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ET-ESP, ET-TUB, and TNF-\u03b1 levels on POD0 and serum C-reactive protein (CRP) on POD1 were significantly elevated in the AL group. The area under the receiver operating characteristic curve (AUROC) for ET-ESP level (0.903) on POD0 showed early and better predictive performance for AL compared to that for ET-TUB (0.869,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.230) and TNF-\u03b1 (0.758,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034) levels on POD0; the AUROC for CRP level (0.711) on POD1 was inferior to other parameters. In subgroup analysis, five (3.7%) of 136 patients with colorectal cancer (CRC) developed AL. Additionally, the ET-ESP level on POD0 showed relatively good predictive performance for AL after CRC (AUROC: ET-ESP [0.871], ET-TUB [0.840], and TNF-\u03b1 [0.737] on POD0).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ET levels in drainage fluid, especially those measured using ESP, on POD0 may have an early predictive ability to detect AL post-CRS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00595-025-03106-x","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T10:29:32Z","timestamp":1753266572000},"page":"64-73","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Endotoxin in drainage fluid as an early and predictive marker of anastomotic leakage after colorectal surgery"],"prefix":"10.1007","volume":"56","author":[{"given":"Takashi","family":"Matsunaga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0947-0116","authenticated-orcid":false,"given":"Toru","family":"Miyake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeru","family":"Maekawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumie","family":"Tsukaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Obata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoharu","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaji","family":"Tani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"3106_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2022.101708","volume":"40","author":"MM Chiarello","year":"2022","unstructured":"Chiarello MM, Fransvea P, Cariati M, Adams NJ, Bianchi V, Brisinda G. 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