{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T08:30:14Z","timestamp":1786609814710,"version":"build-2736575974"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Today"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s00595-026-03286-0","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T12:43:45Z","timestamp":1776084225000},"page":"1828-1834","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic value of number of harvested lymph nodes in Stage III colorectal cancer patients"],"prefix":"10.1007","volume":"56","author":[{"given":"Toshio","family":"Shiraishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Tominaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuma","family":"Takamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Katayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Noda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoko","family":"Tei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rika","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsutoshi","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaido","family":"Oishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Moriyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Onoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nonaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keitaro","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"issue":"3","key":"3286_CR1","first-page":"229","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229\u201363.","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"3286_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10147-019-01485-z","volume":"25","author":"Y Hashiguchi","year":"2020","unstructured":"Hashiguchi Y, Muro K, Saito Y, Ito Y, Ajioka Y, Hamaguchi T, et al. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer. Int J Clin Oncol. 2020;25(1):1\u201342.","journal-title":"Int J Clin Oncol"},{"issue":"12","key":"3286_CR3","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1016\/S1470-2045(20)30527-1","volume":"21","author":"T Andr\u00e9","year":"2020","unstructured":"Andr\u00e9 T, Meyerhardt J, Iveson T, Sobrero A, Yoshino T, Souglakos I, et al. Effect of duration of adjuvant chemotherapy for patients with stage III colon cancer (IDEA collaboration): final results from a prospective, pooled analysis of six randomised, phase 3 trials. Lancet Oncol. 2020;21(12):1620\u20139.","journal-title":"Lancet Oncol"},{"issue":"3","key":"3286_CR4","doi-asserted-by":"publisher","first-page":"329","DOI":"10.6004\/jnccn.2021.0012","volume":"19","author":"AB Benson","year":"2021","unstructured":"Benson AB, Venook AP, Al-Hawary MM, Arain MA, Chen YJ, Ciombor KK, et al. Colon cancer, version 2.2021, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2021;19(3):329\u201359.","journal-title":"J Natl Compr Canc Netw"},{"issue":"8","key":"3286_CR5","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1093\/jnci\/93.8.583","volume":"93","author":"H Nelson","year":"2001","unstructured":"Nelson H, Petrelli N, Carlin A, Couture J, Fleshman J, Guillem J, et al. Guidelines 2000 for colon and rectal cancer surgery. J Natl Cancer Inst. 2001;93(8):583\u201396.","journal-title":"J Natl Cancer Inst"},{"key":"3286_CR6","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s12893-016-0132-7","volume":"16","author":"HL Tsai","year":"2016","unstructured":"Tsai HL, Huang CW, Yeh YS, Ma CJ, Chen CW, Lu CY, et al. Factors affecting number of lymph nodes harvested and the impact of examining a minimum of 12 lymph nodes in stage I-III colorectal cancer patients: a retrospective single institution cohort study of 1167 consecutive patients. BMC Surg. 2016;16:17.","journal-title":"BMC Surg"},{"issue":"3","key":"3286_CR7","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1093\/jnci\/dji020","volume":"97","author":"NN Baxter","year":"2005","unstructured":"Baxter NN, Virnig DJ, Rothenberger DA, Morris AM, Jessurun J, Virnig BA. Lymph node evaluation in colorectal cancer patients: a population-based study. J Natl Cancer Inst. 2005;97(3):219\u201325.","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"3286_CR8","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1007\/DCR.0b013e3181979164","volume":"52","author":"W Kelder","year":"2009","unstructured":"Kelder W, Inberg B, Schaapveld M, Karrenbeld A, Grond J, Wiggers T, et al. Impact of the number of histologically examined lymph nodes on prognosis in colon cancer: a population-based study in the Netherlands. Dis Colon Rectum. 2009;52(2):260\u20137.","journal-title":"Dis Colon Rectum"},{"issue":"1","key":"3286_CR9","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/jso.21532","volume":"102","author":"A Rajput","year":"2010","unstructured":"Rajput A, Romanus D, Weiser MR, ter Veer A, Niland J, Wilson J, et al. Meeting the 12 lymph node (LN) benchmark in colon cancer. J Surg Oncol. 2010;102(1):3\u20139.","journal-title":"J Surg Oncol"},{"issue":"1","key":"3286_CR10","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1186\/s12885-018-4431-5","volume":"18","author":"L Yang","year":"2018","unstructured":"Yang L, Xiong Z, Xie Q, He W, Liu S, Kong P, et al. Prognostic value of total number of lymph nodes retrieved differs between left-sided colon cancer and right-sided colon cancer in stage III patients with colon cancer. BMC Cancer. 2018;18(1):558.","journal-title":"BMC Cancer"},{"issue":"23","key":"3286_CR11","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.1056\/NEJMoa032709","volume":"350","author":"T Andr\u00e9","year":"2004","unstructured":"Andr\u00e9 T, Boni C, Mounedji-Boudiaf L, Navarro M, Tabernero J, Hickish T, et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med. 2004;350(23):2343\u201351.","journal-title":"N Engl J Med"},{"issue":"9","key":"3286_CR12","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1093\/annonc\/mdl029","volume":"17","author":"I Chau","year":"2006","unstructured":"Chau I, Cunningham D. Adjuvant therapy in colon cancer\u2013what, when and how? Ann Oncol. 2006;17(9):1347\u201359.","journal-title":"Ann Oncol"},{"issue":"6","key":"3286_CR13","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1093\/jnci\/djk092","volume":"99","author":"GJ Chang","year":"2007","unstructured":"Chang GJ, Rodriguez-Bigas MA, Skibber JM, Moyer VA. Lymph node evaluation and survival after curative resection of colon cancer: systematic review. J Natl Cancer Inst. 2007;99(6):433\u201341.","journal-title":"J Natl Cancer Inst"},{"issue":"4","key":"3286_CR14","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.humpath.2006.11.009","volume":"38","author":"JR Jass","year":"2007","unstructured":"Jass JR, O\u2019Brien MJ, Riddell RH, Snover DC. Recommendations for the reporting of surgically resected specimens of colorectal carcinoma. Hum Pathol. 2007;38(4):537\u201345.","journal-title":"Hum Pathol"},{"issue":"7","key":"3286_CR15","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.5858\/2000-124-1016-UPFTEO","volume":"124","author":"CC Compton","year":"2000","unstructured":"Compton CC. Updated protocol for the examination of specimens from patients with carcinomas of the colon and rectum, excluding carcinoid tumors, lymphomas, sarcomas, and tumors of the vermiform appendix: a basis for checklists. Cancer Committee. Arch Pathol Lab Med. 2000;124(7):1016\u201325.","journal-title":"Arch Pathol Lab Med"},{"issue":"11","key":"3286_CR16","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1007\/s00384-010-1020-8","volume":"25","author":"HH Chen","year":"2010","unstructured":"Chen HH, Chakravarty KD, Wang JY, Changchien CR, Tang R. Pathological examination of 12 regional lymph nodes and long-term survival in stages I-III colon cancer patients: an analysis of 2,056 consecutive patients in two branches of same institution. Int J Colorectal Dis. 2010;25(11):1333\u201341.","journal-title":"Int J Colorectal Dis"},{"issue":"1","key":"3286_CR17","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.jamcollsurg.2008.10.013","volume":"208","author":"VL Tsikitis","year":"2009","unstructured":"Tsikitis VL, Larson DL, Wolff BG, Kennedy G, Diehl N, Qin R, et al. Survival in stage III colon cancer is independent of the total number of lymph nodes retrieved. J Am Coll Surg. 2009;208(1):42\u20137.","journal-title":"J Am Coll Surg"},{"issue":"6","key":"3286_CR18","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/j.amjsurg.2013.07.022","volume":"207","author":"KM Madbouly","year":"2014","unstructured":"Madbouly KM, Abbas KS, Hussein AM. Metastatic lymph node ratio in stage III rectal carcinoma is a valuable prognostic factor even with less than 12 lymph nodes retrieved: a prospective study. Am J Surg. 2014;207(6):824\u201331.","journal-title":"Am J Surg"},{"issue":"8","key":"3286_CR19","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1200\/JCO.22.00046","volume":"41","author":"D Morton","year":"2023","unstructured":"Morton D, Seymour M, Magill L, Handley K, Glasbey J, Glimelius B, et al. Preoperative chemotherapy for operable colon cancer: mature results of an international randomized controlled trial. J clinical oncol offic j American Soc Clinical Oncol. 2023;41(8):1541\u201352.","journal-title":"J clinical oncol offic j American Soc Clinical Oncol"},{"issue":"5","key":"3286_CR20","doi-asserted-by":"publisher","first-page":"260","DOI":"10.3393\/jksc.2011.27.5.260","volume":"27","author":"YH Park","year":"2011","unstructured":"Park YH, Lee JI, Park JK, Jo HJ, Kang WK, An CH. Clinical significance of lymph node ratio in Stage III colorectal cancer. J Korean Soc Coloproctol. 2011;27(5):260\u20135.","journal-title":"J Korean Soc Coloproctol"},{"issue":"10","key":"3286_CR21","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1111\/j.1463-1318.2010.02435.x","volume":"13","author":"KP Wong","year":"2011","unstructured":"Wong KP, Poon JTC, Fan JKM, Law WL. Prognostic value of lymph node ratio in stage III colorectal cancer. Colorectal Dis. 2011;13(10):1116\u201322.","journal-title":"Colorectal Dis"},{"issue":"1","key":"3286_CR22","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/s41591-022-02115-4","volume":"29","author":"D Kotani","year":"2023","unstructured":"Kotani D, Oki E, Nakamura Y, Yukami H, Mishima S, Bando H, et al. Molecular residual disease and efficacy of adjuvant chemotherapy in patients with colorectal cancer. Nat Med. 2023;29(1):127\u201334.","journal-title":"Nat Med"}],"container-title":["Surgery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00595-026-03286-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00595-026-03286-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00595-026-03286-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T08:01:44Z","timestamp":1786608104000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00595-026-03286-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,13]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["3286"],"URL":"https:\/\/doi.org\/10.1007\/s00595-026-03286-0","relation":{},"ISSN":["0941-1291","1436-2813"],"issn-type":[{"value":"0941-1291","type":"print"},{"value":"1436-2813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,13]]},"assertion":[{"value":"7 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Drs. Toshio Shiraishi, Keisuke Noda, Tetsuro Tominaga, Yuma Takamura, Hiroki Katayama, Shintaro Hashimoto, Mariko Yamashita, Shoko Tei, Rika Ono, Mitsutoshi Ishii, Kaido Oishi, Masaaki Moriyama, Takashi Onoda, Takashi Nonaka, Keitaro Matsumoto have no conflicts of interest or financial ties to disclose.","order":1,"name":"Ethics","label":"Conflict of Interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}