{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T17:25:13Z","timestamp":1793467513678,"version":"4.5.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Van Yuzuncu Yil University","award":["TYD-2024-10821"],"award-info":[{"award-number":["TYD-2024-10821"]}],"id":[{"id":"https:\/\/ror.org\/041jyzp61","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Diabetol"],"DOI":"10.1007\/s00592-026-02738-w","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:11:00Z","timestamp":1784027460000},"page":"1697-1706","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Predictive value of kynurenine pathway metabolites in patients with diabetic kidney disease"],"prefix":"10.1007","volume":"63","author":[{"given":"Mehmet","family":"Erdem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9202-4944","authenticated-orcid":false,"given":"Hamit Hakan","family":"Alp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur","family":"D\u00fczen Oflas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozan","family":"Aydemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130brahim","family":"Aydin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cebrail","family":"Karaca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasin","family":"Sezgin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senar","family":"Ebin\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Naci","family":"Aldemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Alay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"issue":"12","key":"2738_CR1","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1111\/jdi.13895","volume":"13","author":"MK Kim","year":"2022","unstructured":"Kim MK, Kim DM (2022) Current status of diabetic kidney disease and latest trends in management. J Diabetes Investig 13(12):1961\u20131962. https:\/\/doi.org\/10.1111\/jdi.13895","journal-title":"J Diabetes Investig"},{"issue":"5","key":"2738_CR2","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1038\/s41591-019-0415-5","volume":"25","author":"MA Niewczas","year":"2019","unstructured":"Niewczas MA, Pavkov ME, Skupien J, Smiles A, Md Dom ZI, Wilson JM et al (2019) A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes. Nat Med 25(5):805\u2013813. https:\/\/doi.org\/10.1038\/s41591-019-0415-5","journal-title":"Nat Med"},{"issue":"3","key":"2738_CR3","doi-asserted-by":"publisher","first-page":"151431","DOI":"10.1016\/j.semnephrol.2023.151431","volume":"43","author":"Y Oda","year":"2023","unstructured":"Oda Y, Nishi H, Nangaku M (2023) Role of inflammation in progression of chronic kidney disease in type 2 diabetes mellitus: clinical implications. Semin Nephrol 43(3):151431. https:\/\/doi.org\/10.1016\/j.semnephrol.2023.151431","journal-title":"Semin Nephrol"},{"issue":"4","key":"2738_CR4","doi-asserted-by":"publisher","first-page":"753","DOI":"10.3904\/kjim.2021.174","volume":"36","author":"SW Jung","year":"2021","unstructured":"Jung SW, Moon JY (2021) The role of inflammation in diabetic kidney disease. Korean J Intern Med 36(4):753\u2013766. https:\/\/doi.org\/10.3904\/kjim.2021.174","journal-title":"Korean J Intern Med"},{"key":"2738_CR5","doi-asserted-by":"publisher","unstructured":"Chen Y, Guillemin GJ (2009) Kynurenine pathway metabolites in humans: disease and healthy States. Int J Tryptophan Res 2:1\u201319. https:\/\/doi.org\/10.4137\/ijtr.s2097","DOI":"10.4137\/ijtr.s2097"},{"issue":"1","key":"2738_CR6","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s43440-021-00329-w","volume":"74","author":"I Zakrocka","year":"2022","unstructured":"Zakrocka I, Zaluska W (2022) Kynurenine pathway in kidney diseases. Pharmacol Rep 74(1):27\u201339. https:\/\/doi.org\/10.1007\/s43440-021-00329-w","journal-title":"Pharmacol Rep"},{"key":"2738_CR7","doi-asserted-by":"publisher","unstructured":"Koziel K, Urbanska EM (2023) Kynurenine pathway in diabetes mellitus-novel pharmacological target? Cells. https:\/\/doi.org\/10.3390\/cells12030460","DOI":"10.3390\/cells12030460"},{"key":"2738_CR8","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.clnu.2025.01.028","volume":"47","author":"S Mohiti","year":"2025","unstructured":"Mohiti S, Christensen J, Landler NE, Sorensen IM, Thomassen JQ, Bjergfelt SS et al (2025) Serum tryptophan and kynurenine levels and risk of heart failure among patients with chronic kidney disease. Clin Nutr 47:14\u201320. https:\/\/doi.org\/10.1016\/j.clnu.2025.01.028","journal-title":"Clin Nutr"},{"issue":"12","key":"2738_CR9","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.2337\/dc23-1147","volume":"46","author":"JJ Liu","year":"2023","unstructured":"Liu JJ, Ching J, Wee HN, Liu S, Gurung RL, Lee J et al (2023) Plasma tryptophan-kynurenine pathway metabolites and risk for progression to end-stage kidney disease in patients with type 2 diabetes. Diabetes Care 46(12):2223\u20132231. https:\/\/doi.org\/10.2337\/dc23-1147","journal-title":"Diabetes Care"},{"key":"2738_CR10","doi-asserted-by":"publisher","first-page":"117864691769460","DOI":"10.1177\/1178646917694600","volume":"10","author":"S Debnath","year":"2017","unstructured":"Debnath S, Velagapudi C, Redus L, Thameem F, Kasinath B, Hura CE et al (2017) Tryptophan metabolism in patients with chronic kidney disease secondary to type 2 diabetes: relationship to inflammatory markers. Int J Tryptophan Res 10:1178646917694600. https:\/\/doi.org\/10.1177\/1178646917694600","journal-title":"Int J Tryptophan Res"},{"key":"2738_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2025.02.024","author":"C El Chamieh","year":"2025","unstructured":"El Chamieh C, Liabeuf S, Larabi IA, De Pinho NA, Costes-Albrespic M, Frimat L et al (2025) Uncovering the link between kynurenic acid pathway and kidney failure. Kidney Int Rep. https:\/\/doi.org\/10.1016\/j.ekir.2025.02.024","journal-title":"Kidney Int Rep"},{"issue":"4S","key":"2738_CR12","doi-asserted-by":"publisher","first-page":"S117","DOI":"10.1016\/j.kint.2023.10.018","volume":"105","author":"Kidney Disease","year":"2024","unstructured":"Kidney Disease: Improving Global Outcomes CKDWG (2024) KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int 105(4S):S117\u2013S314. https:\/\/doi.org\/10.1016\/j.kint.2023.10.018","journal-title":"Kidney Int"},{"key":"2738_CR13","doi-asserted-by":"publisher","unstructured":"Mogos M, Socaciu C, Socaciu A, Vlad A, Gadalean F, Bob F et al (2023) Identification and characterization of urinary and serum aminoacids in diabetic kidney disease patients using MS-HPLC. Nephrol Dial Transplant. https:\/\/doi.org\/10.1093\/ndt\/gfad063c_5736","DOI":"10.1093\/ndt\/gfad063c_5736"},{"issue":"7","key":"2738_CR14","doi-asserted-by":"publisher","first-page":"6212","DOI":"10.3390\/ijms24076212","volume":"24","author":"L Balint","year":"2023","unstructured":"Balint L, Socaciu C, Socaciu AI, Vlad A, Gadalean F, Bob F et al (2023) Metabolite profiling of the gut\u2013renal\u2013cerebral axis reveals a particular pattern in early diabetic kidney disease in T2DM patients. IJMS 24(7):6212. https:\/\/doi.org\/10.3390\/ijms24076212","journal-title":"IJMS"},{"issue":"1","key":"2738_CR15","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.jdiacomp.2016.08.020","volume":"31","author":"Y Zhang","year":"2017","unstructured":"Zhang Y, Ruan Y, Zhang P, Wang L (2017) Increased indoleamine 2,3-dioxygenase activity in type 2 diabetic nephropathy. J Diabetes Complicat 31(1):223\u2013227. https:\/\/doi.org\/10.1016\/j.jdiacomp.2016.08.020","journal-title":"J Diabetes Complicat"},{"issue":"1","key":"2738_CR16","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.atherosclerosis.2008.08.014","volume":"204","author":"K Pawlak","year":"2009","unstructured":"Pawlak K, Domaniewski T, Mysliwiec M, Pawlak D (2009) The kynurenines are associated with oxidative stress, inflammation and the prevalence of cardiovascular disease in patients with end-stage renal disease. Atherosclerosis 204(1):309\u2013314. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2008.08.014","journal-title":"Atherosclerosis"},{"key":"2738_CR17","doi-asserted-by":"publisher","unstructured":"Hasegawa S, Inagi R (2021) Harnessing metabolomics to describe the pathophysiology underlying progression in diabetic kidney disease. Curr Diab Rep. https:\/\/doi.org\/10.1007\/s11892-021-01390-8","DOI":"10.1007\/s11892-021-01390-8"},{"issue":"2\u20133","key":"2738_CR18","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1159\/000521940","volume":"53","author":"J Zhang","year":"2022","unstructured":"Zhang J, Fuhrer T, Ye H, Kwan B, Montemayor D, Tumova J et al (2022) High-throughput metabolomics and diabetic kidney disease progression: evidence from the chronic renal insufficiency (CRIC) study. Am J Nephrol 53(2\u20133):215\u2013225. https:\/\/doi.org\/10.1159\/000521940","journal-title":"Am J Nephrol"},{"key":"2738_CR19","doi-asserted-by":"publisher","unstructured":"Cernaro V, Loddo S, Macaione V, Ferlazzo VT, Cigala RM, Crea F et al (2020) P0716RAAS inhibition modulates kynurenine levels in a CKD population with and without type 2 diabetes mellitus. Nephrol Dial Transplant. https:\/\/doi.org\/10.1093\/ndt\/gfaa142.P0716","DOI":"10.1093\/ndt\/gfaa142.P0716"},{"issue":"2","key":"2738_CR20","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1111\/jdi.12707","volume":"9","author":"CA Chou","year":"2018","unstructured":"Chou CA, Lin CN, Chiu DT, Chen IW, Chen ST (2018) Tryptophan as a surrogate prognostic marker for diabetic nephropathy. J Diabetes Investig 9(2):366\u2013374. https:\/\/doi.org\/10.1111\/jdi.12707","journal-title":"J Diabetes Investig"},{"issue":"16","key":"2738_CR21","doi-asserted-by":"publisher","first-page":"4703","DOI":"10.3390\/jcm13164703","volume":"13","author":"M Mogos","year":"2024","unstructured":"Mogos M, Socaciu C, Socaciu AI, Vlad A, Gadalean F, Bob F et al (2024) Biomarker profiling with targeted metabolomic analysis of plasma and urine samples in patients with type 2 diabetes mellitus and early diabetic kidney disease. JCM 13(16):4703. https:\/\/doi.org\/10.3390\/jcm13164703","journal-title":"JCM"},{"issue":"4","key":"2738_CR22","doi-asserted-by":"publisher","first-page":"207","DOI":"10.3390\/diagnostics10040207","volume":"10","author":"M-H Wu","year":"2020","unstructured":"Wu M-H, Lin C-N, Chiu DT-Y, Chen S-T (2020) Kynurenine\/tryptophan ratio predicts angiotensin receptor blocker responsiveness in patients with diabetic kidney disease. Diagnostics 10(4):207. https:\/\/doi.org\/10.3390\/diagnostics10040207","journal-title":"Diagnostics"}],"container-title":["Acta Diabetologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-026-02738-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00592-026-02738-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-026-02738-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:32:47Z","timestamp":1792567967000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00592-026-02738-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,14]]},"references-count":22,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["2738"],"URL":"https:\/\/doi.org\/10.1007\/s00592-026-02738-w","relation":{},"ISSN":["1432-5233"],"issn-type":[{"value":"1432-5233","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,14]]},"assertion":[{"value":"10 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments. The study was approved by the Van Y\u00fcz\u00fcnc\u00fc Y\u0131l University Non-Interventional Clinical Research Ethics Committee (decision number: 2023\/11\u2009\u2212\u200905; date: 10.11.2023).","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}}]}}