{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T17:41:00Z","timestamp":1774287660123,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T00:00:00Z","timestamp":1558396800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T00:00:00Z","timestamp":1558396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91732103"],"award-info":[{"award-number":["91732103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21575144, 21727809, 21635008 and 2162106"],"award-info":[{"award-number":["21575144, 21727809, 21635008 and 2162106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Microchim Acta"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1007\/s00604-019-3475-9","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T05:04:54Z","timestamp":1558501494000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Non-enzymatic detection of serum glucose using a fluorescent nanopolymer probe"],"prefix":"10.1007","volume":"186","author":[{"given":"Juan","family":"Qiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianrong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiwu","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,5,21]]},"reference":[{"key":"3475_CR1","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1016\/j.biomaterials.2009.01.011","volume":"30","author":"L De Bartolo","year":"2009","unstructured":"De Bartolo L, Salerno S, Curcio E, Piscioneri A, Rende M, Morelli S, Tasselli F, Bader F, Drioli E (2009) Human hepatocyte functions in a crossed hollow fiber membrane bioreactor. Biomaterials 30:2531\u20132543","journal-title":"Biomaterials"},{"key":"3475_CR2","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1146\/annurev.pharmtox.40.1.43","volume":"40","author":"GL Plaa","year":"2000","unstructured":"Plaa GL (2000) Chlorinated methanes and liver injury: highlights of the past 50 years. Annu Rev Pharmacol Toxicol 40:43\u201365","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"3475_CR3","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.tox.2006.12.013","volume":"232","author":"Y Wu","year":"2007","unstructured":"Wu Y, Li L, Wen T, Li YQ (2007) Protective effects of echinacoside on carbon tetrachloride-induced hepatotoxicity in rats. Toxicology 232:50\u201356","journal-title":"Toxicology"},{"key":"3475_CR4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1078\/0940-2993-00156","volume":"53","author":"H Shimizu","year":"2001","unstructured":"Shimizu H, Uetsuka K, Nakayama H, Doi K (2001) Carbon tetrachloride-induced acute liver injury in Mini and Wistar rats. Exp Toxicol Pathol 53:11\u201318","journal-title":"Exp Toxicol Pathol"},{"issue":"7","key":"3475_CR5","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1046\/j.1440-1746.2003.03064.x","volume":"18","author":"SHINICHIRO TADA","year":"2003","unstructured":"Tada S, Nakamoto N, Kameyama K, Tsunematsu S, Kumagai N, Saito H, Ishii H (2003) Clinical usefulness of edaravone for acute liver injury. J Gastroenterol Hepatol 18:851\u2013857","journal-title":"Journal of Gastroenterology and Hepatology"},{"issue":"11","key":"3475_CR6","doi-asserted-by":"publisher","first-page":"4531","DOI":"10.1007\/s00604-017-2445-3","volume":"184","author":"Longhua Ding","year":"2017","unstructured":"Ding LH, Gong ZJ, Yan M, Yu JH, Song XR (2017) Determination of glucose by using fluorescent silicon nanoparticles and an inner filter caused by peroxidase-induced oxidation of o-phenylenediamine byhydrogen peroxide. Microchim Acta 184: 4531-4536","journal-title":"Microchimica Acta"},{"key":"3475_CR7","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1007\/s00604-018-3099-5","volume":"185","author":"J Ge","year":"2018","unstructured":"Ge J, Xing K, Geng X, Shen XP, Zhang L, Li ZH (2018) Human serum albumin templated MnO2 nanosheets are oxidase mimics for colorimetric determination of hydrogen peroxide and for enzymatic determination of glucose. Microchim Acta 185:559","journal-title":"Microchim Acta"},{"key":"3475_CR8","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s00604-018-3112-z","volume":"186","author":"G Darabdhara","year":"2019","unstructured":"Darabdhara G, Boruah PK, Das MR (2019) Colorimetric determination of glucose in solution and via the use of a paper strip by exploiting the peroxidase and oxidase mimicking activity of bimetallic Cu-Pd nanoparticles deposited on reduced graphene oxide, graphitic carbon nitride, or MoS2 nanosheets. Microchim Acta 186:13","journal-title":"Microchim Acta"},{"key":"3475_CR9","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s00604-019-3291-2","volume":"186","author":"Q Zhong","year":"2019","unstructured":"Zhong Q, Chen Y, Qin X, Wang Y, Yuan C, Xu Y (2019) Colorimetric enzymatic determination of glucose based on etching of gold nanorods by iodine and using carbon quantum dots as peroxidase mimics. Microchim Acta 186:161","journal-title":"Microchim Acta"},{"key":"3475_CR10","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1007\/s00604-019-3290-3","volume":"186","author":"TT Zhao","year":"2019","unstructured":"Zhao TT, Jiang ZW, Zhen SJ, Huang CZ, Li YF (2019) A copper (II)\/cobalt (II) organic gel with enhanced peroxidase-like activity for fluorometric determination of hydrogen peroxide and glucose. Microchim Acta 186:168","journal-title":"Microchim Acta"},{"key":"3475_CR11","first-page":"2405","volume":"11","author":"J Yang","year":"2012","unstructured":"Yang J, Qi L, Ma HM, Chen Y (2012) Fabrication of nylon membrane-based microfluidic chips and its application in color sensing of glucose. Chem J Chin Univ 11:2405\u20132410","journal-title":"Chem J Chin Univ"},{"key":"3475_CR12","doi-asserted-by":"publisher","first-page":"7333","DOI":"10.1039\/C6TB02037B","volume":"4","author":"H Zhu","year":"2016","unstructured":"Zhu H, Li L, Zhou W, Shao ZP, Chen XJ (2016) Advances in non-enzymatic glucose sensors based on metal oxides. J Mater Chem B 4:7333\u20137349","journal-title":"J Mater Chem B"},{"key":"3475_CR13","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.bios.2013.02.010","volume":"45","author":"MM Liu","year":"2013","unstructured":"Liu MM, Liu R, Chen W (2013) Graphene wrapped Cu2O nanocubes: non-enzymatic electrochemical sensors for the detection of glucose and hydrogen peroxide with enhanced stability. Biosens Bioelectron 45:206\u2013212","journal-title":"Biosens Bioelectron"},{"key":"3475_CR14","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.snb.2015.05.019","volume":"219","author":"DQ Feng","year":"2015","unstructured":"Feng DQ, Chen M, Liu GL, Zhu WJ, Sun WS, Zhu R, Wang W (2015) A novel resonance light scattering sensing for glucose based on theconversion of gold nanoclusters into gold nanoparticles. Sensors Actuators B Chem 219:133\u2013138","journal-title":"Sensors Actuators B Chem"},{"key":"3475_CR15","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.snb.2017.05.177","volume":"252","author":"XJ Wang","year":"2017","unstructured":"Wang XJ, Wu Q, Jiang KL, Wang CX, Zhang C (2017) One-step synthesis of water-soluble and highly fluorescent MoS2 quantum dots for detection of hydrogen peroxide and glucose. Sensors Actuators B Chem 252:183\u2013190","journal-title":"Sensors Actuators B Chem"},{"key":"3475_CR16","doi-asserted-by":"publisher","first-page":"3409","DOI":"10.1021\/bm3012715","volume":"13","author":"RJ Ma","year":"2012","unstructured":"Ma RJ, Yang H, Li Z, Liu G, Sun XC, Liu XJ, An YL, Shi LQ (2012) Phenylboronic acid-based complex micelles with enhanced glucose-responsiveness at physiological pH by complexation with glycopolymer. Biomacromolecules 13:3409\u20133417","journal-title":"Biomacromolecules"},{"key":"3475_CR17","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.snb.2006.01.030","volume":"119","author":"QS Wang","year":"2006","unstructured":"Wang QS, Li GQ, Xiao WY, Qi HX, Li GW (2006) Glucose-responsive vesicular sensor based on boronic acid-glucose recognition in the ARS\/PBA\/DBBTAB covesicles. Sensors Actuators B Chem 119:695\u2013700","journal-title":"Sensors Actuators B Chem"},{"issue":"13","key":"3475_CR18","doi-asserted-by":"publisher","first-page":"4388","DOI":"10.1021\/acs.macromol.5b00574","volume":"48","author":"Urara Hasegawa","year":"2015","unstructured":"Hasegawa U, Nishida T, van der Vlies AJ (2015) Dual stimuli-responsive phenylboronic acid-containing framboidal nanoparticles by one-step aqueous dispersion polymerization. Macromolecules 48:4388\u20134393","journal-title":"Macromolecules"},{"key":"3475_CR19","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1021\/jo202250d","volume":"77","author":"JW Tomsho","year":"2012","unstructured":"Tomsho JW, Benkovic SJ (2012) Elucidation of the mechanism of the reaction between phenylboronic acid and a model diol, Alizarin Red S. J Org Chem 77:2098\u20132106","journal-title":"J Org Chem"},{"key":"3475_CR20","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.snb.2011.07.023","volume":"160","author":"K Ngamdee","year":"2011","unstructured":"Ngamdee K, Noipa T, Martwiset S, Tuntulani T, Ngeonta W (2011) Enhancement of sensitivity of glucose sensors from alizarin-boronic acid adducts in aqueous micelles. Sensors Actuators B Chem 160:129\u2013138","journal-title":"Sensors Actuators B Chem"},{"key":"3475_CR21","doi-asserted-by":"publisher","first-page":"11200","DOI":"10.1021\/jo302264g","volume":"77","author":"JW Tomsho","year":"2012","unstructured":"Tomsho JW, Benkovic SJ (2012) Examination of the reactivity of benzoxaboroles and related compounds with a cis-diol. J Org Chem 77:11200\u201311209","journal-title":"J Org Chem"},{"key":"3475_CR22","doi-asserted-by":"publisher","first-page":"17237","DOI":"10.1021\/la1034504","volume":"26","author":"D Zhang","year":"2010","unstructured":"Zhang D, Thompson KL, Pelton R, Armes SP (2010) Controlling deposition and release of polyol-stabilized latex on boronic acid-derivatized cellulose. Langmuir 26:17237\u201317241","journal-title":"Langmuir"},{"key":"3475_CR23","doi-asserted-by":"publisher","first-page":"3702","DOI":"10.1039\/b703856a","volume":"17","author":"F He","year":"2007","unstructured":"He F, Feng FD, Wang S, Li YL, Zhu DD (2007) Fluorescence ratiometric assays of hydrogen peroxide and glucose in serum using conjugated polyelectrolytes. J Mater Chem 17:3702\u20133707","journal-title":"J Mater Chem"},{"key":"3475_CR24","doi-asserted-by":"publisher","first-page":"2938","DOI":"10.1039\/c0ob01224f","volume":"9","author":"LH Feng","year":"2011","unstructured":"Feng LH, Liang F, Wang Y, Xu M, Wang XJ (2011) A highly sensitive water-soluble system to sense glucose in aqueous solution. Org Biomol Chem 9:2938\u20132942","journal-title":"Org Biomol Chem"},{"key":"3475_CR25","doi-asserted-by":"crossref","unstructured":"Yu C, Yam VWW (2009) Glucose sensing via polyanion formation and induced pyrene excimer emission. Chem Commun 11:1347\u20131349","DOI":"10.1039\/b820397k"},{"key":"3475_CR26","doi-asserted-by":"publisher","first-page":"6475","DOI":"10.1021\/ma401096r","volume":"46","author":"YC Zhu","year":"2013","unstructured":"Zhu YC, Quek JY, Lowe AB, Roth PJ (2013) Thermoresponsive (co)polymers through post polymerization modification ofpoly(2-vinyl-4,4-dimethylaziactone). Macromolecules 46:6475\u20136484","journal-title":"Macromolecules"},{"issue":"23","key":"3475_CR27","doi-asserted-by":"publisher","first-page":"21346","DOI":"10.1021\/am5063025","volume":"6","author":"Xiaoyu Mu","year":"2014","unstructured":"Mu XY, Qiao J, Qi L, Dong P, Ma HM (2014) Poly(2-vinyl-4,4-dimethylazlactone-functionalized magnetic nanoparticles as carriers for enzyme immobilization and its application. ACS Appl Mater Interfaces 6: 21346\u201321354","journal-title":"ACS Applied Materials & Interfaces"},{"key":"3475_CR28","doi-asserted-by":"publisher","first-page":"3655","DOI":"10.1002\/pola.10007","volume":"39","author":"SM Heilmann","year":"2001","unstructured":"Heilmann SM, Rasmussen JK, Krepski LR (2001) Chemistry and technology of 2-alkenyl azlactones. J Polym Sci A 39:3655\u20133677","journal-title":"J Polym Sci A"},{"key":"3475_CR29","doi-asserted-by":"publisher","first-page":"13701","DOI":"10.1021\/la8024952","volume":"24","author":"SP Cullen","year":"2008","unstructured":"Cullen SP, Mandel IC, Gopalan P (2008) Surface-anchored poly(2-vinyl-4,4-dimethyl azlactone) brushes as templates for enzyme immobilization. Langmuir 24:13701\u201313709","journal-title":"Langmuir"},{"key":"3475_CR30","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1007\/s00604-018-3189-4","volume":"186","author":"Q Cai","year":"2019","unstructured":"Cai Q, Meng H, Liu Y, Li Z (2019) Fluorometric determination of glucose based on a redox reaction between glucose and aminopropyltriethoxysilane and in-situ formation of blue-green emitting silicon nanodots. Microchim Acta 186:78","journal-title":"Microchim Acta"},{"key":"3475_CR31","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1210\/er.2008-0033","volume":"30","author":"RJ Johnson","year":"2009","unstructured":"Johnson RJ, Perez-Pozo SE, Sautin YY, Manitius J, Sanchez-Lozada LG, Feig DI, Shafiu M, Segal M, Glassock RJ, Shimada M, Roncal C, Nakagawa T (2009) Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes? Endocr Rev 30:96\u2013116","journal-title":"Endocr Rev"},{"key":"3475_CR32","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1373\/49.1.181","volume":"49","author":"T Taguchi","year":"2003","unstructured":"Taguchi T, Miwa I, Mizutani T, Nakajima H, Fukumura Y, Kobayashi I, Yabuuchi M, Miwa I (2003) Determination of D-Mannose in plasma by HPLC. Clin Chem 49:181\u2013183","journal-title":"Clin Chem"},{"key":"3475_CR33","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1172\/JCI106592","volume":"50","author":"SJM Young","year":"1971","unstructured":"Young SJM, Weser E (1971) The metabolism of circulating maltose in man. J Clin Invest 50:986\u2013991","journal-title":"J Clin Invest"},{"key":"3475_CR34","doi-asserted-by":"publisher","first-page":"3848","DOI":"10.1021\/pr3003529","volume":"11","author":"LM Jiang","year":"2012","unstructured":"Jiang LM, Huang J, Wang YL, Tang HR (2012) Metabonomic analysis reveals the CCl4-induced systems alterations for multiple rat rrgans. J Proteome Res 11:3848\u20133859","journal-title":"J Proteome Res"},{"key":"3475_CR35","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.rvsc.2017.05.002","volume":"114","author":"M Hamid","year":"2017","unstructured":"Hamid M, Liu DD, Abdulrahim Y, Liu YH, Qian G, Khan A, Gan F, Huang KH (2017) Amelioration of CCl4-induced liver injury in rats by selenizing Astragalus polysaccharides: role of proinflammatory cytokines, oxidative stress and hepatic stellate cells. Res Vet Sci 114:202\u2013211","journal-title":"Res Vet Sci"},{"key":"3475_CR36","first-page":"785A","volume":"56","author":"T Nishikawa","year":"2012","unstructured":"Nishikawa T, Bellance N, Damm A, Soto-Gutirrez A, Fox IJ, Nagrath D (2012) Changes in glycolysis are an important mechanism for maintaining cell survival in hepatic failure in advanced cirrhosis. Hepatology 56:785A\u2013786A","journal-title":"Hepatology"},{"key":"3475_CR37","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1002\/cbf.1259","volume":"23","author":"SJ Hemmings","year":"2005","unstructured":"Hemmings SJ, Song XY (2005) The effects of dietary flaxseed on the Fischer 344 rat. III. Protection against CCl4-induced liver injury. Cell Biochem Funct 23:389\u2013398","journal-title":"Cell Biochem Funct"}],"container-title":["Microchimica Acta"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00604-019-3475-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00604-019-3475-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00604-019-3475-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T23:35:22Z","timestamp":1589931322000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00604-019-3475-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,21]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["3475"],"URL":"https:\/\/doi.org\/10.1007\/s00604-019-3475-9","relation":{},"ISSN":["0026-3672","1436-5073"],"issn-type":[{"value":"0026-3672","type":"print"},{"value":"1436-5073","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,21]]},"assertion":[{"value":"11 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The author(s) declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}],"article-number":"366"}}