{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:46:48Z","timestamp":1790066808659,"version":"4.0.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T00:00:00Z","timestamp":1512604800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81771929"],"award-info":[{"award-number":["81771929"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31400847"],"award-info":[{"award-number":["31400847"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2017M611911"],"award-info":[{"award-number":["2017M611911"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Program of Suzhou","award":["SYG201605"],"award-info":[{"award-number":["SYG201605"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Microchim Acta"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1007\/s00604-017-2606-4","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T08:49:11Z","timestamp":1512636551000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Colorimetric theophylline aggregation assay using an RNA aptamer and non-crosslinking gold nanoparticles"],"prefix":"10.1007","volume":"185","author":[{"given":"Xiaoyi","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqing","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuguo","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3993-4778","authenticated-orcid":false,"given":"Peng","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,12,7]]},"reference":[{"key":"2606_CR1","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.1021\/cr0680282","volume":"107","author":"SK Ghosh","year":"2007","unstructured":"Ghosh SK, Pal T (2007) Interparticle coupling effect on the surface plasmon resonance of gold nanoparticles: from theory to applications. Chem Rev 107:4797\u20134862","journal-title":"Chem Rev"},{"key":"2606_CR2","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1021\/acs.jpcc.5b11232","volume":"120","author":"NS Abadeer","year":"2016","unstructured":"Abadeer NS, Murphy CJ (2016) Recent progress in cancer thermal therapy using gold nanoparticles. J Phys Chem C 120:4691\u20134716","journal-title":"J Phys Chem C"},{"key":"2606_CR3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.elecom.2014.07.013","volume":"47","author":"P Miao","year":"2014","unstructured":"Miao P, Wang BD, Han K, Tang YG (2014) Electrochemical impedance spectroscopy study of proteolysis using unmodified gold nanoparticles. Electrochem Commun 47:21\u201324","journal-title":"Electrochem Commun"},{"key":"2606_CR4","doi-asserted-by":"crossref","first-page":"7966","DOI":"10.1021\/ac401762e","volume":"85","author":"P Miao","year":"2013","unstructured":"Miao P, Ning LM, Li XX (2013) Gold nanoparticles and cleavage-based dual signal amplification for ultrasensitive detection of silver ions. Anal Chem 85:7966\u20137970","journal-title":"Anal Chem"},{"key":"2606_CR5","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.addr.2008.03.016","volume":"60","author":"P Ghosh","year":"2008","unstructured":"Ghosh P, Han G, De M, Kim CK, Rotello VM (2008) Gold nanoparticles in delivery applications. Adv Drug Deliv Rev 60:1307\u20131315","journal-title":"Adv Drug Deliv Rev"},{"key":"2606_CR6","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nnano.2015.68","volume":"10","author":"MB Ross","year":"2015","unstructured":"Ross MB, JC K, Vaccarezza VM, Schatz GC, Mirkin CA (2015) Nanoscale form dictates mesoscale function in plasmonic DNA-nanoparticle superlattices. Nat Nanotechnol 10:453\u2013458","journal-title":"Nat Nanotechnol"},{"key":"2606_CR7","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00604-012-0928-9","volume":"180","author":"N Haghnazari","year":"2013","unstructured":"Haghnazari N, Alizadeh A, Karami C, Hamidi Z (2013) Simple optical determination of silver ion in aqueous solutions using benzo crown-ether modified gold nanoparticles. Microchim Acta 180:287\u2013294","journal-title":"Microchim Acta"},{"key":"2606_CR8","doi-asserted-by":"crossref","first-page":"6830","DOI":"10.1021\/ac1007909","volume":"82","author":"CY Lin","year":"2010","unstructured":"Lin CY, CJ Y, Lin YH, Tseng WL (2010) Colorimetric sensing of silver(I) and mercury(II) ions based on an assembly of tween 20-stabilized gold nanoparticles. Anal Chem 82:6830\u20136837","journal-title":"Anal Chem"},{"key":"2606_CR9","doi-asserted-by":"crossref","first-page":"7689","DOI":"10.1021\/ac4001157","volume":"85","author":"P Liu","year":"2013","unstructured":"Liu P, Yang XH, Sun S, Wang Q, Wang KM, Huang J, Liu JB, He LL (2013) Enzyme-free colorimetric detection of DNA by using gold nanoparticles and hybridization chain reaction amplification. Anal Chem 85:7689\u20137695","journal-title":"Anal Chem"},{"key":"2606_CR10","doi-asserted-by":"crossref","DOI":"10.1002\/ppsc.201600405","volume":"34","author":"P Miao","year":"2017","unstructured":"Miao P, Tang YG, Mao ZQ, Liu YZ (2017) Adamantane derivatives functionalized gold nanoparticles for colorimetric detection of miRNA. Part Part Syst Charact 34:1600405","journal-title":"Part Part Syst Charact"},{"key":"2606_CR11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bios.2017.07.028","volume":"99","author":"L Cui","year":"2018","unstructured":"Cui L, Li YY, Lu MF, Tang B, Zhang CY (2018) An ultrasensitive electrochemical biosensor for polynucleotide kinase assay based on gold nanoparticle-mediated lambda exonuclease cleavage-induced signal amplification. Biosens Bioelectron 99:1\u20137","journal-title":"Biosens Bioelectron"},{"key":"2606_CR12","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1007\/s00604-017-2349-2","volume":"184","author":"Q Liu","year":"2017","unstructured":"Liu Q, Na WD, Wang L, Su XG (2017) Gold nanocluster-based fluorescent assay for label-free detection of protein kinase and its inhibitors. Microchim Acta 184:3381\u20133387","journal-title":"Microchim Acta"},{"key":"2606_CR13","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.bios.2017.03.040","volume":"94","author":"S Su","year":"2017","unstructured":"Su S, Cao WF, Liu W, Lu ZW, Zhu D, Chao J, Weng LX, Wang LH, Fan CH, Wang LH (2017) Dual-mode electrochemical analysis of microRNA-21 using gold nanoparticle-decorated MoS2 nanosheet. Biosens Bioelectron 94:552\u2013559","journal-title":"Biosens Bioelectron"},{"key":"2606_CR14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00604-014-1329-z","volume":"182","author":"J Zhang","year":"2015","unstructured":"Zhang J, Liu Y, Lv J, Cao Y, Li GX (2015) Dipeptidyl peptidase-IV activity assay and inhibitor screening using a gold nanoparticle-modified gold electrode with an immobilized enzyme substrate. Microchim Acta 182:281\u2013288","journal-title":"Microchim Acta"},{"key":"2606_CR15","first-page":"5078","volume":"11","author":"YM Yin","year":"2010","unstructured":"Yin YM, Cao Y, Xu YY, Li GX (2010) Colorimetric immunoassay for detection of tumor markers. Int J Mol Sci 11:5078\u20135095","journal-title":"Int J Mol Sci"},{"key":"2606_CR16","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1007\/s00604-017-2419-5","volume":"184","author":"P Miao","year":"2017","unstructured":"Miao P, Yang DW, Chen XF, Guo ZZ, Tang YG (2017) Voltammetric determination of tumor necrosis factor-alpha based on the use of an aptamer and magnetic nanoparticles loaded with gold nanoparticles. Microchim Acta 184:3901\u20133907","journal-title":"Microchim Acta"},{"key":"2606_CR17","doi-asserted-by":"crossref","first-page":"8921","DOI":"10.1073\/pnas.132556899","volume":"99","author":"K Ito","year":"2002","unstructured":"Ito K, Lim S, Caramori G, Cosio B, Chung KF, Adcock IM, Barnes PJ (2002) A molecular mechanism of action of theophylline: induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci U S A 99:8921\u20138926","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2606_CR18","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ijpharm.2006.07.045","volume":"328","author":"VS Mastiholimath","year":"2007","unstructured":"Mastiholimath VS, Dandagi PM, Jain SS, Gadad AP, Kulkarni AR (2007) Time and pH dependent colon specific, pulsatile delivery of theophylline for nocturnal asthma. Int J Pharm 328:49\u201356","journal-title":"Int J Pharm"},{"key":"2606_CR19","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1002\/elan.200804558","volume":"21","author":"EE Ferapontova","year":"2009","unstructured":"Ferapontova EE, Gothelf KV (2009) Optimization of the electrochemical RNA-aptamer based biosensor for theophylline by using a methylene blue redox label. Electroanalysis 21:1261\u20131266","journal-title":"Electroanalysis"},{"key":"2606_CR20","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s00604-015-1688-0","volume":"183","author":"Y Wang","year":"2016","unstructured":"Wang Y, Wu T, Bi CY (2016) Simultaneous determination of acetaminophen, theophylline and caffeine using a glassy carbon disk electrode modified with a composite consisting of poly(alizarin violet 3B), multiwalled carbon nanotubes and graphene. Microchim Acta 183:731\u2013739","journal-title":"Microchim Acta"},{"key":"2606_CR21","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jelechem.2016.02.043","volume":"768","author":"YJ Yang","year":"2016","unstructured":"Yang YJ, Guo LL, Zhang WQ (2016) The electropolymerization of CTAB on glassy carbon electrode for simultaneous determination of dopamine, uric acid, tryptophan and theophylline. J Electroanal Chem 768:102\u2013109","journal-title":"J Electroanal Chem"},{"key":"2606_CR22","doi-asserted-by":"crossref","first-page":"12719","DOI":"10.1002\/chem.201201298","volume":"18","author":"Y Sato","year":"2012","unstructured":"Sato Y, Zhang YS, Nishizawa S, Seino T, Nakamura K, Li MJ, Teramae N (2012) Competitive assay for theophylline based on an abasic site-containing DNA duplex aptamer and a fluorescent ligand. Chem Eur J 18:12719\u201312724","journal-title":"Chem Eur J"},{"key":"2606_CR23","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.bios.2017.10.025","volume":"101","author":"J Wang","year":"2018","unstructured":"Wang J, Cheng WB, Meng FY, Yang M, Pan Y, Miao P (2018) Hand-in-hand RNA nanowire-based aptasensor for the detection of theophylline. Biosens Bioelectron 101:153\u2013158","journal-title":"Biosens Bioelectron"},{"key":"2606_CR24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.bios.2010.04.049","volume":"26","author":"JL Chavez","year":"2010","unstructured":"Chavez JL, Lyon W, Kelley-Loughnane N, Stone MO (2010) Theophylline detection using an aptamer and DNA-gold nanoparticle conjugates. Biosens Bioelectron 26:23\u201328","journal-title":"Biosens Bioelectron"},{"key":"2606_CR25","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.bios.2015.03.054","volume":"70","author":"HY Jiang","year":"2015","unstructured":"Jiang HY, Ling K, Tao XJ, Zhang QQ (2015) Theophylline detection in serum using a self-assembling RNA aptamer-based gold nanoparticle sensor. Biosens Bioelectron 70:299\u2013303","journal-title":"Biosens Bioelectron"},{"key":"2606_CR26","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bios.2016.06.024","volume":"86","author":"K Ling","year":"2016","unstructured":"Ling K, Jiang HY, Li Y, Tao XJ, Qiu C, Li FR (2016) A self-assembling RNA aptamer-based graphene oxide sensor for the turn-on detection of theophylline in serum. Biosens Bioelectron 86:8\u201313","journal-title":"Biosens Bioelectron"},{"key":"2606_CR27","doi-asserted-by":"publisher","unstructured":"Wang LH, Liu XF, XF H, Song SP, Fan CH (2006) Unmodified gold nanoparticles as a colorimetric probe for potassium DNA aptamers. Chem Commun: 3780\u20133782. https:\/\/doi.org\/10.1039\/b607448k","DOI":"10.1039\/b607448k"},{"key":"2606_CR28","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1021\/la011278n","volume":"18","author":"SL Cumberland","year":"2002","unstructured":"Cumberland SL, Strouse GF (2002) Analysis of the nature of oxyanion adsorption on gold nanomaterial surfaces. Langmuir 18:269\u2013276","journal-title":"Langmuir"},{"key":"2606_CR29","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.bios.2016.07.042","volume":"86","author":"RD Li","year":"2016","unstructured":"Li RD, Yin BC, Ye BC (2016) Ultrasensitive, colorimetric detection of microRNAs based on isothermal exponential amplification reaction-assisted gold nanoparticle amplification. Biosens Bioelectron 86:1011\u20131016","journal-title":"Biosens Bioelectron"},{"key":"2606_CR30","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/j.bios.2010.02.017","volume":"25","author":"XL Zhu","year":"2010","unstructured":"Zhu XL, Li YX, Yang JH, Liang ZQ, Li GX (2010) Gold nanoparticle-based colorimetric assay of single-nucleotide polymorphism of triplex DNA. Biosens Bioelectron 25:2135\u20132139","journal-title":"Biosens Bioelectron"},{"key":"2606_CR31","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1056\/NEJM197309202891202","volume":"289","author":"PA Mitenko","year":"1973","unstructured":"Mitenko PA, Ogilvie RI (1973) Rational intravenous doses of theophylline. N Engl J Med 289:600\u2013603","journal-title":"N Engl J Med"}],"container-title":["Microchimica Acta"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00604-017-2606-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00604-017-2606-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00604-017-2606-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T14:15:46Z","timestamp":1719670546000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00604-017-2606-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,7]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["2606"],"URL":"https:\/\/doi.org\/10.1007\/s00604-017-2606-4","relation":{},"ISSN":["0026-3672","1436-5073"],"issn-type":[{"value":"0026-3672","type":"print"},{"value":"1436-5073","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,7]]},"article-number":"33"}}