{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T05:11:56Z","timestamp":1774329116646,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2013,2,15]],"date-time":"2013-02-15T00:00:00Z","timestamp":1360886400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Surg Today"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1007\/s00595-013-0517-5","type":"journal-article","created":{"date-parts":[[2013,2,14]],"date-time":"2013-02-14T02:35:30Z","timestamp":1360809330000},"page":"608-612","source":"Crossref","is-referenced-by-count":20,"title":["Regulatory T cells in the blood: a new marker of surgical stress"],"prefix":"10.1007","volume":"43","author":[{"given":"Yu","family":"Saito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuo","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Utsunomiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Morine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Imura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Ikemoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Hanaoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Iwahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michihito","family":"Asanoma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,2,15]]},"reference":[{"key":"517_CR1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ni904","volume":"4","author":"JD Fontenot","year":"2003","unstructured":"Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4CD25 regulatory T cells. Nat Immunol. 2003;4:330\u20136.","journal-title":"Nat Immunol"},{"key":"517_CR2","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.micinf.2004.02.020","volume":"6","author":"S Hori","year":"2004","unstructured":"Hori S, Sakaguchi S. Foxp3: a critical regulator of the development and function of regulatory T cells. Microbes Infect. 2004;6:745\u201351.","journal-title":"Microbes Infect"},{"key":"517_CR3","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1111\/j.1398-9995.2009.02056.x","volume":"64","author":"S Provoost","year":"2009","unstructured":"Provoost S, Maes T, van Durme YM, Gevaert P, Bachert C, Schmidt-Weber CB, et al. Decreased FOXP3 protein expression in patients with asthma. Allergy. 2009;64:1539\u201346.","journal-title":"Allergy"},{"key":"517_CR4","doi-asserted-by":"crossref","first-page":"7635","DOI":"10.4049\/jimmunol.0804251","volume":"183","author":"KM Wheeler","year":"2009","unstructured":"Wheeler KM, Samy ET, Tung KS. Cutting edge: normal regional lymph node enrichment of antigen-specific regulatory T cells with autoimmune disease-suppressive capacity. J Immunol. 2009;183:7635\u20138.","journal-title":"J Immunol"},{"key":"517_CR5","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1182\/blood-2008-01-135319","volume":"112","author":"MA Morse","year":"2008","unstructured":"Morse MA, Hobeika AC, Osada T, Serra D, Niedzwiecki D, Lyerly HK, et al. Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines. Blood. 2008;112:610\u20138.","journal-title":"Blood"},{"key":"517_CR6","doi-asserted-by":"crossref","first-page":"5490","DOI":"10.1158\/0008-5472.CAN-09-0304","volume":"69","author":"E Gounaris","year":"2009","unstructured":"Gounaris E, Blatner NR, Dennis K, Magnusson F, Gurish MF, Strom TB, et al. T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis. Cancer Res. 2009;69:5490\u20137.","journal-title":"Cancer Res"},{"key":"517_CR7","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1097\/01.CCM.0000069345.78884.0F","volume":"31","author":"G Monneret","year":"2003","unstructured":"Monneret G, Debard AL, Venet F, Bohe J, Hequet O, Bienvenu J, et al. Marked elevation of human circulating CD4+CD25+ regulatory T cells in sepsis-induced immunoparalysis. Crit Care Med. 2003;31:2068\u201371.","journal-title":"Crit Care Med"},{"key":"517_CR8","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/BF02483010","volume":"29","author":"Y Haga","year":"1999","unstructured":"Haga Y, Ikei S, Ogawa M. Estimation of physiologic ability and surgical stress (E-PASS) as a new prediction scoring system for postoperative morbidity and mortality following elective gastrointestinal surgery. Surg Today. 1999;29:219\u201325.","journal-title":"Surg Today"},{"key":"517_CR9","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s00268-005-7719-y","volume":"29","author":"Y Oka","year":"2005","unstructured":"Oka Y, Nishijima J, Oku K, Azuma T, Inada K, Miyazaki S, et al. Usefulness of an estimation of physiologic ability and surgical stress (E-PASS) scoring system to predict the incidence of postoperative complications in gastrointestinal surgery. World J Surg. 2005;29:1029\u201333.","journal-title":"World J Surg"},{"key":"517_CR10","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.amjsurg.2004.09.010","volume":"189","author":"H Kaneko","year":"2005","unstructured":"Kaneko H, Takagi S, Otsuka Y, Tsuchiya M, Tamura A, Katagiri T, et al. Laparoscopic liver resection of hepatocellular carcinoma. Am J Surg. 2005;189:190\u20134.","journal-title":"Am J Surg"},{"key":"517_CR11","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s00595-011-0087-3","volume":"42","author":"T Nakagiri","year":"2012","unstructured":"Nakagiri T, Warnecke G, Avsar M, Thissen S, Kruse B, K\u00fchn C, et al. Lung function early after lung transplantation is correlated with the frequency of regulatory T cells. Surg Today. 2012;42:250\u20138.","journal-title":"Surg Today"},{"key":"517_CR12","doi-asserted-by":"crossref","first-page":"178","DOI":"10.2152\/jmi.51.178","volume":"51","author":"T Ikemoto","year":"2004","unstructured":"Ikemoto T, Tashiro S, Yasutomo K, Kishihara K, Kurita N, Miyake H. Donor-specific tolerance induced by simultaneous allogeneic islet transplantation with CD4\u00a0+\u00a0CD25\u00a0+\u00a0T-cell into hepatic parenchyma in mice. J Med Invest. 2004;51:178\u201385.","journal-title":"J Med Invest."},{"key":"517_CR13","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/01.mpa.0000240275.68279.13","volume":"33","author":"T Ikemoto","year":"2006","unstructured":"Ikemoto T, Yamaguchi T, Morine Y, Imura S, Soejima Y, Fujii M, et al. Clinical roles of increased populations of Foxp3\u00a0+\u00a0CD4\u00a0+\u00a0T cells in peripheral blood from advanced pancreatic cancer patients. Pancreas. 2006;33:386\u201390.","journal-title":"Pancreas"},{"key":"517_CR14","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/1043-4666(94)90040-X","volume":"6","author":"K Sakamoto","year":"1994","unstructured":"Sakamoto K, Arakawa H, Mita S, et al. Elevation of circulating interleukin 6 after surgery: factors influencing the serum level. Cytokine. 1994;6:181\u20136.","journal-title":"Cytokine"},{"key":"517_CR15","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/1043-4666(92)90070-8","volume":"4","author":"Y Oka","year":"1992","unstructured":"Oka Y, Murata A, Nishijima J, et al. Circulating interleukin 6 as a useful marker for predicting postoperative complications. Cytokine. 1992;4:298\u2013304.","journal-title":"Cytokine"},{"key":"517_CR16","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s00464-005-0305-4","volume":"20","author":"HB Rahr","year":"2006","unstructured":"Rahr HB, Bendix J, Ahlburg P, et al. Coagulation, inflammatory and stress responses in a randomized comparison of open and laparoscopic repair of recurrent inguinal hernia. Surg Endosc. 2006;20:468\u201372.","journal-title":"Surg Endosc"},{"key":"517_CR17","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1097\/01.CCM.0000069345.78884.0F","volume":"31","author":"G Monneret","year":"2003","unstructured":"Monneret G, Debard AL, Venet F, et al. Marked elevation of human irculating CD4+CD25+ regulatory T cells in sepsisinduced immunoparalysis. Crit Care Med. 2003;31:2068\u201371.","journal-title":"Crit Care Med"},{"key":"517_CR18","doi-asserted-by":"crossref","first-page":"7943","DOI":"10.4049\/jimmunol.177.11.7943","volume":"177","author":"PO Scumpia","year":"2006","unstructured":"Scumpia PO, Delano MJ, Kelly KM, et al. Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis. J Immunol. 2006;177:7943\u20139.","journal-title":"J Immunol"},{"key":"517_CR19","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1097\/CCM.0b013e3181e78ad0","volume":"38","author":"DC Nascimento","year":"2010","unstructured":"Nascimento DC, Alves-Filho JC, S\u00f4nego F, Fukada SY, Pereira MS, Benjamim C, et al. Role of regulatory T cells in long-term immune dysfunction associated with severe sepsis. Crit Care Med. 2010;38:1718\u201325.","journal-title":"Crit Care Med"},{"key":"517_CR20","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1097\/00003246-199607000-00010","volume":"24","author":"RC Bone","year":"1996","unstructured":"Bone RC. Sir Isaac Newton, sepsis, SIRS, and CARS. Crit Care Med. 1996;24:1125\u20138.","journal-title":"Crit Care Med"},{"key":"517_CR21","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.4049\/jimmunol.178.4.2018","volume":"178","author":"SG Zheng","year":"2007","unstructured":"Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA. IL-2 is essential for TGF-\u03b2 to convert naive CD4+CD25\u2212 cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J Immunol. 2007;178:2018\u201327.","journal-title":"J Immunol"},{"key":"517_CR22","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1080\/03009740701482800","volume":"36","author":"Z Jiao","year":"2007","unstructured":"Jiao Z, Wang W, Jia R, Li J, You H, Chen L, et al. Accumulation of FoxP3-expressing CD4+CD25+ T cells with distinct chemokine receptors in synovial fluid of patients with active rheumatoid arthritis. Scand J Rheumatol. 2007;36:428\u201333.","journal-title":"Scand J Rheumatol"}],"container-title":["Surgery Today"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00595-013-0517-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00595-013-0517-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00595-013-0517-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T14:45:13Z","timestamp":1562683513000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00595-013-0517-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,15]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["517"],"URL":"https:\/\/doi.org\/10.1007\/s00595-013-0517-5","relation":{},"ISSN":["0941-1291","1436-2813"],"issn-type":[{"value":"0941-1291","type":"print"},{"value":"1436-2813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,15]]}}}