page":"1374507","DOI":"10.3389\/fendo.2024.1374507","volume":"15","author":"X Sheng","year":"2024","unstructured":"Sheng X, Hu L, Li T et al (2024) Clinical efficacy and mechanism of the combination of autologous platelet-rich gel and Recombinant human acidic fibroblast growth factor in the management of refractory diabetic foot. Front Endocrinol (Lausanne) 15:1374507","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2555_CR30","first-page":"13796","volume":"10","author":"L Yang","year":"2017","unstructured":"Yang L, Gao L, Lv Y, Wang J (2017) Autologous platelet-rich gel for lower-extremity ischemic ulcers in patients with type 2 diabetes. Int J Clin Exp Med 10:13796\u201313801","journal-title":"Int J Clin Exp Med"},{"key":"2555_CR31","doi-asserted-by":"publisher","first-page":"e3657","DOI":"10.1002\/dmrr.3657","volume":"40","author":"NC Schaper","year":"2024","unstructured":"Schaper NC, van Netten JJ, Apelqvist J et al (2024) Practical guidelines on the prevention and management of diabetes-related foot disease (IWGDF 2023 update). Diabetes Metab Res Rev 40:e3657","journal-title":"Diabetes Metab Res Rev"},{"key":"2555_CR32","doi-asserted-by":"publisher","first-page":"7914","DOI":"10.3390\/ijms25147914","volume":"25","author":"PA Everts","year":"2024","unstructured":"Everts PA, Lana JF, Alexander RW et al (2024) Profound properties of protein-rich, platelet-rich plasma matrices as novel, multi-purpose biological platforms in tissue repair, regeneration, and wound healing. Int J Mol Sci 25:7914","journal-title":"Int J Mol Sci"},{"key":"2555_CR33","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.jhsa.2011.12.026","volume":"37","author":"JM Saucedo","year":"2012","unstructured":"Saucedo JM, Yaffe MA, Berschback JC, Hsu WK, Kalainov DM (2012) Platelet-rich plasma. J Hand Surg Am 37:587\u2013589 quiz 90","journal-title":"J Hand Surg Am"},{"key":"2555_CR34","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.1016\/j.mayocp.2021.01.030","volume":"96","author":"W Qu","year":"2021","unstructured":"Qu W, Wang Z, Hunt C et al (2021) The effectiveness and safety of Platelet-Rich plasma for chronic wounds: A systematic review and Meta-analysis. Mayo Clin Proc 96:2407\u20132417","journal-title":"Mayo Clin Proc"},{"key":"2555_CR35","first-page":"e43452","volume":"15","author":"V Kunder","year":"2023","unstructured":"Kunder V, Sharma KC, Rizvi Z, Soubelet R, Ducharme M (2023) The use of Platelet-Rich plasma in the treatment of diabetic foot ulcers. Scoping Rev Cureus 15:e43452","journal-title":"Scoping Rev Cureus"},{"key":"2555_CR36","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1097\/01.ASW.0000577140.19174.9e","volume":"32","author":"W Gude","year":"2019","unstructured":"Gude W, Hagan D, Abood F, Clausen P (2019) Aurix gel is an effective intervention for chronic diabetic foot ulcers: a pragmatic randomized controlled trial. Adv Skin Wound Care 32:416\u2013426","journal-title":"Adv Skin Wound Care"}],"container-title":["Acta Diabetologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-025-02555-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00592-025-02555-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-025-02555-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:41:16Z","timestamp":1761907276000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00592-025-02555-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,2]]},"references-count":36,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["2555"],"URL":"https:\/\/doi.org\/10.1007\/s00592-025-02555-7","relation":{},"ISSN":["1432-5233"],"issn-type":[{"value":"1432-5233","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,2]]},"assertion":[{"value":"3 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"This is a meta-analysis, not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}