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The primary endpoint was change in the Cancer Fatigue Scale (CFS) score from baseline and the secondary endpoints were the Cancer Dyspnea Scale (CDS) scores, the Kihon Checklist, and respiratory function.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The mean change in the CFS score 8\u00a0weeks postoperatively was\u2009\u2212\u20095.56 in the ninjin\u2019yoeito group and\u2009\u2212\u20095.53 in the conventional treatment group (<jats:italic>P<\/jats:italic>\u2009=\u20090.425), but this outcome did not meet the primary endpoint. Changes in the mean CDS scores 8\u00a0weeks postoperatively were\u2009\u2212\u20095.60 and\u2009\u2212\u20093.38 in the ninjin\u2019yoeito and conventional groups, respectively, with a difference of\u2009\u2212\u20091.95 (<jats:italic>P<\/jats:italic>\u2009=\u20090.049). The changes in the mean vital capacity 8\u00a0weeks postoperatively were\u2009\u2212\u2009340.5\u00a0mL in the ninjin\u2019yoeito group and\u2009\u2212\u2009473.5\u00a0mL in the conventional treatment group, with a difference of\u2009+\u2009135.1\u00a0mL (<jats:italic>P<\/jats:italic>\u2009=\u20090.041). The ninjin\u2019yoeito group had a significantly lower proportion of patients with malnutrition 16\u00a0weeks postoperatively than the conventional treatment group (<jats:italic>P<\/jats:italic>\u2009=\u20090.040).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The results of this study show that ninjin\u2019yoeito is effective for alleviating respiratory symptoms and improving malnutrition after lung cancer surgery.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00595-024-02977-w","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T13:31:46Z","timestamp":1735047106000},"page":"693-704","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ninjin\u2019yoeito improves respiratory symptoms after lung cancer surgery: a prospective randomized study"],"prefix":"10.1007","volume":"55","author":[{"given":"Suguru","family":"Mitsui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yugo","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Nishikubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takefumi","family":"Doi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Tane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Hokka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Imai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimasa","family":"Maniwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"2977_CR1","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/S0003-4975(01)02804-1","volume":"72","author":"I Nagahiro","year":"2001","unstructured":"Nagahiro I, Andou A, Aoe M, Sano Y, Date H, Shimizu N. 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