{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:10:16Z","timestamp":1790719816483,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Today"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1007\/s00595-022-02493-9","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T10:25:43Z","timestamp":1648203943000},"page":"1560-1567","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Frequency and prognostic impact of cachexia during drug treatment for unresectable advanced gastric cancer patients"],"prefix":"10.1007","volume":"52","author":[{"given":"Tsutomu","family":"Namikawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Marui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichiro","family":"Yokota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Fujieda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Munekage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunao","family":"Uemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromichi","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kitagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiya","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Hanazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,24]]},"reference":[{"key":"2493_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209\u201349.","journal-title":"CA Cancer J Clin"},{"key":"2493_CR2","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1200\/JCO.2006.05.9758","volume":"24","author":"A Ohtsu","year":"2006","unstructured":"Ohtsu A, Yoshida S, Saijo N. Disparities in gastric cancer chemotherapy between the East and West. J Clin Oncol. 2006;24:2188\u201396.","journal-title":"J Clin Oncol"},{"key":"2493_CR3","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1200\/JOP.2016.016832","volume":"12","author":"AR Bruggeman","year":"2016","unstructured":"Bruggeman AR, Kamal AH, LeBlanc TW, Ma JD, Baracos VE, Roeland EJ. Cancer cachexia: beyond weight loss. J Oncol Pract. 2016;12:1163\u201371.","journal-title":"J Oncol Pract"},{"key":"2493_CR4","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1002\/jcsm.12059","volume":"6","author":"CC Ezeoke","year":"2015","unstructured":"Ezeoke CC, Morley JE. Pathophysiology of anorexia in the cancer cachexia syndrome. J Cachexia Sarcopenia Muscle. 2015;6:287\u2013302.","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"2493_CR5","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.nut.2018.05.021","volume":"57","author":"E \u00c1lvaro Sanz","year":"2019","unstructured":"\u00c1lvaro Sanz E, Garrido Siles M, Rey Fern\u00e1ndez L, Villatoro Rold\u00e1n R, Rueda Dom\u00ednguez A, Abil\u00e9s J. Nutritional risk and malnutrition rates at diagnosis of cancer in patients treated in outpatient settings: early intervention protocol. Nutrition. 2019;57:148\u201353.","journal-title":"Nutrition"},{"key":"2493_CR6","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.clnu.2008.06.013","volume":"27","author":"WJ Evans","year":"2008","unstructured":"Evans WJ, Morley JE, Argil\u00e9s J, Bales C, Baracos V, Guttridge D, et al. Cachexia: a new definition. Clin Nutr. 2008;27:793\u20139.","journal-title":"Clin Nutr"},{"key":"2493_CR7","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","volume":"12","author":"K Fearon","year":"2011","unstructured":"Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011;12:489\u201395.","journal-title":"Lancet Oncol"},{"key":"2493_CR8","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1016\/j.clnu.2016.12.003","volume":"36","author":"P Caillet","year":"2017","unstructured":"Caillet P, Liuu E, Raynaud Simon A, Bonnefoy M, Guerin O, Berrut G, et al. Association between cachexia, chemotherapy and outcomes in older cancer patients: a systematic review. Clin Nutr. 2017;36:1473\u201382.","journal-title":"Clin Nutr"},{"key":"2493_CR9","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/apm.1965.64.1.31","volume":"64","author":"P Lauren","year":"1965","unstructured":"Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand. 1965;64:31\u201349.","journal-title":"Acta Pathol Microbiol Scand"},{"key":"2493_CR10","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/S0140-6736(10)61121-X","volume":"376","author":"YJ Bang","year":"2010","unstructured":"Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A, ToGA Trial Investigators, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastrooesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet. 2010;376:687\u201397.","journal-title":"Lancet"},{"key":"2493_CR11","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S1470-2045(08)70035-4","volume":"9","author":"W Koizumi","year":"2008","unstructured":"Koizumi W, Narahara H, Hara T, Takagane A, Akiya T, Takagi M, et al. S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial. Lancet Oncol. 2008;9:215\u201321.","journal-title":"Lancet Oncol"},{"key":"2493_CR12","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/S1470-2045(09)70259-1","volume":"10","author":"N Boku","year":"2009","unstructured":"Boku N, Yamamoto S, Fukuda H, Shirao K, Doi T, Sawaki A, Gastrointestinal Oncology Study Group of the Japan Clinical Oncology Group, et al. Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: A randomised phase 3 study. Lancet Oncol. 2009;10:1063\u20139.","journal-title":"Lancet Oncol"},{"key":"2493_CR13","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1016\/S1470-2045(14)70420-6","volume":"15","author":"H Wilke","year":"2014","unstructured":"Wilke H, Muro K, Van Cutsem E, Oh SC, Bodoky G, Shimada Y, RAINBOW Study Group, et al. Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (Rainbow): a double-blind, randomised phase 3 trial. Lancet Oncol. 2014;15:1224\u201335.","journal-title":"Lancet Oncol"},{"key":"2493_CR14","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1016\/S0140-6736(17)31827-5","volume":"390","author":"YK Kang","year":"2017","unstructured":"Kang YK, Boku N, Satoh T, Ryu MH, Chao Y, Kato K, et al. Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2017;390:2461\u201371.","journal-title":"Lancet"},{"key":"2493_CR15","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1016\/S1470-2045(18)30739-3","volume":"19","author":"K Shitara","year":"2018","unstructured":"Shitara K, Doi T, Dvorkin M, Mansoor W, Arkenau HT, Prokharau A, et al. Trifluridine\/tipiracil versus placebo in patients with heavily pretreated metastatic gastric cancer (TAGS): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol. 2018;19:1437\u201348.","journal-title":"Lancet Oncol"},{"key":"2493_CR16","doi-asserted-by":"publisher","first-page":"5271","DOI":"10.1007\/s00520-020-05346-8","volume":"28","author":"S Mitsunaga","year":"2020","unstructured":"Mitsunaga S, Kasamatsu E, Machii K. Incidence and frequency of cancer cachexia during chemotherapy for advanced pancreatic ductal adenocarcinoma. Support Care Cancer. 2020;28:5271\u20139.","journal-title":"Support Care Cancer"},{"key":"2493_CR17","doi-asserted-by":"publisher","first-page":"5010","DOI":"10.1007\/s12325-020-01516-6","volume":"37","author":"M Shibata","year":"2020","unstructured":"Shibata M, Fukahori M, Kasamatsu E, Machii K, Hamauchi S. A retrospective cohort study to investigate the incidence of cachexia during chemotherapy in patients with colorectal cancer. Adv Ther. 2020;37:5010\u201322.","journal-title":"Adv Ther"},{"key":"2493_CR18","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s00520-020-05479-w","volume":"29","author":"M Fukahori","year":"2021","unstructured":"Fukahori M, Shibata M, Hamauchi S, Kasamatsu E, Machii K. A retrospective cohort study to investigate the incidence of cancer-related weight loss during chemotherapy in gastric cancer patients. Support Care Cancer. 2021;29:341\u20138.","journal-title":"Support Care Cancer"},{"key":"2493_CR19","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1007\/s10120-015-0481-4","volume":"19","author":"CY Ock","year":"2016","unstructured":"Ock CY, Oh DY, Lee J, Kim TY, Lee KH, Han SW, et al. Weight loss at the first month of palliative chemotherapy predicts survival outcomes in patients with advanced gastric cancer. Gastric Cancer. 2016;19:597\u2013606.","journal-title":"Gastric Cancer"},{"key":"2493_CR20","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1007\/s00520-014-2534-3","volume":"23","author":"M Kimura","year":"2015","unstructured":"Kimura M, Naito T, Kenmotsu H, Taira T, Wakuda K, Oyakawa T, et al. Prognostic impact of cancer cachexia in patients with advanced non-small cell lung cancer. Support Care Cancer. 2015;23:1699\u2013708.","journal-title":"Support Care Cancer"},{"key":"2493_CR21","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1001\/jamasurg.2018.1645","volume":"153","author":"EM Minnella","year":"2018","unstructured":"Minnella EM, Awasthi R, Loiselle SE, Agnihotram RV, Ferri LE, Carli F. Effect of exercise and nutrition prehabilitation on functional capacity in esophagogastric cancer surgery: a randomized clinical trial. JAMA Surg. 2018;153:1081\u20139.","journal-title":"JAMA Surg"},{"key":"2493_CR22","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1002\/jcsm.12420","volume":"10","author":"M Muscaritoli","year":"2019","unstructured":"Muscaritoli M, Molfino A, Scala F, Christoforidi K, Manneh-Vangramberen IM, De Lorenzo F. Nutritional and metabolic derangements in Mediterranean cancer patients and survivors: the ECPC 2016 survey. J Cachexia Sarcopenia Muscle. 2019;10:517\u201325.","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"2493_CR23","doi-asserted-by":"publisher","first-page":"2928","DOI":"10.1245\/s10434-016-5221-4","volume":"23","author":"H Imamura","year":"2016","unstructured":"Imamura H, Nishikawa K, Kishi K, Inoue K, Matsuyama J, Akamaru Y, et al. Effects of an oral elemental nutritional supplement on post-gastrectomy body weight loss in gastric cancer patients: a randomized controlled clinical trial. Ann Surg Oncol. 2016;23:2928\u201335.","journal-title":"Ann Surg Oncol"},{"key":"2493_CR24","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1046\/j.0007-1323.2001.02046.x","volume":"89","author":"W Yu","year":"2002","unstructured":"Yu W, Seo BY, Chung HY. Postoperative body-weight loss and survival after curative resection for gastric cancer. Br J Surg. 2002;89:467\u201370.","journal-title":"Br J Surg"},{"key":"2493_CR25","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1007\/s10147-017-1089-y","volume":"22","author":"T Aoyama","year":"2017","unstructured":"Aoyama T, Sato T, Maezawa Y, Kano K, Hayashi T, Yamada T, et al. Postoperative weight loss leads to poor survival through poor S-1 efficacy in patients with stage II\/III gastric cancer. Int J Clin Oncol. 2017;22:476\u201383.","journal-title":"Int J Clin Oncol"},{"key":"2493_CR26","doi-asserted-by":"publisher","first-page":"221","DOI":"10.21873\/invivo.11463","volume":"33","author":"T Aoyama","year":"2019","unstructured":"Aoyama T, Maezawa Y, Yoshikawa T, Segami K, Kano K, Hayashi T, et al. Comparison of weight and body composition after gastrectomy between elderly and non-elderly patients with gastric cancer. In Vivo. 2019;33:221\u20137.","journal-title":"In Vivo"},{"key":"2493_CR27","first-page":"807","volume":"36","author":"H Kubo","year":"2016","unstructured":"Kubo H, Komatsu S, Ichikawa D, Kawaguchi T, Kosuga T, Okamoto K, et al. Impact of body weight loss on recurrence after curative gastrectomy for gastric cancer. Anticancer Res. 2016;36:807\u201313.","journal-title":"Anticancer Res"},{"key":"2493_CR28","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1097\/SLA.0b013e318167748c","volume":"247","author":"M Fein","year":"2008","unstructured":"Fein M, Fuchs KH, Thalheimer A, Freys SM, Heimbucher J, Thiede A. Long-term benefits of Roux-en-Y pouch reconstruction after total gastrectomy: a randomized trial. Ann Surg. 2008;247:759\u201365.","journal-title":"Ann Surg"},{"key":"2493_CR29","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1080\/01635581.2017.1267774","volume":"69","author":"K Takayoshi","year":"2017","unstructured":"Takayoshi K, Uchino K, Nakano M, Ikejiri K, Baba E. Weight loss during initial chemotherapy predicts survival in patients with advanced gastric cancer. Nutr Cancer. 2017;69:408\u201315.","journal-title":"Nutr Cancer"},{"key":"2493_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2019.04.009","volume":"70","author":"XY Chen","year":"2020","unstructured":"Chen XY, Zhang XZ, Ma BW, Li B, Zhou DL, Liu ZC, et al. A comparison of four common malnutrition risk screening tools for detecting cachexia in patients with curable gastric cancer. Nutrition. 2020;70: 110498. https:\/\/doi.org\/10.1016\/j.nut.2019.04.009.","journal-title":"Nutrition"},{"key":"2493_CR31","doi-asserted-by":"publisher","first-page":"7067","DOI":"10.21873\/anticanres.14734","volume":"40","author":"H Fujii","year":"2020","unstructured":"Fujii H, Makiyama A, Iihara H, Okumura N, Yamamoto S, Imai T, et al. Cancer cachexia reduces the efficacy of nivolumab treatment in patients with advanced gastric cancer. Anticancer Res. 2020;40:7067\u201375.","journal-title":"Anticancer Res"},{"key":"2493_CR32","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.3390\/nu12071905","volume":"12","author":"HS Lim","year":"2020","unstructured":"Lim HS, Lee B, Cho I, Cho GS. Nutritional and clinical factors affecting weight and fat-free mass loss after gastrectomy in patients with gastric cancer. Nutrients. 2020;12:1905.","journal-title":"Nutrients"},{"key":"2493_CR33","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1245\/s10434-015-5065-3","volume":"23","author":"JL Davis","year":"2016","unstructured":"Davis JL, Selby LV, Chou JF, Schattner M, Ilson DH, Capanu M, et al. Patterns and predictors of weight loss after gastrectomy for cancer. Ann Surg Oncol. 2016;23:1639\u201345.","journal-title":"Ann Surg Oncol"},{"key":"2493_CR34","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.21873\/anticanres.13340","volume":"39","author":"K Kuwada","year":"2019","unstructured":"Kuwada K, Kuroda S, Kikuchi S, Yoshida R, Nishizaki M, Kagawa S, et al. Clinical impact of sarcopenia on gastric cancer. Anticancer Res. 2019;39:2241\u20139.","journal-title":"Anticancer Res"},{"key":"2493_CR35","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1152\/physrev.00012.2004","volume":"85","author":"M Kojima","year":"2005","unstructured":"Kojima M, Kangawa K. Ghrelin: structure and function. Physiol Rev. 2005;85:495\u2013522.","journal-title":"Physiol Rev"},{"key":"2493_CR36","doi-asserted-by":"publisher","first-page":"4294","DOI":"10.1002\/cncr.32406","volume":"125","author":"S Hamauchi","year":"2019","unstructured":"Hamauchi S, Furuse J, Takano T, Munemoto Y, Furuya K, Baba H, et al. A multicenter, open-label, single-arm study of anamorelin (ONO-7643) in advanced gastrointestinal cancer patients with cancer cachexia. Cancer. 2019;125:4294\u2013302.","journal-title":"Cancer"},{"key":"2493_CR37","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1002\/cncr.31128","volume":"124","author":"N Katakami","year":"2018","unstructured":"Katakami N, Uchino J, Yokoyama T, Naito T, Kondo M, Yamada K, et al. Anamorelin (ONO-7643) for the treatment of patients with non-small cell lung cancer and cachexia: Results from a randomized, double-blind, placebo-controlled, multicenter study of Japanese patients (ONO-7643-04). Cancer. 2018;124:606\u201316.","journal-title":"Cancer"},{"key":"2493_CR38","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s12032-020-01439-w","volume":"37","author":"D Zhou","year":"2020","unstructured":"Zhou D, Zhang Y, Mamtawla G, Wan S, Gao X, Zhang L, et al. Iron overload is related to muscle wasting in patients with cachexia of gastric cancer: using quantitative proteome analysis. Med Oncol. 2020;37:113.","journal-title":"Med Oncol"}],"container-title":["Surgery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00595-022-02493-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00595-022-02493-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00595-022-02493-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T02:11:19Z","timestamp":1666663879000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00595-022-02493-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,24]]},"references-count":38,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["2493"],"URL":"https:\/\/doi.org\/10.1007\/s00595-022-02493-9","relation":{},"ISSN":["0941-1291","1436-2813"],"issn-type":[{"value":"0941-1291","type":"print"},{"value":"1436-2813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,24]]},"assertion":[{"value":"24 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}