{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:06:41Z","timestamp":1779368801078,"version":"3.53.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Today"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s00595-025-03200-0","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T14:47:45Z","timestamp":1763995665000},"page":"888-895","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical significance of the naples prognostic score in patients with colorectal liver metastases"],"prefix":"10.1007","volume":"56","author":[{"given":"Hiroshi","family":"Nakanishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0664-5830","authenticated-orcid":false,"given":"Mitsuru","family":"Yanagaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Shiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Toyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Tsunematsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Shirai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michinori","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Taniai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Haruki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenei","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Ikegami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"3200_CR1","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1002\/ags3.12227","volume":"3","author":"R Adam","year":"2019","unstructured":"Adam R, Kitano Y. Multidisciplinary approach of liver metastases from colorectal cancer. Ann Gastroenterol Surg. 2019;3:50\u20136.","journal-title":"Ann Gastroenterol Surg"},{"key":"3200_CR2","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.semcancer.2013.02.005","volume":"23","author":"CA Dumitru","year":"2013","unstructured":"Dumitru CA, Lang S, Brandau S. Modulation of neutrophil granulocytes in the tumor microenvironment: mechanisms and consequences for tumor progression. Semin Cancer Biol. 2013;23:141\u20138.","journal-title":"Semin Cancer Biol"},{"key":"3200_CR3","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.lungcan.2017.07.024","volume":"111","author":"S Diem","year":"2017","unstructured":"Diem S, Schmid S, Krapf M, Flatz L, Born D, Jochum W, et al. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as prognostic markers in patients with non-small cell lung cancer (NSCLC) treated with nivolumab. Lung Cancer. 2017;111:176\u201381.","journal-title":"Lung Cancer"},{"key":"3200_CR4","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.ejca.2016.05.011","volume":"63","author":"KA Klute","year":"2016","unstructured":"Klute KA, Brouwer J, Jhawer M, Sachs H, Gangadin A, Ocean A, et al. Chemotherapy dose intensity predicted by baseline nutrition assessment in gastrointestinal malignancies: a multicentre analysis. Eur J Cancer. 2016;63:189\u2013200.","journal-title":"Eur J Cancer"},{"key":"3200_CR5","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1016\/j.pan.2021.08.003","volume":"21","author":"S Itoh","year":"2021","unstructured":"Itoh S, Tsujita E, Fukuzawa K, Sugimachi K, Iguchi T, Ninomiya M, et al. Prognostic significance of preoperative PNI and CA19-9 for pancreatic ductal adenocarcinoma: a multi-institutional retrospective study. Pancreatology. 2021;21:1356\u201363.","journal-title":"Pancreatology"},{"key":"3200_CR6","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1007\/s10120-017-0744-3","volume":"21","author":"D Kuroda","year":"2018","unstructured":"Kuroda D, Sawayama H, Kurashige J, Iwatsuki M, Eto T, Tokunaga R, et al. Controlling nutritional status (CONUT) score is a prognostic marker for gastric cancer patients after curative resection. Gastric Cancer. 2018;21:204\u201312.","journal-title":"Gastric Cancer"},{"key":"3200_CR7","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1097\/DCR.0000000000000961","volume":"60","author":"G Galizia","year":"2017","unstructured":"Galizia G, Lieto E, Auricchio A, Cardella F, Mabilia A, Podzemny V, et al. Naples prognostic score, based on nutritional and inflammatory status, is an independent predictor of long-term outcome in patients undergoing surgery for colorectal cancer. Dis Colon Rectum. 2017;60:1273\u201384.","journal-title":"Dis Colon Rectum"},{"key":"3200_CR8","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.2217\/fon-2021-1530","volume":"18","author":"J Xuan","year":"2022","unstructured":"Xuan J, Peng J, Wang S, Cai Y. Prognostic significance of Naples prognostic score in non-small-cell lung cancer patients with brain metastases. Future Oncol. 2022;18:1545\u201355.","journal-title":"Future Oncol"},{"key":"3200_CR9","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1186\/s12957-023-03198-0","volume":"21","author":"J Yang","year":"2023","unstructured":"Yang J, Lv L, Zhao F, Mei X, Zhou H, Yu F. The value of the preoperative Naples prognostic score in predicting prognosis in gallbladder cancer surgery patients. World J Surg Oncol. 2023;21:303.","journal-title":"World J Surg Oncol"},{"key":"3200_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2021.617744","volume":"8","author":"J Xiong","year":"2021","unstructured":"Xiong J, Hu H, Kang W, Liu H, Ma F, Ma S, et al. Prognostic impact of preoperative Naples prognostic score in gastric cancer patients undergoing surgery. Front Surg. 2021;8:617744.","journal-title":"Front Surg"},{"key":"3200_CR11","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1007\/s00595-025-03055-5","volume":"55","author":"M Ohkuma","year":"2025","unstructured":"Ohkuma M, Takano Y, Goto K, Okamoto A, Koyama M, Abe T, et al. Significance of Naples prognostic score for postoperative complications after colorectal cancer surgery. Surg Today. 2025. https:\/\/doi.org\/10.1007\/s00595-025-03055-5.","journal-title":"Surg Today"},{"key":"3200_CR12","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","volume":"240","author":"D Dindo","year":"2004","unstructured":"Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240:205\u201313.","journal-title":"Ann Surg"},{"key":"3200_CR13","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.ejso.2018.02.209","volume":"44","author":"A Dupr\u00e9","year":"2018","unstructured":"Dupr\u00e9 A, Malik HZ. Inflammation and cancer: what a surgical oncologist should know. Eur J Surg Oncol. 2018;44:566\u201370.","journal-title":"Eur J Surg Oncol"},{"key":"3200_CR14","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/nri1703","volume":"5","author":"M Karin","year":"2005","unstructured":"Karin M, Greten FR. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol. 2005;5:749\u201359.","journal-title":"Nat Rev Immunol"},{"key":"3200_CR15","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1038\/nrc3611","volume":"13","author":"E Elinav","year":"2013","unstructured":"Elinav E, Nowarski R, Thaiss CA, Hu B, Jin C, Flavell RA. Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nat Rev Cancer. 2013;13:759\u201371.","journal-title":"Nat Rev Cancer"},{"key":"3200_CR16","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju124","volume":"106","author":"AJ Templeton","year":"2014","unstructured":"Templeton AJ, McNamara MG, \u0160eruga B, Vera-Badillo FE, Aneja P, Oca\u00f1a A, et al. Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J Natl Cancer Inst. 2014;106:dju124.","journal-title":"J Natl Cancer Inst"},{"key":"3200_CR17","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s13058-016-0794-1","volume":"19","author":"JL Ethier","year":"2017","unstructured":"Ethier JL, Desautels D, Templeton A, Shah PS, Amir E. Prognostic role of neutrophil-to-lymphocyte ratio in breast cancer: a systematic review and meta-analysis. Breast Cancer Res. 2017;19:2.","journal-title":"Breast Cancer Res"},{"key":"3200_CR18","doi-asserted-by":"publisher","first-page":"3267","DOI":"10.1002\/ijc.32640","volume":"145","author":"J Kang","year":"2019","unstructured":"Kang J, Chang Y, Ahn J, Oh S, Koo DH, Lee YG, et al. Neutrophil-to-lymphocyte ratio and risk of lung cancer mortality in a low-risk population: a cohort study. Int J Cancer. 2019;145:3267\u201375.","journal-title":"Int J Cancer"},{"key":"3200_CR19","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s00441-010-0955-y","volume":"340","author":"SJ Peters","year":"2010","unstructured":"Peters SJ, Vanhaecke T, Papeleu P, Rogiers V, Haagsman HP, van Norren K. Co-culture of primary rat hepatocytes with rat liver epithelial cells enhances interleukin-6-induced acute-phase protein response. Cell Tissue Res. 2010;340:451\u20137.","journal-title":"Cell Tissue Res"},{"key":"3200_CR20","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/nature07205","volume":"454","author":"A Mantovani","year":"2008","unstructured":"Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008;454:436\u201344.","journal-title":"Nature"},{"key":"3200_CR21","first-page":"797","volume":"29","author":"JI de Ulibarri Perez","year":"2014","unstructured":"de Ulibarri Perez JI, Fernandez G, Rodriguez Salvanes F, Diaz Lopez AM. Nutritional screening; control of clinical undernutrition with analytical parameters. Nutr Hosp. 2014;29:797\u2013811.","journal-title":"Nutr Hosp"},{"key":"3200_CR22","first-page":"37","volume":"96","author":"H Okuyama","year":"2007","unstructured":"Okuyama H, Ichikawa Y, Sun Y, Hamazaki T, Lands WE. Cancer and all-cause mortalities are lower in the higher total cholesterol groups among general populations. World Rev Nutr Diet. 2007;96:37\u201354.","journal-title":"World Rev Nutr Diet"},{"key":"3200_CR23","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s10147-017-1172-4","volume":"23","author":"HW Kang","year":"2018","unstructured":"Kang HW, Seo SP, Kim WT, Yun SJ, Lee SC, Kim WJ, et al. Low preoperative serum cholesterol level is associated with aggressive pathologic features and poor cancer-specific survival in patients with surgically treated renal cell carcinoma. Int J Clin Oncol. 2018;23:142\u201350.","journal-title":"Int J Clin Oncol"},{"key":"3200_CR24","first-page":"Cr240","volume":"12","author":"O Cengiz","year":"2006","unstructured":"Cengiz O, Kocer B, S\u00fcrmeli S, Santicky MJ, Soran A. Are pretreatment serum albumin and cholesterol levels prognostic tools in patients with colorectal carcinoma? Med Sci Monit. 2006;12:Cr240\u20137.","journal-title":"Med Sci Monit"},{"key":"3200_CR25","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/1097-0142(19940115)73:2<253::AID-CNCR2820730204>3.0.CO;2-F","volume":"73","author":"S Dess\u00ec","year":"1994","unstructured":"Dess\u00ec S, Batetta B, Pulisci D, Spano O, Anchisi C, Tessitore L, et al. Cholesterol content in tumor tissues is inversely associated with high-density lipoprotein cholesterol in serum in patients with Gastrointestinal cancer. Cancer. 1994;73:253\u20138.","journal-title":"Cancer"},{"key":"3200_CR26","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1158\/0008-5472.CAN-15-2613","volume":"76","author":"OF Kuzu","year":"2016","unstructured":"Kuzu OF, Noory MA, Robertson GP. The role of cholesterol in cancer. Cancer Res. 2016;76:2063\u201370.","journal-title":"Cancer Res"},{"key":"3200_CR27","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.semcancer.2012.12.002","volume":"23","author":"M van Egmond","year":"2013","unstructured":"van Egmond M, Bakema JE. Neutrophils as effector cells for antibody-based immunotherapy of cancer. Semin Cancer Biol. 2013;23:190\u20139.","journal-title":"Semin Cancer Biol"},{"key":"3200_CR28","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01201","volume":"10","author":"M Laviron","year":"2019","unstructured":"Laviron M, Combadiere C, Boissonnas A. Tracking monocytes and macrophages in tumors with live imaging. Front Immunol. 2019;10:1201.","journal-title":"Front Immunol"},{"key":"3200_CR29","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.cell.2010.03.014","volume":"141","author":"BZ Qian","year":"2010","unstructured":"Qian BZ, Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell. 2010;141:39\u201351.","journal-title":"Cell"},{"key":"3200_CR30","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1111\/j.1538-7836.2010.04131.x","volume":"9","author":"NM Bambace","year":"2011","unstructured":"Bambace NM, Holmes CE. The platelet contribution to cancer progression. J Thromb Haemost. 2011;9:237\u201349.","journal-title":"J Thromb Haemost"},{"key":"3200_CR31","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s10585-010-9311-6","volume":"27","author":"T Wiesner","year":"2010","unstructured":"Wiesner T, Bugl S, Mayer F, Hartmann JT, Kopp HG. Differential changes in platelet VEGF, Tsp, CXCL12, and CXCL4 in patients with metastatic cancer. Clin Exp Metastasis. 2010;27:141\u20139.","journal-title":"Clin Exp Metastasis"},{"key":"3200_CR32","doi-asserted-by":"publisher","first-page":"e101119","DOI":"10.1371\/journal.pone.0101119","volume":"9","author":"X Zhou","year":"2014","unstructured":"Zhou X, Du Y, Huang Z, Xu J, Qiu T, Wang J, et al. Prognostic value of PLR in various cancers: a meta-analysis. PLoS One. 2014;9:e101119.","journal-title":"PLoS One"},{"key":"3200_CR33","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.ctrv.2015.10.003","volume":"41","author":"TF Nishijima","year":"2015","unstructured":"Nishijima TF, Muss HB, Shachar SS, Tamura K, Takamatsu Y. Prognostic value of lymphocyte-to-monocyte ratio in patients with solid tumors: a systematic review and meta-analysis. Cancer Treat Rev. 2015;41:971\u20138.","journal-title":"Cancer Treat Rev"},{"key":"3200_CR34","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1007\/s00595-025-02993-4","volume":"55","author":"K Okazaki","year":"2025","unstructured":"Okazaki K, Furukawa K, Haruki K, Onda S, Shirai Y, Tsunematsu M, et al. Prognostic significance of the hemoglobin, albumin, lymphocyte, platelet (HALP) score after hepatectomy for colorectal liver metastases. Surg Today. 2025;55:1052\u201360.","journal-title":"Surg Today"}],"container-title":["Surgery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00595-025-03200-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00595-025-03200-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00595-025-03200-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:30:10Z","timestamp":1779366610000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00595-025-03200-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,24]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["3200"],"URL":"https:\/\/doi.org\/10.1007\/s00595-025-03200-0","relation":{},"ISSN":["0941-1291","1436-2813"],"issn-type":[{"value":"0941-1291","type":"print"},{"value":"1436-2813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,24]]},"assertion":[{"value":"28 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}