{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:25:59Z","timestamp":1786980359280,"version":"build-2736575974"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Today"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s00595-025-03163-2","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T13:13:47Z","timestamp":1762434827000},"page":"515-524","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic discrepancies between surgery-first and neoadjuvant-treated resected pancreatic cancer in the same pathological stage"],"prefix":"10.1007","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9912-9119","authenticated-orcid":false,"given":"Suguru","family":"Yamada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Nomoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Sanada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akimasa","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"issue":"19","key":"3163_CR1","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1056\/NEJMoa1011923","volume":"364","author":"T Conroy","year":"2011","unstructured":"Conroy T, Desseigne F, Ychou M, Bouche O, Guimbaud R, Becouarn Y, et al. Folfirinox versus gemcitabine for metastatic pancreatic cancer. N Engl J Med. 2011;364(19):1817\u201325.","journal-title":"N Engl J Med"},{"issue":"18","key":"3163_CR2","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1056\/NEJMoa1304369","volume":"369","author":"DD Von Hoff","year":"2013","unstructured":"Von Hoff DD, Ervin T, Arena FP, Chiorean EG, Infante J, Moore M, et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med. 2013;369(18):1691\u2013703.","journal-title":"N Engl J Med"},{"key":"3163_CR3","unstructured":"Network NCC. NCCN clinical practice guidelines in oncology (NCCN Guidelines\u00ae). Version 2 2025. NCCN; 2025."},{"key":"3163_CR4","doi-asserted-by":"crossref","unstructured":"Unno M, Motoi F, Matsuyama Y, Satoi S, Toyama H, Matsumoto I et al. Neoadjuvant chemotherapy with gemcitabine and S-1 versus upfront surgery for resectable pancreatic cancer: results of the randomized phase II\/III Prep-02\/JSAP05 trial. Ann Surg. 2025.","DOI":"10.1097\/SLA.0000000000006730"},{"issue":"39","key":"3163_CR5","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001647","volume":"94","author":"T Fujii","year":"2015","unstructured":"Fujii T, Yamada S, Murotani K, Kanda M, Sugimoto H, Nakao A, et al. Inverse probability of treatment weighting analysis of upfront surgery versus neoadjuvant chemoradiotherapy followed by surgery for pancreatic adenocarcinoma with arterial abutment. Medicine (Baltimore). 2015;94(39):e1647.","journal-title":"Medicine (Baltimore)"},{"issue":"6","key":"3163_CR6","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1097\/SLA.0000000000005430","volume":"275","author":"J Yamaguchi","year":"2022","unstructured":"Yamaguchi J, Yokoyama Y, Fujii T, Yamada S, Takami H, Kawashima H. Results of a phase II study on the use of neoadjuvant chemotherapy (FOLFIRINOX or GEM\/nab-PTX) for borderline-resectable pancreatic cancer (NUPAT-01). Ann Surg. 2022;275(6):1043\u20139.","journal-title":"Ann Surg"},{"key":"3163_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2024.03.012","author":"S Yamada","year":"2024","unstructured":"Yamada S, Hashimoto D, Yamamoto T, Yamaki S, Oshima K, Murotani K, et al. Reconsideration of the clinical impact of neoadjuvant therapy in resectable and borderline resectable pancreatic cancer: a dual-institution collaborative clinical study. Pancreatology. 2024. https:\/\/doi.org\/10.1016\/j.pan.2024.03.012.","journal-title":"Pancreatology"},{"key":"3163_CR8","first-page":"1","volume":"00","author":"S Satoi","year":"2019","unstructured":"Satoi S, Yamamoto T, Yamaki S, Sakaguchi T, Sekimoto M. Surgical indication for and desirable outcomes of conversion surgery in patients with initially unresectable pancreatic ductal adenocarcinoma. Ann Gastroenterol Surg. 2019;00:1\u20138.","journal-title":"Ann Gastroenterol Surg"},{"issue":"1","key":"3163_CR9","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/ags3.12613","volume":"7","author":"T Igarashi","year":"2023","unstructured":"Igarashi T, Yamada S, Hoshino Y, Murotani K, Baba H, Takami H, et al. Prognostic factors in conversion surgery following nab-paclitaxel with gemcitabine and subsequent chemoradiotherapy for unresectable locally advanced pancreatic cancer: results of a dual-center study. Ann Gastroenterol Surg. 2023;7(1):157\u201366.","journal-title":"Ann Gastroenterol Surg"},{"issue":"3","key":"3163_CR10","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1002\/bjs.1800820340","volume":"82","author":"A Nakao","year":"1995","unstructured":"Nakao A, Harada A, Nonami T, Kaneko T, Murakami H, Inoue S, et al. Lymph node metastases in carcinoma of the head of the pancreas region. Br J Surg. 1995;82(3):399\u2013402.","journal-title":"Br J Surg"},{"issue":"8","key":"3163_CR11","first-page":"1090","volume":"84","author":"A Nakao","year":"1997","unstructured":"Nakao A, Harada A, Nonami T, Kaneko T, Nomoto S, Koyama H, et al. Lymph node metastasis in carcinoma of the body and tail of the pancreas. Br J Surg. 1997;84(8):1090\u20132.","journal-title":"Br J Surg"},{"key":"3163_CR12","unstructured":"Amin MBES, Greene FL, et al. AJCC cancer staging manual. 8th ed. ed: Springer; 2017."},{"key":"3163_CR13","volume-title":"Classification of pancretic Carcinoma. Fourth english edition ed","author":"Japan Pancreas Society","year":"2017","unstructured":"Japan Pancreas Society. Classification of pancretic Carcinoma. Fourth english edition ed. Tokyo: Kanehara & Co., Ltd.; 2017."},{"issue":"6","key":"3163_CR14","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1007\/s00534-013-0616-0","volume":"20","author":"S Satoi","year":"2013","unstructured":"Satoi S, Yamaue H, Kato K, Takahashi S, Hirono S, Takeda S. Role of adjuvant surgery for patients with initially unresectable pancreatic cancer with a long\u2010term favorable response to non\u2010surgical anti\u2010cancer treatments: results of a project study for pancreatic surgery by the Japanese Society of Hepato\u2010Biliary\u2010Pancreatic Surgery. J Hepatobiliary Pancreat Sci. 2013;20(6):590\u2013600.","journal-title":"J Hepatobiliary Pancreat Sci"},{"issue":"Suppl 1","key":"3163_CR15","doi-asserted-by":"publisher","first-page":"S110","DOI":"10.21037\/jgo-20-243","volume":"12","author":"S Yamada","year":"2021","unstructured":"Yamada S, Fujii T, Yamamoto T, Takami H, Yoshioka I, Yamaki S, et al. Conversion surgery in patients with pancreatic cancer and peritoneal metastasis. J Gastrointest Oncol. 2021;12(Suppl 1):S110\u20137.","journal-title":"J Gastrointest Oncol"},{"key":"3163_CR16","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-023-02782-x","author":"S Yamada","year":"2024","unstructured":"Yamada S, Oshima K, Nomoto K, Sunagawa Y, Oshima Y, Nakao A. The survival in octogenarians undergoing surgery for pancreatic cancer and its association with the nutritional status. Surg Today. 2024. https:\/\/doi.org\/10.1007\/s00595-023-02782-x.","journal-title":"Surg Today"},{"issue":"5","key":"3163_CR17","first-page":"426","volume":"40","author":"A Nakao","year":"1993","unstructured":"Nakao A, Takagi H. Isolated pancreatectomy for pancreatic head carcinoma using catheter bypass of the portal vein. Hepatogastroenterology. 1993;40(5):426\u20139.","journal-title":"Hepatogastroenterology"},{"issue":"3","key":"3163_CR18","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1002\/jhbp.1092","volume":"29","author":"A Nakao","year":"2022","unstructured":"Nakao A. Isolated pancreatectomy using mesenteric approach. J Hepatobiliary Pancreat Sci. 2022;29(3):293\u2013300.","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"3163_CR19","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-025-03062-6","author":"Y Matsui","year":"2025","unstructured":"Matsui Y, Hashimoto D, Nakagawa N, Yamaki S, Hayashi M, Takami H, et al. Long-term outcomes of prophylactic right-half dissection of the superior mesenteric artery nerve plexus in pancreatoduodenectomy for pancreatic ductal adenocarcinoma: five-year results from a randomized phase II trial. Surg Today. 2025. https:\/\/doi.org\/10.1007\/s00595-025-03062-6.","journal-title":"Surg Today"},{"key":"3163_CR20","doi-asserted-by":"crossref","unstructured":"Brierley JDGM, Wittekind C. UICC TNM Classification of Malignant Tumours, 8th Edition: Wiley Blackwell; 2016.","DOI":"10.1002\/9780471420194.tnmc26.pub3"},{"issue":"1","key":"3163_CR21","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.radonc.2015.03.019","volume":"115","author":"CC Wang","year":"2015","unstructured":"Wang CC, Cheng JC, Tsai CL, Lee JM, Huang PM, Lin CC, et al. Pathological stage after neoadjuvant chemoradiation and esophagectomy superiorly predicts survival in patients with esophageal squamous cell carcinoma. Radiother Oncol. 2015;115(1):9\u201315.","journal-title":"Radiother Oncol"},{"issue":"1","key":"3163_CR22","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5283-3","volume":"19","author":"Z Li","year":"2019","unstructured":"Li Z, Wang Y, Ying X, Shan F, Wu Z, Zhang L, et al. Different prognostic implication of YpTNM stage and pTNM stage for gastric cancer: a propensity score-matched analysis. BMC Cancer. 2019;19(1):80.","journal-title":"BMC Cancer"},{"issue":"11","key":"3163_CR23","first-page":"1723","volume":"32","author":"JP Chuang","year":"2024","unstructured":"Chuang JP, Tsai HL, Su WC, Chen PJ, Huang CW, Chang TK, et al. Is YpTNM staging a comparable predictor as pTNM staging for survival in non-metastatic rectal cancer after preoperative chemoradiation therapy? Oncol Res. 2024;32(11):1723\u201332.","journal-title":"Oncol Res"},{"issue":"4","key":"3163_CR24","doi-asserted-by":"publisher","first-page":"2799","DOI":"10.1245\/s10434-024-16792-7","volume":"32","author":"HS Kim","year":"2025","unstructured":"Kim HS, Chae H, Lim SY, Jeong H, Yoon SJ, Shin SH, et al. Prognostic accuracy of YpTNM stage in patients with pancreatic cancer in the era of modern neoadjuvant therapy. Ann Surg Oncol. 2025;32(4):2799\u2013808.","journal-title":"Ann Surg Oncol"},{"issue":"10041","key":"3163_CR25","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/S0140-6736(16)30583-9","volume":"388","author":"K Uesaka","year":"2016","unstructured":"Uesaka K, Boku N, Fukutomi A, Okamura Y, Konishi M, Matsumoto I, et al. Adjuvant chemotherapy of S-1 versus gemcitabine for resected pancreatic cancer: a phase 3, open-label, randomised, non-inferiority trial (JASPAC 01). Lancet. 2016;388(10041):248\u201357.","journal-title":"Lancet"},{"key":"3163_CR26","doi-asserted-by":"crossref","unstructured":"Yamada S, Fujii T, Yokoyama Y, Kawashima H, Maeda O, Suzuki K et al. Phase I study of chemoradiotherapy using gemcitabine plus nab-paclitaxel for unresectable locally advanced pancreatic cancer. Cancer Chemother Pharmacol. 2018.","DOI":"10.1016\/j.hpb.2018.06.1962"},{"key":"3163_CR27","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.748","author":"S Yamada","year":"2020","unstructured":"Yamada S, Yokoyama Y, Sonohara F, Yamaguchi J, Takami H, Hayashi M, et al. Tumor marker recovery rather than major pathological response is a preferable prognostic factor in patients with pancreatic ductal adenocarcinoma with preoperative therapy. J Hepatobiliary Pancreat Sci. 2020;27(8):487\u2013495https:\/\/doi.org\/10.1002\/jhbp.748.","journal-title":"J Hepatobiliary Pancreat Sci"},{"issue":"20","key":"3163_CR28","doi-asserted-by":"publisher","first-page":"2773","DOI":"10.1200\/JCO.2010.34.4911","volume":"29","author":"C Aschele","year":"2011","unstructured":"Aschele C, Cionini L, Lonardi S, Pinto C, Cordio S, Rosati G, et al. Primary tumor response to preoperative chemoradiation with or without oxaliplatin in locally advanced rectal cancer: pathologic results of the STAR-01 randomized phase III trial. J Clin Oncol. 2011;29(20):2773\u201380.","journal-title":"J Clin Oncol"},{"issue":"8","key":"3163_CR29","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.1093\/annonc\/mdt141","volume":"24","author":"S Lorenzen","year":"2013","unstructured":"Lorenzen S, Thuss-Patience P, Al-Batran SE, Lordick F, Haller B, Schuster T, et al. Impact of pathologic complete response on disease-free survival in patients with esophagogastric adenocarcinoma receiving preoperative docetaxel-based chemotherapy. Ann Oncol. 2013;24(8):2068\u201373.","journal-title":"Ann Oncol"}],"container-title":["Surgery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00595-025-03163-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00595-025-03163-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00595-025-03163-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T07:49:03Z","timestamp":1774338543000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00595-025-03163-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,6]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["3163"],"URL":"https:\/\/doi.org\/10.1007\/s00595-025-03163-2","relation":{},"ISSN":["0941-1291","1436-2813"],"issn-type":[{"value":"0941-1291","type":"print"},{"value":"1436-2813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,6]]},"assertion":[{"value":"17 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no commercial affiliations that could pose any conflicts of interest in connection with this study. This research did not receive any specific grants from funding agencies in the public, commercial, or not-for-profit sectors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}