{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T21:11:50Z","timestamp":1773695510730,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T00:00:00Z","timestamp":1515715200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21575114"],"award-info":[{"award-number":["21575114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21775121"],"award-info":[{"award-number":["21775121"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21475104"],"award-info":[{"award-number":["21475104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Industry Development Project by the Science and Technology Department of Shaanxi Province","award":["2016GY-214"],"award-info":[{"award-number":["2016GY-214"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Microchim Acta"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s00604-017-2667-4","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T07:11:07Z","timestamp":1515741067000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Selective extraction of theophylline from plasma by copper-doped magnetic microspheres prior to its quantification by HPLC"],"prefix":"10.1007","volume":"185","author":[{"given":"Peihong","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiwei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaozhan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinmao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,1,12]]},"reference":[{"key":"2667_CR1","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1007\/s00604-014-1413-4","volume":"182","author":"F Bates","year":"2015","unstructured":"Bates F, Valle MD (2015) Voltammetric sensor for theophylline using sol-gel immobilized molecularly imprinted polymer particles. Microchim Acta 182:933\u2013942","journal-title":"Microchim Acta"},{"key":"2667_CR2","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1002\/jssc.200800529","volume":"32","author":"MJ Li","year":"2009","unstructured":"Li MJ, Zhou JY, Gu X, Wang Y, Huang XJ, Yan C (2009) Quantitative capillary electrophoresis and its application in analysis of alkaloids in tea, coffee, coca cola, and theophylline tablets. J Sep Sci 32:267\u2013274","journal-title":"J Sep Sci"},{"key":"2667_CR3","doi-asserted-by":"publisher","first-page":"4152","DOI":"10.1039\/c1an15318h","volume":"136","author":"P Liu","year":"2011","unstructured":"Liu P, Liu RY, Guan GJ, Jiang CL, Wang SH, Zhang ZP (2011) Surface-enhanced raman scattering sensor for theophylline determination by molecular imprinting on silver nanoparticles. Analyst 136:4152\u20134158","journal-title":"Analyst"},{"key":"2667_CR4","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.micromeso.2016.03.048","volume":"228","author":"GQ Xiao","year":"2016","unstructured":"Xiao GQ, Wen RM, Wei DM, Wu D (2016) A novel hyper-cross-linked polymeric adsorbent with high microporous surface area and its adsorption to theophylline from aqueous solution. Microporous Mesoporous Mater 228:168\u2013173","journal-title":"Microporous Mesoporous Mater"},{"key":"2667_CR5","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s00604-010-0455-5","volume":"171","author":"XW Kan","year":"2010","unstructured":"Kan XW, Liu TT, Zhou H, Li C, Fang B (2010) Molecular imprinting polymer electrosensor based on gold nanoparticles for theophylline recognition and determination. Microchim Acta 171:423\u2013429","journal-title":"Microchim Acta"},{"key":"2667_CR6","doi-asserted-by":"publisher","first-page":"33047","DOI":"10.1039\/C4RA05293E","volume":"4","author":"F Yan","year":"2014","unstructured":"Yan F, Liu ZY, Chen JL, Sun XY, Li XJ, Su MX, Li B, Di B (2014) Nanoscale zeolitic imidazolate framework-8 as a selective adsorbent for theophylline over caffeine and diprophylline. RSC Adv 4:33047\u201333054","journal-title":"RSC Adv"},{"key":"2667_CR7","doi-asserted-by":"publisher","first-page":"4256","DOI":"10.1021\/ja711326b","volume":"130","author":"EE Ferapontova","year":"2008","unstructured":"Ferapontova EE, Olsen EM, Gothelf KV (2008) An RNA aptamer-based electrochemical biosensor for detection of theophylline in serum. J Am Chem Soc 130:4256\u20134258","journal-title":"J Am Chem Soc"},{"key":"2667_CR8","doi-asserted-by":"publisher","first-page":"3636","DOI":"10.1021\/ac980264s","volume":"70","author":"WM Mullett","year":"1998","unstructured":"Mullett WM, Lai EPC (1998) Determination of theophylline in serum by molecularly imprinted solid-phase extraction with pulsed elution. Anal Chem 70:3636\u20133641","journal-title":"Anal Chem"},{"key":"2667_CR9","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.jchromb.2006.09.008","volume":"846","author":"K Saka","year":"2007","unstructured":"Saka K, Uemura K, Shintani-Ishida K, Yoshida KI (2007) Acetic acid improves the sensitivity of theophylline analysis by gas chromatography-mass spectrometry. J Chromatogr B 846:240\u2013244","journal-title":"J Chromatogr B"},{"key":"2667_CR10","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.aca.2005.01.064","volume":"538","author":"CW Huck","year":"2005","unstructured":"Huck CW, Guggenbichler W, Bonn GK (2005) Analysis of caffeine, theobromine and theophylline in coffee by near infrared spectroscopy (NIRS) compared to high-performance liquid chromatography (HPLC) coupled to mass spectrometry. Anal Chim Acta 538:195\u2013203","journal-title":"Anal Chim Acta"},{"key":"2667_CR11","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.1021\/acs.analchem.5b04575","volume":"88","author":"B Chovelon","year":"2016","unstructured":"Chovelon B, Durand G, Dausse E, Toulm\u00e9 JJ, Faure P, Peyrin E, Ravelet C (2016) ELAKCA: enzyme-linked aptamer kissing complex assay as a small molecule sensing platform. Anal Chem 88:2570\u20132575","journal-title":"Anal Chem"},{"key":"2667_CR12","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1007\/s00604-015-1688-0","volume":"183","author":"Y Wang","year":"2016","unstructured":"Wang Y, Wu T, Bi CY (2016) Simultaneous determination of acetaminophen, theophylline and caffeine using a glassy carbon disk electrode modified with a composite consisting of poly(Alizarin Violet 3B), multiwalled carbon nanotubes and graphene. Microchim Acta 183:731\u2013739","journal-title":"Microchim Acta"},{"key":"2667_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00604-016-2007-0","volume":"184","author":"X JH","year":"2017","unstructured":"Xu JH, Wang YZ, Hu SS (2017) Nanocomposites of graphene and graphene oxides: synthesis, molecular functionalization and application in electrochemical sensors and biosensors. A review. Microchim Acta 184:1\u201344","journal-title":"Microchim Acta"},{"key":"2667_CR14","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.bios.2016.06.024","volume":"86","author":"K Ling","year":"2016","unstructured":"Ling K, Jiang HY, Li Y, Tao XJ, Qiu C, Li FR (2016) A self-assembling RNA aptamer-based graphene oxide sensor for the turn-on detection of theophylline in serum. Biosens Bioelectron 86:8\u201313","journal-title":"Biosens Bioelectron"},{"key":"2667_CR15","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.bios.2014.09.056","volume":"67","author":"JK Ahn","year":"2015","unstructured":"Ahn JK, Park KS, Won BY, Park HG (2015) A novel electrochemical method to detect theophylline utilizing silver ions captured within abasic site-incorporated duplex DNA. Biosens Bioelectron 67:590\u2013594","journal-title":"Biosens Bioelectron"},{"key":"2667_CR16","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s00604-016-2016-z","volume":"184","author":"T Cheng","year":"2017","unstructured":"Cheng T, Zhang Y, Liu XY, Zhang XY, Zhang HX (2017) Surfactant assisted enrichment of nucleosides by using a sorbent consisting of magnetic polysulfone capsules and mesoporous silica nanoparticles modified with phenylboronic acid. Microchim Acta 184:271\u2013278","journal-title":"Microchim Acta"},{"key":"2667_CR17","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s00604-013-1117-1","volume":"181","author":"QF Zhu","year":"2014","unstructured":"Zhu QF, Ma C, Chen HX, Wu YQ, Huang JL (2014) A molecular imprint-coated stirrer bar for selective extraction of caffeine, theobromine and theophylline. Microchim Acta 181:303\u2013311","journal-title":"Microchim Acta"},{"key":"2667_CR18","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.bios.2008.11.033","volume":"25","author":"AR Khorrami","year":"2009","unstructured":"Khorrami AR, Rashidpur A (2009) Design of a new cartridge for selective solid phase extraction using molecularly imprinted polymers: selective extraction of theophylline from human serum samples. Biosens Bioelectron 25:647\u2013651","journal-title":"Biosens Bioelectron"},{"key":"2667_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.talanta.2016.01.046","volume":"152","author":"WY Tang","year":"2016","unstructured":"Tang WY, Li GZ, Row KH, Zhu T (2016) Preparation of hybrid molecularly imprinted polymer with double-templates for rapid simultaneous purification of theophylline and chlorogenic acid in green tea. Talanta 152:1\u20138","journal-title":"Talanta"},{"key":"2667_CR20","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1039\/c2an16096j","volume":"137","author":"WT Bi","year":"2012","unstructured":"Bi WT, Tian ML, Row KH (2012) Facile synthesis and application of poly(ionic liquid)-bonded silica hybrid materials. Analyst 137:2017\u20132020","journal-title":"Analyst"},{"key":"2667_CR21","doi-asserted-by":"publisher","first-page":"47114","DOI":"10.1039\/C4RA06412G","volume":"4","author":"H Sereshti","year":"2014","unstructured":"Sereshti H, Khosraviani M, Samadi S, Amini-Fazl MS (2014) Simultaneous determination of theophylline, theobromine and caffeine in different tea beverages by graphene-oxide based ultrasonic-assisted dispersive micro solid-phase extraction combined with HPLC-UV. RSC Adv 4:47114\u201347120","journal-title":"RSC Adv"},{"key":"2667_CR22","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.talanta.2014.02.001","volume":"123","author":"J Bian","year":"2014","unstructured":"Bian J, Xue Y, Yao K, Gu X, Yan C, Wang Y (2014) Solid-phase extraction approach for phospholipids profiling by titania-coated silica microspheres prior to reversed-phase liquid chromatography-evaporative light scattering detection and tandem mass spectrometry analysis. Talanta 123:233\u2013240","journal-title":"Talanta"},{"key":"2667_CR23","doi-asserted-by":"publisher","first-page":"10512","DOI":"10.1021\/ac4025297","volume":"85","author":"ST Wang","year":"2013","unstructured":"Wang ST, Huang W, Lu W, Yuan BF, Feng YQ (2013) TiO2-based solid phase extraction strategy for highly effective elimination of normal ribonucleosides before detection of 2\u2032-deoxynucleosides\/low-abundance 2\u2032-O-modified ribonucleosides. Anal Chem 85:10512\u201310518","journal-title":"Anal Chem"},{"key":"2667_CR24","doi-asserted-by":"publisher","first-page":"10122","DOI":"10.1021\/ac502876u","volume":"86","author":"Q Wu","year":"2014","unstructured":"Wu Q, Wu DP, Guan YF (2014) Hybrid titania-zirconia nanoparticles coated adsorbent for highly selective capture of nucleosides from human urine in physiological condition. Anal Chem 86:10122\u201310130","journal-title":"Anal Chem"},{"key":"2667_CR25","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.chroma.2014.07.091","volume":"1361","author":"ST Wang","year":"2014","unstructured":"Wang ST, Huang W, Deng YF, Gao Q, Yuan BF, Feng YQ (2014) \u201cOld\u201d metal oxide affinity chromatography as \u201cnovel\u201d strategy for specific capture of cis-diol-containing compounds. J Chromatogr A 1361:100\u2013107","journal-title":"J Chromatogr A"},{"key":"2667_CR26","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1007\/s00604-017-2096-4","volume":"184","author":"HF Li","year":"2017","unstructured":"Li HF, Xie T, Ye LL, Wang YW, Xie CG (2017) Core-shell magnetic molecularly imprinted polymer nanoparticles for the extraction of triazophos residues from vegetables. Microchim Acta 184:1011\u20131019","journal-title":"Microchim Acta"},{"key":"2667_CR27","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.chroma.2016.04.048","volume":"1448","author":"H Fan","year":"2016","unstructured":"Fan H, Chen PH, Wang CZ, Wei YM (2016) Zirconium-doped magnetic microspheres for the selective enrichment of cis-diol-containing ribonucleosides. J Chromatogr A 1448:20\u201331","journal-title":"J Chromatogr A"},{"key":"2667_CR28","doi-asserted-by":"publisher","first-page":"50011","DOI":"10.1039\/C5RA03951G","volume":"5","author":"T Wang","year":"2015","unstructured":"Wang T, Yang WC, Song TT, Li CF, Zhang LY, Wang HY, Chai LY (2015) Cu doped Fe3O4 magnetic adsorbent for arsenic: synthesis, property, and sorption application. RSC Adv 5:50011\u201350018","journal-title":"RSC Adv"},{"key":"2667_CR29","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.aca.2015.06.015","volume":"886","author":"W Wang","year":"2015","unstructured":"Wang W, He MF, Wang CZ, Wei YM (2015) Enhanced binding capacity of boronate affinity adsorbent via surface modification of silica by combination of atom transfer radical polymerization and chain-end functionalization for high-efficiency enrichment of cis-diol molecules. Anal Chim Acta 886:66\u201374","journal-title":"Anal Chim Acta"},{"key":"2667_CR30","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.chroma.2016.03.055","volume":"1443","author":"WM Zhang","year":"2016","unstructured":"Zhang WM, Lin MX, Tong P, Lu QM, Zhang L (2016) Ferrite nanospheres-based magnetic solid-phase extraction for determination of domoic acid in seawater samples using high-performance liquid chromatography with tandem mass spectrometry. J Chromatogr A 1443:54\u201361","journal-title":"J Chromatogr A"},{"key":"2667_CR31","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jchromb.2015.03.023","volume":"990","author":"T Oshima","year":"2015","unstructured":"Oshima T, Oshima C, Baba Y (2015) Selective extraction of histidine derivatives by metal affinity with a copper(II)-chelating ligand complex in an aqueous two-phase system. J Chromatogr B 990:73\u201379","journal-title":"J Chromatogr B"},{"key":"2667_CR32","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.ica.2016.08.015","volume":"453","author":"R Tatikonda","year":"2016","unstructured":"Tatikonda R, Kalenius E, Haukka M (2016) Synthesis and characterization of zwitterionic Zn(II) and Cu(II) coordination compounds with ring-substituted 2,2\u2032-biimidazole derivatives. Inorg Chim Acta 453:298\u2013304","journal-title":"Inorg Chim Acta"},{"key":"2667_CR33","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.chroma.2014.03.077","volume":"1353","author":"O Gonz\u00e1lez","year":"2014","unstructured":"Gonz\u00e1lez O, Blanco ME, Iriarte G, Bartolom\u00e9 L, Maguregui MI, Alonso RM (2014) Bioanalytical chromatographic method validation according to current regulations, with a special focus on the non-well defined parameters limit of quantification, robustness and matrix effect. J Chromatogr A 1353:10\u201327","journal-title":"J Chromatogr A"},{"key":"2667_CR34","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.1007\/s00216-010-4618-3","volume":"400","author":"K Ardjomand-Woelkart","year":"2011","unstructured":"Ardjomand-Woelkart K, Kollroser M, Li L, Derendorf H, Butterweck V, Bauer R (2011) Development and validation of a LC-MS\/MS method based on a new 96-well hybrid-SPE\u2122-precipitation technique for quantification of CYP450 substrates\/metabolites in rat plasma. Anal Bioanal Chem 400:2371\u20132381","journal-title":"Anal Bioanal Chem"},{"key":"2667_CR35","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1007\/s00604-014-1376-5","volume":"182","author":"H Dai","year":"2015","unstructured":"Dai H, Xiao DL, He H, Li H, Yuan DH, Zhang C (2015) Synthesis and analytical applications of molecularly imprinted polymers on the surface of carbon nanotubes: a review. Microchim Acta 182:893\u2013908","journal-title":"Microchim Acta"}],"container-title":["Microchimica Acta"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00604-017-2667-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00604-017-2667-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00604-017-2667-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T19:30:32Z","timestamp":1547235032000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00604-017-2667-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,12]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["2667"],"URL":"https:\/\/doi.org\/10.1007\/s00604-017-2667-4","relation":{},"ISSN":["0026-3672","1436-5073"],"issn-type":[{"value":"0026-3672","type":"print"},{"value":"1436-5073","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,12]]},"assertion":[{"value":"9 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 December 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}],"article-number":"113"}}