{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:06:08Z","timestamp":1784293568920,"version":"3.55.0"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Today"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s00595-026-03297-x","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T16:43:19Z","timestamp":1777048999000},"page":"1437-1446","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimal patient selection beyond the current selection criteria for liver transplantation for unresectable colorectal liver metastasis"],"prefix":"10.1007","volume":"56","author":[{"given":"Masayuki","family":"Okuno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Fukumitsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Nishino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunori","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Ogiso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamichi","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuro","family":"Hatano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"issue":"10","key":"3297_CR1","doi-asserted-by":"publisher","first-page":"e2236666","DOI":"10.1001\/jamanetworkopen.2022.36666","volume":"5","author":"N Reboux","year":"2022","unstructured":"Reboux N, Jooste V, Goungounga J, Robaszkiewicz M, Nousbaum JB, Bouvier AM. Incidence and Survival in Synchronous and Metachronous Liver Metastases From Colorectal Cancer. JAMA Netw Open. 2022;5(10):e2236666.","journal-title":"JAMA Netw Open"},{"issue":"2","key":"3297_CR2","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1002\/jhbp.510","volume":"25","author":"K Sakamoto","year":"2018","unstructured":"Sakamoto K, Honda G, Beppu T, Kotake K, Yamamoto M, Takahashi K, et al. Comprehensive data of 3,820 patients newly diagnosed with colorectal liver metastasis between 2005 and 2007: report of a nationwide survey in Japan. J Hepatobiliary Pancreat Sci. 2018;25(2):115\u201323.","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"3297_CR3","doi-asserted-by":"crossref","unstructured":"Sakamoto K, Beppu T, Honda G, Kotake K, Yamamoto M, Takahashi K, et al. Third report of a nationwide survey in Japan. J Hepatobiliary Pancreat Sci. and 2023;2014(5):570\u201390. Comprehensive data of 4502 patients newly diagnosed with colorectal liver metastasis between 2015 and 2017, and prognostic data of 2427 patients newly diagnosed with colorectal liver metastasis in 2013.","DOI":"10.1002\/jhbp.1252"},{"issue":"11","key":"3297_CR4","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1002\/bjs.1800771115","volume":"77","author":"J Scheele","year":"1990","unstructured":"Scheele J, Stangl R, Altendorf-Hofmann A. Hepatic metastases from colorectal carcinoma: impact of surgical resection on the natural history. Br J Surg. 1990;77(11):1241\u20136.","journal-title":"Br J Surg"},{"issue":"8","key":"3297_CR5","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1002\/jhbp.747","volume":"27","author":"M Okuno","year":"2020","unstructured":"Okuno M, Hatano E, Toda R, Nishino H, Nakamura K, Ishii T, et al. Conversion to complete resection with mFOLFOX6 with bevacizumab or cetuximab based on K-RAS status for unresectable colorectal liver metastasis (BECK study): Long-term results of survival. J Hepatobiliary Pancreat Sci. 2020;27(8):496\u2013509.","journal-title":"J Hepatobiliary Pancreat Sci"},{"issue":"6","key":"3297_CR6","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.ejso.2016.08.019","volume":"43","author":"M Okuno","year":"2017","unstructured":"Okuno M, Hatano E, Nishino H, Seo S, Taura K, Uemoto S. Does response rate of chemotherapy with molecular target agents correlate with the conversion rate and survival in patients with unresectable colorectal liver metastases? A systematic review. Eur J Surg Oncol. 2017;43(6):1003\u201312.","journal-title":"Eur J Surg Oncol"},{"issue":"5","key":"3297_CR7","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1097\/SLA.0b013e3182823957","volume":"257","author":"M Hagness","year":"2013","unstructured":"Hagness M, Foss A, Line PD, Scholz T, J\u00f8rgensen PF, Fosby B, et al. Liver transplantation for nonresectable liver metastases from colorectal cancer. Ann Surg. 2013;257(5):800\u20136.","journal-title":"Ann Surg"},{"issue":"2","key":"3297_CR8","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1097\/SLA.0000000000003404","volume":"271","author":"S Dueland","year":"2020","unstructured":"Dueland S, Syversveen T, Solheim JM, Solberg S, Grut H, Bj\u00f8rnbeth BA, et al. Survival Following Liver Transplantation for Patients With Nonresectable Liver-only Colorectal Metastases. Ann Surg. 2020;271(2):212\u20138.","journal-title":"Ann Surg"},{"issue":"2","key":"3297_CR9","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1097\/SLA.0000000000005703","volume":"278","author":"JM Solheim","year":"2023","unstructured":"Solheim JM, Dueland S, Line PD, Hagness M. Transplantation for Nonresectable Colorectal Liver Metastases: Long-Term Follow-Up of the First Prospective Pilot Study. Ann Surg. 2023;278(2):239\u201345.","journal-title":"Ann Surg"},{"issue":"11","key":"3297_CR10","doi-asserted-by":"publisher","first-page":"e088188","DOI":"10.1136\/bmjopen-2024-088188","volume":"14","author":"K Fukumitsu","year":"2024","unstructured":"Fukumitsu K, Kageyama S, Ito T, Oimoto N, Ogiso S, Anazawa T, et al. Living-donor liver transplantation for non-resectable colorectal liver metastases: protocol for a multicentric, single-arm study. BMJ Open. 2024;14(11):e088188.","journal-title":"BMJ Open"},{"issue":"10458","key":"3297_CR11","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1016\/S0140-6736(24)01595-2","volume":"404","author":"R Adam","year":"2024","unstructured":"Adam R, Piedvache C, Chiche L, Adam JP, Salam\u00e9 E, Bucur P, et al. Liver transplantation plus chemotherapy versus chemotherapy alone in patients with permanently unresectable colorectal liver metastases (TransMet): results from a multicentre, open-label, prospective, randomised controlled trial. Lancet. 2024;404(10458):1107\u201318.","journal-title":"Lancet"},{"issue":"4","key":"3297_CR12","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1245\/s10434-013-3449-9","volume":"21","author":"M Hagness","year":"2014","unstructured":"Hagness M, Foss A, Egge TS, Dueland S. Patterns of recurrence after liver transplantation for nonresectable liver metastases from colorectal cancer. Ann Surg Oncol. 2014;21(4):1323\u20139.","journal-title":"Ann Surg Oncol"},{"issue":"3","key":"3297_CR13","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1097\/00000658-199909000-00004","volume":"230","author":"Y Fong","year":"1999","unstructured":"Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH. Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Ann Surg. 1999;230(3):309\u201318. discussion 18\u201321.","journal-title":"Ann Surg"},{"issue":"5","key":"3297_CR14","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1097\/SLA.0b013e318142d964","volume":"246","author":"HZ Malik","year":"2007","unstructured":"Malik HZ, Prasad KR, Halazun KJ, Aldoori A, Al-Mukhtar A, Gomez D, et al. Preoperative prognostic score for predicting survival after hepatic resection for colorectal liver metastases. Ann Surg. 2007;246(5):806\u201314.","journal-title":"Ann Surg"},{"issue":"1","key":"3297_CR15","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1007\/s00534-011-0460-z","volume":"19","author":"T Beppu","year":"2012","unstructured":"Beppu T, Sakamoto Y, Hasegawa K, Honda G, Tanaka K, Kotera Y, et al. A nomogram predicting disease-free survival in patients with colorectal liver metastases treated with hepatic resection: multicenter data collection as a Project Study for Hepatic Surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery. J Hepatobiliary Pancreat Sci. 2012;19(1):72\u201384.","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"3297_CR16","doi-asserted-by":"crossref","unstructured":"Dasari BVM, Raptis D, Syn N, Serrablo A, Ramia JM, Laurenzi A et al. Development and validation of a novel risk score to predict overall survival following surgical clearance of bilobar colorectal liver metastases. BJS Open 2023;7(5):zrad085.","DOI":"10.1093\/bjsopen\/zrad164"},{"issue":"1","key":"3297_CR17","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1097\/SLA.0000000000002319","volume":"269","author":"KW Brudvik","year":"2019","unstructured":"Brudvik KW, Jones RP, Giuliante F, Shindoh J, Passot G, Chung MH, et al. RAS Mutation Clinical Risk Score to Predict Survival After Resection of Colorectal Liver Metastases. Ann Surg. 2019;269(1):120\u20136.","journal-title":"Ann Surg"},{"issue":"2","key":"3297_CR18","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1111\/ajt.15682","volume":"20","author":"S Dueland","year":"2020","unstructured":"Dueland S, Grut H, Syversveen T, Hagness M, Line PD. Selection criteria related to long-term survival following liver transplantation for colorectal liver metastasis. Am J Transpl. 2020;20(2):530\u20137.","journal-title":"Am J Transpl"},{"issue":"9","key":"3297_CR19","doi-asserted-by":"publisher","first-page":"e232932","DOI":"10.1001\/jamasurg.2023.2932","volume":"158","author":"S Dueland","year":"2023","unstructured":"Dueland S, Smedman TM, Syversveen T, Grut H, Hagness M, Line PD. Long-Term Survival, Prognostic Factors, and Selection of Patients With Colorectal Cancer for Liver Transplant: A Nonrandomized Controlled Trial. JAMA Surg. 2023;158(9):e232932.","journal-title":"JAMA Surg"},{"issue":"5","key":"3297_CR20","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1245\/s10434-019-07164-7","volume":"26","author":"GW Ha","year":"2019","unstructured":"Ha GW, Kim JH, Lee MR. Oncologic Effects of Primary Tumor-Sidedness on Patients with Stages 1\u20133 Colon Cancer: A Meta-Analysis. Ann Surg Oncol. 2019;26(5):1366\u201375.","journal-title":"Ann Surg Oncol"},{"issue":"10","key":"3297_CR21","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1007\/s00535-020-01706-7","volume":"55","author":"D Shida","year":"2020","unstructured":"Shida D, Inoue M, Tanabe T, Moritani K, Tsukamoto S, Yamauchi S, et al. Prognostic impact of primary tumor location in Stage III colorectal cancer-right-sided colon versus left-sided colon versus rectum: a nationwide multicenter retrospective study. J Gastroenterol. 2020;55(10):958\u201368.","journal-title":"J Gastroenterol"},{"issue":"7","key":"3297_CR22","doi-asserted-by":"publisher","first-page":"e173695","DOI":"10.1001\/jamaoncol.2017.3695","volume":"4","author":"J Taieb","year":"2018","unstructured":"Taieb J, Kourie HR, Emile JF, Le Malicot K, Balogoun R, Tabernero J, et al. Association of Prognostic Value of Primary Tumor Location in Stage III Colon Cancer With RAS and BRAF Mutational Status. JAMA Oncol. 2018;4(7):e173695.","journal-title":"JAMA Oncol"},{"issue":"5","key":"3297_CR23","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1245\/s10434-019-07209-x","volume":"26","author":"D Shida","year":"2019","unstructured":"Shida D, Tanabe T, Boku N, Takashima A, Yoshida T, Tsukamoto S, et al. Prognostic Value of Primary Tumor Sidedness for Unresectable Stage IV Colorectal Cancer: A Retrospective Study. Ann Surg Oncol. 2019;26(5):1358\u201365.","journal-title":"Ann Surg Oncol"},{"issue":"12","key":"3297_CR24","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1016\/j.hpb.2019.03.365","volume":"21","author":"EK Elizabeth McCracken","year":"2019","unstructured":"Elizabeth McCracken EK, Samsa GP, Fisher DA, Farrow NE, Landa K, Shah KN, et al. Prognostic significance of primary tumor sidedness in patients undergoing liver resection for metastatic colorectal cancer. HPB (Oxford). 2019;21(12):1667\u201375.","journal-title":"HPB (Oxford)"},{"issue":"5","key":"3297_CR25","doi-asserted-by":"publisher","first-page":"e0217411","DOI":"10.1371\/journal.pone.0217411","volume":"14","author":"E Gasser","year":"2019","unstructured":"Gasser E, Braunwarth E, Riedmann M, Cardini B, Fadinger N, Presl J, et al. Primary tumour location affects survival after resection of colorectal liver metastases: A two-institutional cohort study with international validation, systematic meta-analysis and a clinical risk score. PLoS ONE. 2019;14(5):e0217411.","journal-title":"PLoS ONE"},{"issue":"6","key":"3297_CR26","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1001\/jamasurg.2021.0267","volume":"156","author":"S Dueland","year":"2021","unstructured":"Dueland S, Yaqub S, Syversveen T, Carling U, Hagness M, Brudvik KW, et al. Survival Outcomes After Portal Vein Embolization and Liver Resection Compared With Liver Transplant for Patients With Extensive Colorectal Cancer Liver Metastases. JAMA Surg. 2021;156(6):550\u20137.","journal-title":"JAMA Surg"},{"key":"3297_CR27","doi-asserted-by":"crossref","unstructured":"Waldstein S, Spengler M, Pinchuk IV, Yee NS. Impact of Colorectal Cancer Sidedness and Location on Therapy and Clinical Outcomes: Role of Blood-Based Biopsy for Personalized Treatment. J Pers Med. 2023;13(7):1114.","DOI":"10.3390\/jpm13071114"},{"issue":"2","key":"3297_CR28","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1097\/XCS.0000000000000734","volume":"237","author":"L Rajendran","year":"2023","unstructured":"Rajendran L, Claasen MP, McGilvray ID, Cattral MS, Ghanekar A, Selzner N, et al. Toronto Management of Initially Unresectable Liver Metastasis from Colorectal Cancer in a Living Donor Liver Transplant Program. J Am Coll Surg. 2023;237(2):231\u201342.","journal-title":"J Am Coll Surg"},{"issue":"11","key":"3297_CR29","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/S2468-1253(21)00219-3","volume":"6","author":"GK Bonney","year":"2021","unstructured":"Bonney GK, Chew CA, Lodge P, Hubbard J, Halazun KJ, Trunecka P, et al. Liver transplantation for non-resectable colorectal liver metastases: the International Hepato-Pancreato-Biliary Association consensus guidelines. Lancet Gastroenterol Hepatol. 2021;6(11):933\u201346.","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"6","key":"3297_CR30","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1001\/jamasurg.2022.0300","volume":"157","author":"R Hernandez-Alejandro","year":"2022","unstructured":"Hernandez-Alejandro R, Ruffolo LI, Sasaki K, Tomiyama K, Orloff MS, Pineda-Solis K, et al. Recipient and Donor Outcomes After Living-Donor Liver Transplant for Unresectable Colorectal Liver Metastases. JAMA Surg. 2022;157(6):524\u201330.","journal-title":"JAMA Surg"},{"issue":"9227","key":"3297_CR31","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/S0140-6736(00)02528-9","volume":"356","author":"M Buyse","year":"2000","unstructured":"Buyse M, Thirion P, Carlson RW, Burzykowski T, Molenberghs G, Piedbois P. Relation between tumour response to first-line chemotherapy and survival in advanced colorectal cancer: a meta-analysis. Meta-Analysis Group in Cancer. Lancet. 2000;356(9227):373\u20138.","journal-title":"Lancet"},{"issue":"33","key":"3297_CR32","doi-asserted-by":"publisher","first-page":"5344","DOI":"10.1200\/JCO.2008.17.5299","volume":"26","author":"DG Blazer","year":"2008","unstructured":"Blazer DG, Kishi Y, Maru DM, Kopetz S, Chun YS, Overman MJ, et al. Pathologic response to preoperative chemotherapy: a new outcome end point after resection of hepatic colorectal metastases. J Clin Oncol. 2008;26(33):5344\u201351.","journal-title":"J Clin Oncol"},{"issue":"6","key":"3297_CR33","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1097\/01.sla.0000145964.08365.01","volume":"240","author":"R Adam","year":"2004","unstructured":"Adam R, Pascal G, Castaing D, Azoulay D, Delvart V, Paule B, et al. Tumor progression while on chemotherapy: a contraindication to liver resection for multiple colorectal metastases? Ann Surg. 2004;240(6):1052\u201361. discussion 61\u2009\u2013\u20094.","journal-title":"Ann Surg"},{"issue":"6","key":"3297_CR34","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.hpb.2023.02.011","volume":"25","author":"K Menon","year":"2023","unstructured":"Menon K, Vijayashanker A, Murphy J, Line PD, Isaac J, Adair A, et al. Liver transplantation for isolated unresectable colorectal liver metastases - Protocol for a service evaluation in the United Kingdom - UKCoMET study. HPB (Oxford). 2023;25(6):684\u201392.","journal-title":"HPB (Oxford)"},{"issue":"9","key":"3297_CR35","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1001\/jamasurg.2024.2057","volume":"159","author":"MM Byrne","year":"2024","unstructured":"Byrne MM, Ch\u00e1vez-Villa M, Ruffolo LI, Wanis KN, Belt B, Tomiyama K, et al. Progression-Free Survival for Liver Transplant vs Alternative Therapy in Unresectable Colorectal Liver Metastasis. JAMA Surg. 2024;159(9):1089\u201391.","journal-title":"JAMA Surg"},{"issue":"1","key":"3297_CR36","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s12957-018-1549-5","volume":"17","author":"F Rauchfu\u00df","year":"2019","unstructured":"Rauchfu\u00df F, Nadalin S, K\u00f6nigsrainer A, Settmacher U. Living donor liver transplantation with two-stage hepatectomy for patients with isolated, irresectable colorectal liver-the LIVER-T(W)O-HEAL study. World J Surg Oncol. 2019;17(1):11.","journal-title":"World J Surg Oncol"},{"issue":"4","key":"3297_CR37","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1245\/s10434-014-4158-8","volume":"22","author":"S Stremitzer","year":"2015","unstructured":"Stremitzer S, Stift J, Graf A, Singh J, Starlinger P, Gruenberger B, et al. CEA change after neoadjuvant chemotherapy including bevacizumab and clinical outcome in patients undergoing liver resection for colorectal liver metastases. Ann Surg Oncol. 2015;22(4):1315\u201323.","journal-title":"Ann Surg Oncol"},{"issue":"4","key":"3297_CR38","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1245\/s10434-009-0887-5","volume":"17","author":"RJ de Haas","year":"2010","unstructured":"de Haas RJ, Wicherts DA, Flores E, Ducreux M, L\u00e9vi F, Paule B, et al. Tumor marker evolution: comparison with imaging for assessment of response to chemotherapy in patients with colorectal liver metastases. Ann Surg Oncol. 2010;17(4):1010\u201323.","journal-title":"Ann Surg Oncol"},{"issue":"6","key":"3297_CR39","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1200\/JCO.2012.45.2011","volume":"32","author":"LA Diaz","year":"2014","unstructured":"Diaz LA, Bardelli A. Liquid biopsies: genotyping circulating tumor DNA. J Clin Oncol. 2014;32(6):579\u201386.","journal-title":"J Clin Oncol"},{"issue":"11","key":"3297_CR40","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.annonc.2024.08.2240","volume":"35","author":"K Kataoka","year":"2024","unstructured":"Kataoka K, Mori K, Nakamura Y, Watanabe J, Akazawa N, Hirata K, et al. Survival benefit of adjuvant chemotherapy based on molecular residual disease detection in resected colorectal liver metastases: subgroup analysis from CIRCULATE-Japan GALAXY. Ann Oncol. 2024;35(11):1015\u201325.","journal-title":"Ann Oncol"},{"key":"3297_CR41","doi-asserted-by":"publisher","first-page":"106081","DOI":"10.1016\/j.ebiom.2025.106081","volume":"123","author":"N Crnovrsanin","year":"2026","unstructured":"Crnovrsanin N, Zeeuw JM, Ali M, Kemna R, Alipanahi B, Lumbard K, et al. Combining cell-free DNA fragmentomes and total tumour volume improves prognostication and tumour response evaluation in patients with colorectal cancer liver metastases. EBioMedicine. 2026;123:106081.","journal-title":"EBioMedicine"},{"issue":"7","key":"3297_CR42","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1007\/s11605-023-05723-8","volume":"27","author":"CJ Wehrle","year":"2023","unstructured":"Wehrle CJ, Raj R, Aykun N, Orabi D, Estfan B, Kamath S, et al. Liquid Biopsy by ctDNA in Liver Transplantation for Colorectal Cancer Liver Metastasis. J Gastrointest Surg. 2023;27(7):1498\u2013509.","journal-title":"J Gastrointest Surg"},{"issue":"12","key":"3297_CR43","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1038\/bjc.2015.142","volume":"112","author":"M Schirripa","year":"2015","unstructured":"Schirripa M, Bergamo F, Cremolini C, Casagrande M, Lonardi S, Aprile G, et al. BRAF and RAS mutations as prognostic factors in metastatic colorectal cancer patients undergoing liver resection. Br J Cancer. 2015;112(12):1921\u20138.","journal-title":"Br J Cancer"},{"key":"3297_CR44","doi-asserted-by":"crossref","unstructured":"Gagni\u00e8re J, Dupr\u00e9 A, Gholami SS, Pezet D, Boerner T, G\u00f6nen M et al. Is Hepatectomy Justified for BRAF Mutant Colorectal Liver Metastases? A Multi-institutional Analysis of 1497 Patients. Ann Surg. 2020;271(1):147-154.","DOI":"10.1097\/SLA.0000000000002968"},{"issue":"4","key":"3297_CR45","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1097\/SLA.0b013e3182a5025a","volume":"258","author":"JN Vauthey","year":"2013","unstructured":"Vauthey JN, Zimmitti G, Kopetz SE, Shindoh J, Chen SS, Andreou A, et al. RAS mutation status predicts survival and patterns of recurrence in patients undergoing hepatectomy for colorectal liver metastases. Ann Surg. 2013;258(4):619\u201326. discussion 26\u2009\u2013\u20097.","journal-title":"Ann Surg"},{"issue":"8","key":"3297_CR46","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/S1470-2045(10)70130-3","volume":"11","author":"W De Roock","year":"2010","unstructured":"De Roock W, Claes B, Bernasconi D, De Schutter J, Biesmans B, Fountzilas G, et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol. 2010;11(8):753\u201362.","journal-title":"Lancet Oncol"},{"issue":"10","key":"3297_CR47","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1002\/bjs.9870","volume":"102","author":"KW Brudvik","year":"2015","unstructured":"Brudvik KW, Kopetz SE, Li L, Conrad C, Aloia TA, Vauthey JN. Meta-analysis of KRAS mutations and survival after resection of colorectal liver metastases. Br J Surg. 2015;102(10):1175\u201383.","journal-title":"Br J Surg"},{"issue":"35","key":"3297_CR48","doi-asserted-by":"publisher","first-page":"5931","DOI":"10.1200\/JCO.2009.22.4295","volume":"27","author":"SD Richman","year":"2009","unstructured":"Richman SD, Seymour MT, Chambers P, Elliott F, Daly CL, Meade AM, et al. KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: results from the MRC FOCUS trial. J Clin Oncol. 2009;27(35):5931\u20137.","journal-title":"J Clin Oncol"},{"issue":"6","key":"3297_CR49","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1097\/SLA.0000000000002664","volume":"269","author":"GA Margonis","year":"2019","unstructured":"Margonis GA, Buettner S, Andreatos N, Wagner D, Sasaki K, Barbon C, et al. Prognostic Factors Change Over Time After Hepatectomy for Colorectal Liver Metastases: A Multi-institutional, International Analysis of 1099 Patients. Ann Surg. 2019;269(6):1129\u201337.","journal-title":"Ann Surg"},{"issue":"3","key":"3297_CR50","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1002\/bjs5.50278","volume":"4","author":"TM Smedman","year":"2020","unstructured":"Smedman TM, Line PD, Hagness M, Syversveen T, Grut H, Dueland S. Liver transplantation for unresectable colorectal liver metastases in patients and donors with extended criteria (SECA-II arm D study). BJS Open. 2020;4(3):467\u201377.","journal-title":"BJS Open"},{"issue":"23","key":"3297_CR51","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.1056\/NEJMoa2017699","volume":"383","author":"T Andr\u00e9","year":"2020","unstructured":"Andr\u00e9 T, Shiu KK, Kim TW, Jensen BV, Jensen LH, Punt C, et al. Pembrolizumab in Microsatellite-Instability-High Advanced Colorectal Cancer. N Engl J Med. 2020;383(23):2207\u201318.","journal-title":"N Engl J Med"},{"key":"3297_CR52","doi-asserted-by":"publisher","first-page":"113433","DOI":"10.1016\/j.ejca.2023.113433","volume":"196","author":"B Saberzadeh-Ardestani","year":"2024","unstructured":"Saberzadeh-Ardestani B, Jones JC, McWilliams RR, Tougeron D, Halfdanarson TR, Guimbaud R, et al. Metastatic site and clinical outcome of patients with deficient mismatch repair metastatic colorectal cancer treated with an immune checkpoint inhibitor in the first-line setting. Eur J Cancer. 2024;196:113433.","journal-title":"Eur J Cancer"},{"key":"3297_CR53","doi-asserted-by":"crossref","unstructured":"Grut H, Line PD, Syversveen T, Dueland S. Metabolic Tumor Volume from 18F-FDG PET\/CT in Combination with Radiologic Measurements to Predict Long-Term Survival Following Transplantation for Colorectal Liver Metastases. Cancers (Basel). 2023;16(1):19.","DOI":"10.3390\/cancers16010019"},{"issue":"2","key":"3297_CR54","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1007\/s00259-017-3843-9","volume":"45","author":"H Grut","year":"2018","unstructured":"Grut H, Dueland S, Line PD, Revheim ME. The prognostic value of 18F-FDG PET\/CT prior to liver transplantation for nonresectable colorectal liver metastases. Eur J Nucl Med Mol Imaging. 2018;45(2):218\u201325.","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"3","key":"3297_CR55","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1097\/LVT.0000000000000535","volume":"31","author":"CJ Wehrle","year":"2025","unstructured":"Wehrle CJ, Ch\u00e1vez-Villa M, Byrne M, Kusakabe J, Gross A, Mahajan P, et al. Pretransplant metabolic tumor volume predicts recurrence following liver transplantation for colorectal metastasis: A multicenter study. Liver Transpl. 2025;31(3):298\u2013310.","journal-title":"Liver Transpl"},{"issue":"2","key":"3297_CR56","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","volume":"45","author":"EA Eisenhauer","year":"2009","unstructured":"Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 2009;45(2):228\u201347.","journal-title":"Eur J Cancer"},{"issue":"5","key":"3297_CR57","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1007\/BF02557264","volume":"9","author":"D Jaeck","year":"2002","unstructured":"Jaeck D, Nakano H, Bachellier P, Inoue K, Weber JC, Oussoultzoglou E, et al. Significance of hepatic pedicle lymph node involvement in patients with colorectal liver metastases: a prospective study. Ann Surg Oncol. 2002;9(5):430\u20138.","journal-title":"Ann Surg Oncol"},{"issue":"8","key":"3297_CR58","first-page":"1081","volume":"84","author":"KT Beckurts","year":"1997","unstructured":"Beckurts KT, Holscher AH, Thorban S, Bollschweiler E, Siewert JR. Significance of lymph node involvement at the hepatic hilum in the resection of colorectal liver metastases. Br J Surg. 1997;84(8):1081\u20134.","journal-title":"Br J Surg"},{"issue":"22","key":"3297_CR59","doi-asserted-by":"publisher","first-page":"3672","DOI":"10.1200\/JCO.2007.15.7297","volume":"26","author":"R Adam","year":"2008","unstructured":"Adam R, de Haas RJ, Wicherts DA, Aloia TA, Delvart V, Azoulay D, et al. Is hepatic resection justified after chemotherapy in patients with colorectal liver metastases and lymph node involvement? J Clin Oncol. 2008;26(22):3672\u201380.","journal-title":"J Clin Oncol"},{"issue":"2","key":"3297_CR60","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1245\/s10434-011-1902-1","volume":"19","author":"C Pulitano","year":"2012","unstructured":"Pulitano C, Bodingbauer M, Aldrighetti L, Choti MA, Castillo F, Schulick RD, et al. Colorectal liver metastasis in the setting of lymph node metastasis: defining the benefit of surgical resection. Ann Surg Oncol. 2012;19(2):435\u201342.","journal-title":"Ann Surg Oncol"},{"issue":"2","key":"3297_CR61","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.ejso.2016.10.033","volume":"43","author":"S Nanji","year":"2017","unstructured":"Nanji S, Tsang ME, Wei X, Booth CM. Regional lymph node involvement in patients undergoing liver resection for colorectal cancer metastases. Eur J Surg Oncol. 2017;43(2):322\u20139.","journal-title":"Eur J Surg Oncol"},{"issue":"9","key":"3297_CR62","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1002\/bjs.10822","volume":"105","author":"M Okuno","year":"2018","unstructured":"Okuno M, Goumard C, Mizuno T, Kopetz S, Omichi K, Tzeng CD, et al. Prognostic impact of perihepatic lymph node metastases in patients with resectable colorectal liver metastases. Br J Surg. 2018;105(9):1200\u20139.","journal-title":"Br J Surg"},{"issue":"1","key":"3297_CR63","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s40644-023-00529-y","volume":"23","author":"HB Zhu","year":"2023","unstructured":"Zhu HB, Xu D, Sun XF, Li XT, Zhang XY, Wang K, et al. Prediction of hepatic lymph node metastases based on magnetic resonance imaging before and after preoperative chemotherapy in patients with colorectal liver metastases underwent surgical resection. Cancer Imaging. 2023;23(1):18.","journal-title":"Cancer Imaging"},{"key":"3297_CR64","doi-asserted-by":"crossref","unstructured":"Hess GF, Aegerter NLE, Zeindler J, Vosbeck J, Neusch\u00fctz KJ, M\u00fcller PC et al. Impact of Positive Lymph Nodes after Systematic Perihilar Lymphadenectomy in Colorectal Liver Metastases. J Clin Med. 2024;13(17):5301.","DOI":"10.3390\/jcm13175301"},{"issue":"7","key":"3297_CR65","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1002\/jso.21357","volume":"100","author":"EF Viana","year":"2009","unstructured":"Viana EF, Herman P, Siqueira SC, Taka T, Carvalho P, Coelho FF, et al. Lymphadenectomy in colorectal cancer liver metastases resection: incidence of hilar lymph nodes micrometastasis. J Surg Oncol. 2009;100(7):534\u20137.","journal-title":"J Surg Oncol"},{"issue":"1","key":"3297_CR66","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12893-017-0233-y","volume":"17","author":"D Pindak","year":"2017","unstructured":"Pindak D, Pavlendova J, Tomas M, Dolnik J, Duchon R, Pechan J. Selective versus routine lymphadenectomy in the treatment of liver metastasis from colorectal cancer: a retrospective cohort study. BMC Surg. 2017;17(1):34.","journal-title":"BMC Surg"},{"issue":"6","key":"3297_CR67","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1097\/SLA.0b013e3181a334d9","volume":"249","author":"E Oussoultzoglou","year":"2009","unstructured":"Oussoultzoglou E, Romain B, Panaro F, Rosso E, Pessaux P, Bachellier P, et al. Long-term survival after liver resection for colorectal liver metastases in patients with hepatic pedicle lymph nodes involvement in the era of new chemotherapy regimens. Ann Surg. 2009;249(6):879\u201386.","journal-title":"Ann Surg"},{"issue":"7","key":"3297_CR68","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1002\/bjs.1800830717","volume":"83","author":"D Elias","year":"1996","unstructured":"Elias D, Saric J, Jaeck D, Arnaud JP, Gayet B, Rivoire M, et al. Prospective study of microscopic lymph node involvement of the hepatic pedicle during curative hepatectomy for colorectal metastases. Br J Surg. 1996;83(7):942\u20135.","journal-title":"Br J Surg"},{"issue":"2","key":"3297_CR69","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1097\/01.sla.0000217606.59625.9d","volume":"244","author":"SR Grobmyer","year":"2006","unstructured":"Grobmyer SR, Wang L, Gonen M, Fong Y, Klimstra D, D\u2019Angelica M, et al. Perihepatic lymph node assessment in patients undergoing partial hepatectomy for malignancy. Ann Surg. 2006;244(2):260\u20134.","journal-title":"Ann Surg"},{"issue":"1","key":"3297_CR70","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1245\/s10434-011-1994-7","volume":"19","author":"C Rau","year":"2012","unstructured":"Rau C, Blanc B, Ronot M, Dokmak S, Aussilhou B, Faivre S, et al. Neither preoperative computed tomography nor intra-operative examination can predict metastatic lymph node in the hepatic pedicle in patients with colorectal liver metastasis. Ann Surg Oncol. 2012;19(1):163\u20138.","journal-title":"Ann Surg Oncol"}],"container-title":["Surgery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00595-026-03297-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00595-026-03297-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00595-026-03297-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:02:08Z","timestamp":1784293328000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00595-026-03297-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,24]]},"references-count":70,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["3297"],"URL":"https:\/\/doi.org\/10.1007\/s00595-026-03297-x","relation":{},"ISSN":["0941-1291","1436-2813"],"issn-type":[{"value":"0941-1291","type":"print"},{"value":"1436-2813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,24]]},"assertion":[{"value":"11 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Masayuki Okuno and the co-authors have no conflicts of interest to declare.","order":1,"name":"Ethics","label":"<b>Conflict of interest<\/b>","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Because this is a literature review article, IRB approval was not required.","order":2,"name":"Ethics","label":"<b>Ethical approval<\/b>","group":{"name":"EthicsHeading","label":"Declarations"}}]}}