{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T09:01:47Z","timestamp":1779958907504,"version":"3.53.1"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Diabetol"],"DOI":"10.1007\/s00592-026-02660-1","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T09:35:54Z","timestamp":1771407354000},"page":"865-886","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac-restricted Nrf2 activation blocks diabetic cardiomyopathy via Akt-driven glycolysis and AMPK-PGC-1\u03b1 fatty-acid oxidation"],"prefix":"10.1007","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3447-9360","authenticated-orcid":false,"given":"Ying","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayun","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zunyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuling","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"issue":"1","key":"2660_CR1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00125-017-4390-4","volume":"61","author":"G Jia","year":"2018","unstructured":"Jia G, Whaley-Connell A, Sowers JR (2018) Diabetic cardiomyopathy: a hyperglycaemia- and insulin-resistance-induced heart disease. Diabetologia 61(1):21\u201328","journal-title":"Diabetologia"},{"issue":"4","key":"2660_CR2","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1007\/s00125-014-3171-6","volume":"57","author":"H Bugger","year":"2014","unstructured":"Bugger H, Abel ED (2014) Molecular mechanisms of diabetic cardiomyopathy. Diabetologia 57(4):660\u2013671","journal-title":"Diabetologia"},{"issue":"11","key":"2660_CR3","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1161\/CIRCRESAHA.120.315913","volume":"126","author":"RH Ritchie","year":"2020","unstructured":"Ritchie RH, Abel ED (2020) Basic mechanisms of diabetic heart disease. Circ Res 126(11):1501\u20131525","journal-title":"Circ Res"},{"issue":"9","key":"2660_CR4","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/s41569-020-0339-2","volume":"17","author":"Y Tan","year":"2020","unstructured":"Tan Y, Zhang Z, Zheng C, Wintergerst KA, Keller BB, Cai L (2020) Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence. Nat Rev Cardiol 17(9):585\u2013607","journal-title":"Nat Rev Cardiol"},{"issue":"1","key":"2660_CR5","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1038\/s41420-023-01553-4","volume":"9","author":"JL Huo","year":"2023","unstructured":"Huo JL, Feng Q, Pan S, Fu WJ, Liu Z, Liu Z (2023) Diabetic cardiomyopathy: early diagnostic biomarkers, pathogenetic mechanisms, and therapeutic interventions. Cell Death Discov 9(1):256","journal-title":"Cell Death Discov"},{"issue":"1","key":"2660_CR6","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s10741-013-9377-8","volume":"19","author":"M Isfort","year":"2014","unstructured":"Isfort M, Stevens SC, Schaffer S, Jong CJ, Wold LE (2014) Metabolic dysfunction in diabetic cardiomyopathy. Heart Fail Rev 19(1):35\u201348","journal-title":"Heart Fail Rev"},{"key":"2660_CR7","doi-asserted-by":"publisher","first-page":"1375400","DOI":"10.3389\/fcvm.2024.1375400","volume":"11","author":"Y Zeng","year":"2024","unstructured":"Zeng Y, Li Y, Jiang W, Hou N (2024) Molecular mechanisms of metabolic dysregulation in diabetic cardiomyopathy. Front Cardiovasc Med 11:1375400","journal-title":"Front Cardiovasc Med"},{"key":"2660_CR8","doi-asserted-by":"publisher","first-page":"110817","DOI":"10.1016\/j.biopha.2020.110817","volume":"132","author":"L Li","year":"2020","unstructured":"Li L, Chen X, Su C, Wang Q, Li R, Jiao W, Luo H, Tian Y, Tang J, Li X et al (2020) Si-Miao-Yong-An Decoction preserves cardiac function and regulates GLC\/AMPK\/NF-\u03baB and GLC\/PPAR\u03b1\/PGC-1\u03b1 pathways in diabetic mice. Biomed Pharmacother 132:110817","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"2660_CR9","doi-asserted-by":"publisher","first-page":"826","DOI":"10.7150\/ijbs.65938","volume":"18","author":"Z Guo","year":"2022","unstructured":"Guo Z, Tuo H, Tang N, Liu FY, Ma SQ, An P, Yang D, Wang MY, Fan D, Yang Z et al (2022) Neuraminidase 1 deficiency attenuates cardiac dysfunction, oxidative stress, fibrosis, inflammatory via AMPK-SIRT3 pathway in diabetic cardiomyopathy mice. Int J Biol Sci 18(2):826\u2013840","journal-title":"Int J Biol Sci"},{"issue":"5","key":"2660_CR10","doi-asserted-by":"publisher","first-page":"337","DOI":"10.4093\/dmj.2014.38.5.337","volume":"38","author":"J Chen","year":"2014","unstructured":"Chen J, Zhang Z, Cai L (2014) Diabetic cardiomyopathy and its prevention by nrf2: current status. Diabetes Metab J 38(5):337\u2013345","journal-title":"Diabetes Metab J"},{"key":"2660_CR11","doi-asserted-by":"publisher","first-page":"1492499","DOI":"10.3389\/fcvm.2025.1492499","volume":"12","author":"H Gu","year":"2025","unstructured":"Gu H, Liu J, Jiang J, Ma H, Wu S, Sun L, Yao L (2025) The role of Nrf2 signaling pathway in diabetic cardiomyopathy: from pathogenesis to traditional Chinese medicine interventions. Front Cardiovasc Med 12:1492499","journal-title":"Front Cardiovasc Med"},{"issue":"2","key":"2660_CR12","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1152\/physiolgenomics.00041.2017","volume":"50","author":"QM Chen","year":"2018","unstructured":"Chen QM, Maltagliati AJ (2018) Nrf2 at the heart of oxidative stress and cardiac protection. Physiol Genomics 50(2):77\u201397","journal-title":"Physiol Genomics"},{"issue":"12","key":"2660_CR13","doi-asserted-by":"publisher","first-page":"2463","DOI":"10.2337\/db22-0623","volume":"71","author":"M Dodson","year":"2022","unstructured":"Dodson M, Shakya A, Anandhan A, Chen J, Garcia JGN, Zhang DD (2022) NRF2 and diabetes: the Good, the Bad, and the complex. Diabetes 71(12):2463\u20132476","journal-title":"Diabetes"},{"issue":"2","key":"2660_CR14","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.apsb.2021.10.005","volume":"12","author":"X Wang","year":"2022","unstructured":"Wang X, Chen X, Zhou W, Men H, Bao T, Sun Y, Wang Q, Tan Y, Keller BB, Tong Q et al (2022) Ferroptosis is essential for diabetic cardiomyopathy and is prevented by Sulforaphane via AMPK\/NRF2 pathways. Acta Pharm Sin B 12(2):708\u2013722","journal-title":"Acta Pharm Sin B"},{"issue":"2","key":"2660_CR15","doi-asserted-by":"publisher","first-page":"e31149","DOI":"10.1002\/jcp.31149","volume":"239","author":"G Yang","year":"2024","unstructured":"Yang G, Zhang Q, Dong C, Hou G, Li J, Jiang X, Xin Y (2024) Nrf2 prevents diabetic cardiomyopathy via antioxidant effect and normalization of glucose and lipid metabolism in the heart. J Cell Physiol 239(2):e31149","journal-title":"J Cell Physiol"},{"issue":"4","key":"2660_CR16","doi-asserted-by":"publisher","first-page":"612","DOI":"10.7150\/ijms.88476","volume":"21","author":"Z Song","year":"2024","unstructured":"Song Z, Wang J, Zhang L (2024) Ferroptosis: A new mechanism in diabetic cardiomyopathy. Int J Med Sci 21(4):612\u2013622","journal-title":"Int J Med Sci"},{"issue":"3","key":"2660_CR17","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.cell.2017.04.001","volume":"169","author":"BD Manning","year":"2017","unstructured":"Manning BD, Toker A (2017) AKT\/PKB signaling: navigating the network. Cell 169(3):381\u2013405","journal-title":"Cell"},{"issue":"1","key":"2660_CR18","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.ccr.2012.05.016","volume":"22","author":"Y Mitsuishi","year":"2012","unstructured":"Mitsuishi Y, Taguchi K, Kawatani Y, Shibata T, Nukiwa T, Aburatani H, Yamamoto M, Motohashi H (2012) Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. Cancer Cell 22(1):66\u201379","journal-title":"Cancer Cell"},{"issue":"2","key":"2660_CR19","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1093\/cvr\/cvae250","volume":"121","author":"A Zoccarato","year":"2025","unstructured":"Zoccarato A, Smyrnias I, Reumiller CM, Hafstad AD, Chong M, Richards DA, Santos CXC, Visnagri A, Verma S, Bromage DI et al (2025) NRF2 activation in the heart induces glucose metabolic reprogramming and reduces cardiac dysfunction via upregulation of the Pentose phosphate pathway. Cardiovasc Res 121(2):339\u2013352","journal-title":"Cardiovasc Res"},{"issue":"9","key":"2660_CR20","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.1161\/ATVBAHA.111.241984","volume":"32","author":"ED Abel","year":"2012","unstructured":"Abel ED, O\u2019Shea KM, Ramasamy R (2012) Insulin resistance: metabolic mechanisms and consequences in the heart. Arterioscler Thromb Vasc Biol 32(9):2068\u20132076","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2660_CR21","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/j.redox.2017.04.038","volume":"12","author":"G Shanmugam","year":"2017","unstructured":"Shanmugam G, Narasimhan M, Tamowski S, Darley-Usmar V, Rajasekaran NS (2017) Constitutive activation of Nrf2 induces a stable reductive state in the mouse myocardium. Redox Biol 12:937\u2013945","journal-title":"Redox Biol"},{"key":"2660_CR22","doi-asserted-by":"crossref","unstructured":"Marino F, Salerno N, Scalise M, Salerno L, Torella A, Molinaro C, Chiefalo A, Filardo A, Siracusa C, Panuccio G et al (2023) Streptozotocin-Induced type 1 and 2 diabetes mellitus mouse models show different Functional, cellular and molecular patterns of diabetic cardiomyopathy. Int J Mol Sci 24(2):1132","DOI":"10.3390\/ijms24021132"},{"issue":"4","key":"2660_CR23","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/BF01002772","volume":"11","author":"LC Junqueira","year":"1979","unstructured":"Junqueira LC, Bignolas G, Brentani RR (1979) Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections. Histochem J 11(4):447\u2013455","journal-title":"Histochem J"},{"key":"2660_CR24","first-page":"271","volume":"357","author":"TD O\u2019Connell","year":"2007","unstructured":"O\u2019Connell TD, Rodrigo MC, Simpson PC (2007) Isolation and culture of adult mouse cardiac myocytes. Methods Mol Biol 357:271\u2013296","journal-title":"Methods Mol Biol"},{"issue":"3","key":"2660_CR25","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.lfs.2006.08.038","volume":"80","author":"Q Li","year":"2006","unstructured":"Li Q, Fang CX, Nunn JM, Zhang J, LaCour KH, Ren J (2006) Characterization of cardiomyocyte excitation\u2013contraction coupling in the FVB\/N-C57BL\/6 intercrossed chocolate brown mice. Life Sci 80(3):187\u2013192","journal-title":"Life Sci"},{"issue":"4","key":"2660_CR26","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","volume":"55","author":"SA Bustin","year":"2009","unstructured":"Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, Kubista M, Mueller R, Nolan T, Pfaffl MW, Shipley GL et al (2009) The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem 55(4):611\u2013622","journal-title":"Clin Chem"},{"issue":"1","key":"2660_CR27","doi-asserted-by":"publisher","first-page":"100245","DOI":"10.1016\/j.xpro.2020.100245","volume":"2","author":"X Gu","year":"2021","unstructured":"Gu X, Ma Y, Liu Y, Wan Q (2021) Measurement of mitochondrial respiration in adherent cells by seahorse XF96 cell Mito stress test. STAR Protoc 2(1):100245","journal-title":"STAR Protoc"},{"issue":"14","key":"2660_CR28","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1093\/bioinformatics\/btm254","volume":"23","author":"S Davis","year":"2007","unstructured":"Davis S, Meltzer PS (2007) GEOquery: a Bridge between the gene expression omnibus (GEO) and bioconductor. Bioinformatics 23(14):1846\u20131847","journal-title":"Bioinformatics"},{"issue":"12","key":"2660_CR29","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S (2014) Moderated Estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15(12):550","journal-title":"Genome Biol"},{"issue":"7","key":"2660_CR30","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W (2015) Smyth GK: Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res 43(7):e47","journal-title":"Nucleic Acids Res"},{"key":"2660_CR31","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder P, Horvath S (2008) WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 9:559","journal-title":"BMC Bioinformatics"},{"issue":"43","key":"2660_CR32","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES et al (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 102(43):15545\u201315550","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"2660_CR33","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y, He QY (2012) ClusterProfiler: an R package for comparing biological themes among gene clusters. Omics 16(5):284\u2013287","journal-title":"Omics"},{"issue":"7","key":"2660_CR34","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","volume":"177","author":"T Stuart","year":"2019","unstructured":"Stuart T, Butler A, Hoffman P, Hafemeister C, Papalexi E, Mauck WM, Hao Y, Stoeckius M, Smibert P, Satija R (2019) Comprehensive integration of Single-Cell data. Cell 177(7):1888\u20131902e1821","journal-title":"Cell"},{"issue":"1","key":"2660_CR35","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1186\/s13059-019-1874-1","volume":"20","author":"C Hafemeister","year":"2019","unstructured":"Hafemeister C, Satija R (2019) Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression. Genome Biol 20(1):296","journal-title":"Genome Biol"},{"key":"2660_CR36","doi-asserted-by":"crossref","unstructured":"Zappia L, Oshlack A (2018) Clustering trees: a visualization for evaluating clusterings at multiple resolutions. Gigascience 7(7):giy083","DOI":"10.1093\/gigascience\/giy083"},{"issue":"1","key":"2660_CR37","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1186\/s12859-018-2435-4","volume":"19","author":"M Foroutan","year":"2018","unstructured":"Foroutan M, Bhuva DD, Lyu R, Horan K, Cursons J, Davis MJ (2018) Single sample scoring of molecular phenotypes. BMC Bioinformatics 19(1):404","journal-title":"BMC Bioinformatics"},{"issue":"6294","key":"2660_CR38","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1126\/science.aaf2403","volume":"353","author":"PL St\u00e5hl","year":"2016","unstructured":"St\u00e5hl PL, Salm\u00e9n F, Vickovic S, Lundmark A, Navarro JF, Magnusson J, Giacomello S, Asp M, Westholm JO, Huss M et al (2016) Visualization and analysis of gene expression in tissue sections by Spatial transcriptomics. Science 353(6294):78\u201382","journal-title":"Science"},{"key":"2660_CR39","doi-asserted-by":"publisher","first-page":"697643","DOI":"10.3389\/fphar.2021.697643","volume":"12","author":"L Chen","year":"2021","unstructured":"Chen L, Han Z, Shi Z, Liu C, Lu Q (2021) Melatonin alleviates renal injury in mouse model of sepsis. Front Pharmacol 12:697643","journal-title":"Front Pharmacol"},{"key":"2660_CR40","doi-asserted-by":"publisher","first-page":"1146960","DOI":"10.3389\/fphar.2023.1146960","volume":"14","author":"X Guo","year":"2023","unstructured":"Guo X, Lei M, Zhao J, Wu M, Ren Z, Yang X, Ouyang C, Liu X, Liu C, Chen Q (2023) Tirzepatide ameliorates Spatial learning and memory impairment through modulation of aberrant insulin resistance and inflammation response in diabetic rats. Front Pharmacol 14:1146960","journal-title":"Front Pharmacol"},{"key":"2660_CR41","doi-asserted-by":"publisher","first-page":"111275","DOI":"10.1016\/j.fct.2020.111275","volume":"140","author":"C Li","year":"2020","unstructured":"Li C, Song P, Lei F, Lu S, Xu D, Zheng G, Yang X, Wu Y, Ma P (2020) The synergistic or adjuvant effect of DINP combined with OVA as a possible mechanism to promote an immune response. Food Chem Toxicol 140:111275","journal-title":"Food Chem Toxicol"},{"issue":"1","key":"2660_CR42","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1177\/0748233719900861","volume":"36","author":"F Liang","year":"2020","unstructured":"Liang F, Yan B (2020) Oxidative damage in the liver and kidney induced by dermal exposure to diisononyl phthalate in Balb\/c mice. Toxicol Ind Health 36(1):30\u201340","journal-title":"Toxicol Ind Health"},{"key":"2660_CR43","doi-asserted-by":"publisher","first-page":"850053","DOI":"10.3389\/fphar.2022.850053","volume":"13","author":"W Liao","year":"2022","unstructured":"Liao W, Rao Z, Wu L, Chen Y, Li C (2022) Cariporide attenuates Doxorubicin-Induced cardiotoxicity in rats by inhibiting oxidative Stress, inflammation and apoptosis partly through regulation of Akt\/GSK-3\u03b2 and Sirt1 signaling pathway. Front Pharmacol 13:850053","journal-title":"Front Pharmacol"},{"key":"2660_CR44","doi-asserted-by":"crossref","unstructured":"Min Q, Liu J, Zhang Y, Yang B, Wan Y, Wu J (2020) Dual network hydrogels incorporated with bone morphogenic Protein-7-Loaded hyaluronic acid complex nanoparticles for inducing chondrogenic differentiation of Synovium-Derived mesenchymal stem cells. Pharmaceutics 12(7):613","DOI":"10.3390\/pharmaceutics12070613"},{"key":"2660_CR45","doi-asserted-by":"crossref","unstructured":"Min Q, Yu X, Liu J, Zhang Y, Wan Y, Wu J (2020) Controlled delivery of Insulin-like growth Factor-1 from bioactive Glass-Incorporated Alginate-Poloxamer\/Silk fibroin hydrogels. Pharmaceutics 12(6):574","DOI":"10.3390\/pharmaceutics12060574"},{"key":"2660_CR46","doi-asserted-by":"publisher","first-page":"152881","DOI":"10.1016\/j.tox.2021.152881","volume":"460","author":"C Wang","year":"2021","unstructured":"Wang C, Hu L, Guo S, Yao Q, Liu X, Zhang B, Meng X, Yang X (2021) Phosphocreatine attenuates doxorubicin-induced cardiotoxicity by inhibiting oxidative stress and activating TAK1 to promote myocardial survival in vivo and in vitro. Toxicology 460:152881","journal-title":"Toxicology"},{"key":"2660_CR47","doi-asserted-by":"publisher","first-page":"110955","DOI":"10.1016\/j.fct.2019.110955","volume":"136","author":"X Wang","year":"2020","unstructured":"Wang X, Yan X, Yang Y, Yang W, Zhang Y, Wang J, Ye D, Wu Y, Ma P, Yan B (2020) Dibutyl phthalate-mediated oxidative stress induces Splenic injury in mice and the attenuating effects of vitamin E and Curcumin. Food Chem Toxicol 136:110955","journal-title":"Food Chem Toxicol"},{"issue":"1","key":"2660_CR48","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41401-021-00635-2","volume":"43","author":"ZY Zhu","year":"2022","unstructured":"Zhu ZY, Liu YD, Gong Y, Jin W, Topchiy E, Turdi S, Gao YF, Culver B, Wang SY, Ge W et al (2022) Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP\/PS1 murine model of alzheimer\u2019s disease via Inhibition of ACSL4-dependent ferroptosis. Acta Pharmacol Sin 43(1):39\u201349","journal-title":"Acta Pharmacol Sin"},{"key":"2660_CR49","doi-asserted-by":"publisher","first-page":"116113","DOI":"10.1016\/j.biopha.2023.116113","volume":"171","author":"C Zhao","year":"2024","unstructured":"Zhao C, Zhu X, Tan J, Mei C, Cai X, Kong F (2024) Lipid-based nanoparticles to address the limitations of GBM therapy by overcoming the blood-brain barrier, targeting glioblastoma stem cells, and counteracting the immunosuppressive tumor microenvironment. Biomed Pharmacother 171:116113","journal-title":"Biomed Pharmacother"},{"key":"2660_CR50","doi-asserted-by":"publisher","first-page":"152933","DOI":"10.1016\/j.tox.2021.152933","volume":"462","author":"Z Zhang","year":"2021","unstructured":"Zhang Z, Yu J, Xie J, Liu D, Fan Y, Ma H, Wang C, Hong Z (2021) Improvement roles of zinc supplementation in low dose lead induced testicular damage and glycolytic Inhibition in mice. Toxicology 462:152933","journal-title":"Toxicology"},{"issue":"1","key":"2660_CR51","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1080\/10717544.2021.1905749","volume":"28","author":"J Zhang","year":"2021","unstructured":"Zhang J, Hu X, Zheng G, Yao H, Liang H (2021) In vitro and in vivo antitumor effects of lupeol-loaded galactosylated liposomes. Drug Deliv 28(1):709\u2013718","journal-title":"Drug Deliv"},{"key":"2660_CR52","doi-asserted-by":"publisher","first-page":"653887","DOI":"10.3389\/fphar.2021.653887","volume":"12","author":"Y Ye","year":"2021","unstructured":"Ye Y, Liu X, Wu N, Han Y, Wang J, Yu Y, Chen Q (2021) Efficacy and safety of Berberine alone for several metabolic disorders: A systematic review and Meta-Analysis of randomized clinical trials. Front Pharmacol 12:653887","journal-title":"Front Pharmacol"},{"key":"2660_CR53","doi-asserted-by":"publisher","first-page":"109920","DOI":"10.1016\/j.biopha.2020.109920","volume":"125","author":"Y Xu","year":"2020","unstructured":"Xu Y, Ouyang C, Lyu D, Lin Z, Zheng W, Xiao F, Xu Z, Ding L (2020) Diabetic nephropathy execrates epithelial-to-mesenchymal transition (EMT) via miR-2467-3p\/Twist1 pathway. Biomed Pharmacother 125:109920","journal-title":"Biomed Pharmacother"},{"key":"2660_CR54","doi-asserted-by":"publisher","first-page":"640758","DOI":"10.3389\/fphar.2021.640758","volume":"12","author":"Y Wu","year":"2021","unstructured":"Wu Y, Chen Q, Wen B, Wu N, He B, Chen J (2021) Berberine reduces A\u03b2(42) deposition and Tau hyperphosphorylation via ameliorating Endoplasmic reticulum stress. Front Pharmacol 12:640758","journal-title":"Front Pharmacol"},{"key":"2660_CR55","doi-asserted-by":"publisher","first-page":"113732","DOI":"10.1016\/j.fct.2023.113732","volume":"175","author":"J Wen","year":"2023","unstructured":"Wen J, Qin S, Li Y, Zhang P, Zhan X, Fang M, Shi C, Mu W, Kan W, Zhao J et al (2023) Flavonoids derived from licorice suppress LPS-induced acute lung injury in mice by inhibiting the cGAS-STING signaling pathway. Food Chem Toxicol 175:113732","journal-title":"Food Chem Toxicol"},{"issue":"11","key":"2660_CR56","doi-asserted-by":"publisher","first-page":"2300","DOI":"10.1038\/s41401-024-01327-3","volume":"45","author":"BL Yang","year":"2024","unstructured":"Yang BL, Long YY, Lei Q, Gao F, Ren WX, Cao YL, Wu D, Xu LY, Qu J, Li H et al (2024) Lethal pulmonary thromboembolism in mice induced by intravenous human umbilical cord mesenchymal stem cell-derived large extracellular vesicles in a dose- and tissue factor-dependent manner. Acta Pharmacol Sin 45(11):2300\u20132312","journal-title":"Acta Pharmacol Sin"},{"key":"2660_CR57","doi-asserted-by":"publisher","first-page":"813073","DOI":"10.3389\/fphar.2022.813073","volume":"13","author":"Y Yang","year":"2022","unstructured":"Yang Y, Ge FL, Tang JF, Qin SL, Zeng R, Yao ML, Xiao XH, Bai ZF, Tang CL (2022) A review of herb-induced liver injury in Mainland China. Front Pharmacol 13:813073","journal-title":"Front Pharmacol"},{"key":"2660_CR58","doi-asserted-by":"publisher","first-page":"1459539","DOI":"10.3389\/fphar.2024.1459539","volume":"15","author":"N Yu","year":"2024","unstructured":"Yu N, Fu Y, Fan Q, Lin L, Ning Z, Leng D, Hu M, She T (2024) Antitumor properties of Griseofulvin and its toxicity. Front Pharmacol 15:1459539","journal-title":"Front Pharmacol"},{"issue":"1","key":"2660_CR59","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/s41401-023-01144-0","volume":"45","author":"W Yu","year":"2024","unstructured":"Yu W, Wang L, Ren WY, Xu HX, Wu NN, Yu DH, Reiter RJ, Zha WL, Guo QD, Ren J (2024) SGLT2 inhibitor empagliflozin alleviates cardiac remodeling and contractile anomalies in a FUNDC1-dependent manner in experimental parkinson\u2019s disease. Acta Pharmacol Sin 45(1):87\u201397","journal-title":"Acta Pharmacol Sin"},{"key":"2660_CR60","doi-asserted-by":"publisher","first-page":"175836","DOI":"10.1016\/j.ejphar.2023.175836","volume":"953","author":"YN Yu","year":"2023","unstructured":"Yu YN, Ren YY, Shao ZL, Chen BL, Cui BY, Chao CY, Guo LJ, Guo S, Zhang MX, Wang SX et al (2023) Perillaldehyde improves diabetic cardiomyopathy by upregulating miR-133a-3p to regulate GSK-3beta. Eur J Pharmacol 953:175836","journal-title":"Eur J Pharmacol"},{"key":"2660_CR61","doi-asserted-by":"publisher","first-page":"110736","DOI":"10.1016\/j.intimp.2023.110736","volume":"123","author":"W Zha","year":"2023","unstructured":"Zha W, Zhao Q, Xiao Y, Gan Y, Wei J, Yu M, Xu Y, Xu Q, Wu S, Yu W (2023) Mitochonic acid 5 rescues cardiomyocytes from doxorubicin-induced toxicity via repressing the TNF-alpha\/NF-kappaB\/NLRP3-mediated pyroptosis. Int Immunopharmacol 123:110736","journal-title":"Int Immunopharmacol"},{"issue":"10","key":"2660_CR62","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1097\/CAD.0000000000001366","volume":"33","author":"C Zhan","year":"2022","unstructured":"Zhan C, Zhou H, Zhang W, Si C (2022) Hsa_circ_0000877 facilitates the progression of diffuse large B-cell lymphoma by miR-370-3p\/mitogen-activated protein kinase kinase kinase kinase 4\/Hippo pathway. Anticancer Drugs 33(10):1091\u20131102","journal-title":"Anticancer Drugs"},{"key":"2660_CR63","doi-asserted-by":"publisher","first-page":"736655","DOI":"10.3389\/fphar.2021.736655","volume":"12","author":"P Zhang","year":"2021","unstructured":"Zhang P, Cheng X, Sun H, Li Y, Mei W, Zeng C (2021) Atractyloside protect mice against liver steatosis by activation of autophagy via ANT-AMPK-mTORC1 signaling pathway. Front Pharmacol 12:736655","journal-title":"Front Pharmacol"},{"issue":"2","key":"2660_CR64","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1159\/000527465","volume":"108","author":"P Zhang","year":"2023","unstructured":"Zhang P, Sun H, Yang D, Wang Y, Cheng J, Zeng C (2023) Oral administration of Artemisia argyi polysaccharide increases Estrogen level and maintains blood lipid homeostasis in ovariectomized rats. Pharmacology 108(2):147\u2013156","journal-title":"Pharmacology"},{"key":"2660_CR65","doi-asserted-by":"publisher","first-page":"1337749","DOI":"10.3389\/fphar.2024.1337749","volume":"15","author":"S Zhang","year":"2024","unstructured":"Zhang S, Pu Y, Liu J, Li L, An C, Wu Y, Zhang W, Zhang W, Qu S, Yan W (2024) Exploring the multifaceted potential of (R)-ketamine beyond antidepressant applications. Front Pharmacol 15:1337749","journal-title":"Front Pharmacol"},{"issue":"8","key":"2660_CR66","doi-asserted-by":"publisher","first-page":"3476","DOI":"10.1016\/j.apsb.2024.05.003","volume":"14","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Liu LH, Xu B, Zhang Z, Yang M, He Y, Chen J, Zhang Y, Hu Y, Chen X et al (2024) Screening antimicrobial peptides and probiotics using multiple deep learning and directed evolution strategies. Acta Pharm Sin B 14(8):3476\u20133492","journal-title":"Acta Pharm Sin B"},{"key":"2660_CR67","doi-asserted-by":"publisher","first-page":"760338","DOI":"10.3389\/fphar.2021.760338","volume":"12","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Xiao F, Zhou Q, Diao T, Zhang M, Liu D, Wang Z, Huang T, Wu Y, Bai Y et al (2021) The potential protective effect of iridoid glycosides isolated from osmanthus Fragrans seeds against the development of immune liver injury in mice. Front Pharmacol 12:760338","journal-title":"Front Pharmacol"},{"key":"2660_CR68","doi-asserted-by":"publisher","first-page":"111785","DOI":"10.1016\/j.intimp.2024.111785","volume":"131","author":"ZW Zhang","year":"2024","unstructured":"Zhang ZW, Tang MQ, Liu W, Song Y, Gao MJ, Ni P, Zhang DD, Mo QG, Zhao BQ (2024) Dapagliflozin prevents kidney podocytes pyroptosis via miR-155-5p\/HO-1\/NLRP3 axis modulation. Int Immunopharmacol 131:111785","journal-title":"Int Immunopharmacol"},{"issue":"11","key":"2660_CR69","doi-asserted-by":"publisher","first-page":"e23830","DOI":"10.1002\/jbt.23830","volume":"38","author":"S Zhong","year":"2024","unstructured":"Zhong S, Li Y, Zhu X, Li Z, Jin C, Zhao Y (2024) Knockdown of circ_0006225 overcomes resistance to cisplatin and suppresses growth in lung cancer by miR-1236-3p\/ANKRD22 axis. J Biochem Mol Toxicol 38(11):e23830","journal-title":"J Biochem Mol Toxicol"},{"key":"2660_CR70","doi-asserted-by":"publisher","first-page":"105662","DOI":"10.1016\/j.tiv.2023.105662","volume":"93","author":"C Zhou","year":"2023","unstructured":"Zhou C, Yang Y, Hu L, Meng X, Guo X, Lei M, Ren Z, Chen Q, Ouyang C, Yang X (2023) Effects of miR-143 regulation on cardiomyocytes apoptosis in doxorubicin cardiotoxicity based on integrated bioinformatics analysis. Toxicol Vitro 93:105662","journal-title":"Toxicol Vitro"}],"container-title":["Acta Diabetologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-026-02660-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00592-026-02660-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-026-02660-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T08:03:13Z","timestamp":1779955393000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00592-026-02660-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,18]]},"references-count":70,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["2660"],"URL":"https:\/\/doi.org\/10.1007\/s00592-026-02660-1","relation":{},"ISSN":["1432-5233"],"issn-type":[{"value":"1432-5233","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,18]]},"assertion":[{"value":"24 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}