{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:12:13Z","timestamp":1789053133368,"version":"build-2803163510"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Today"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To clarify the relationships between the changes in hepatokines and weight loss, and between these changes and the metabolic effects, and the roles played by these changes, after laparoscopic sleeve gastrectomy (LSG).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We recruited 25 Japanese patients with severe obesity, who underwent LSG. We measured two hepatokines: selenoprotein P (SeP) and leukocyte cell-derived chemotaxin 2 (LECT2), at the baseline, and then 6\u00a0months and 1\u00a0year after LSG. Finally, we compared the changes in the hepatokines with the parameters of type 2 diabetes (T2D) and non-alcoholic steatohepatitis (NASH).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Changes in LECT2 were correlated with the percentage of total weight loss (\u03c1\u2009=\u2009\u2212\u00a00.499, <jats:italic>P<\/jats:italic>\u2009=\u20090.024) and the decrease in total fat area (\u03c1\u2009=\u20090.559, <jats:italic>P<\/jats:italic>\u2009=\u20090.003). The changes in SeP were correlated with those in hemoglobin A1c (\u03c1\u2009=\u20090.526, <jats:italic>P<\/jats:italic>\u2009=\u20090.043) and the insulinogenic index (\u03c1\u2009=\u20090.638, <jats:italic>P<\/jats:italic>\u2009=\u20090.010) in T2D patients. In patients with NASH, the LECT2 levels were correlated with liver steatosis (\u03c1\u2009=\u20090.601).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>SeP levels decrease in association with HbA1c reduction, whereas LECT2 levels are associated with reductions in fat mass and NASH scores after LSG. Hepatokines may be involved in the pathology of obesity and its complications.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00595-023-02767-w","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T19:02:21Z","timestamp":1699902141000},"page":"581-590","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Relationship between the changes in hepatokine levels and metabolic effects after laparoscopic sleeve gastrectomy in severely obese patients"],"prefix":"10.1007","volume":"54","author":[{"given":"Akira","family":"Umemura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshinari","family":"Takamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Takayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumie","family":"Takeshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Toya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Kakisaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Ishigaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"key":"2767_CR1","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1507\/endocrj.EJ19-0255","volume":"66","author":"H Misu","year":"2019","unstructured":"Misu H. Identification of hepatokines involved in pathology of type 2 diabetes and obesity. Endocr J. 2019;66:659\u201362.","journal-title":"Endocr J"},{"key":"2767_CR2","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1007\/s13340-018-0368-9","volume":"9","author":"H Misu","year":"2018","unstructured":"Misu H. Pathophysiological significance of hepatokine overproduction in type 2 diabetes. Diabetol Int. 2018;9:224\u201333.","journal-title":"Diabetol Int"},{"key":"2767_CR3","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/nrendo.2017.56","volume":"13","author":"RCR Meex","year":"2017","unstructured":"Meex RCR, Watt MJ. Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance. Nat Rev Endocrinol. 2017;13:509\u201320.","journal-title":"Nat Rev Endocrinol"},{"key":"2767_CR4","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.cmet.2010.09.015","volume":"12","author":"H Misu","year":"2010","unstructured":"Misu H, Takamura T, Takayama H, Hayashi H, Matsuzawa-Nagata N, Kurita S, et al. A liver-derived secretory protein, selenoprotein P, causes insulin resistance. Cell Metab. 2010;12:483\u201395.","journal-title":"Cell Metab"},{"key":"2767_CR5","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/nm.4295","volume":"23","author":"H Misu","year":"2017","unstructured":"Misu H, Takayama H, Saito Y, Mita Y, Kikuchi A, Ishii KA, et al. Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle. Nat Med. 2017;23:508\u201316.","journal-title":"Nat Med"},{"key":"2767_CR6","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.2337\/db13-0728","volume":"63","author":"F Lan","year":"2014","unstructured":"Lan F, Misu H, Chikamoto K, Takayama H, Kikuchi A, Mohri K, et al. LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance. Diabetes. 2014;63:1649\u201364.","journal-title":"Diabetes"},{"key":"2767_CR7","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1016\/j.bbrc.2016.08.117","volume":"478","author":"K Chikamoto","year":"2016","unstructured":"Chikamoto K, Misu H, Takayama H, Kikuchi A, Ishii KA, Lan F, et al. Rapid response of the steatosis-sensing hepatokine LECT2 during diet-induced weight cycling in mice. Biochem Biophys Res Commun. 2016;478:1310\u20136.","journal-title":"Biochem Biophys Res Commun"},{"key":"2767_CR8","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/s41598-020-80689-0","volume":"11","author":"N Takata","year":"2021","unstructured":"Takata N, Ishii KA, Takayama H, Nagashimada M, Kamoshita K, Tanaka T, et al. LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH. Sci Rep. 2021;11:555.","journal-title":"Sci Rep"},{"key":"2767_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s13340-021-00551-0","volume":"13","author":"A Sasaki","year":"2021","unstructured":"Sasaki A, Yokote K, Naitoh T, Fujikura J, Hayashi K, Hirota Y, et al. Metabolic surgery in treatment of obese Japanese patients with type 2 diabetes: a joint consensus statement from the Japanese Society for Treatment of Obesity, the Japan Diabetes Society, and the Japan Society for the Study of Obesity. Diabetol Int. 2021;13:1\u201330.","journal-title":"Diabetol Int"},{"key":"2767_CR10","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1002\/jcla.21824","volume":"30","author":"M Tanaka","year":"2016","unstructured":"Tanaka M, Saito Y, Misu H, Kato S, Kita Y, Takeshita Y, et al. Development of a Sol Particle Homogeneous Immunoassay for Measuring Full-Length Selenoprotein P in Human Serum. J Clin Lab Anal. 2016;30:114\u201322.","journal-title":"J Clin Lab Anal"},{"key":"2767_CR11","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1002\/hep.21496","volume":"45","author":"P Angulo","year":"2007","unstructured":"Angulo P, Hui JM, Marchesini G, Bugianesi E, George J, Farrell GC, et al. The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology. 2007;45:846\u201354.","journal-title":"Hepatology"},{"key":"2767_CR12","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1111\/j.1572-0241.1999.01377.x","volume":"94","author":"EM Brunt","year":"1999","unstructured":"Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol. 1999;94:2467\u201374.","journal-title":"Am J Gastroenterol"},{"key":"2767_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/pin.12485","volume":"67","author":"M Sakamoto","year":"2017","unstructured":"Sakamoto M, Tsujikawa H, Effendi K, Ojima H, Harada K, Zen Y, et al. Pathological findings of nonalcoholic steatohepatitis and nonalcoholic fatty liver disease. Pathol Int. 2017;67:1\u20137.","journal-title":"Pathol Int"},{"key":"2767_CR14","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.cmet.2023.01.006","volume":"35","author":"N Stefan","year":"2023","unstructured":"Stefan N, Schick F, Birkenfeld AL, H\u00e4ring HU, White MF. The role of hepatokines in NAFLD. Cell Metab. 2023;35:236\u201352.","journal-title":"Cell Metab"},{"key":"2767_CR15","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.jare.2022.08.006","volume":"47","author":"Z Zhang","year":"2023","unstructured":"Zhang Z, Yuan Y, Hu L, Tang J, Meng Z, Dai L, et al. ANGPTL8 accelerates liver fibrosis mediated by HFD-induced inflammatory activity via LILRB2\/ERK signaling pathways. J Adv Res. 2023;47:41\u201356.","journal-title":"J Adv Res"},{"key":"2767_CR16","doi-asserted-by":"publisher","first-page":"292","DOI":"10.7150\/ijbs.66834","volume":"18","author":"XH Liu","year":"2022","unstructured":"Liu XH, Qi LW, Alolga RN, Liu Q. Implication of the hepatokine, fibrinogen-like protein 1 in liver diseases, metabolic disorders and cancer: The need to harness its full potential. Int J Biol Sci. 2022;18:292\u2013300.","journal-title":"Int J Biol Sci"},{"key":"2767_CR17","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1074\/jbc.M113.479386","volume":"289","author":"H Takayama","year":"2014","unstructured":"Takayama H, Misu H, Iwama H, Chikamoto K, Saito Y, Murao K, et al. Metformin suppresses expression of the selenoprotein P gene via an AMP-activated kinase (AMPK)\/FoxO3a pathway in H4IIEC3 hepatocytes. J Biol Chem. 2014;289:335\u201345.","journal-title":"J Biol Chem"},{"key":"2767_CR18","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.jhep.2020.03.039","volume":"73","author":"M Eslam","year":"2020","unstructured":"Eslam M, Newsome PN, Sarin SK, Anstee QM, Targher G, Romero-Gomez M, et al. A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement. J Hepatol. 2020;73:202\u20139.","journal-title":"J Hepatol"},{"key":"2767_CR19","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1007\/s00595-021-02266-w","volume":"51","author":"H Nikai","year":"2021","unstructured":"Nikai H, Sasaki A, Umemura A, Takahashi N, Nitta H, Akasaka R, et al. Predictive scoring system for advanced liver fibrosis in Japanese patients with severe obesity. Surg Today. 2021;51:1513\u201320.","journal-title":"Surg Today"},{"key":"2767_CR20","doi-asserted-by":"publisher","first-page":"15392","DOI":"10.1038\/s41598-021-94937-4","volume":"11","author":"K Kakisaka","year":"2021","unstructured":"Kakisaka K, Sasaki A, Umemura A, Nikai H, Suzuki Y, Nishiya M, et al. High frequency and long persistency of ballooning hepatocyte were associated with glucose intolerance in patients with severe obesity. Sci Rep. 2021;11:15392.","journal-title":"Sci Rep"},{"key":"2767_CR21","doi-asserted-by":"publisher","first-page":"164","DOI":"10.3389\/fendo.2014.00164","volume":"5","author":"A Sasaki","year":"2014","unstructured":"Sasaki A, Nitta H, Otsuka K, Umemura A, Baba S, Obuchi T, et al. Bariatric surgery and non-alcoholic fatty liver disease: current and potential future treatments. Front Endocrinol (Lausanne). 2014;5:164.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2767_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2020.100193","volume":"3","author":"T Gwag","year":"2020","unstructured":"Gwag T, Reddy Mooli RG, Li D, Lee S, Lee EY, Wang S. Macrophage-derived thrombospondin 1 promotes obesity-associated non-alcoholic fatty liver disease. JHEP Rep. 2020;3: 100193.","journal-title":"JHEP Rep"},{"key":"2767_CR23","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1159\/000527780","volume":"79","author":"M Li","year":"2023","unstructured":"Li M, Liu L, Kang Y, Huang S, Xiao Y. Circulating THBS1: A Risk Factor for Nonalcoholic Fatty Liver Disease in Obese Children. Ann Nutr Metab. 2023;79:16\u201328.","journal-title":"Ann Nutr Metab"},{"key":"2767_CR24","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1002\/oby.23445","volume":"30","author":"J Kim","year":"2022","unstructured":"Kim J, Lee SK, Kim D, Lee E, Park CY, Choe H, et al. Adipose tissue LECT2 expression is associated with obesity and insulin resistance in Korean women. Obesity (Silver Spring). 2022;30:1430\u201341.","journal-title":"Obesity (Silver Spring)"},{"key":"2767_CR25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174717","volume":"12","author":"HJ Yoo","year":"2017","unstructured":"Yoo HJ, Hwang SY, Choi JH, Lee HJ, Chung HS, Seo JA, et al. Association of leukocyte cell-derived chemotaxin 2 (LECT2) with NAFLD, metabolic syndrome, and atherosclerosis. PLoS ONE. 2017;12: e0174717.","journal-title":"PLoS ONE"},{"key":"2767_CR26","doi-asserted-by":"publisher","first-page":"2920","DOI":"10.3390\/biomedicines10112920","volume":"10","author":"N Takahashi","year":"2022","unstructured":"Takahashi N, Sasaki A, Umemura A, Sugai T, Kakisaka K, Ishigaki Y. Identification of a Fatty Acid for Diagnosing Non-Alcoholic Steatohepatitis in Patients with Severe Obesity Undergoing Metabolic Surgery. Biomedicines. 2022;10:2920.","journal-title":"Biomedicines"},{"key":"2767_CR27","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1111\/j.1440-1827.1998.tb03855.x","volume":"48","author":"H Nagai","year":"1998","unstructured":"Nagai H, Hamada T, Uchida T, Yamagoe S, Suzuki K. Systemic expression of a newly recognized protein, LECT2, in the human body. Pathol Int. 1998;48:882\u20136.","journal-title":"Pathol Int"}],"container-title":["Surgery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00595-023-02767-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00595-023-02767-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00595-023-02767-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T02:04:50Z","timestamp":1716170690000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00595-023-02767-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,13]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["2767"],"URL":"https:\/\/doi.org\/10.1007\/s00595-023-02767-w","relation":{},"ISSN":["0941-1291","1436-2813"],"issn-type":[{"value":"0941-1291","type":"print"},{"value":"1436-2813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,13]]},"assertion":[{"value":"28 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"We have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Our study protocol was approved by the institutional ethics committee (H27-42, MH2022-056) and undertaken within the ethical principles stipulated in the Declaration of Helsinki and its later amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"We obtained informed consent from each of the participants for this study and patient anonymity was strictly preserved.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}