{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:35:35Z","timestamp":1789950935721,"version":"4.0.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Takeda Pharmaceutical Company Limited"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Today"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Short bowel syndrome (SBS) with intestinal failure (SBS-IF) requires long-term parenteral nutrition (PN). This study investigated the real-world etiologies of SBS, treatment patterns, and PN-related outcomes among adult patients with SBS-IF in Japan.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This retrospective, observational cohort study was based on data from April, 2008 to January, 2020 from one of the largest hospital-based claim databases in Japan. Analyzed patients were aged\u2009\u2265\u200916\u00a0years, had received continuous PN for\u2009\u2265\u20096\u00a0months, and had SBS or undergone SBS-related surgery with a diagnosis of a causative disease. The primary endpoint was PN weaning.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We analyzed data for 393 patients. The most frequent causes of SBS-IF were ileus (31.8%), Crohn\u2019s disease (20.1%), and mesenteric ischemia (16.0%). Of 144\/393 (36.6%) patients who were weaned off their PN, 48 (33.3%) were subsequently restarted on PN. Of 276\/393 (70.2%) patients whose PN was initiated in hospital, 156 (56.5%) transitioned to home management. The mean duration of initial PN was 450.4 and 675.5\u00a0days for patients who were able or unable to be weaned off PN, respectively. Sepsis (67.4%), catheter-related bloodstream infections (49.1%), and liver disorders (45.0%) were the most reported PN-related complications.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Most patients with SBS-IF in Japan could not be weaned off PN and suffered life-threatening complications.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00595-022-02469-9","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T15:56:01Z","timestamp":1645631761000},"page":"1350-1357","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Etiologies and treatments of chronic intestinal failure-short bowel syndrome (SBS) in Japanese adults: a real-world observational study"],"prefix":"10.1007","volume":"52","author":[{"given":"Tsunekazu","family":"Mizushima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Udagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Tazuke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroomi","family":"Okuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovelle","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,23]]},"reference":[{"issue":"4","key":"2469_CR1","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.jviscsurg.2017.12.012","volume":"155","author":"L Billiauws","year":"2018","unstructured":"Billiauws L, Maggiori L, Joly F, Panis Y. 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The Department of Therapeutics for Inflammatory Bowel Diseases is supported by an unrestricted grant from Kinshukai Medical Corporation. Shiro Nakamura: honoraria from Takeda Pharmaceutical Company Limited, AbbVie Inc, Pfizer Japan Inc., Mitsubishi Tanabe Pharma Corporation, EA pharma Co. Ltd, Mochida pharmaceutical Co. Ltd, and Janssen Pharmaceutical Co. Ltd; research funding from Mitsubishi Tanabe Pharma Corporation. Eri Udagawa, Miyuki Hasegawa, and Jovelle Fernandez: employees of Takeda Pharmaceutical Company Limited. Jovelle Fernandez: owns stock in Takeda Pharmaceutical Company Limited and GSK. Hiroomi Okuyama: received fees for advisory and promotional materials (e.g., manuscript) from Takeda Pharmaceutical Company Limited. Yuko Tazuke: no conflict of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}