{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T08:31:25Z","timestamp":1793349085164,"version":"4.5.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Today"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1007\/s00595-026-03456-0","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T12:35:44Z","timestamp":1786106144000},"page":"3051-3059","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prior cholecystectomy may identify a biologically aggressive subset of RAS-mutated proximal colon cancer: A 13-year retrospective cohort study"],"prefix":"10.1007","volume":"56","author":[{"given":"Masashi","family":"Tsunematsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1686-3228","authenticated-orcid":false,"given":"Koichiro","family":"Haruki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Yanagaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Shirai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Tanji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Onda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Taniai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michinori","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenei","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Ikegami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"3456_CR1","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1038\/s42003-022-03884-x","volume":"5","author":"D Sobral","year":"2022","unstructured":"Sobral D, Martins M, Kaplan S, Golkaram M, Salmans M, Khan N, et al. Genetic and microenvironmental intratumor heterogeneity impacts colorectal cancer evolution and metastatic development. Commun Biol. 2022;5:937.","journal-title":"Commun Biol"},{"key":"3456_CR2","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1002\/ags3.12853","volume":"8","author":"Y Kajiwara","year":"2024","unstructured":"Kajiwara Y, Ueno H. Essential updates 2022\u20132023: Surgical and adjuvant therapies for locally advanced colorectal cancer. Ann Gastroenterol Surg. 2024;8:977\u201386.","journal-title":"Ann Gastroenterol Surg"},{"key":"3456_CR3","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1007\/s00595-024-02827-9","volume":"54","author":"H Sada","year":"2024","unstructured":"Sada H, Hinoi T, Niitsu H, Ohdan H, Yamamoto S, Endo S, et al. Japan Society of Laparoscopic Colorectal Surgery. Right-sided versus left-sided colorectal cancer in elderly patients: a sub-analysis of a large multicenter case-control study in Japan. Surg Today. 2024;54:1173\u201383.","journal-title":"Surg Today"},{"key":"3456_CR4","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s00535-023-01955-2","volume":"58","author":"T Ugai","year":"2023","unstructured":"Ugai T, Akimoto N, Haruki K, Harrison TA, Cao Y, Qu C, et al. Prognostic role of detailed colorectal location and tumor molecular features: analyses of 13,101 colorectal cancer patients including 2994 early-onset cases. J Gastroenterol. 2023;58:229\u201345.","journal-title":"J Gastroenterol"},{"key":"3456_CR5","doi-asserted-by":"publisher","first-page":"712","DOI":"10.14309\/ajg.0000000000002171","volume":"118","author":"T Ugai","year":"2023","unstructured":"Ugai T, Haruki K, Harrison TA, Cao Y, Qu C, Chan AT, et al. Molecular Characteristics of Early-Onset Colorectal Cancer According to Detailed Anatomical Locations: Comparison With Later-Onset Cases. Am J Gastroenterol. 2023;118:712\u201326.","journal-title":"Am J Gastroenterol"},{"key":"3456_CR6","doi-asserted-by":"crossref","unstructured":"Cong J, Liu P, Han Z, Ying W, Li C, Yang Y et al. Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8\u2009+\u2009T cell effector functions. Immunity. 2024;57:876\u2009\u2013\u200989.e11.","DOI":"10.1016\/j.immuni.2024.02.014"},{"key":"3456_CR7","doi-asserted-by":"publisher","first-page":"815999","DOI":"10.3389\/fendo.2022.815999","volume":"13","author":"Y Ma","year":"2022","unstructured":"Ma Y, Qu R, Zhang Y, Jiang C, Zhang Z, Fu W. Progress in the study of colorectal cancer caused by altered gut microbiota after cholecystectomy. Front Endocrinol (Lausanne). 2022;13:815999.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"3456_CR8","doi-asserted-by":"publisher","first-page":"7638","DOI":"10.1038\/s41467-025-62956-8","volume":"16","author":"B Tang","year":"2025","unstructured":"Tang B, Li S, Li X, He J, Zhou A, Wu L, et al. Cholecystectomy-related gut microbiota dysbiosis exacerbates colorectal tumorigenesis. Nat Commun. 2025;16:7638.","journal-title":"Nat Commun"},{"key":"3456_CR9","doi-asserted-by":"crossref","unstructured":"Tsunematsu M, Haruki K, Yanamoto K, Takehana T, Ishizaki S, Yanagaki M et al. Differential prognostic impact of prior cholecystectomy between proximal and distal colorectal cancer: a 12-year retrospective cohort study of 3487 consecutive patients. Ann Gastroenterol Surg. 2026;10:1\u20138.","DOI":"10.1002\/ags3.70190"},{"key":"3456_CR10","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s00595-024-02900-3","volume":"55","author":"K Chen","year":"2025","unstructured":"Chen K, Okamura Y, Hatakeyama K, Shiomi A, Kagawa H, Hino H, et al. The KRAS G12D mutation increases the risk of unresectable recurrence of resectable colorectal liver-only metastasis. Surg Today. 2025;55:273\u201382.","journal-title":"Surg Today"},{"key":"3456_CR11","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/s12943-021-01441-4","volume":"20","author":"G Zhu","year":"2021","unstructured":"Zhu G, Pei L, Xia H, Tang Q, Bi F. Role of oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer. Mol Cancer. 2021;20:143.","journal-title":"Mol Cancer"},{"key":"3456_CR12","doi-asserted-by":"publisher","first-page":"e240029","DOI":"10.6004\/jnccn.2024.0029","volume":"22","author":"AB Benson","year":"2024","unstructured":"Benson AB, Venook AP, Adam M, Chang G, Chen YJ, Ciombor KK, et al. Colon Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2024;22:e240029.","journal-title":"J Natl Compr Canc Netw"},{"key":"3456_CR13","doi-asserted-by":"publisher","first-page":"2107387","DOI":"10.1080\/19490976.2022.2107387","volume":"14","author":"Y Liu","year":"2022","unstructured":"Liu Y, Xu J, Ren X, Zhang Y, Ke Z, Zhou J, et al. Cholecystectomy-induced secondary bile acids accumulation ameliorates colitis through inhibiting monocyte\/macrophage recruitment. Gut Microbes. 2022;14:2107387.","journal-title":"Gut Microbes"},{"key":"3456_CR14","doi-asserted-by":"publisher","first-page":"2168101","DOI":"10.1080\/19490976.2023.2168101","volume":"15","author":"Y Xu","year":"2023","unstructured":"Xu Y, Wang J, Wu X, et al. Gut microbiota alteration after cholecystectomy contributes to post-cholecystectomy diarrhea via bile acids stimulating colonic serotonin. Gut Microbes. 2023;15:2168101.","journal-title":"Gut Microbes"},{"key":"3456_CR15","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1038\/s41419-020-02819-w","volume":"11","author":"Y Xu","year":"2020","unstructured":"Xu Y, Wang J, Wu X, Jing H, Zhang S, Hu Z, et al. Farnesoid X receptor antagonizes Wnt\/\u03b2-catenin signaling in colorectal tumorigenesis. Cell Death Dis. 2020;11:640.","journal-title":"Cell Death Dis"},{"key":"3456_CR16","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1002\/ijc.21365","volume":"118","author":"SA Shah","year":"2006","unstructured":"Shah SA, Volkov Y, Arfin Q, Abdel-Latif MM, Kelleher D. Ursodeoxycholic acid inhibits interleukin 1 beta [corrected] and deoxycholic acid-induced activation of NF-kappaB and AP-1 in human colon cancer cells. Int J Cancer. 2006;118:532\u201339.","journal-title":"Int J Cancer"},{"key":"3456_CR17","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1177\/15353702221131858","volume":"248","author":"H Bernstein","year":"2023","unstructured":"Bernstein H, Bernstein C. Bile acids as carcinogens in the colon and at other sites in the gastrointestinal system. Exp Biol Med (Maywood). 2023;248:79\u201389.","journal-title":"Exp Biol Med (Maywood)"},{"key":"3456_CR18","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.7150\/ijms.97574","volume":"21","author":"Q Yang","year":"2024","unstructured":"Yang Q, Qu R, Lu S, Zhang Y, Zhang Z, Fu W. Biological and Clinical Characteristics of Proximal Colon Cancer: Far from Its Anatomical Subsite. Int J Med Sci. 2024;21:1824\u201339.","journal-title":"Int J Med Sci"},{"key":"3456_CR19","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1177\/15353702221131858","volume":"248","author":"H Bernstein","year":"2023","unstructured":"Bernstein H, Bernstein C. Bile acids as carcinogens in the colon and at other sites in the gastrointestinal system. Exp Biol Med (Maywood). 2023;248:79\u201389.","journal-title":"Exp Biol Med (Maywood)"},{"key":"3456_CR20","doi-asserted-by":"publisher","first-page":"5674","DOI":"10.1038\/s41467-021-25965-x","volume":"12","author":"S Okumura","year":"2021","unstructured":"Okumura S, Konishi Y, Narukawa M, Sugiura Y, Yoshimoto S, Arai Y, et al. Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion. Nat Commun. 2021;12:5674.","journal-title":"Nat Commun"},{"key":"3456_CR21","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s00595-019-01889-4","volume":"50","author":"K Fukata","year":"2020","unstructured":"Fukata K, Yuasa N, Takeuchi E, Miyake H, Nagai H, Yoshioka Y, et al. Clinical and prognostic differences between surgically resected right-sided and left-sided colorectal cancer. Surg Today. 2020;50:267\u201374.","journal-title":"Surg Today"},{"key":"3456_CR22","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.jss.2024.10.018","volume":"304","author":"RA Mu\u00f1oz","year":"2024","unstructured":"Mu\u00f1oz RA, Ramos AA, Miranda FJ, De La Rosa JE, Mu\u00f1oz AE, Ram\u00edrez AA, et al. Cholecystectomy is a risk factor for proximal colon cancer that may also relate to its aggressiveness. J Surg Res. 2024;304:152\u201361.","journal-title":"J Surg Res"}],"container-title":["Surgery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00595-026-03456-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00595-026-03456-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00595-026-03456-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:49:59Z","timestamp":1793346599000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00595-026-03456-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,7]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["3456"],"URL":"https:\/\/doi.org\/10.1007\/s00595-026-03456-0","relation":{},"ISSN":["0941-1291","1436-2813"],"issn-type":[{"value":"0941-1291","type":"print"},{"value":"1436-2813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,7]]},"assertion":[{"value":"27 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflicts of interest associated with the present study, except that Toru Ikegami serves as an editorial board member of the Annals of Gastroenterological Surgery.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Institutional Ethics Committee of the Saku Central Hospital Advanced Care Center [R202507-03].","order":2,"name":"Ethics","label":"Ethics statements","group":{"name":"EthicsHeading","label":"Declarations"}}]}}