{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:43:30Z","timestamp":1793396610410,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T00:00:00Z","timestamp":1594339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T00:00:00Z","timestamp":1594339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Today"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s00595-020-02061-z","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T08:03:51Z","timestamp":1594368231000},"page":"1594-1600","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The pivotal predictor of severe postoperative complications of pancreatoduodenectomy: complex links of bacterial contamination from preoperative biliary drainage"],"prefix":"10.1007","volume":"50","author":[{"given":"Rumi","family":"Itoyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohisa","family":"Okabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Yusa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunori","family":"Imai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromitsu","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yo-ichi","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Baba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,10]]},"reference":[{"key":"2061_CR1","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.ijsu.2018.11.016","volume":"60","author":"F Yuan","year":"2018","unstructured":"Yuan F, Essaji Y, Belley-Cote EP, Gafni A, Latchupatula L, Ruo L, et al. Postoperative complications in elderly patients following pancreaticoduodenectomy lead to increased postoperative mortality and costs. A retrospective cohort study. Int J Surg. 2018;60:204\u20139.","journal-title":"Int J Surg."},{"key":"2061_CR2","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1002\/jhbp.322","volume":"23","author":"K Sahora","year":"2016","unstructured":"Sahora K, Morales-Oyarvide V, Ferrone C, Fong ZV, Warshaw AL, Lillemoe KD, et al. Preoperative biliary drainage does not increase major complications in pancreaticoduodenectomy: a large single center experience from the Massachusetts General Hospital. J Hepato-Biliary-Pancreat Sci. 2016;23:181\u20137.","journal-title":"J Hepato-Biliary-Pancreat Sci"},{"key":"2061_CR3","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1097\/00000658-199908000-00001","volume":"230","author":"SP Povoski","year":"1999","unstructured":"Povoski SP, Karpeh MS Jr, Conlon KC, Blumgart LH, Brennan MF. Association of preoperative biliary drainage with postoperative outcome following pancreaticoduodenectomy. Ann Surg. 1999;230:131\u201342.","journal-title":"Ann Surg"},{"key":"2061_CR4","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1056\/NEJMoa0903230","volume":"362","author":"NA van der Gaag","year":"2010","unstructured":"van der Gaag NA, Rauws EA, van Eijck CH, Bruno MJ, van der Harst E, Kubben FJ, et al. Preoperative biliary drainage for cancer of the head of the pancreas. New Engl J Med. 2010;362:129\u201337.","journal-title":"New Engl J Med"},{"key":"2061_CR5","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1097\/SLA.0b013e3181fd36a2","volume":"252","author":"WJ Eshuis","year":"2010","unstructured":"Eshuis WJ, van der Gaag NA, Rauws EA, van Eijck CH, Bruno MJ, Kuipers EJ, et al. Therapeutic delay and survival after surgery for cancer of the pancreatic head with or without preoperative biliary drainage. Ann Surg. 2010;252:840\u20139.","journal-title":"Ann Surg"},{"key":"2061_CR6","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1097\/MPA.0b013e3181bd65de","volume":"39","author":"G Garcea","year":"2010","unstructured":"Garcea G, Chee W, Ong SL, Maddern GJ. Preoperative biliary drainage for distal obstruction: the case against revisited. Pancreas. 2010;39:119\u201326.","journal-title":"Pancreas"},{"key":"2061_CR7","first-page":"391","volume":"17","author":"YD Qiu","year":"2011","unstructured":"Qiu YD, Bai JL, Xu FG, Ding YT. Effect of preoperative biliary drainage on malignant obstructive jaundice: a meta-analysis. Wold J Gastroenterol. 2011;17:391\u20136.","journal-title":"Wold J Gastroenterol"},{"key":"2061_CR8","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1097\/00000658-200207000-00005","volume":"236","author":"ME Sewnath","year":"2002","unstructured":"Sewnath ME, Karsten TM, Prins MH, Rauws EJ, Obertop H, Gouma DJ. A meta-analysis on the efficacy of preoperative biliary drainage for tumors causing obstructive jaundice. Ann Surg. 2002;236:17\u201327.","journal-title":"Ann Surg"},{"key":"2061_CR9","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.surg.2016.11.001","volume":"161","author":"F Scheufele","year":"2017","unstructured":"Scheufele F, Schorn S, Demir IE, Sargut M, Tieftrunk E, Calavrezos L, et al. Preoperative biliary stenting versus operation first in jaundiced patients due to malignant lesions in the pancreatic head: a meta-analysis of current literature. Surgery. 2017;161:939\u201350.","journal-title":"Surgery"},{"key":"2061_CR10","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1007\/s11605-008-0618-4","volume":"13","author":"NA van der Gaag","year":"2009","unstructured":"van der Gaag NA, Kloek JJ, de Castro SM, Busch OR, van Gulik TM, Gouma DJ. Preoperative biliary drainage in patients with obstructive jaundice: history and current status. J Gastrointest Surg. 2009;13:814\u201320.","journal-title":"J Gastrointest Surg"},{"key":"2061_CR11","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.jamcollsurg.2015.03.058","volume":"221","author":"A Sauvanet","year":"2015","unstructured":"Sauvanet A, Boher JM, Paye F, Bachellier P, Sa Cuhna A, Le Treut YP, et al. Severe jaundice increases early severe morbidity and decreases long-term survival after pancreaticoduodenectomy for pancreatic adenocarcinoma. J Am Coll Surg. 2015;221:380\u20139.","journal-title":"J Am Coll Surg"},{"key":"2061_CR12","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1186\/s12957-016-0933-2","volume":"14","author":"H Moole","year":"2016","unstructured":"Moole H, Bechtold M, Puli SR. Efficacy of preoperative biliary drainage in malignant obstructive jaundice: a meta-analysis and systematic review. World J Surg Oncol. 2016;14:182.","journal-title":"World J Surg Oncol"},{"key":"2061_CR13","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s00423-012-1000-2","volume":"398","author":"J Singhirunnusorn","year":"2013","unstructured":"Singhirunnusorn J, Roger L, Chopin-Laly X, Lepilliez V, Ponchon T, Adham M. Value of preoperative biliary drainage in a consecutive series of resectable periampullary lesions. From randomized studies to real medical practice. Langenbeck Arch Surg. 2013;398:295\u2013302.","journal-title":"Langenbeck Arch Surg."},{"key":"2061_CR14","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1007\/s11605-009-1046-9","volume":"13","author":"JJ Mezhir","year":"2009","unstructured":"Mezhir JJ, Brennan MF, Baser RE, D'Angelica MI, Fong Y, DeMatteo RP, et al. A matched case-control study of preoperative biliary drainage in patients with pancreatic adenocarcinoma: routine drainage is not justified. J Gastrointest Surgery. 2009;13:2163\u20139.","journal-title":"J Gastrointest Surgery"},{"key":"2061_CR15","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.jiac.2018.05.007","volume":"24","author":"Y Takahashi","year":"2018","unstructured":"Takahashi Y, Takesue Y, Fujiwara M, Tatsumi S, Ichiki K, Fujimoto J, et al. Risk factors for surgical site infection after major hepatobiliary and pancreatic surgery. J Infect Chemother. 2018;24:739\u201343.","journal-title":"J Infect Chemother"},{"key":"2061_CR16","doi-asserted-by":"publisher","first-page":"212","DOI":"10.14701\/ahbps.2017.21.4.212","volume":"21","author":"ZQ Ng","year":"2017","unstructured":"Ng ZQ, Suthananthan AE, Rao S. Effect of preoperative biliary stenting on post-operative infectious complications in pancreaticoduodenectomy. Ann Hepato-Biliary-Pancreat Surg. 2017;21:212\u20136.","journal-title":"Ann Hepato-Biliary-Pancreat Surg"},{"key":"2061_CR17","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.asjsur.2016.10.004","volume":"41","author":"A El Nakeeb","year":"2018","unstructured":"El Nakeeb A, Salem A, Mahdy Y, El Dosoky M, Said R, Ellatif MA, et al. Value of preoperative biliary drainage on postoperative outcome after pancreaticoduodenectomy: a case-control study. Asian J Surg. 2018;41:155\u201362.","journal-title":"Asian J Surg"},{"key":"2061_CR18","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.ijsu.2018.02.057","volume":"52","author":"K Yamashita","year":"2018","unstructured":"Yamashita K, Kato D, Sasaki T, Shiwaku H, Ishii F, Naito S, et al. Contaminated drainage fluid and pancreatic fistula after pancreatoduodenectomy: a retrospective study. Int J Surg. 2018;52:314\u20139.","journal-title":"Int J Surg"},{"key":"2061_CR19","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.surg.2013.03.016","volume":"154","author":"LJ Jinkins","year":"2013","unstructured":"Jinkins LJ, Parmar AD, Han Y, Duncan CB, Sheffield KM, Brown KM, et al. Current trends in preoperative biliary stenting in patients with pancreatic cancer. Surgery. 2013;154:179\u201389.","journal-title":"Surgery"},{"key":"2061_CR20","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0016-5107(04)02169-8","volume":"60","author":"M Christensen","year":"2004","unstructured":"Christensen M, Matzen P, Schulze S, Rosenberg J. Complications of ERCP: a prospective study. Gastrointest Endoscopy. 2004;60:721\u201331.","journal-title":"Gastrointest Endoscopy"},{"key":"2061_CR21","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00595-017-1568-9","volume":"48","author":"AZ Le Bian","year":"2018","unstructured":"Le Bian AZ, Fuks D, Dalla Valle R, Cesaretti M, Violi V, Costi R. Effectiveness and risk of biliary drainage prior to pancreatoduodenectomy: review of current status. Surg Today. 2018;48:371\u20139.","journal-title":"Surg Today."},{"key":"2061_CR22","first-page":"489","volume":"61","author":"D Hashimoto","year":"2014","unstructured":"Hashimoto D, Hirota M, Chikamoto A, Beppu T, Baba H. Short-term outcome of new end-to-side inserting pancreatico-jejunostomy without stiches on the pancreatic cut end. Hepatogastroenterology. 2014;61:489\u201392.","journal-title":"Hepatogastroenterology"},{"key":"2061_CR23","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.surg.2016.11.014","volume":"161","author":"C Bassi","year":"2017","unstructured":"Bassi C, Marchegiani G, Dervenis C, et al. The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 years after. Surgery. 2017;161:584\u201391.","journal-title":"Surgery"},{"key":"2061_CR24","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.surg.2007.05.005","volume":"142","author":"MN Wente","year":"2007","unstructured":"Wente MN, Bassi C, Dervenis C, Fingerhut A, Gouma DJ, Izbicki JR, et al. Delayed gastric emptying (DGE) after pancreatic surgery: a suggested definition by the International Study Group of Pancreatic Surgery (ISGPS). Surgery. 2007;142:761\u20138.","journal-title":"Surgery"},{"key":"2061_CR25","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1097\/01.sla.0000246856.03918.9a","volume":"244","author":"ML DeOliveira","year":"2006","unstructured":"DeOliveira ML, Winter JM, Schafer M, Cunningham SC, Cameron JL, Yeo CJ, et al. Assessment of complications after pancreatic surgery: a novel grading system applied to 633 patients undergoing pancreaticoduodenectomy. Ann Surg. 2006;244:931\u20137.","journal-title":"Ann Surg"},{"key":"2061_CR26","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.hpb.2017.12.007","volume":"20","author":"PJ Lee","year":"2018","unstructured":"Lee PJ, Podugu A, Wu D, Lee AC, Stevens T, Windsor JA. Preoperative biliary drainage in resectable pancreatic cancer: a systematic review and network meta-analysis. HPB. 2018;20:477\u201386.","journal-title":"HPB"},{"key":"2061_CR27","doi-asserted-by":"crossref","first-page":"e5253","DOI":"10.1097\/MD.0000000000005253","volume":"95","author":"H Lin","year":"2016","unstructured":"Lin H, Li S, Liu X. The safety and efficacy of nasobiliary drainage versus biliary stenting in malignant biliary obstruction: a systematic review and meta-analysis. Medicine. 2016;95:e5253.","journal-title":"Medicine"},{"key":"2061_CR28","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1002\/bjs.7228","volume":"97","author":"Y Takahashi","year":"2010","unstructured":"Takahashi Y, Nagino M, Nishio H, Ebata T, Igami T, Nimura Y. Percutaneous transhepatic biliary drainage catheter tract recurrence in cholangiocarcinoma. Br J Surg. 2010;97:1860\u20136.","journal-title":"Br J Surg"},{"key":"2061_CR29","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1001\/jamaoncol.2015.3670","volume":"2","author":"S Inamdar","year":"2016","unstructured":"Inamdar S, Slattery E, Bhalla R, Sejpal DV, Trindade AJ. Comparison of adverse events for endoscopic vs percutaneous biliary drainage in the treatment of malignant biliary tract obstruction in an inpatient national cohort. JAMA Oncol. 2016;2:112\u20137.","journal-title":"JAMA Oncol"},{"key":"2061_CR30","doi-asserted-by":"publisher","first-page":"3273","DOI":"10.1007\/s00464-015-4075-3","volume":"29","author":"TJ Strom","year":"2015","unstructured":"Strom TJ, Klapman JB, Springett GM, Meredith KL, Hoffe SE, Choi J, et al. Comparative long-term outcomes of upfront resected pancreatic cancer after preoperative biliary drainage. Surg Endosc. 2015;29:3273\u201381.","journal-title":"Surg Endosc"},{"key":"2061_CR31","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.amjsurg.2017.01.010","volume":"214","author":"F Miura","year":"2017","unstructured":"Miura F, Sano K, Wada K, Shibuya M, Ikeda Y, Takahashi K, et al. Prognostic impact of type of preoperative biliary drainage in patients with distal cholangiocarcinoma. Am J Surg. 2017;214:256\u201361.","journal-title":"Am J Surg"},{"key":"2061_CR32","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jamcollsurg.2005.09.006","volume":"202","author":"A Cortes","year":"2006","unstructured":"Cortes A, Sauvanet A, Bert F, Janny S, Sockeel P, Kianmanesh R, et al. Effect of bile contamination on immediate outcomes after pancreaticoduodenectomy for tumor. J Am Coll Surg. 2006;202:93\u20139.","journal-title":"J Am Coll Surg"},{"key":"2061_CR33","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1097\/SLA.0000000000002838","volume":"268","author":"M Sandini","year":"2018","unstructured":"Sandini M, Honselmann KC, Birnbaum DJ, Gavazzi F, Chirica M, Wellner U, et al. Preoperative biliary stenting and major morbidity after pancreatoduodenectomy: does elapsed time matter? The FRAGERITA Study Group. Ann Surg. 2018;268:808\u201314.","journal-title":"Ann Surg"},{"issue":"6","key":"2061_CR34","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/11024150260284815","volume":"168","author":"L Nehez","year":"2002","unstructured":"Nehez L, Andersson R. Compromise of immune function in obstructive jaundice. Eur J Surg. 2002;168(6):315\u201328.","journal-title":"Eur J Surg"},{"key":"2061_CR35","first-page":"177","volume":"16","author":"V Papadopoulos","year":"2007","unstructured":"Papadopoulos V, Filippou D, Manolis E, Mimidis K. Haemostasis impairment in patients with obstructive jaundice. J Gastrointest Liver Dis. 2007;16:177\u201386.","journal-title":"J Gastrointest Liver Dis"},{"key":"2061_CR36","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1007\/s11605-017-3381-6","volume":"21","author":"S Dolejs","year":"2017","unstructured":"Dolejs S, Zarzaur BL, Zyromski NJ, Pitt HA, Riall TS, Hall BL, et al. Does hyperbilirubinemia contribute to adverse patient outcomes following pancreatoduodenectomy? J Gastrointest Surg. 2017;21:647\u201356.","journal-title":"J Gastrointest Surg"},{"key":"2061_CR37","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s11605-018-3959-7","volume":"23","author":"TF Seykora","year":"2019","unstructured":"Seykora TF, Maggino L, Malleo G, Lee MKT, Roses R, Salvia R, et al. Evolving the paradigm of early drain removal following pancreatoduodenectomy. J Gastrointest Surg. 2019;23:135\u201344.","journal-title":"J Gastrointest Surg."},{"key":"2061_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/01.sla.0000218077.14035.a6","volume":"244","author":"M Kawai","year":"2006","unstructured":"Kawai M, Tani M, Terasawa H, Ina S, Hirono S, Nishioka R, et al. Early removal of prophylactic drains reduces the risk of intra-abdominal infections in patients with pancreatic head resection: prospective study for 104 consecutive patients. Ann Surg. 2006;244:1\u20137.","journal-title":"Ann Surg"},{"key":"2061_CR39","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/S0016-5107(98)70038-0","volume":"48","author":"FM Pedersen","year":"1998","unstructured":"Pedersen FM, Lassen AT, de Muckadell OBS. Randomized trial of stent placed above and across the sphincter of Oddi in malignant bile duct obstruction. Gastroint Endosc. 1998;48:574\u20139.","journal-title":"Gastroint Endosc."}],"container-title":["Surgery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00595-020-02061-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00595-020-02061-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00595-020-02061-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T00:23:55Z","timestamp":1625876635000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00595-020-02061-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,10]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["2061"],"URL":"https:\/\/doi.org\/10.1007\/s00595-020-02061-z","relation":{},"ISSN":["0941-1291","1436-2813"],"issn-type":[{"value":"0941-1291","type":"print"},{"value":"1436-2813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,10]]},"assertion":[{"value":"25 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Rumi Itoyama and the co-authors have no conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}