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The potential conflicts of interest with regard to our study are as follows: Toru Kono, Mitsuo Shimada and Yoshihiko Maehara received grant support from Tsumura Co., Ltd.; Hiroki Sokuoka is an employee of the Japanese Foundation for Multidisciplinary Treatment of Cancer; Satoshi Morita received personal fees from Tsumura Co., Ltd., outside the submitted work; Junichi Sakamoto received honorarium from Tsumura Co., Ltd., for invited lectures.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}