{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T15:39:15Z","timestamp":1780328355808,"version":"3.54.1"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"The fund for Endocrine and metabolic diseases key laboratory of Shanxi Province","award":["(202104010910009)"],"award-info":[{"award-number":["(202104010910009)"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Diabetol"],"DOI":"10.1007\/s00592-025-02603-2","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T11:51:56Z","timestamp":1762257116000},"page":"325-332","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mechanism and treatment progress of endoplasmic reticulum stress pathway in diabetic neuropathy"],"prefix":"10.1007","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5455-5664","authenticated-orcid":false,"given":"Nannan","family":"Lai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"issue":"Suppl","key":"2603_CR1","doi-asserted-by":"publisher","first-page":"S60","DOI":"10.1016\/j.molmet.2019.06.012","volume":"27s","author":"R Ghosh","year":"2019","unstructured":"Ghosh R, Colon-Negron K, Papa FR (2019) Endoplasmic reticulum stress, degeneration of pancreatic islet \u03b2-cells, and therapeutic modulation of the unfolded protein response in diabetes. Mol Metab 27s(Suppl):S60-s68","journal-title":"Mol Metab"},{"issue":"2","key":"2603_CR2","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1007\/s00125-012-2762-3","volume":"56","author":"DL Eizirik","year":"2013","unstructured":"Eizirik DL, Miani M, Cardozo AK (2013) Signalling danger: Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation. Diabetologia 56(2):234\u2013241","journal-title":"Diabetologia"},{"issue":"4","key":"2603_CR3","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1089\/ars.2013.5807","volume":"21","author":"PD O\u2019Brien","year":"2014","unstructured":"O\u2019Brien PD et al (2014) ER stress in diabetic peripheral neuropathy: A new therapeutic target. Antioxid Redox Signal 21(4):621\u2013633","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"2603_CR4","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20950-9","volume":"8","author":"W Yao","year":"2018","unstructured":"Yao W et al (2018) IRE1\u03b1 siRNA relieves endoplasmic reticulum stress-induced apoptosis and alleviates diabetic peripheral neuropathy in vivo and in vitro. Sci Rep 8(1):2579","journal-title":"Sci Rep"},{"key":"2603_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00602","volume":"8","author":"Y Wu","year":"2020","unstructured":"Wu Y et al (2020) The reciprocal causation of the ASK1-JNK1\/2 pathway and endoplasmic reticulum stress in diabetes-induced cognitive decline. Front Cell Dev Biol 8:602","journal-title":"Front Cell Dev Biol"},{"issue":"4","key":"2603_CR6","doi-asserted-by":"publisher","first-page":"515","DOI":"10.4103\/0971-5916.200887","volume":"144","author":"L Demirtas","year":"2016","unstructured":"Demirtas L et al (2016) Apoptosis, autophagy & endoplasmic reticulum stress in diabetes mellitus. Indian J Med Res 144(4):515\u2013524","journal-title":"Indian J Med Res"},{"issue":"1\u20132","key":"2603_CR7","first-page":"29","volume":"569","author":"M Schr\u00f6der","year":"2005","unstructured":"Schr\u00f6der M, Kaufman RJ (2005) ER stress and the unfolded protein response. Mutat Res 569(1\u20132):29\u201363","journal-title":"Mutat Res"},{"issue":"3","key":"2603_CR8","first-page":"411","volume":"125","author":"S Sundar Rajan","year":"2007","unstructured":"Sundar Rajan S et al (2007) Endoplasmic reticulum (ER) stress & diabetes. Indian J Med Res 125(3):411\u2013424","journal-title":"Indian J Med Res"},{"key":"2603_CR9","doi-asserted-by":"publisher","DOI":"10.2174\/0113816128362557250314054528","author":"H Yu","year":"2025","unstructured":"Yu H et al (2025) Qizhi kebitong formula ameliorates sciatic nerve injury in Streptozocin-induced diabetic mice through PERK\/ATF4\/CHOP endoplasmic reticulum stress signaling pathway. Curr Pharm Des. https:\/\/doi.org\/10.2174\/0113816128362557250314054528","journal-title":"Curr Pharm Des"},{"key":"2603_CR10","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-015-0031-7","volume":"16","author":"ZS Wang","year":"2015","unstructured":"Wang ZS et al (2015) Astragaloside IV attenuates proteinuria in streptozotocin-induced diabetic nephropathy via the inhibition of endoplasmic reticulum stress. BMC Nephrol 16:44","journal-title":"BMC Nephrol"},{"issue":"8","key":"2603_CR11","doi-asserted-by":"publisher","first-page":"2276","DOI":"10.1007\/s00125-012-2573-6","volume":"55","author":"C Sims-Robinson","year":"2012","unstructured":"Sims-Robinson C (2012) Central nervous system endoplasmic reticulum stress in a murine model of type 2 diabetes. Diabetologia 55(8):2276\u20132284","journal-title":"Diabetologia"},{"issue":"1","key":"2603_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02175-1","volume":"10","author":"Y Yang","year":"2025","unstructured":"Yang Y et al (2025) Diabetic neuropathy: cutting-edge research and future directions. Signal Transduct Target Ther 10(1):132","journal-title":"Signal Transduct Target Ther"},{"key":"2603_CR13","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.expneurol.2012.11.001","volume":"247","author":"S Lupachyk","year":"2013","unstructured":"Lupachyk S (2013) Endoplasmic reticulum stress contributes to prediabetic peripheral neuropathy. Exp Neurol 247:342\u2013348","journal-title":"Exp Neurol"},{"issue":"1","key":"2603_CR14","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-023-00698-3","volume":"29","author":"Y Hu","year":"2023","unstructured":"Hu Y et al (2023) Compound qiying granules alleviates diabetic peripheral neuropathy by inhibiting endoplasmic reticulum stress and apoptosis. Mol Med 29(1):98","journal-title":"Mol Med"},{"issue":"1","key":"2603_CR15","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-025-01843-1","volume":"25","author":"X Zeng","year":"2025","unstructured":"Zeng X et al (2025) Relationship of Asprosin and diabetes: a meta-analysis. BMC Endocr Disord 25(1):15","journal-title":"BMC Endocr Disord"},{"issue":"42","key":"2603_CR16","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001604","volume":"94","author":"X Zheng","year":"2015","unstructured":"Zheng X (2015) Relationship between myo-inositol supplementary and gestational diabetes mellitus: a meta-analysis. Medicine 94(42):e1604","journal-title":"Medicine"}],"container-title":["Acta Diabetologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-025-02603-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00592-025-02603-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-025-02603-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T17:08:10Z","timestamp":1772557690000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00592-025-02603-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,4]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["2603"],"URL":"https:\/\/doi.org\/10.1007\/s00592-025-02603-2","relation":{},"ISSN":["1432-5233"],"issn-type":[{"value":"1432-5233","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,4]]},"assertion":[{"value":"10 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare that there are no financial or non-financial conflicts of interest related to this work. This review did not receive specific funding from any commercial entity.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}