{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:39:26Z","timestamp":1793140766841,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T00:00:00Z","timestamp":1590624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T00:00:00Z","timestamp":1590624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100012039","name":"Yancheng Institute of Technology","doi-asserted-by":"publisher","award":["NO.154203621"],"award-info":[{"award-number":["NO.154203621"]}],"id":[{"id":"10.13039\/100012039","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012039","name":"Yancheng Institute of Technology","doi-asserted-by":"publisher","award":["NO.154203620"],"award-info":[{"award-number":["NO.154203620"]}],"id":[{"id":"10.13039\/100012039","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"crossref","award":["BK20191041"],"award-info":[{"award-number":["BK20191041"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.21671101"],"award-info":[{"award-number":["No.21671101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Microchim Acta"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1007\/s00604-020-04337-0","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T15:04:01Z","timestamp":1590678241000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["N, P-co-doped carbon dots as a dual-mode colorimetric\/ratiometric fluorescent sensor for formaldehyde and cell imaging via an\u00a0aminal reaction-induced aggregation process"],"prefix":"10.1007","volume":"187","author":[{"given":"Jian","family":"Qu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6620-7966","authenticated-orcid":false,"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojin","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,28]]},"reference":[{"key":"4337_CR1","doi-asserted-by":"publisher","first-page":"7508","DOI":"10.1002\/anie.201802143","volume":"57","author":"KJ Bruemmer","year":"2018","unstructured":"Bruemmer KJ, Green O, Su TA, Shabat D, Chang CJ (2018) Chemiluminescent probes for activity-based sensing of formaldehyde released from folate degradation in living mice. Angew Chem Int Ed 57:7508\u20137512","journal-title":"Angew Chem Int Ed"},{"key":"4337_CR2","doi-asserted-by":"publisher","first-page":"2841","DOI":"10.1021\/acs.accounts.9b00386","volume":"52","author":"J Ohata","year":"2019","unstructured":"Ohata J, Bruemmer KJ, Chang CJ (2019) Activity-based sensing methods for monitoring the reactive carbon species carbon monoxide and formaldehyde in living systems. Acc Chem Res 52:2841\u20132848","journal-title":"Acc Chem Res"},{"key":"4337_CR3","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.yrtph.2004.05.001","volume":"40","author":"H Heck","year":"2004","unstructured":"Heck H, Casanova M (2004) The implausibility of leukemia induction by formaldehyde: a critical review of the biological evidence on distant-site toxicity. Regul Toxicol Pharmacol 40:92\u2013106","journal-title":"Regul Toxicol Pharmacol"},{"key":"4337_CR4","doi-asserted-by":"publisher","first-page":"10802","DOI":"10.1039\/C9TC03386F","volume":"7","author":"P Du","year":"2019","unstructured":"Du P, Ran WG, Li WP, Luo LH, Huang XY (2019) Morphology evolution of Eu3+-activated NaTbF4 nanorods: a highly-efficient near-ultraviolet light-triggered red-emitting platform towards application in white light-emitting diodes. J Mater Chem C 7:10802\u201310809","journal-title":"J Mater Chem C"},{"key":"4337_CR5","doi-asserted-by":"crossref","unstructured":"Du P, Cai PQ, Li W.P., Luo, LH, Hou YP, Liu ZG (2019) Ratiometric optical thermometer based on the use of manganese (II)-doped Cs3Cu2I5 thermochromic and fluorescent halides. Microchim Acta 186: 730","DOI":"10.1007\/s00604-019-3881-z"},{"key":"4337_CR6","doi-asserted-by":"crossref","unstructured":"Qu J, Xia Q, Ji W, Jing S, Zhu DR, Li L, Huang L, An ZF, Xin CQ, Ni Y, Li M, Jia JD, Song YL, Huang W (2018) A ferrocene\u2229europium assembly showing phototriggered anticancer activity and fluorescent modality imaging. 47: 1479-1487","DOI":"10.1039\/C7DT04492E"},{"key":"4337_CR7","doi-asserted-by":"publisher","first-page":"14318","DOI":"10.1021\/acsami.6b03224","volume":"8","author":"S El Sayed","year":"2016","unstructured":"El Sayed S, Pascual L, Licchelli M, Mart\u00ednez-M\u00e1\u00f1ez R, Gil S, Costero AM, Sancen\u00f3n F (2016) Chromogenic detection of aqueous formaldehyde using functionalized silica nanoparticles. ACS Appl Mater Interfaces 8:14318\u201314322","journal-title":"ACS Appl Mater Interfaces"},{"key":"4337_CR8","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1021\/acssuschemeng.7b02941","volume":"6","author":"HJ Li","year":"2018","unstructured":"Li HJ, Sun X, Xue F, Ou N, Sun BW, Qian DJ, Chen M, Wang D, Yang JH, Wang XY (2018) Redox induced fluorescence on-off switching based on nitrogen enriched graphene quantum dots for formaldehyde detection and bioimaging. ACS Sustain Chem Eng 6:1708\u20131716","journal-title":"ACS Sustain Chem Eng"},{"key":"4337_CR9","doi-asserted-by":"publisher","first-page":"8775","DOI":"10.1021\/acssuschemeng.8b01124","volume":"6","author":"Q Lin","year":"2018","unstructured":"Lin Q, Fan YQ, Gong GF, Mao PP, Wang J, Guan XW, Liu J, Zhang YM, Yao H, Wei TB (2018) Ultrasensitive detection of formaldehyde in gas and solutions by a catalyst preplaced sensor based on a pillar[5] arene derivative. ACS Sustain Chem Eng 6:8775\u20138781","journal-title":"ACS Sustain Chem Eng"},{"key":"4337_CR10","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1007\/s00396-018-4427-3","volume":"29","author":"K Chaiendoo","year":"2018","unstructured":"Chaiendoo K, Boonchiangma S, Promarak V, Ngeontae W (2018) New sensitive strategy for formaldehyde sensing by in situ generation of luminescent silver nanoclusters. Colloid Polym Sci 29:1995\u20132004","journal-title":"Colloid Polym Sci"},{"key":"4337_CR11","doi-asserted-by":"publisher","first-page":"15149","DOI":"10.1021\/acs.inorgchem.8b02411","volume":"57","author":"S Nandi","year":"2018","unstructured":"Nandi S, Sharma E, Trivedi V, Biswas S (2018) Metal-organic framework showing selective and sensitive detection of exogenous and endogenous formaldehyde. Inorg Chem 57:15149\u201315157","journal-title":"Inorg Chem"},{"key":"4337_CR12","doi-asserted-by":"crossref","unstructured":"Chaiendoo K, Sooksin S, Kulchat S, Promarak V, Tuntulani T, Ngeontae W (2018) A new formaldehyde sensor from silver nanoclusters modified Tollens\u2019 reagent 255:41\u201348","DOI":"10.1016\/j.foodchem.2018.02.030"},{"key":"4337_CR13","doi-asserted-by":"publisher","first-page":"3356","DOI":"10.1002\/anie.201510373","volume":"55","author":"Y Tang","year":"2016","unstructured":"Tang Y, Kong X, Xu A, Dong B, Lin W (2016) Development of a two-photon fluorescent probe for imaging of endogenous formaldehyde in living tissues. Angew Chem Int Ed 55:3356\u20133359","journal-title":"Angew Chem Int Ed"},{"key":"4337_CR14","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.snb.2018.05.069","volume":"270","author":"H Yang","year":"2018","unstructured":"Yang H, Fang G, Guo M, Ning P, Feng Y, Yu H, Meng X (2018) A ratiometric two-photon fluorescent probe for selective detection of endogenous formaldehyde via aza-Cope reaction. Sens Actuators B: Chem 270:318\u2013326","journal-title":"Sens Actuators B: Chem"},{"key":"4337_CR15","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1007\/s00604-019-3820-z","volume":"186","author":"X Cheng","year":"2019","unstructured":"Cheng X, Xu J, Wang L, Xu GH, Wei FG, Cai YY, Hu Q, Cen Y (2019) A redox modulated ratiometric fluorometric method based on the use of dual-color carbon dots for determination of the activity of enzymes participating in ascorbic acid-related reactions. Microchim Acta 186:818","journal-title":"Microchim Acta"},{"key":"4337_CR16","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1007\/s00604-019-3803-0","volume":"186","author":"J Wang","year":"2019","unstructured":"Wang J, Qiu Y, Li DQ, Liu XY, Jiang CX, Huang L, Wen HM, Hu J (2019) Ratiometric fluorometric and visual determination of cyanide based on the use of carbon dots and gold nanoclusters. Microchim Acta 186:809","journal-title":"Microchim Acta"},{"key":"4337_CR17","doi-asserted-by":"publisher","first-page":"8458","DOI":"10.1039\/C9NR01678C","volume":"11","author":"H Liu","year":"2019","unstructured":"Liu H, Sun Y, Li Z, Yang J, Aryee AA, Qu L, Du D, Lin Y (2019) Lysosome-targeted carbon dots for ratiometric imaging of formaldehyde in living cells. Nanoscale 11:8458\u20138463","journal-title":"Nanoscale"},{"key":"4337_CR18","doi-asserted-by":"publisher","first-page":"6377","DOI":"10.1039\/C9NR00039A","volume":"11","author":"S Chen","year":"2019","unstructured":"Chen S, Jia Y, Zou GY, Yu YL, Wang JH (2019) A ratiometric fluorescent nanoprobe based on naphthalimide derivative-functionalized carbon dots for imaging lysosomal formaldehyde in HeLa cells. Nanoscale 11:6377\u20136383","journal-title":"Nanoscale"},{"key":"4337_CR19","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1039\/C8MH00966J","volume":"6","author":"KD Patel","year":"2019","unstructured":"Patel KD, Singh RK, Kim HW (2019) Carbon-based nanomaterials as an emerging platform for theranostics. Mater Horiz 6:434\u2013469","journal-title":"Mater Horiz"},{"key":"4337_CR20","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1007\/s00604-019-3443-4","volume":"186","author":"ZX Wang","year":"2019","unstructured":"Wang ZX, Jin X, Gao YF, Kong FY, Wang WJ, Wang W (2019) Fluorometric and colorimetric determination of hypochlorite using carbon nanodots doped with boron and nitrogen. Microchim Acta 186:328","journal-title":"Microchim Acta"},{"key":"4337_CR21","doi-asserted-by":"publisher","first-page":"32225","DOI":"10.1039\/C7RA04781A","volume":"7","author":"Y Li","year":"2017","unstructured":"Li Y, Lin H, Luo C, Wang Y, Jiang C, Qi R, Huang R, Travas-sejdic J, Peng H (2017) Aggregation induced red shift emission of phosphorus doped carbon dots. RSC Adv 7:32225\u201332228","journal-title":"RSC Adv"},{"key":"4337_CR22","doi-asserted-by":"publisher","first-page":"17278","DOI":"10.1039\/C5NR05549K","volume":"7","author":"X Sun","year":"2015","unstructured":"Sun X, Bruckner C, Lei Y (2015) One-pot and ultrafast synthesis of nitrogen and phosphorus co-doped carbon dots possessing bright dual wavelength fluorescence emission. Nanoscale 7:17278\u201317282","journal-title":"Nanoscale"},{"key":"4337_CR23","doi-asserted-by":"publisher","first-page":"4221","DOI":"10.1039\/C7AN01136A","volume":"142","author":"H Liu","year":"2017","unstructured":"Liu H, Li RS, Zhou J, Huang CZ (2017) Branched polyethylenimine-functionalized carbon dots as sensitive and selective fluorescent probes for N-acetylcysteine via an off-on mechanism. Analyst 142:4221\u20134227","journal-title":"Analyst"},{"key":"4337_CR24","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.carbon.2017.12.004","volume":"129","author":"B Zhi","year":"2018","unstructured":"Zhi B, Gallagher MJ, Frank BP, Lyons TY, Qiu TA, Da J, Mensch AC, Hamers RJ, Rosenzweig Z, Fairbrother DH, Haynes CL (2018) Investigation of phosphorous doping effects on polymeric carbon dots: fluorescence, photostability, and environmental impact. Carbon 129:438\u2013449","journal-title":"Carbon"},{"key":"4337_CR25","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.snb.2018.04.134","volume":"269","author":"X Fu","year":"2018","unstructured":"Fu X, Sheng L, Yu Y, Ma M, Cai Z, Huang X (2018) Rapid and universal detection of ovalbumin based on N,O,P-co-doped carbon dots-fluorescence resonance energy transfer technology. Sens Actuators B: Chem 269:278\u2013287","journal-title":"Sens Actuators B: Chem"},{"key":"4337_CR26","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.bios.2017.05.035","volume":"97","author":"J Wang","year":"2017","unstructured":"Wang J, Sheng R, Li H, Zhang Z, Wang N, Zhang Z, Huang CZ (2017) Highly fluorescent carbon dots as selective and visual probes for sensing copper ions in living cells via an electron transfer process. Biosens Bioelectron 97:157\u2013163","journal-title":"Biosens Bioelectron"},{"key":"4337_CR27","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s12274-014-0644-3","volume":"8","author":"S Zhu","year":"2015","unstructured":"Zhu S, Song Y, Zhao X, Shao J, Zhang J, Yang B (2015) The photoluminescence mechanism in carbon dots (graphene quantum dots, carbon nanodots, and polymer dots): current state and future perspective. Nano Res 8:355\u2013381","journal-title":"Nano Res"},{"key":"4337_CR28","doi-asserted-by":"publisher","first-page":"115256","DOI":"10.1016\/j.carbpol.2019.115256","volume":"226","author":"L Wei","year":"2019","unstructured":"Wei L, Tan W, Wang G, Li Q, Dong F, Guo Z (2019) The antioxidant and antifungal activity of chitosan derivatives bearing Schiff bases and quaternary ammonium salts. Carbohyd polym 226:115256\u2013115266","journal-title":"Carbohyd polym"},{"key":"4337_CR29","doi-asserted-by":"publisher","first-page":"115151","DOI":"10.1016\/j.carbpol.2019.115151","volume":"224","author":"YA Wang","year":"2019","unstructured":"Wang YA, Liu T, Zhong GQ (2019) Synthesis, characterization and applications of copper (II) complexes with Schiff bases derived from chitooligosaccharide and iodosubstituted salicylaldehyde. Carbohyd Polym 224:115151\u2013115157","journal-title":"Carbohyd Polym"},{"key":"4337_CR30","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.talanta.2017.03.083","volume":"169","author":"H Jin","year":"2017","unstructured":"Jin H, Gui R, Wang Y, Sun J (2017) Carrot-derived carbon dots modified with polyethyleneimine and Nile blue for ratiometric two-photon fluorescence turn-on sensing of sulfide anion in biological fluids. Talanta 169:141\u2013148","journal-title":"Talanta"},{"key":"4337_CR31","doi-asserted-by":"publisher","first-page":"1800369","DOI":"10.1002\/advs.201800369","volume":"5","author":"Z Zhou","year":"2018","unstructured":"Zhou Z, Tian P, Liu X, Mei S, Zhou D, Li D, Jing P, Zhang W, Guo R, Qu S, Rogach AL (2018) Hydrogen peroxide-treated carbon dot phosphor with a bathochromic-shifted, aggregation-enhanced emission for light-emitting devices and visible light communication. Adv Sci 5:1800369\u20131800378","journal-title":"Adv Sci"},{"key":"4337_CR32","doi-asserted-by":"publisher","first-page":"7794","DOI":"10.1039\/C6NR00605A","volume":"8","author":"Z Gan","year":"2016","unstructured":"Gan Z, Xu H, Hao Y (2016) Mechanism for excitation-dependent photoluminescence from graphene quantum dots and other graphene oxide derivates: consensus, debates and challenges. Nanoscale 8:7794\u20137807","journal-title":"Nanoscale"},{"key":"4337_CR33","doi-asserted-by":"publisher","first-page":"14417","DOI":"10.1021\/acsomega.8b01660","volume":"3","author":"W Chen","year":"2018","unstructured":"Chen W, Han J, Wang X, Liu X, Liu F, Wang F, Yu RQ, Jiang JH (2018) Aggregation-induced emission-based fluorescence probe for fast and sensitive imaging of formaldehyde in living cells. ACS Omega 3:14417\u201314422","journal-title":"ACS Omega"},{"key":"4337_CR34","doi-asserted-by":"publisher","first-page":"5652","DOI":"10.1039\/C9TC01288E","volume":"7","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Yan B (2019) A portable self-calibrating logic detector for gradient detection of formaldehyde based on luminescent metal organic frameworks. J Mater Chem C 7:5652\u20135657","journal-title":"J Mater Chem C"},{"key":"4337_CR35","doi-asserted-by":"publisher","first-page":"18189","DOI":"10.1021\/acsomega.8b02590","volume":"3","author":"HW Chen","year":"2018","unstructured":"Chen HW, Li H, Song QH (2018) BODIPY-substituted hydrazine as a fluorescent probe for rapid and sensitive detection of formaldehyde in aqueous solutions and in live cells. ACS Omega 3:18189\u201318195","journal-title":"ACS Omega"}],"container-title":["Microchimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00604-020-04337-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00604-020-04337-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00604-020-04337-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:32:57Z","timestamp":1622161977000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00604-020-04337-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,28]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["4337"],"URL":"https:\/\/doi.org\/10.1007\/s00604-020-04337-0","relation":{},"ISSN":["0026-3672","1436-5073"],"issn-type":[{"value":"0026-3672","type":"print"},{"value":"1436-5073","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,28]]},"assertion":[{"value":"24 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no .","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"355"}}