{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T15:01:51Z","timestamp":1789225311535,"version":"build-2803163510"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Today"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1007\/s00595-024-02972-1","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T13:53:22Z","timestamp":1733234002000},"page":"941-952","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prognostic impact of osteosarcopenia on postoperative outcomes in patients with biliary tract cancer"],"prefix":"10.1007","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7257-3586","authenticated-orcid":false,"given":"Tomonari","family":"Shimagaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keishi","family":"Sugimachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Tomino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi","family":"Onishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomichi","family":"Koga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Kasagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasue","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"issue":"3","key":"2972_CR1","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.cger.2011.03.003","volume":"27","author":"IH Rosenberg","year":"2011","unstructured":"Rosenberg IH. Sarcopenia: origins and clinical relevance. Clin Geriatr Med. 2011;27(3):337\u20139.","journal-title":"Clin Geriatr Med"},{"issue":"4","key":"2972_CR2","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1093\/ageing\/afq034","volume":"39","author":"AJ Cruz-Jentoft","year":"2010","unstructured":"Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, et al. Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010;39(4):412\u201323.","journal-title":"Age Ageing"},{"issue":"13","key":"2972_CR3","doi-asserted-by":"publisher","first-page":"3579","DOI":"10.1245\/s10434-011-1976-9","volume":"18","author":"MS Sabel","year":"2011","unstructured":"Sabel MS, Lee J, Cai S, Englesbe MJ, Holcombe S, Wang S. Sarcopenia as a prognostic factor among patients with stage III melanoma. Ann Surg Oncol. 2011;18(13):3579\u201385.","journal-title":"Ann Surg Oncol"},{"issue":"11","key":"2972_CR4","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1007\/s10147-021-01997-7","volume":"26","author":"D Strassmann","year":"2021","unstructured":"Strassmann D, Hensen B, Grunwald V, Stange K, Eggers H, Langer F, et al. Impact of sarcopenia in advanced and metastatic soft tissue sarcoma. Int J Clin Oncol. 2021;26(11):2151\u201360.","journal-title":"Int J Clin Oncol"},{"issue":"11","key":"2972_CR5","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1002\/bjs.9258","volume":"100","author":"N Harimoto","year":"2013","unstructured":"Harimoto N, Shirabe K, Yamashita YI, Ikegami T, Yoshizumi T, Soejima Y, et al. Sarcopenia as a predictor of prognosis in patients following hepatectomy for hepatocellular carcinoma. Br J Surg. 2013;100(11):1523\u201330.","journal-title":"Br J Surg"},{"issue":"6","key":"2972_CR6","first-page":"815","volume":"12","author":"SP Shin","year":"2022","unstructured":"Shin SP, Koh DH. Clinical impact of sarcopenia on cholangiocarcinoma. Life (Basel). 2022;12(6):815.","journal-title":"Life (Basel)."},{"issue":"4","key":"2972_CR7","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1002\/bjs.7823","volume":"99","author":"MG van Vledder","year":"2012","unstructured":"van Vledder MG, Levolger S, Ayez N, Verhoef C, Tran TC, Ijzermans JN. Body composition and outcome in patients undergoing resection of colorectal liver metastases. Br J Surg. 2012;99(4):550\u20137.","journal-title":"Br J Surg"},{"issue":"9321","key":"2972_CR8","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1016\/S0140-6736(02)08761-5","volume":"359","author":"JA Kanis","year":"2002","unstructured":"Kanis JA. Diagnosis of osteoporosis and assessment of fracture risk. Lancet. 2002;359(9321):1929\u201336.","journal-title":"Lancet"},{"issue":"12","key":"2972_CR9","doi-asserted-by":"publisher","first-page":"3318","DOI":"10.1172\/JCI27071","volume":"115","author":"LG Raisz","year":"2005","unstructured":"Raisz LG. Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Investig. 2005;115(12):3318\u201325.","journal-title":"J Clin Investig"},{"issue":"7","key":"2972_CR10","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1007\/s00595-019-01954-y","volume":"50","author":"M Sharshar","year":"2020","unstructured":"Sharshar M, Kaido T, Shirai H, Okumura S, Yao S, Miyachi Y, et al. Impact of the preoperative bone mineral density on the outcomes after resection of pancreatic cancer. Surg Today. 2020;50(7):757\u201366.","journal-title":"Surg Today"},{"issue":"8","key":"2972_CR11","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1002\/lt.24458","volume":"22","author":"P Sharma","year":"2016","unstructured":"Sharma P, Parikh ND, Yu J, Barman P, Derstine BA, Sonnenday CJ, et al. Bone mineral density predicts posttransplant survival among hepatocellular carcinoma liver transplant recipients. Liver Transpl. 2016;22(8):1092\u20138.","journal-title":"Liver Transpl"},{"issue":"12","key":"2972_CR12","doi-asserted-by":"publisher","first-page":"3715","DOI":"10.1245\/s10434-017-6040-y","volume":"24","author":"D Yamada","year":"2017","unstructured":"Yamada D, Eguchi H, Iwagami Y, Mukai Y, Hashimoto Y, Asaoka T, et al. Patients treated with preoperative chemoradiation for pancreatic ductal adenocarcinoma have impaired bone density, a predictor of distant metastasis. Ann Surg Oncol. 2017;24(12):3715\u201324.","journal-title":"Ann Surg Oncol"},{"issue":"11","key":"2972_CR13","doi-asserted-by":"publisher","first-page":"6465","DOI":"10.21873\/anticanres.13009","volume":"38","author":"T Toshima","year":"2018","unstructured":"Toshima T, Yoshizumi T, Ikegami T, Harada N, Itoh S, Mano Y, et al. Impact of osteopenia in liver cirrhosis: special reference to standard bone mineral density with age. Anticancer Res. 2018;38(11):6465\u201371.","journal-title":"Anticancer Res"},{"issue":"3","key":"2972_CR14","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1002\/jcsm.12567","volume":"11","author":"B Kirk","year":"2020","unstructured":"Kirk B, Zanker J, Duque G. Osteosarcopenia: epidemiology, diagnosis, and treatment-facts and numbers. J Cachexia Sarcopenia Muscle. 2020;11(3):609\u201318.","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"5","key":"2972_CR15","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1016\/j.amjsurg.2019.03.010","volume":"218","author":"K Yugawa","year":"2019","unstructured":"Yugawa K, Itoh S, Kurihara T, Yoshiya S, Mano Y, Takeishi K, et al. Skeletal muscle mass predicts the prognosis of patients with intrahepatic cholangiocarcinoma. Am J Surg. 2019;218(5):952\u20138.","journal-title":"Am J Surg"},{"issue":"10","key":"2972_CR16","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1007\/s10147-021-01986-w","volume":"26","author":"K Abe","year":"2021","unstructured":"Abe K, Furukawa K, Okamoto T, Matsumoto M, Futagawa Y, Haruki K, et al. Impact of osteopenia on surgical and oncological outcomes in patients with pancreatic cancer. Int J Clin Oncol. 2021;26(10):1929\u201337.","journal-title":"Int J Clin Oncol"},{"issue":"1","key":"2972_CR17","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1007\/s00268-019-05206-5","volume":"44","author":"T Toshima","year":"2020","unstructured":"Toshima T, Yoshizumi T, Kosai-Fujimoto Y, Inokuchi S, Yoshiya S, Takeishi K, et al. Prognostic impact of osteopenia in patients who underwent living donor liver transplantation for hepatocellular carcinoma. World J Surg. 2020;44(1):258\u201367.","journal-title":"World J Surg"},{"issue":"5","key":"2972_CR18","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.ctrv.2012.08.003","volume":"39","author":"DC McMillan","year":"2013","unstructured":"McMillan DC. The systemic inflammation-based Glasgow Prognostic Score: a decade of experience in patients with cancer. Cancer Treat Rev. 2013;39(5):534\u201340.","journal-title":"Cancer Treat Rev"},{"issue":"8","key":"2972_CR19","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1038\/bjc.2012.92","volume":"106","author":"DJ Pinato","year":"2012","unstructured":"Pinato DJ, North BV, Sharma R. A novel, externally validated inflammation-based prognostic algorithm in hepatocellular carcinoma: the prognostic nutritional index (PNI). Br J Cancer. 2012;106(8):1439\u201345.","journal-title":"Br J Cancer"},{"issue":"4","key":"2972_CR20","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/bjc.2012.292","volume":"107","author":"MJ Proctor","year":"2012","unstructured":"Proctor MJ, McMillan DC, Morrison DS, Fletcher CD, Horgan PG, Clarke SJ. A derived neutrophil to lymphocyte ratio predicts survival in patients with cancer. Br J Cancer. 2012;107(4):695\u20139.","journal-title":"Br J Cancer"},{"issue":"3","key":"2972_CR21","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.amjsurg.2015.03.022","volume":"210","author":"H Zhang","year":"2015","unstructured":"Zhang H, Xia H, Zhang L, Zhang B, Yue D, Wang C. Clinical significance of preoperative neutrophil-lymphocyte vs platelet-lymphocyte ratio in primary operable patients with non-small cell lung cancer. Am J Surg. 2015;210(3):526\u201335.","journal-title":"Am J Surg"},{"issue":"1","key":"2972_CR22","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s11657-022-01060-6","volume":"17","author":"J Watanabe","year":"2022","unstructured":"Watanabe J, Saitsu A, Miki A, Kotani K, Sata N. Prognostic value of preoperative low bone mineral density in patients with digestive cancers: a systematic review and meta-analysis. Arch Osteoporos. 2022;17(1):33.","journal-title":"Arch Osteoporos"},{"issue":"3","key":"2972_CR23","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.pan.2023.02.002","volume":"23","author":"T Takeda","year":"2023","unstructured":"Takeda T, Sasaki T, Okamoto T, Ishitsuka T, Yamada M, Nakagawa H, et al. Prognostic impact of osteosarcopenia in patients with advanced pancreatic cancer receiving gemcitabine plus nab-paclitaxel. Pancreatology. 2023;23(3):275\u201382.","journal-title":"Pancreatology"},{"issue":"2","key":"2972_CR24","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.semarthrit.2015.04.014","volume":"45","author":"RH Straub","year":"2015","unstructured":"Straub RH, Cutolo M, Pacifici R. Evolutionary medicine and bone loss in chronic inflammatory diseases\u2014a theory of inflammation-related osteopenia. Semin Arthritis Rheum. 2015;45(2):220\u20138.","journal-title":"Semin Arthritis Rheum"},{"issue":"7","key":"2972_CR25","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1002\/jbmr.1608","volume":"27","author":"CJ Cain","year":"2012","unstructured":"Cain CJ, Rueda R, McLelland B, Collette NM, Loots GG, Manilay JO. Absence of sclerostin adversely affects B-cell survival. J Bone Miner Res. 2012;27(7):1451\u201361.","journal-title":"J Bone Miner Res"},{"issue":"4","key":"2972_CR26","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1158\/1541-7786.MCR-05-0261","volume":"4","author":"H Lu","year":"2006","unstructured":"Lu H, Ouyang W, Huang C. Inflammation, a key event in cancer development. Mol Cancer Res. 2006;4(4):221\u201333.","journal-title":"Mol Cancer Res"},{"issue":"2","key":"2972_CR27","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ccell.2020.06.001","volume":"38","author":"JD Hayes","year":"2020","unstructured":"Hayes JD, Dinkova-Kostova AT, Tew KD. Oxidative stress in cancer. Cancer Cell. 2020;38(2):167\u201397.","journal-title":"Cancer Cell"},{"issue":"5","key":"2972_CR28","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","volume":"12","author":"K Fearon","year":"2011","unstructured":"Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011;12(5):489\u201395.","journal-title":"Lancet Oncol"},{"issue":"6","key":"2972_CR29","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1002\/ags3.12686","volume":"7","author":"T Shimagaki","year":"2023","unstructured":"Shimagaki T, Sugimachi K, Mano Y, Onishi E, Iguchi T, Nakashima Y, et al. Cachexia index as a prognostic predictor after resection of pancreatic ductal adenocarcinoma. Ann Gastroenterol Surg. 2023;7(6):977\u201386.","journal-title":"Ann Gastroenterol Surg"},{"issue":"1","key":"2972_CR30","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jhep.2015.02.031","volume":"63","author":"N Fujiwara","year":"2015","unstructured":"Fujiwara N, Nakagawa H, Kudo Y, Tateishi R, Taguri M, Watadani T, et al. Sarcopenia, intramuscular fat deposition, and visceral adiposity independently predict the outcomes of hepatocellular carcinoma. J Hepatol. 2015;63(1):131\u201340.","journal-title":"J Hepatol"},{"key":"2972_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109095","volume":"111","author":"L Hu","year":"2022","unstructured":"Hu L, Liu R, Zhang L. Advance in bone destruction participated by JAK\/STAT in rheumatoid arthritis and therapeutic effect of JAK\/STAT inhibitors. Int Immunopharmacol. 2022;111: 109095.","journal-title":"Int Immunopharmacol"},{"key":"2972_CR32","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.724911","volume":"12","author":"L Zhang","year":"2021","unstructured":"Zhang L, Sun Y. Muscle-bone crosstalk in chronic obstructive pulmonary disease. Front Endocrinol (Lausanne). 2021;12: 724911.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"10","key":"2972_CR33","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.3390\/nu9101126","volume":"9","author":"A Hammad","year":"2017","unstructured":"Hammad A, Kaido T, Aliyev V, Mandato C, Uemoto S. Nutritional therapy in liver transplantation. Nutrients. 2017;9(10):1126.","journal-title":"Nutrients"}],"container-title":["Surgery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00595-024-02972-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00595-024-02972-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00595-024-02972-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T06:26:06Z","timestamp":1750400766000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00595-024-02972-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,3]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["2972"],"URL":"https:\/\/doi.org\/10.1007\/s00595-024-02972-1","relation":{},"ISSN":["0941-1291","1436-2813"],"issn-type":[{"value":"0941-1291","type":"print"},{"value":"1436-2813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,3]]},"assertion":[{"value":"6 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest in association with the present study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study protocol complied with the ethical guidelines for human clinical research established by the Japanese Ministry of Health, Labour, and Welfare, as well as with the 1964 Helsinki Declaration and its later amendments, and was approved by the Ethics and Indications Committee of the National Hospital Organization Kyushu Cancer Center (No. 2019-54).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Animal studies"}}]}}