{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T06:58:41Z","timestamp":1793429921923,"version":"4.5.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Today"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s00595-025-03177-w","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T11:05:17Z","timestamp":1765623917000},"page":"411-420","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Research progress of stem cell transplantation in the treatment of anal fistula"],"prefix":"10.1007","volume":"56","author":[{"given":"XiaoJuan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SiYu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,13]]},"reference":[{"issue":"3","key":"3177_CR1","doi-asserted-by":"publisher","first-page":"257","DOI":"10.4252\/wjsc.v16.i3.257","volume":"16","author":"MY Park","year":"2024","unstructured":"Park MY, Yoon YS, Park JH, Lee JL, Yu CS. Long-term outcome of stem cell transplantation with and without anti-tumor necrotic factor therapy in perianal fistula with Crohn\u2019s disease. World J Stem Cells. 2024;16(3):257\u201366. https:\/\/doi.org\/10.4252\/wjsc.v16.i3.257.","journal-title":"World J Stem Cells"},{"issue":"3","key":"3177_CR2","first-page":"289","volume":"73","author":"N Fathallah","year":"2023","unstructured":"Fathallah N, Alam A, Kassouri L, Barr\u00e9 A, Spindler L, De Parades V. Management of secondary lesions in ano-perineal crohn\u2019s disease. Rev Prat. 2023;73(3):289\u201395.","journal-title":"Rev Prat"},{"issue":"1","key":"3177_CR3","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/s13287-023-03331-6","volume":"14","author":"H Wang","year":"2023","unstructured":"Wang H, Jiang HY, Zhang YX, Jin HY, Fei BY, Jiang JL. Mesenchymal stem cells transplantation for perianal fistulas: a systematic review and meta-analysis of clinical trials. Stem Cell Res Ther. 2023;14(1):103. https:\/\/doi.org\/10.1186\/s13287-023-03331-6.","journal-title":"Stem Cell Res Ther"},{"issue":"3","key":"3177_CR4","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1097\/DCR.0000000000002379","volume":"66","author":"HR Dalby","year":"2023","unstructured":"Dalby HR, Dige A, Pedersen BG, et al. Efficacy of injection of freshly collected autologous adipose tissue into complex cryptoglandular anal fistulas. Dis Colon Rectum. 2023;66(3):443. https:\/\/doi.org\/10.1097\/DCR.0000000000002379.","journal-title":"Dis Colon Rectum"},{"issue":"10051","key":"3177_CR5","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1016\/S0140-6736(16)31203-X","volume":"388","author":"J Pan\u00e9s","year":"2016","unstructured":"Pan\u00e9s J, Garc\u00eda-Olmo D, Van Assche G, Colombel JF, Reinisch W, Baumgart DC, et al. Expanded allogeneic adipose-derived mesenchymal stem cells for complex perianal fistulas: a phase III randomized, double-blind controlled trial. Lancet. 2016;388(10051):1281\u201390. https:\/\/doi.org\/10.1016\/S0140-6736(16)31203-X.","journal-title":"Lancet"},{"issue":"2","key":"3177_CR6","doi-asserted-by":"publisher","first-page":"3368","DOI":"10.1053\/j.gastro.2019.05.037","volume":"157","author":"AL Lightner","year":"2019","unstructured":"Lightner AL. Regenerative medicine interventions in refractory perianal fistulizing crohn\u2019s disease: ready for primetime? Gastroenterology. 2019;157(2):3368. https:\/\/doi.org\/10.1053\/j.gastro.2019.05.037.","journal-title":"Gastroenterology"},{"issue":"7","key":"3177_CR7","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1097\/DCR.0b013e318255364a","volume":"55","author":"D Garcia-Olmo","year":"2012","unstructured":"Garcia-Olmo D, Herreros D, Pascual I, Pascual JA, Del-Valle E, Zorrilla J, et al. Autologous expanded adipose-derived stem cells for the treatment of complex cryptoglandular perianal fistulas: a phase III randomized clinical trial (FATT 1: fistula advanced therapy trial 1) and long-term evaluation. Dis Colon Rectum. 2012;55(7):762\u201372. https:\/\/doi.org\/10.1097\/DCR.0b013e318255364a. PMID: 22706128.","journal-title":"Dis Colon Rectum"},{"key":"3177_CR8","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001863","author":"VM Maciel Guti\u00e9rrez","year":"2021","unstructured":"Maciel Guti\u00e9rrez VM, Guti\u00e9rrez Guillen SG, Centeno Flores MW, Valenzuela P\u00e9rez JA, Abarca Rend\u00f3n FM, Hern\u00e1ndez Garc\u00eda FS, et al. Safety of allogeneic adipose tissue-derived mesenchymal stem cells for the treatment of complex perianal fistulas not associated with Crohn\u2019s disease: a phase i clinical trial. Dis Colon Rectum. 2021. https:\/\/doi.org\/10.1097\/DCR.0000000000001863.","journal-title":"Dis Colon Rectum"},{"issue":"1","key":"3177_CR9","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1186\/s13287-020-01995-y","volume":"11","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Ni M, Zhou C, et al. Autologous adipose-derived stem cells for the treatment of complex cryptoglandular perianal fistula: a prospective case-control study. Stem Cell Res Ther. 2020;11(1):475. https:\/\/doi.org\/10.1186\/s13287-020-01995-y.","journal-title":"Stem Cell Res Ther"},{"issue":"5","key":"3177_CR10","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/s10151-019-01994-z","volume":"23","author":"S Choi","year":"2019","unstructured":"Choi S, Jeon BG, Chae G, Lee SJ. The clinical efficacy of stem cell therapy for complex perianal fistulas: a meta-analysis. Tech Coloproctol. 2019;23(5):411\u201327. https:\/\/doi.org\/10.1007\/s10151-019-01994-z.","journal-title":"Tech Coloproctol"},{"key":"3177_CR11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/bs.pmbts.2023.02.012","volume":"199","author":"Z Tian","year":"2023","unstructured":"Tian Z, Yu T, Liu J, Wang T, Higuchi A. Introduction to stem cells. Prog Mol Biol Transl Sci. 2023;199:3\u201332. https:\/\/doi.org\/10.1016\/bs.pmbts.2023.02.012.","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"1","key":"3177_CR12","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1186\/s13287-023-03406-4","volume":"14","author":"M Liu","year":"2023","unstructured":"Liu M, Zhou R, Zou W, et al. Machine learning-identified stemness features and constructed stemness-related subtype with prognosis, chemotherapy, and immunotherapy responses for non-small cell lung cancer patients. Stem Cell Res Ther. 2023;14(1):238. https:\/\/doi.org\/10.1186\/s13287-023-03406-4.","journal-title":"Stem Cell Res Ther"},{"key":"3177_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2024.102143","volume":"87","author":"K Kikkawa","year":"2024","unstructured":"Kikkawa K, Tamaki M, Maruno K, et al. Kidney transplantation after ABO-incompatible hematopoietic stem cell transplantation: a case report and literature review. Transpl Immunol. 2024;87:102143. https:\/\/doi.org\/10.1016\/j.trim.2024.102143.","journal-title":"Transpl Immunol"},{"issue":"6","key":"3177_CR14","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/j.stem.2018.05.004","volume":"22","author":"J Galipeau","year":"2018","unstructured":"Galipeau J, Sens\u00e9b\u00e9 L. Mesenchymal stromal cells: clinical challenges and therapeutic opportunities. Cell Stem Cell. 2018;22(6):824\u201333. https:\/\/doi.org\/10.1016\/j.stem.2018.05.004.","journal-title":"Cell Stem Cell"},{"issue":"6","key":"3177_CR15","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1159\/000515351","volume":"211","author":"G Tejeda","year":"2022","unstructured":"Tejeda G, Ciciriello AJ, Dumont CM. Biomaterial strategies to bolster neural stem cell-mediated repair of the central nervous system. Cells Tissues Organs. 2022;211(6):655\u201369. https:\/\/doi.org\/10.1159\/000515351.","journal-title":"Cells Tissues Organs"},{"key":"3177_CR16","doi-asserted-by":"publisher","DOI":"10.4103\/NRR.NRR-D-22-00311","author":"FQ Meng","year":"2024","unstructured":"Meng FQ, Li CC, Xu WJ, et al. Induced pluripotent stem cell-derived mesenchymal stem cells enhance acellular nerve allografts to promote peripheral nerve regeneration by facilitating angiogenesis. Neural Regen Res. 2024. https:\/\/doi.org\/10.4103\/NRR.NRR-D-22-00311.","journal-title":"Neural Regen Res"},{"key":"3177_CR17","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6918090","volume":"2019","author":"X Qin","year":"2019","unstructured":"Qin X, Wang P, Huang Y, Li Y, Chao M, Wang W. Adipose-derived stem cells are an efficient treatment for fistula-in-ano of Japanese rabbit. Stem Cells Int. 2019;2019:6918090. https:\/\/doi.org\/10.1155\/2019\/6918090.","journal-title":"Stem Cells Int"},{"issue":"10","key":"3177_CR18","doi-asserted-by":"publisher","first-page":"6281","DOI":"10.1007\/s12035-022-02967-4","volume":"59","author":"A Asgari Taei","year":"2022","unstructured":"Asgari Taei A, Khodabakhsh P, Nasoohi S, Farahmandfar M, Dargahi L. Paracrine effects of mesenchymal stem cells in ischemic stroke: opportunities and challenges. Mol Neurobiol. 2022;59(10):6281\u2013306. https:\/\/doi.org\/10.1007\/s12035-022-02967-4.","journal-title":"Mol Neurobiol"},{"issue":"1","key":"3177_CR19","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s11658-024-00551-3","volume":"29","author":"Z Vahidinia","year":"2024","unstructured":"Vahidinia Z, Azami Tameh A, Barati S, Izadpanah M, Seyed Hosseini E. Nrf2 activation: a key mechanism in stem cell exosomes-mediated therapies. Cell Mol Biol Lett. 2024;29(1):30. https:\/\/doi.org\/10.1186\/s11658-024-00551-3.","journal-title":"Cell Mol Biol Lett"},{"issue":"8","key":"3177_CR20","doi-asserted-by":"publisher","first-page":"5221","DOI":"10.1111\/odi.14982","volume":"30","author":"Y Liu","year":"2024","unstructured":"Liu Y, Zhang Z, Ma C, Song J, Hu J, Liu Y. Transplanted MSCs promote alveolar bone repair via hypoxia-induced extracellular vesicle secretion. Oral Dis. 2024;30(8):5221\u201331. https:\/\/doi.org\/10.1111\/odi.14982.","journal-title":"Oral Dis"},{"issue":"1","key":"3177_CR21","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.70048","volume":"17","author":"X Wang","year":"2025","unstructured":"Wang X, Zeng Z, Li D, et al. Advancements and challenges in immune protection strategies for islet transplantation. J Diabetes. 2025;17(1):e70048. https:\/\/doi.org\/10.1111\/1753-0407.70048.","journal-title":"J Diabetes"},{"issue":"17","key":"3177_CR22","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202306577","volume":"11","author":"P Song","year":"2024","unstructured":"Song P, Han T, Wu Z, et al. Transplantation of neural stem cells loaded in an igf-1 bioactive supramolecular nanofiber hydrogel for the effective treatment of spinal cord injury. Adv Sci. 2024;11(17):e2306577. https:\/\/doi.org\/10.1002\/advs.202306577.","journal-title":"Adv Sci"},{"key":"3177_CR23","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7045245","volume":"2018","author":"Z Chen","year":"2018","unstructured":"Chen Z, Chen L, Zeng C, Wang WE. Functionally improved mesenchymal stem cells to better treat myocardial infarction. Stem Cells Int. 2018;2018:7045245. https:\/\/doi.org\/10.1155\/2018\/7045245.","journal-title":"Stem Cells Int"},{"issue":"7","key":"3177_CR24","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.jacc.2016.11.009","volume":"69","author":"JM Hare","year":"2017","unstructured":"Hare JM, DiFede DL, Rieger AC, Florea V, Landin AM, El-Khorazaty J, et al. Randomized comparison of allogeneic versus autologous mesenchymal stem cells for nonischemic dilated cardiomyopathy. J Am Coll Cardiol. 2017;69(7):526\u201337. https:\/\/doi.org\/10.1016\/j.jacc.2016.11.009.","journal-title":"J Am Coll Cardiol"},{"key":"3177_CR25","doi-asserted-by":"publisher","DOI":"10.1159\/000542206","author":"JRN Lemos","year":"2024","unstructured":"Lemos JRN, Skyler JS. Challenges in beta cell replacement for type 1 diabetes. Horm Res Paediatr. 2024. https:\/\/doi.org\/10.1159\/000542206.","journal-title":"Horm Res Paediatr"},{"issue":"16","key":"3177_CR26","doi-asserted-by":"publisher","first-page":"e35836","DOI":"10.1016\/j.heliyon.2024.e35836","volume":"10","author":"L Wei","year":"2024","unstructured":"Wei L, Yan W, Shah W, et al. Advancements and challenges in stem cell transplantation for regenerative medicine. Heliyon. 2024;10(16):e35836. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e35836.","journal-title":"Heliyon"},{"issue":"26","key":"3177_CR27","doi-asserted-by":"publisher","first-page":"2268","DOI":"10.1182\/blood.2023020079","volume":"142","author":"ES Hellstrom-Lindberg","year":"2023","unstructured":"Hellstrom-Lindberg ES, Krger N. Clinical decision-making and treatment of myelodysplastic syndromes. Blood. 2023;142(26):2268\u201381. https:\/\/doi.org\/10.1182\/blood.2023020079.","journal-title":"Blood"},{"key":"3177_CR28","doi-asserted-by":"publisher","first-page":"825166","DOI":"10.3389\/fsurg.2022.825166","volume":"9","author":"H Huang","year":"2022","unstructured":"Huang H, Ji L, Gu Y, Li Y, Xu S. Efficacy and safety of sphincter-preserving surgery in the treatment of complex anal fistula: A network meta-analysis. Front Surg. 2022;9:825166. https:\/\/doi.org\/10.3389\/fsurg.2022.825166.","journal-title":"Front Surg"},{"issue":"21","key":"3177_CR29","doi-asserted-by":"publisher","first-page":"e25868","DOI":"10.1097\/MD.0000000000025868","volume":"100","author":"HH Hung","year":"2021","unstructured":"Hung HH, Lee HC, Yeung CY, et al. Importance of early detection of infantile inflammatory bowel disease with defective IL-10 pathway: A case report. Med (Baltim). 2021;100(21):e25868. https:\/\/doi.org\/10.1097\/MD.0000000000025868.","journal-title":"Med (Baltim)"},{"key":"3177_CR30","doi-asserted-by":"publisher","first-page":"1329343","DOI":"10.3389\/fneur.2024.1329343","volume":"15","author":"J Zhao","year":"2024","unstructured":"Zhao J, Qu K, Jia S, et al. Efficacy and efficacy-influencing factors of stem cell transplantation on patients with parkinson\u2019s disease: a systematic review and meta-analysis. Front Neurol. 2024;15:1329343. https:\/\/doi.org\/10.3389\/fneur.2024.1329343.","journal-title":"Front Neurol"},{"issue":"8","key":"3177_CR31","doi-asserted-by":"publisher","first-page":"e13787","DOI":"10.1111\/eci.13787","volume":"52","author":"CF Coerkamp","year":"2022","unstructured":"Coerkamp CF, Hoogewerf M, van Putte BP, Appelman Y, Doevendans PA. Revascularization strategies for patients with established chronic coronary syndrome. Eur J Clin Invest. 2022;52(8):e13787. https:\/\/doi.org\/10.1111\/eci.13787.","journal-title":"Eur J Clin Invest"},{"issue":"3","key":"3177_CR32","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1097\/ICU.0000000000000938","volume":"34","author":"JY Lee","year":"2023","unstructured":"Lee JY, Knight RJ, Deng SX. Future regenerative therapies for corneal disease. Curr Opin Ophthalmol. 2023;34(3):267\u201372. https:\/\/doi.org\/10.1097\/ICU.0000000000000938.","journal-title":"Curr Opin Ophthalmol"}],"container-title":["Surgery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00595-025-03177-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00595-025-03177-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00595-025-03177-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T07:48:52Z","timestamp":1774338532000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00595-025-03177-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,13]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["3177"],"URL":"https:\/\/doi.org\/10.1007\/s00595-025-03177-w","relation":{},"ISSN":["0941-1291","1436-2813"],"issn-type":[{"value":"0941-1291","type":"print"},{"value":"1436-2813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,13]]},"assertion":[{"value":"9 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable. This review did not involve direct participation of human subjects.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable. All data in this review were derived from publicly available literature, with no identifiable personal information.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}