{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:47:15Z","timestamp":1782398835120,"version":"3.54.5"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100016003","name":"Mie University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100016003","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Today"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Long-term data on the risk factors for fistulizing disease (FD) after ileal pouch-anal anastomosis (IPAA) for ulcerative colitis are limited. This study aimed to identify the predictors of FD after ileostomy closure and evaluate the impact of FD on pouch failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed 374 patients who underwent mucosal restorative proctocolectomy with handsewn IPAA between 2004 and 2022. Cox proportional hazards regression and log-rank tests were used to assess the FD-free survival and risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After excluding 59 patients, 315 patients were analyzed. FD developed in 20 (6.3%) of these patients. Multivariate analysis showed that a monthly prednisolone (PSL) dose\u2009\u2265\u2009450\u00a0mg before IPAA and chronic pouchitis were independent risk factors for FD (odds ratio [OR] 2.96, 95% CI: 1.15\u20137.64,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025; OR 3.85, 95% CI: 1.52\u20139.78,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0045). Patients with PSL\u2009\u2265\u2009450\u00a0mg or chronic pouchitis had significantly poorer FD-free survival (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0004 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0002, respectively). Pouch failure occurred more frequently in patients with FD than in those without FD (30.0% vs. 1.0%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>High steroid exposure before IPAA and chronic pouchitis were significant predictors of FD, which strongly increased the risk of pouch failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00595-026-03246-8","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T11:47:26Z","timestamp":1770637646000},"page":"1360-1368","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk factors for fistulizing disease of the pouch after ileal pouch-Anal anastomosis for ulcerative colitis"],"prefix":"10.1007","volume":"56","author":[{"given":"Yoshiki","family":"Okita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinaga","family":"Okugawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Imaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadanobu","family":"Shimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahito","family":"Kitajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikio","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhki","family":"Koike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeyuki","family":"Yoshiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Ohi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Toiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"issue":"6","key":"3246_CR1","first-page":"814","volume":"84","author":"J Romanos","year":"1997","unstructured":"Romanos J, Samarasekera DN, Stebbing JF, Jewell DP, Kettlewell MG, Mortensen NJ. Outcome of 200 restorative proctocolectomy operations: the John Radcliffe Hospital experience. Br J Surg. 1997;84(6):814\u20138.","journal-title":"Br J Surg"},{"key":"3246_CR2","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1007\/s00595-024-02944-5","volume":"55","author":"T Ogino","year":"2025","unstructured":"Ogino T, Sekido Y, Mizushima T, Fujii M, Mori R, Takeda M, et al. Temporary loop end ileostomy reduces the risk of stoma outlet obstruction: a comparative clinical study in patients undergoing restorative proctocolectomy and ileal pouch-anal anastomosis. Surg Today. 2025;55:5:638\u201345.","journal-title":"Surg Today"},{"key":"3246_CR3","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1007\/s00595-025-02997-0","volume":"55","author":"K Higashi","year":"2025","unstructured":"Higashi K, Koike Y, Sato Y, Ruiya M, Yamashita S, Nagano Y, et al. Clinical evaluation of platelet-to-albumin ratio as a predictor of surgical site infection in pediatric patients with ulcerative colitis. Surg Today. 2025;55:8:1116\u201323.","journal-title":"Surg Today"},{"issue":"9","key":"3246_CR4","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1093\/ibd\/izz005","volume":"25","author":"EL Barnes","year":"2019","unstructured":"Barnes EL, Kochar B, Jessup HR, Herfarth HH. The incidence and definition of Crohn\u2019s disease of the pouch: a systematic review and meta-analysis. Inflamm Bowel Dis. 2019;25(9):1474\u201380.","journal-title":"Inflamm Bowel Dis"},{"issue":"5","key":"3246_CR5","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1093\/ibd\/izy020","volume":"24","author":"RL Dalal","year":"2018","unstructured":"Dalal RL, Shen B, Schwartz DA. Management of pouchitis and other common complications of the pouch. Inflamm Bowel Dis. 2018;24(5):989\u201396.","journal-title":"Inflamm Bowel Dis"},{"key":"3246_CR6","doi-asserted-by":"crossref","unstructured":"Lightner AL, Pemberton JH, Loftus EJ Jr. Crohn\u2019s disease of the ileoanal pouch. Inflamm Bowel Dis. 2016;22(6):1502\u20138.","DOI":"10.1097\/MIB.0000000000000712"},{"issue":"10","key":"3246_CR7","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1093\/ibd\/izad228","volume":"30","author":"M Reijntjes","year":"2024","unstructured":"Reijntjes M, de Jong D, Wessels E, Goetgebuer R, Bemelman W, Ponsioen C, et al. Crohn\u2019s disease of the ileoanal pouch: a high rate of potential overdiagnoses. Inflamm Bowel Dis. 2024;30(10):1635\u201341.","journal-title":"Inflamm Bowel Dis"},{"issue":"2","key":"3246_CR8","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1097\/00000658-199508000-00003","volume":"222","author":"VW Fazio","year":"1995","unstructured":"Fazio VW, Ziv Y, Church JM, Oakley JR, Lavery IC, Milsom JW, et al. Ileal pouch-anal anastomoses complications and function in 1005 patients. Ann Surg. 1995;222(2):120\u20137.","journal-title":"Ann Surg"},{"issue":"3","key":"3246_CR9","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.dld.2022.05.009","volume":"55","author":"G Pellino","year":"2023","unstructured":"Pellino G, Celentano V, Vinci D, Romano FM, Pedone A, Vigorita V, et al. Ileoanal pouch-related fistulae: a systematic review with meta-analysis on incidence, treatment options and outcomes. Dig Liver Dis. 2023;55(3):342\u20139.","journal-title":"Dig Liver Dis"},{"issue":"9","key":"3246_CR10","doi-asserted-by":"publisher","first-page":"2918","DOI":"10.1007\/s00261-023-03888-z","volume":"48","author":"M Maspero","year":"2023","unstructured":"Maspero M, Hull TL. Clinical approach to patients with an ileal pouch. Abdom Radiol. 2023;48(9):2918\u201329.","journal-title":"Abdom Radiol"},{"issue":"1","key":"3246_CR11","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1097\/DCR.0000000000002114","volume":"65","author":"TM Heimann","year":"2022","unstructured":"Heimann TM, Swaminathan S, Slater GI, Kurtz RJ. Perianal fistula after ileoanal pouch in patients with ulcerative colitis: a review of 475 patients operated on at a major IBD center. Dis Colon Rectum. 2022;65(1):76\u201382.","journal-title":"Dis Colon Rectum"},{"issue":"11","key":"3246_CR12","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1097\/DCR.0000000000000918","volume":"60","author":"AL Lightner","year":"2017","unstructured":"Lightner AL, Fletcher JG, Pemberton JH, Mathis KL, Raffals LE, Smyrk T. Crohn\u2019s disease of the pouch: a true diagnosis or an oversubscribed diagnosis of exclusion? Dis Colon Rectum. 2017;60(11):1201\u20138.","journal-title":"Dis Colon Rectum"},{"key":"3246_CR13","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1159\/000351443","volume":"30","author":"T Araki","year":"2013","unstructured":"Araki T, Okita Y, Fujikawa H, Inoue Y, Mohri Y, Kusunoki M. Full mucosal proctectomy initiated below the dentate line may prevent the development of a perianal fistula after ileal pouch-anal anastomosis for ulcerative colitis. Dig Surg. 2013;30:219\u201324.","journal-title":"Dig Surg"},{"key":"3246_CR14","unstructured":"Ministry of Health, Labour and Welfare Research Grant for Intractable Diseases. Research Project on Intractable Inflammatory Bowel Diseases (Hisamatsu Group). Diagnostic Criteria and Treatment Guidelines for Ulcerative Colitis and Crohn\u2019s Disease. Fiscal Year 2024 Research Report. 2024."},{"issue":"10","key":"3246_CR15","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1016\/S2468-1253(21)00101-1","volume":"6","author":"B Shen","year":"2021","unstructured":"Shen B, Kochhar GS, Kariv R, Liu X, Navaneethan U, Rubin DT, et al. Diagnosis and classification of ileal pouch disorders: consensus guidelines from the International Ileal Pouch Consortium. The Lancet Gastroenterology & Hepatology. 2021;6(10):826\u201349.","journal-title":"The Lancet Gastroenterology & Hepatology"},{"issue":"6","key":"3246_CR16","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1007\/s10350-004-6652-8","volume":"46","author":"B Shen","year":"2003","unstructured":"Shen B, Achkar JP, Connor JT, Ormsby AH, Remzi FH, Bevins CL, et al. Modified pouchitis disease activity index: a simplified approach to the diagnosis of pouchitis. Dis Colon Rectum. 2003;46(6):748\u201353.","journal-title":"Dis Colon Rectum"},{"issue":"1","key":"3246_CR17","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S2468-1253(21)00214-4","volume":"7","author":"B Shen","year":"2022","unstructured":"Shen B, Kochhar GS, Rubin DT, Kane SV, Navaneethan U, Bernstein CN, et al. Treatment of pouchitis, Crohn\u2019s disease, cuffitis, and other inflammatory disorders of the pouch: consensus guidelines from the International Ileal Pouch Consortium. The Lancet Gastroenterology & Hepatology. 2022;7(1):69\u201395.","journal-title":"The Lancet Gastroenterology & Hepatology"},{"issue":"3","key":"3246_CR18","first-page":"178","volume":"62","author":"P Reissman","year":"1996","unstructured":"Reissman P, Teoh TA, Weiss EG, Nogueras JJ, Wexner SD. Functional outcome of the double stapled ileoanal reservoir in patients more than 60 years of age. Am Surg. 1996;62(3):178\u201383.","journal-title":"Am Surg"},{"issue":"1","key":"3246_CR19","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/BF00337578","volume":"10","author":"K Mikkola","year":"1995","unstructured":"Mikkola K, Luukkonen P, Jarvinen HJ. Long-term results of restorative proctocolectomy for ulcerative colitis. Int J Colorectal Dis. 1995;10(1):10\u20134.","journal-title":"Int J Colorectal Dis"},{"issue":"6","key":"3246_CR20","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s003840050115","volume":"12","author":"HT Tan","year":"1997","unstructured":"Tan HT, Connolly AB, Morton D, Keighley MR. Results of restorative proctocolectomy in the elderly. Int J Colorectal Dis. 1997;12(6):319\u201322.","journal-title":"Int J Colorectal Dis"},{"issue":"7","key":"3246_CR21","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1007\/s10350-007-0246-1","volume":"50","author":"M Lim","year":"2007","unstructured":"Lim M, Sagar P, Abdulgader A, Thekkinkattil D, Burke D. The impact of preoperative immunomodulation on pouch-related septic complications after ileal pouch-anal anastomosis. Dis Colon Rectum. 2007;50(7):943\u201351.","journal-title":"Dis Colon Rectum"},{"issue":"12","key":"3246_CR22","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1007\/DCR.0b013e3181beb3f0","volume":"52","author":"SS Forbes","year":"2009","unstructured":"Forbes SS, O\u2019Connor BI, Victor JC, Cohen Z, McLeod RS. Sepsis is a major predictor of failure after ileal pouch-anal anastomosis. Dis Colon Rectum. 2009;52(12):1975\u201381.","journal-title":"Dis Colon Rectum"},{"key":"3246_CR23","doi-asserted-by":"crossref","unstructured":"Scott NA, Dozois RR, Beart RW Jr., Pemberton JH, Wolff BG, Ilstrup DM. Postoperative intra-abdominal and pelvic sepsis complicating ileal pouch-anal anastomosis. Int J Colorectal Dis. 1988;3(3):149\u201352.","DOI":"10.1007\/BF01648357"},{"issue":"10","key":"3246_CR24","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1002\/bjs.5071","volume":"92","author":"PP Tekkis","year":"2005","unstructured":"Tekkis PP, Fazio VW, Remzi F, Heriot AG, Manilich E, Strong SA. Risk factors associated with ileal pouch-related fistula following restorative proctocolectomy. Br J Surg. 2005;92(10):1270\u20136.","journal-title":"Br J Surg"},{"key":"3246_CR25","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1007\/s00535-017-1389-z","volume":"53","author":"M Uchino","year":"2018","unstructured":"Uchino M, Ikeuchi H, Sugita A, Futami K, Watanabe T, Fukushima K, et al. Pouch functional outcomes after restorative proctocolectomy with ileal-pouch reconstruction in patients with ulcerative colitis: Japanese multi-center nationwide cohort study. J Gastroenterol. 2018;53:5:642\u201351.","journal-title":"J Gastroenterol"},{"key":"3246_CR26","doi-asserted-by":"crossref","unstructured":"Shen B, Fazio VW, Remzi FH, Brzezinski A, Bennett AE, Lopez R et al. Risk factors for diseases of ileal pouch-anal anastomosis after restorative proctocolectomy for ulcerative colitis. Clin Gastroenterol Hepatol, 2006;4;1:81\u2009\u2013\u20099; quiz 2\u20133.","DOI":"10.1016\/j.cgh.2005.10.018"},{"issue":"8","key":"3246_CR27","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1111\/j.1365-2036.2010.04249.x","volume":"31","author":"R Kariv","year":"2010","unstructured":"Kariv R, Plesec TP, Gaffney K, Lian L, Fazio VW, Remzi FH, et al. Pyloric gland metaplasia and pouchitis in patients with ileal pouch-anal anastomoses. Aliment Pharmacol Ther. 2010;31(8):862\u201373.","journal-title":"Aliment Pharmacol Ther"},{"issue":"4","key":"3246_CR28","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1097\/MPG.0000000000002406","volume":"69","author":"L Jarchin","year":"2019","unstructured":"Jarchin L, Spencer EA, Khaitov S, Greenstein A, Jossen J, Lai J, et al. De novo Crohn\u2019s disease of the pouch in children undergoing ileal pouch-anal anastomosis for ulcerative colitis. J Pediatr Gastroenterol Nutr. 2019;69(4):455\u201360.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"3246_CR29","doi-asserted-by":"crossref","unstructured":"Lightner AL, Mathis KL, Dozois EJ, Hahnsloser D, Loftus EV Jr., Raffals LE, et al. Results at up to 30 years after ileal pouch-anal anastomosis for chronic ulcerative colitis. Inflamm Bowel Dis. 2017;23(5):781\u201390.","DOI":"10.1097\/MIB.0000000000001061"},{"issue":"2","key":"3246_CR30","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.cgh.2007.11.006","volume":"6","author":"B Shen","year":"2008","unstructured":"Shen B, Remzi FH, Lavery IC, Lashner BA, Fazio VW. A proposed classification of ileal pouch disorders and associated complications after restorative proctocolectomy. Clin Gastroenterol Hepatol. 2008;6(2):145\u201358. quiz 24.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"3246_CR31","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.14309\/ajg.0000000000002348","volume":"11811","author":"P Santiago","year":"2023","unstructured":"Santiago P, Barnes EL, Raffals LE. Classification and management of disorders of the J pouch. Am J Gastroenterol. 2023;11811:1931\u20139.","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"3246_CR32","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1097\/DCR.0000000000001285","volume":"62","author":"PH Sossenheimer","year":"2019","unstructured":"Sossenheimer PH, Glick LR, Dachman AH, Skowron KB, Rubin MA, Umanskiy K, et al. Abnormal Pouchogram Predicts Pouch Failure Even in Asymptomatic Patients. Dis Colon Rectum. 2019;62(4):463\u20139.","journal-title":"Dis Colon Rectum"},{"key":"3246_CR33","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1007\/s00268-006-0131-4","volume":"31","author":"C Miki","year":"2007","unstructured":"Miki C, Ohmori Y, Yoshiyama S, Toiyama Y, Araki T, Uchida K, et al. Factors predicting postoperative infectious complications and early induction of inflammatory mediators in ulcerative colitis patients. World J Surg. 2007;31:3:522\u20139. discussion 30\u2009\u2013\u20091.","journal-title":"World J Surg"},{"issue":"2","key":"3246_CR34","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/DCR.0b013e3181bb0d1d","volume":"53","author":"M Uchino","year":"2010","unstructured":"Uchino M, Ikeuchi H, Matsuoka H, Tsuchida T, Tomita N, Takesue Y. Risk factors associated with surgical site infection after ileal pouch-anal anastomosis in ulcerative colitis. Dis Colon Rectum. 2010;53(2):143\u20139.","journal-title":"Dis Colon Rectum"},{"issue":"2","key":"3246_CR35","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/ncpendmet0745","volume":"4","author":"A McMaster","year":"2008","unstructured":"McMaster A, Ray DW. Drug insight: selective agonists and antagonists of the glucocorticoid receptor. Nat Clin Pract Endocrinol Metab. 2008;4(2):91\u2013101.","journal-title":"Nat Clin Pract Endocrinol Metab"},{"issue":"7","key":"3246_CR36","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1136\/annrheumdis-2011-200702","volume":"71","author":"WG Dixon","year":"2012","unstructured":"Dixon WG, Abrahamowicz M, Beauchamp ME, Ray DW, Bernatsky S, Suissa S, et al. Immediate and delayed impact of oral glucocorticoid therapy on risk of serious infection in older patients with rheumatoid arthritis: a nested case-control analysis. Ann Rheum Dis. 2012;71(7):1128\u201333.","journal-title":"Ann Rheum Dis"},{"key":"3246_CR37","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.2147\/CCID.S224211","volume":"13","author":"E Niculet","year":"2020","unstructured":"Niculet E, Bobeica C, Tatu AL. Glucocorticoid-induced skin atrophy: the old and the new. Clin Cosmet Investig Dermatol. 2020;13:1041\u201350.","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"3","key":"3246_CR38","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1097\/MPG.0000000000002159","volume":"68","author":"JB Mitsuya","year":"2019","unstructured":"Mitsuya JB, Gonzalez R, Thomas R, El-Baba M. The effect of biologics on postoperative complications in children with inflammatory bowel disease and bowel resection. J Pediatr Gastroenterol Nutr. 2019;68(3):334\u20138.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"3246_CR39","doi-asserted-by":"publisher","DOI":"10.1177\/1756284820937089","volume":"13","author":"J Zanelli","year":"2020","unstructured":"Zanelli J, Chandrapalan S, Patel A, Arasaradnam RP. The impact of pre-operative biologic therapy on post-operative surgical outcomes in ulcerative colitis: a systematic review and meta-analysis. Therap Adv Gastroenterol. 2020;13:1756284820937089.","journal-title":"Therap Adv Gastroenterol"},{"key":"3246_CR40","doi-asserted-by":"publisher","first-page":"e153","DOI":"10.1016\/j.surge.2020.09.001","volume":"195","author":"LW Byrne","year":"2021","unstructured":"Byrne LW, McKay D. Does perioperative biological therapy increase 30-day post-operative complication rates in inflammatory bowel disease patients undergoing intra-abdominal surgery? A systematic review. Surgeon. 2021;195:e153\u201367.","journal-title":"Surgeon"},{"issue":"10","key":"3246_CR41","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1111\/codi.15074","volume":"22","author":"LM Reza","year":"2020","unstructured":"Reza LM, Lung PFC, Lightner AL, Hart AL, Clark SK, Tozer PJ. Perianal fistula and the ileoanal pouch - different aetiologies require distinct evaluation. Colorectal Dis. 2020;22(10):1436\u20139.","journal-title":"Colorectal Dis"},{"key":"3246_CR42","unstructured":"van der Ploeg VA, Maeda Y, Faiz OD, Hart AL, Clark SK. The prevalence of chronic peri-pouch sepsis in patients treated for antibiotic-dependent or refractory primary idiopathic pouchitis. Colorectal Dis, 2017;19;9:827\u2009\u2013\u200931."}],"container-title":["Surgery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00595-026-03246-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00595-026-03246-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00595-026-03246-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T13:57:06Z","timestamp":1782395826000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00595-026-03246-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,9]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["3246"],"URL":"https:\/\/doi.org\/10.1007\/s00595-026-03246-8","relation":{},"ISSN":["0941-1291","1436-2813"],"issn-type":[{"value":"0941-1291","type":"print"},{"value":"1436-2813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,9]]},"assertion":[{"value":"30 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"We have no conflicts of interest to declare","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Conflict of interest"}}]}}