{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T02:03:01Z","timestamp":1769047381773,"version":"3.49.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2019,7,6]],"date-time":"2019-07-06T00:00:00Z","timestamp":1562371200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,7,6]],"date-time":"2019-07-06T00:00:00Z","timestamp":1562371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41576098, 81773483"],"award-info":[{"award-number":["41576098, 81773483"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo","doi-asserted-by":"publisher","award":["2017A610231"],"award-info":[{"award-number":["2017A610231"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo","doi-asserted-by":"publisher","award":["2017A610228"],"award-info":[{"award-number":["2017A610228"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo","doi-asserted-by":"publisher","award":["2017A610069"],"award-info":[{"award-number":["2017A610069"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Department of Zhejiang province of China","award":["2016C33176"],"award-info":[{"award-number":["2016C33176"]}]},{"name":"Science and Technology Department of Zhejiang province of China","award":["LGF18B070002"],"award-info":[{"award-number":["LGF18B070002"]}]},{"name":"K.C. Wong Magna Fund"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Microchim Acta"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s00604-019-3611-6","type":"journal-article","created":{"date-parts":[[2019,7,6]],"date-time":"2019-07-06T09:02:23Z","timestamp":1562403743000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A ratiometric electrochemiluminescent tetracycline assay based on the combined use of carbon nanodots, Ru(bpy)32+, and magnetic solid phase microextraction"],"prefix":"10.1007","volume":"186","author":[{"given":"Yunxia","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luyao","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongzhen","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,7,6]]},"reference":[{"key":"3611_CR1","doi-asserted-by":"publisher","first-page":"4170","DOI":"10.1002\/anie.201612160","volume":"56","author":"F Arcudi","year":"2017","unstructured":"Arcudi F, \u0110or\u0111evi\u0107 L, Prato M (2017) Rationally designed carbon nanodots towards pure white-light emission. Angew Chem Int Ed 56:4170\u20131473","journal-title":"Angew Chem Int Ed"},{"key":"3611_CR2","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1021\/ar400023s","volume":"47","author":"C Ding","year":"2013","unstructured":"Ding C, Zhu A, Tian Y (2013) Functional surface engineering of C-dots for fluorescent biosensing and in vivo bioimaging. Acc Chem Res 47:20\u201330","journal-title":"Acc Chem Res"},{"key":"3611_CR3","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1039\/C1CC15290D","volume":"48","author":"Z Lin","year":"2012","unstructured":"Lin Z, Xue W, Chen H, Lin JM (2012) Classical oxidant induced chemiluminescence of fluorescent carbon dots. Chem Commun 48:1051\u20131053","journal-title":"Chem Commun"},{"key":"3611_CR4","doi-asserted-by":"publisher","first-page":"5895","DOI":"10.1021\/cm1018844","volume":"22","author":"Y Dong","year":"2010","unstructured":"Dong Y, Zhou N, Lin X, Jianpeng L, Chi Y, Chen G (2010) Extraction of electrochemiluminescent oxidized carbon quantum dots from activated carbon. Chem Mater 22:5895\u20135899","journal-title":"Chem Mater"},{"key":"3611_CR5","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.bios.2015.01.034","volume":"68","author":"L Wu","year":"2015","unstructured":"Wu L, Ma C, Zheng X, Liu H, Yu J (2015) Paper-based electrochemiluminescence origami device for protein detection using assembled cascade DNA\u2013carbon dots nanotags based on rolling circle amplification. Biosens Bioelectron 68:413\u2013420","journal-title":"Biosens Bioelectron"},{"key":"3611_CR6","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1002\/bio.2752","volume":"30","author":"J Xu","year":"2015","unstructured":"Xu J, Zhou Y, Cheng G, Dong M, Liu S, Huang C (2015) Carbon dots as a luminescence sensor for ultrasensitive detection of phosphate and their bioimaging properties. Luminescence 30:411\u2013415","journal-title":"Luminescence"},{"key":"3611_CR7","doi-asserted-by":"publisher","first-page":"6111","DOI":"10.1039\/C7CS00235A","volume":"46","author":"H Gam","year":"2017","unstructured":"Gam H, Bcm M, Reisner E (2017) Carbon dots as photosensitisers for solar-driven catalysis. Chem Soc Rev 46:6111\u20136123","journal-title":"Chem Soc Rev"},{"key":"3611_CR8","doi-asserted-by":"publisher","first-page":"4564","DOI":"10.1021\/ja809073f","volume":"131","author":"L Zheng","year":"2009","unstructured":"Zheng L, Chi Y, Dong Y, Lin J, Wang B (2009) Electrochemiluminescence of water-soluble carbon nanocrystals released electrochemically from graphite. J Am Chem Soc 131:4564\u20134565","journal-title":"J Am Chem Soc"},{"key":"3611_CR9","doi-asserted-by":"publisher","first-page":"2973","DOI":"10.1007\/s10008-015-2913-9","volume":"19","author":"Q Li","year":"2015","unstructured":"Li Q, Tang W, Wang Y, Di J, Yang J, Wu Y (2015) Electrochemiluminescence immunosensor for ketamine detection based on polyamidoamine-coated carbon dot film. J Solid State Electrochem 19:2973\u20132980","journal-title":"J Solid State Electrochem"},{"key":"3611_CR10","doi-asserted-by":"publisher","first-page":"2710","DOI":"10.1039\/b307550h","volume":"9","author":"R Wilson","year":"2003","unstructured":"Wilson R, Johansson MK (2003) Photoluminescence and electrochemiluminescence of a Ru(II)(bpy)3-quencher dual-labeled oligonucleotide probe. Chem Commun 9:2710\u20132711","journal-title":"Chem Commun"},{"key":"3611_CR11","doi-asserted-by":"publisher","first-page":"15935","DOI":"10.1021\/jacs.6b08239","volume":"138","author":"G Valenti","year":"2017","unstructured":"Valenti G, Rampazzo E, Bonacchi S, Petrizza L, Marcaccio M, Montalti M, Prodi L, Paolucci F (2017) Variable doping induces mechanism swapping in electrogenerated chemiluminescence of Ru(bpy)3\n                           2+ Core\u2013Shell silica nanoparticles. J Am Chem Soc 138:15935\u201315942","journal-title":"J Am Chem Soc"},{"key":"3611_CR12","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1002\/anie.200603491","volume":"46","author":"X Liu","year":"2010","unstructured":"Liu X, Shi L, Niu W, Li H, Xu G (2010) Environmentally friendly and highly sensitive ruthenium(II) tris(2,2'-bipyridyl) electrochemiluminescent system using 2-(dibutylamino)ethanol as co-reactant. Angew Chem 46:421\u2013424","journal-title":"Angew Chem"},{"key":"3611_CR13","doi-asserted-by":"publisher","first-page":"3127","DOI":"10.1149\/1.2086171","volume":"137","author":"JK Leland","year":"1990","unstructured":"Leland JK (1990) Electrogenerated chemiluminescence: an oxidative-reduction type ECL reaction sequence using tripropyl amine. J Electrochem Soc 137:3127\u20133131","journal-title":"J Electrochem Soc"},{"key":"3611_CR14","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.carbon.2017.05.045","volume":"121","author":"BP Qi","year":"2017","unstructured":"Qi BP, Zhang X, Shang BB, Xiang D, Qu W, Zhang S (2017) A facile method to sensitively monitor chlorinated phenols based on Ru(bpy)3\n                           2+ electrochemiluminescent system using graphene quantum dots as coreactants. Carbon 121:72\u201378","journal-title":"Carbon"},{"key":"3611_CR15","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.bios.2016.03.069","volume":"89","author":"L Li","year":"2017","unstructured":"Li L, Liu D, Mao H, You T (2017) Multifunctional solid-state electrochemiluminescence sensing platform based on poly(ethylenimine) capped N-doped carbon dots as novel co-reactant. Biosens Bioelectron 89:489\u2013495","journal-title":"Biosens Bioelectron"},{"key":"3611_CR16","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.bios.2017.02.027","volume":"92","author":"Q Liu","year":"2017","unstructured":"Liu Q, Ma C, Liu XP, Wei YP, Mao CJ, Zhu JJ (2017) A novel electrochemiluminescence biosensor for the detection of microRNAs based on a DNA functionalized nitrogen doped carbon quantum dots as signal enhancers. Biosens Bioelectron 92:273\u2013279","journal-title":"Biosens Bioelectron"},{"key":"3611_CR17","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.aca.2015.08.055","volume":"895","author":"L Li","year":"2015","unstructured":"Li L, Yu B, Zhang X, You T (2015) A novel electrochemiluminescence sensor based on Ru(bpy)3\n                           (2+)\/N-doped carbon nanodots system for the detection of bisphenol A. Anal Chim Acta 895:104\u2013111","journal-title":"Anal Chim Acta"},{"key":"3611_CR18","doi-asserted-by":"publisher","first-page":"4971","DOI":"10.1002\/ange.201703021","volume":"129","author":"S Carrara","year":"2017","unstructured":"Carrara S, Arcudi F, Prato M, De CL (2017) Amine-rich nitrogen-doped carbon NanoDots as platform for self-enhancing Electrochemiluminescence. Angew Chem 129:4971\u20134971","journal-title":"Angew Chem"},{"key":"3611_CR19","doi-asserted-by":"publisher","first-page":"5321","DOI":"10.1021\/ac400992u","volume":"85","author":"HR Zhang","year":"2013","unstructured":"Zhang HR, Xu JJ, Chen HY (2013) Electrochemiluminescence ratiometry: a new approach to DNA biosensing. Anal Chem 85:5321\u20135325","journal-title":"Anal Chem"},{"key":"3611_CR20","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.bios.2018.01.052","volume":"106","author":"Y Wang","year":"2018","unstructured":"Wang Y, Shan D, Wu G, Wang H, Ru F, Zhang X, Li L, Qian Y, Lu X (2018) A novel \"dual-potential\" ratiometric electrochemiluminescence DNA sensor based on enhancing and quenching effect by G-quadruplex\/ hemin and Au-Luminol bifunctional nanoparticles. Biosens Bioelectron 106:64\u201370","journal-title":"Biosens Bioelectron"},{"key":"3611_CR21","doi-asserted-by":"publisher","first-page":"4871","DOI":"10.1021\/acs.analchem.8b00517","volume":"90","author":"H Wang","year":"2018","unstructured":"Wang H, Pu G, Devaramani S, Wang Y, Yang Z, Li L, Ma X, Lu X (2018) Bimodal Electrochemiluminescence of G-CNQDs in the presence of double coreactants for ascorbic acid detection. Anal Chem 90:4871\u20134877","journal-title":"Anal Chem"},{"key":"3611_CR22","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.aca.2014.10.037","volume":"853","author":"M Solliec","year":"2015","unstructured":"Solliec M, Roy-Lachapelle A, Sauv\u00e9 S (2015) Quantitative performance of liquid chromatography coupled to Q-Exactive high resolution mass spectrometry (HRMS) for the analysis of tetracyclines in a complex matrix. Anal Chim Acta 853:415\u2013424","journal-title":"Anal Chim Acta"},{"key":"3611_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.chroma.2017.12.041","volume":"1534","author":"L Lian","year":"2017","unstructured":"Lian L, Lv J, Wang X, Lou D (2017) Magnetic solid\u2013phase extraction of tetracyclines using ferrous oxide coated magnetic silica microspheres from water samples. J Chromatogr A 1534:1\u20139","journal-title":"J Chromatogr A"},{"key":"3611_CR24","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.seppur.2013.03.046","volume":"117","author":"X Bao","year":"2013","unstructured":"Bao X, Qiang Z, Ling W, Chang JH (2013) Sonohydrothermal synthesis of MFe2O4 magnetic nanoparticles for adsorptive removal of tetracyclines from water. Sep Purif Technol 117:104\u2013110","journal-title":"Sep Purif Technol"},{"key":"3611_CR25","doi-asserted-by":"publisher","first-page":"3187","DOI":"10.1016\/j.jchromb.2009.08.012","volume":"877","author":"G Qu","year":"2009","unstructured":"Qu G, Zheng S, Liu Y, Xie W, Wu A, Zhang D (2009) Metal ion mediated synthesis of molecularly imprinted polymers targeting tetracyclines in aqueous samples. J Chromatogr B 877:3187\u20133193","journal-title":"J Chromatogr B"},{"key":"3611_CR26","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.jcis.2011.06.032","volume":"362","author":"X Zhang","year":"2011","unstructured":"Zhang X, Niu H, Pan Y, Shi Y, Cai Y (2011) Modifying the surface of Fe3O4\/SiO2 magnetic nanoparticles with C18\/NH2 mixed group to get an efficient sorbent for anionic organic pollutants. J Colloid Interface Sci 362:107\u2013112","journal-title":"J Colloid Interface Sci"},{"issue":"15","key":"3611_CR27","doi-asserted-by":"publisher","first-page":"9961","DOI":"10.1021\/acsami.6b01511","volume":"8","author":"Y Wang","year":"2016","unstructured":"Wang Y, Yin Z, Xie Z, Zhao X, Zhou C, Zhou S, Chen P (2016) Polysiloxane functionalized carbon dots and their cross-linked flexible silicone rubbers for color conversion and encapsulation of white LEDs. ACS Appl Mater Interfaces 8(15):9961\u20139968","journal-title":"ACS Appl Mater Interfaces"},{"key":"3611_CR28","doi-asserted-by":"publisher","first-page":"7901","DOI":"10.1021\/acsami.8b00947","volume":"10","author":"N Wang","year":"2018","unstructured":"Wang N, Zheng AQ, Liu X, Chen J, Yang T, Chen ML, Wang JH (2018) Deep eutectic solvent assisted preparation of nitrogen\/chloride doped carbon dots for intracellular biological sensing and live cell imaging. ACS Appl Mater Interfaces 10:7901\u20137909","journal-title":"ACS Appl Mater Interfaces"},{"key":"3611_CR29","doi-asserted-by":"publisher","first-page":"3053","DOI":"10.1021\/acssuschemeng.6b00018","volume":"4","author":"J Liao","year":"2016","unstructured":"Liao J, Cheng Z, Zhou L (2016) Nitrogen-doping enhanced fluorescent carbon dots: green synthesis and their applications for bioimaging and label-free detection of Au3+ ions. ACS Sustain Chem Eng 4:3053\u20133061","journal-title":"ACS Sustain Chem Eng"},{"key":"3611_CR30","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.compositesa.2015.03.015","volume":"73","author":"X Zeng","year":"2015","unstructured":"Zeng X, Yu S, Sun R, Xu JB (2015) Mechanical reinforcement while remaining electrical insulation of glass fibre\/polymer composites using core\u2013shell CNT@SiO2 hybrids as fillers. Compos Part A 73:260\u2013268","journal-title":"Compos Part A"},{"key":"3611_CR31","doi-asserted-by":"publisher","first-page":"21068","DOI":"10.1021\/jp907956g","volume":"113","author":"H Chen","year":"2009","unstructured":"Chen H, Lu X, Deng C, Yan X (2009) Facile synthesis of uniform microspheres composed of a magnetite core and copper silicate nanotube shell for removal of microcystins in water. J Phys Chem C 113:21068\u201321073","journal-title":"J Phys Chem C"},{"key":"3611_CR32","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3390\/nano7030053","volume":"7","author":"G Song","year":"2017","unstructured":"Song G, Li Z, Li K, Zhang L, Meng A (2017) SiO2\/ZnO composite hollow sub-micron fibers: fabrication from facile single capillary electrospinning and their photoluminescence properties. Nanomaterials 7:53\u201362","journal-title":"Nanomaterials"},{"issue":"15","key":"3611_CR33","first-page":"7224","volume":"86","author":"L Yan-Min","year":"2014","unstructured":"Yan-Min L, Lei B, Jing-Ya Z, Zhi-Ling Z, Dai-Wen P (2014) Revealing carbon nanodots as coreactants of the anodic electrochemiluminescence of Ru(bpy)3\n                           2+analytical. Chemistry 86(15):7224\u20137228","journal-title":"Chemistry"}],"container-title":["Microchimica Acta"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00604-019-3611-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00604-019-3611-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00604-019-3611-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T04:51:14Z","timestamp":1612932674000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00604-019-3611-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,6]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["3611"],"URL":"https:\/\/doi.org\/10.1007\/s00604-019-3611-6","relation":{},"ISSN":["0026-3672","1436-5073"],"issn-type":[{"value":"0026-3672","type":"print"},{"value":"1436-5073","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,6]]},"assertion":[{"value":"25 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The author(s) declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}],"article-number":"512"}}