{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:13:15Z","timestamp":1790356395016,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T00:00:00Z","timestamp":1628294400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T00:00:00Z","timestamp":1628294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Microchim Acta"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s00604-021-04937-4","type":"journal-article","created":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T04:15:48Z","timestamp":1628309748000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Colorimetric determination of phenolic compounds using peroxidase mimics based on biomolecule-free hybrid nanoflowers consisting of graphitic carbon nitride and copper"],"prefix":"10.1007","volume":"188","author":[{"given":"Thinh Viet","family":"Dang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam Su","family":"Heo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Jin","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Moon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Young","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1844-0939","authenticated-orcid":false,"given":"Moon Il","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,7]]},"reference":[{"key":"4937_CR1","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1039\/C8CS00457A","volume":"48","author":"J Wu","year":"2019","unstructured":"Wu J, Wang X, Wang Q, Lou Z, Li S, Zhu Y, Qin L, Wei H (2019) Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (II). Chem Soc Rev 48:1004\u20131076","journal-title":"Chem Soc Rev"},{"key":"4937_CR2","doi-asserted-by":"publisher","first-page":"4357","DOI":"10.1021\/acs.chemrev.8b00672","volume":"119","author":"Y Huang","year":"2019","unstructured":"Huang Y, Ren J, Qu X (2019) Nanozymes: classification, catalytic mechanisms, activity regulation, and applications. Chem Rev 119:4357\u20134412","journal-title":"Chem Rev"},{"key":"4937_CR3","doi-asserted-by":"crossref","first-page":"756278","DOI":"10.1155\/2015\/756278","volume":"2015","author":"HY Shin","year":"2015","unstructured":"Shin HY, Park TJ, Kim MI (2015) Recent research trends and future prospects in nanozymes. J Nanomater 2015:756278","journal-title":"J Nanomater"},{"key":"4937_CR4","doi-asserted-by":"publisher","first-page":"12776","DOI":"10.1039\/C9NJ03006A","volume":"43","author":"C Song","year":"2019","unstructured":"Song C, Ding W, Liu H, Zhao W, Yao Y, Yao C (2019) Label-free colorimetric detection of deoxyribonuclease I activity based on the DNA-enhanced peroxidase-like activity of MIL-53 (Fe). New J Chem 43:12776\u201312784","journal-title":"New J Chem"},{"key":"4937_CR5","doi-asserted-by":"publisher","first-page":"1905410","DOI":"10.1002\/adfm.201905410","volume":"30","author":"MS Kim","year":"2020","unstructured":"Kim MS, Lee J, Kim HS, Cho A, Shim KH, Le TN, An SSA, Han JW, Kim MI, Lee J (2020) Heme cofactor-resembling Fe\u2013N single site embedded graphene as nanozymes to selectively detect H2O2 with high sensitivity. Adv Funct Mater 30:1905410","journal-title":"Adv Funct Mater"},{"key":"4937_CR6","doi-asserted-by":"publisher","first-page":"11994","DOI":"10.1021\/acs.analchem.9b02901","volume":"91","author":"L Jiao","year":"2019","unstructured":"Jiao L, Xu W, Yan H, Wu Y, Liu C, Du D, Lin Y, Zhu C (2019) Fe\u2013N\u2013C single-atom nanozymes for the intracellular hydrogen peroxide detection. Anal Chem 91:11994\u201311999","journal-title":"Anal Chem"},{"key":"4937_CR7","doi-asserted-by":"crossref","unstructured":"Li B, Chen D, Wang J, Yan Z, Jiang L, Duan D, He J, Luo Z, Zhang J, Yuan F (2014) MOFzyme: intrinsic protease-like activity of Cu-MOF. Sci Rep 4","DOI":"10.1038\/srep06759"},{"key":"4937_CR8","doi-asserted-by":"publisher","first-page":"2573","DOI":"10.1039\/C9EN01443H","volume":"7","author":"J Yang","year":"2020","unstructured":"Yang J, Li J, Ng DHL, Yang P, Yang WN, Liu Y (2020) Micromotor-assisted highly efficient Fenton catalysis by a laccase\/Fe-BTC-NiFe2O4 nanozyme hybrid with a 3D hierarchical structure. Environ Sci Nano 7:2573\u20132583","journal-title":"Environ Sci Nano"},{"key":"4937_CR9","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.bios.2014.03.023","volume":"59","author":"T Lin","year":"2014","unstructured":"Lin T, Zhong L, Wang J, Guo L, Wu H, Guo Q, Fu F, Chen G (2014) Graphite-like carbon nitrides as peroxidase mimetics and their applications to glucose detection. Biosens Bioelectron 59:89\u201393","journal-title":"Biosens Bioelectron"},{"key":"4937_CR10","doi-asserted-by":"publisher","first-page":"145142","DOI":"10.1016\/j.apsusc.2019.145142","volume":"508","author":"R Kavitha","year":"2020","unstructured":"Kavitha R, Nithya PM, Kumar SG (2020) Noble metal deposited graphitic carbon nitride based heterojunction photocatalysts. Appl Surf Sci 508:145142","journal-title":"Appl Surf Sci"},{"key":"4937_CR11","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.snb.2015.04.074","volume":"216","author":"F Qiao","year":"2015","unstructured":"Qiao F, Wang J, Ai S, Li L (2015) As a new peroxidase mimetics: the synthesis of selenium doped graphitic carbon nitride nanosheets and applications on colorimetric detection of H2O2 and xanthine. Sensors Actuators B Chem 216:418\u2013427","journal-title":"Sensors Actuators B Chem"},{"key":"4937_CR12","doi-asserted-by":"publisher","first-page":"12327","DOI":"10.1021\/acs.analchem.7b03335","volume":"89","author":"Y-M Wang","year":"2017","unstructured":"Wang Y-M, Liu J-W, Adkins GB, Shen W, Trinh MP, Duan L-Y, Jiang J-H, Zhong W (2017) Enhancement of the intrinsic peroxidase-like activity of graphitic carbon nitride nanosheets by ssDNAs and its application for detection of exosomes. Anal Chem 89:12327\u201312333","journal-title":"Anal Chem"},{"key":"4937_CR13","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1007\/s00604-020-04249-z","volume":"187","author":"NS Heo","year":"2020","unstructured":"Heo NS, Song HP, Lee SM, Cho H-J, Kim HJ, Huh YS, Kim MI (2020) Rosette-shaped graphitic carbon nitride acts as a peroxidase mimic in a wide pH range for fluorescence-based determination of glucose with glucose oxidase. Microchim Acta 187:286","journal-title":"Microchim Acta"},{"key":"4937_CR14","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1007\/s13206-018-2409-7","volume":"12","author":"TD Tran","year":"2018","unstructured":"Tran TD, Kim MI (2018) Organic-inorganic hybrid nanoflowers as potent materials for biosensing and biocatalytic applications. Biochip J 12:268\u2013279","journal-title":"Biochip J"},{"key":"4937_CR15","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.ccr.2017.09.008","volume":"352","author":"J Cui","year":"2017","unstructured":"Cui J, Jia S (2017) Organic\u2013inorganic hybrid nanoflowers: a novel host platform for immobilizing biomolecules. Coord Chem Rev 352:249\u2013263","journal-title":"Coord Chem Rev"},{"key":"4937_CR16","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/nnano.2012.80","volume":"7","author":"J Ge","year":"2012","unstructured":"Ge J, Lei J, Zare RN (2012) Protein\u2013inorganic hybrid nanoflowers. Nat Nanotechnol 7:428\u2013432","journal-title":"Nat Nanotechnol"},{"key":"4937_CR17","doi-asserted-by":"publisher","first-page":"127225","DOI":"10.1016\/j.snb.2019.127225","volume":"303","author":"S Wu","year":"2020","unstructured":"Wu S, Guo D, Xu X, Pan J, Niu X (2020) Colorimetric quantification and discrimination of phenolic pollutants based on peroxidase-like Fe3O4 nanoparticles. Sensors Actuators B Chem 303:127225","journal-title":"Sensors Actuators B Chem"},{"key":"4937_CR18","doi-asserted-by":"publisher","first-page":"11083","DOI":"10.1002\/anie.201304034","volume":"52","author":"YS Jun","year":"2013","unstructured":"Jun YS, Park J, Lee SU, Thomas A, Hong WH, Stucky GD (2013) Three-dimensional macroscopic assemblies of low-dimensional carbon nitrides for enhanced hydrogen evolution. Angew Chem Int Ed 52:11083\u201311087","journal-title":"Angew Chem Int Ed"},{"key":"4937_CR19","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.snb.2018.12.028","volume":"283","author":"BS Batule","year":"2019","unstructured":"Batule BS, Park KS, Gautam S, Cheon HJ, Kim MI, Park HG (2019) Intrinsic peroxidase-like activity of sonochemically synthesized protein copper nanoflowers and its application for the sensitive detection of glucose. Sensors Actuators B Chem 283:749\u2013754","journal-title":"Sensors Actuators B Chem"},{"key":"4937_CR20","doi-asserted-by":"publisher","first-page":"4312","DOI":"10.1021\/acsnano.8b09519","volume":"13","author":"MS Kim","year":"2019","unstructured":"Kim MS, Cho S, Joo SH, Lee J, Kwak SK, Kim MI, Lee J (2019) N-and B-codoped graphene: a strong candidate to replace natural peroxidase in sensitive and selective bioassays. ACS Nano 13:4312\u20134321","journal-title":"ACS Nano"},{"key":"4937_CR21","doi-asserted-by":"publisher","first-page":"111473","DOI":"10.1016\/j.bios.2019.111473","volume":"141","author":"R Jin","year":"2019","unstructured":"Jin R, Kong D, Zhao X, Li H, Yan X, Liu F, Sun P, Du D, Lin Y, Lu G (2019) Tandem catalysis driven by enzymes directed hybrid nanoflowers for on-site ultrasensitive detection of organophosphorus pesticide. Biosens Bioelectron 141:111473","journal-title":"Biosens Bioelectron"},{"key":"4937_CR22","doi-asserted-by":"publisher","first-page":"1801507","DOI":"10.1002\/adhm.201801507","volume":"8","author":"HJ Cheon","year":"2019","unstructured":"Cheon HJ, Adhikari MD, Chung M, Tran TD, Kim J, Kim MI (2019) Magnetic nanoparticles-embedded enzyme-inorganic hybrid nanoflowers with enhanced peroxidase-like activity and substrate channeling for glucose biosensing. Adv Healthcare Mater 8:1801507","journal-title":"Adv Healthcare Mater"},{"key":"4937_CR23","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1016\/j.ijbiomac.2019.11.129","volume":"155","author":"I Lee","year":"2020","unstructured":"Lee I, Cheon HJ, Adhikari MD, Tran TD, Yeon KM, Kim MI, Kim J (2020) Glucose oxidase-copper hybrid nanoflowers embedded with magnetic nanoparticles as an effective antibacterial agent. Int J Biol Macromol 155:1520\u20131531","journal-title":"Int J Biol Macromol"},{"key":"4937_CR24","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.apcata.2011.10.006","volume":"409","author":"L Ge","year":"2011","unstructured":"Ge L, Han C, Liu J, Li Y (2011) Enhanced visible light photocatalytic activity of novel polymeric g-C3N4 loaded with Ag nanoparticles. Appl Catal A Gen 409:215\u2013222","journal-title":"Appl Catal A Gen"},{"key":"4937_CR25","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.aca.2019.09.072","volume":"1091","author":"N Wu","year":"2019","unstructured":"Wu N, Wang Y-T, Wang X-Y, Guo F-N, Wen H, Yang T, Wang JH (2019) Enhanced peroxidase-like activity of AuNPs loaded graphitic carbon nitride nanosheets for colorimetric biosensing. Anal Chim Acta 1091:69\u201375","journal-title":"Anal Chim Acta"},{"key":"4937_CR26","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/nnano.2007.260","volume":"2","author":"L Gao","year":"2007","unstructured":"Gao L, Zhuang J, Nie L, Zhang J, Zhang Y, Gu N, Wang T, Feng J, Yang D, Perrett S (2007) Intrinsic peroxidase-like activity of ferromagnetic nanoparticles. Nat Nanotechnol 2:577\u2013583","journal-title":"Nat Nanotechnol"},{"key":"4937_CR27","doi-asserted-by":"publisher","first-page":"4386","DOI":"10.1039\/C5CC00040H","volume":"51","author":"Y Huang","year":"2015","unstructured":"Huang Y, Ran X, Lin Y, Ren J, Qu X (2015) Self-assembly of an organic\u2013inorganic hybrid nanoflower as an efficient biomimetic catalyst for self-activated tandem reactions. Chem Commun 51:4386\u20134389","journal-title":"Chem Commun"},{"key":"4937_CR28","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1016\/j.snb.2017.08.204","volume":"255","author":"Y Song","year":"2018","unstructured":"Song Y, Zhao M, Li H, Wang X, Cheng Y, Ding L, Fan S, Chen S (2018) Facile preparation of urchin-like NiCo2O4 microspheres as oxidase mimetic for colormetric assay of hydroquinone. Sensors Actuators B Chem 255:1927\u20131936","journal-title":"Sensors Actuators B Chem"},{"issue":"10","key":"4937_CR29","doi-asserted-by":"publisher","first-page":"4236","DOI":"10.1016\/j.bios.2011.03.038","volume":"26","author":"Y Yuan","year":"2011","unstructured":"Yuan Y, Gou X, Yuan R, Chai Y, Zhuo Y, Mao L, Gan X (2011) Electrochemical aptasensor based on the dual-amplification of G-quadruplex horseradish peroxidase-mimicking DNAzyme and blocking reagent-horseradish peroxidase. Biosens Bioelectron 26(10):4236\u20134240","journal-title":"Biosens Bioelectron"},{"key":"4937_CR30","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.snb.2018.11.079","volume":"283","author":"X Wang","year":"2019","unstructured":"Wang X, Zhao M, Song Y, Liu Q, Zhang Y, Zhuang Y, Chen S (2019) Synthesis of ZnFe2O4\/ZnO heterostructures decorated three-dimensional graphene foam as peroxidase mimetics for colorimetric assay of hydroquinone. Sensors Actuators B Chem 283:130\u2013137","journal-title":"Sensors Actuators B Chem"},{"key":"4937_CR31","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.snb.2015.11.083","volume":"225","author":"L-P Zhang","year":"2016","unstructured":"Zhang L-P, Xing Y-P, Liu L-H, Zhou X-H, Shi H-C (2016) Fenton reaction-triggered colorimetric detection of phenols in water samples using unmodified gold nanoparticles. Sensors Actuators B Chem 225:593\u2013599","journal-title":"Sensors Actuators B Chem"},{"key":"4937_CR32","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1007\/s13738-017-1047-7","volume":"14","author":"F Keshvari","year":"2017","unstructured":"Keshvari F, Bahram M (2017) Selective, sensitive and reliable colorimetric sensor for catechol detection based on anti-aggregation of unmodified gold nanoparticles utilizing boronic acid\u2013diol reaction: optimization by experimental design methodology. J Iran Chem Soc 14:977\u2013984","journal-title":"J Iran Chem Soc"},{"key":"4937_CR33","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.aca.2015.04.052","volume":"885","author":"A Hayat","year":"2015","unstructured":"Hayat A, Cunningham J, Bulbul G, Andreescu S (2015) Evaluation of the oxidase like activity of nanoceria and its application in colorimetric assays. Anal Chim Acta 885:140\u2013147","journal-title":"Anal Chim Acta"},{"key":"4937_CR34","doi-asserted-by":"publisher","first-page":"9729","DOI":"10.1021\/ac301110d","volume":"84","author":"RS Alkasir","year":"2012","unstructured":"Alkasir RS, Ornatska M, Andreescu S (2012) Colorimetric paper bioassay for the detection of phenolic compounds. Anal Chem 84:9729\u20139737","journal-title":"Anal Chem"},{"key":"4937_CR35","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.snb.2013.02.021","volume":"181","author":"X-H Zhou","year":"2013","unstructured":"Zhou X-H, Liu L-H, Bai X, Shi H-C (2013) A reduced graphene oxide based biosensor for high-sensitive detection of phenols in water samples. Sensors Actuators B Chem 181:661\u2013667","journal-title":"Sensors Actuators B Chem"}],"container-title":["Microchimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00604-021-04937-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00604-021-04937-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00604-021-04937-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:28:55Z","timestamp":1725582535000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00604-021-04937-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,7]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["4937"],"URL":"https:\/\/doi.org\/10.1007\/s00604-021-04937-4","relation":{},"ISSN":["0026-3672","1436-5073"],"issn-type":[{"value":"0026-3672","type":"print"},{"value":"1436-5073","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,7]]},"assertion":[{"value":"15 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"293"}}