{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:55:03Z","timestamp":1787068503583,"version":"build-2736575974"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["UMO-2018\/30\/E\/ST4\/00481"],"award-info":[{"award-number":["UMO-2018\/30\/E\/ST4\/00481"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012526","name":"Wydzial Chemiczny, Politechniki Warszawskiej","doi-asserted-by":"publisher","award":["504\/04496\/1020\/45.010401"],"award-info":[{"award-number":["504\/04496\/1020\/45.010401"]}],"id":[{"id":"10.13039\/501100012526","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004421","name":"Politechnika Warszawska","doi-asserted-by":"publisher","award":["Scholarship Plus programme"],"award-info":[{"award-number":["Scholarship Plus programme"]}],"id":[{"id":"10.13039\/501100004421","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Microchim Acta"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The presented work concerns pattern-based sensing with quantum dots for the identification and quantification of neurotransmitters by means of excitation-emission fluorescence spectroscopy (2D fluorescence). In the framework of this study, glutathione capped CdSeS\/ZnS nanocrystals were used as non-specific nanoreceptors capable of differentiated interaction with neurotransmitters. The pattern-based sensing with QDs was realized by using excitation-emission fluorescence spectroscopy to provide analyte-specific multidimensional optical information. These characteristic fluorescent response patterns were processed by unfolded partial least squares\u2013discriminant analysis, showing that satisfactory identification of all investigated neurotransmitters: dopamine, norepinephrine, epinephrine, serotonin, GABA, and acetylcholine, can be achieved through the proposed sensing strategy. The impact of the considered fluorescence signal (datum, i.e. zeroth-order data acquired per sample; spectrum, i.e. first-order data acquired per sample; excitation-emission matrix, i.e. second-order data acquired per sample) on the sensing capability of glutathione capped QDs\u00a0was also verified. The best performance parameters such as accuracy, precision, sensitivity, and specificity were obtained using excitation-emission matrices (88.9\u201393.3%, 0.93\u20130.95, 0.89\u20130.93, and 0.99\u20131.00, respectively). Thus, it was revealed that excitation-emission fluorescence spectroscopy may improve the recognition of neurotransmitters while using only one type of nanoreceptor. Furthermore, is was demonstrated that the proposed excitation-emission fluorescence spectroscopy assisted QD assay coupled with unfolded partial least squares regression can be successfully utilized for quantitative determination of catecholamine neurotransmitters at the\u00a0micromolar concentration range with\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    in the range 0.916\u20130.987. Consequently, the proposed sensing strategy has the potential to significantly simplify the sensing element and to expand the pool of bioanalytes so far detectable with the use of QDs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s00604-021-04984-x","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T04:02:56Z","timestamp":1631678576000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Excitation-emission fluorescence matrix acquired from glutathione capped CdSeS\/ZnS quantum dots in combination with chemometric tools for pattern-based sensing of neurotransmitters"],"prefix":"10.1007","volume":"188","author":[{"given":"Klaudia","family":"G\u0142owacz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Drozd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8265-1039","authenticated-orcid":false,"given":"Patrycja","family":"Ciosek-Skibi\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,15]]},"reference":[{"key":"4984_CR1","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.trac.2016.07.008","volume":"83","author":"A Foubert","year":"2016","unstructured":"Foubert A, Beloglazova NV, Rajkovic A, Sas B, Madder A, Goryacheva IY, de Saeger S (2016) Bioconjugation of quantum dots: review & impact on future application. TrAC - Trends Anal Chem 83:31\u201348. https:\/\/doi.org\/10.1016\/j.trac.2016.07.008","journal-title":"TrAC - Trends Anal Chem"},{"key":"4984_CR2","doi-asserted-by":"publisher","first-page":"7602","DOI":"10.1002\/anie.200800169","volume":"47","author":"R Gill","year":"2008","unstructured":"Gill R, Zayats M, Willner I (2008) Semiconductor quantum dots for bioanalysis. Angew Chemie - Int Ed 47:7602\u20137625. https:\/\/doi.org\/10.1002\/anie.200800169","journal-title":"Angew Chemie - Int Ed"},{"key":"4984_CR3","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1021\/bc200151q","volume":"22","author":"SS Kelkar","year":"2011","unstructured":"Kelkar SS, Reineke TM (2011) Theranostics: combining imaging and therapy. Bioconjug Chem 22:1879\u20131903. https:\/\/doi.org\/10.1021\/bc200151q","journal-title":"Bioconjug Chem"},{"key":"4984_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.aca.2010.05.026","volume":"673","author":"WR Algar","year":"2010","unstructured":"Algar WR, Tavares AJ, Krull UJ (2010) Beyond labels: a review of the application of quantum dots as integrated components of assays, bioprobes, and biosensors utilizing optical transduction. Anal Chim Acta 673:1\u201325. https:\/\/doi.org\/10.1016\/j.aca.2010.05.026","journal-title":"Anal Chim Acta"},{"key":"4984_CR5","doi-asserted-by":"publisher","first-page":"2850","DOI":"10.1039\/c4cp04761c","volume":"17","author":"A Veamatahau","year":"2015","unstructured":"Veamatahau A, Jiang B, Seifert T, Makuta S, Latham K, Kanehara M, Teranishi T, Tachibana Y (2015) Origin of surface trap states in CdS quantum dots: relationship between size dependent photoluminescence and sulfur vacancy trap states. Phys Chem Chem Phys 17:2850\u20132858. https:\/\/doi.org\/10.1039\/c4cp04761c","journal-title":"Phys Chem Chem Phys"},{"key":"4984_CR6","doi-asserted-by":"publisher","first-page":"12005","DOI":"10.1088\/2050-6120\/aaf6f8","volume":"7","author":"M Chern","year":"2019","unstructured":"Chern M, Kays JC, Bhuckory S, Dennis AM (2019) Sensing with photoluminescent semiconductor quantum dots. Methods Appl Fluoresc 7:12005. https:\/\/doi.org\/10.1088\/2050-6120\/aaf6f8","journal-title":"Methods Appl Fluoresc"},{"key":"4984_CR7","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1021\/ac503819e","volume":"87","author":"J Liu","year":"2015","unstructured":"Liu J, Li G, Yang X, Wang K, Li L, Liu W, Shi X, Guo Y (2015) Exciton energy transfer-based quantum dot fluorescence sensing array: \u201cchemical noses\u201d for discrimination of different nucleobases. Anal Chem 87:876\u2013883. https:\/\/doi.org\/10.1021\/ac503819e","journal-title":"Anal Chem"},{"key":"4984_CR8","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.cbpa.2010.08.024","volume":"14","author":"EV Anslyn","year":"2010","unstructured":"Anslyn EV, Rotello VM (2010) Chemosensory models: approaches and applications of differential sensing. Curr Opin Chem Biol 14:683\u2013684. https:\/\/doi.org\/10.1016\/j.cbpa.2010.08.024","journal-title":"Curr Opin Chem Biol"},{"key":"4984_CR9","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.trac.2019.03.006","volume":"114","author":"SF Wong","year":"2019","unstructured":"Wong SF, Khor SM (2019) State-of-the-art of differential sensing techniques in analytical sciences. TrAC - Trends Anal Chem 114:108\u2013125. https:\/\/doi.org\/10.1016\/j.trac.2019.03.006","journal-title":"TrAC - Trends Anal Chem"},{"key":"4984_CR10","doi-asserted-by":"publisher","first-page":"7840","DOI":"10.1021\/cr5005524","volume":"115","author":"L You","year":"2015","unstructured":"You L, Zha D, Anslyn EV (2015) Recent advances in supramolecular analytical chemistry using optical sensing. Chem Rev 115:7840\u20137892. https:\/\/doi.org\/10.1021\/cr5005524","journal-title":"Chem Rev"},{"key":"4984_CR11","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1021\/acsnano.5b06433","volume":"10","author":"WJ Peveler","year":"2016","unstructured":"Peveler WJ, Roldan A, Hollingsworth N, Porter MJ, Parkin IP (2016) Multichannel detection and differentiation of explosives with a quantum dot array. ACS Nano 10:1139\u20131146. https:\/\/doi.org\/10.1021\/acsnano.5b06433","journal-title":"ACS Nano"},{"key":"4984_CR12","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1021\/acs.analchem.5b03109","volume":"88","author":"Q Xu","year":"2016","unstructured":"Xu Q, Zhang Y, Tang B, Zhang CY (2016) Multicolor quantum dot-based chemical nose for rapid and array-free differentiation of multiple proteins. Anal Chem 88:2051\u20132058. https:\/\/doi.org\/10.1021\/acs.analchem.5b03109","journal-title":"Anal Chem"},{"key":"4984_CR13","doi-asserted-by":"publisher","first-page":"4253","DOI":"10.1021\/ac5045302","volume":"87","author":"Z Yuan","year":"2015","unstructured":"Yuan Z, Du Y, Tseng YT et al (2015) Fluorescent gold nanodots based sensor array for proteins discrimination. Anal Chem 87:4253\u20134259. https:\/\/doi.org\/10.1021\/ac5045302","journal-title":"Anal Chem"},{"key":"4984_CR14","doi-asserted-by":"publisher","first-page":"8118","DOI":"10.1002\/anie.201101882","volume":"50","author":"P Wu","year":"2011","unstructured":"Wu P, Miao LN, Wang HF, Shao XG, Yan XP (2011) A multidimensional sensing device for the discrimination of proteins based on manganese-doped ZnS quantum dots. Angew Chemie - Int Ed 50:8118\u20138121. https:\/\/doi.org\/10.1002\/anie.201101882","journal-title":"Angew Chemie - Int Ed"},{"key":"4984_CR15","doi-asserted-by":"publisher","first-page":"3655","DOI":"10.3390\/s19173655","volume":"19","author":"M Zabadaj","year":"2019","unstructured":"Zabadaj M, Ciosek-Skibi\u0144ska P (2019) Quantum dots-assisted 2d fluorescence for pattern based sensing of amino acids, oligopeptides and neurotransmitters. Sensors (Switzerland) 19:3655. https:\/\/doi.org\/10.3390\/s19173655","journal-title":"Sensors (Switzerland)"},{"key":"4984_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/8395212","volume":"2018","author":"T Drami\u0107anin","year":"2018","unstructured":"Drami\u0107anin T, Lenhardt Ackovi\u0107 L, Zekovi\u0107 I (2018) Drami\u0107anin MD (2018) detection of adulterated honey by fluorescence excitation-emission matrices. J Spectrosc 2018:1\u20136. https:\/\/doi.org\/10.1155\/2018\/8395212","journal-title":"J Spectrosc"},{"key":"4984_CR17","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S0304-4203(03)00072-0","volume":"82","author":"CA Stedmon","year":"2003","unstructured":"Stedmon CA, Markager S, Bro R (2003) Tracing dissolved organic matter in aquatic environments using a new approach to fluorescence spectroscopy. Mar Chem 82:239\u2013254. https:\/\/doi.org\/10.1016\/S0304-4203(03)00072-0","journal-title":"Mar Chem"},{"key":"4984_CR18","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1002\/btpr.2381","volume":"33","author":"M Zabadaj","year":"2017","unstructured":"Zabadaj M, Chreptowicz K, Mierzejewska J, Ciosek P (2017) Two-dimensional fluorescence as soft sensor in the monitoring of biotransformation performed by yeast. Biotechnol Prog 33:299\u2013307. https:\/\/doi.org\/10.1002\/btpr.2381","journal-title":"Biotechnol Prog"},{"key":"4984_CR19","doi-asserted-by":"publisher","first-page":"42080","DOI":"10.1039\/c8ra08751b","volume":"8","author":"H Ramsay","year":"2018","unstructured":"Ramsay H, Simon D, Steele E, Hebert A, Oleschuk RD, Stamplecoskie KG (2018) The power of fluorescence excitation-emission matrix (EEM) spectroscopy in the identification and characterization of complex mixtures of fluorescent silver clusters. RSC Adv 8:42080\u201342086. https:\/\/doi.org\/10.1039\/c8ra08751b","journal-title":"RSC Adv"},{"key":"4984_CR20","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.chemolab.2014.12.004","volume":"141","author":"B Hemmateenejad","year":"2015","unstructured":"Hemmateenejad B, Safavi A, Honarasa F (2015) Determination of nanoparticles concentration by multivariate curve resolution. Chemom Intell Lab Syst 141:88\u201393. https:\/\/doi.org\/10.1016\/j.chemolab.2014.12.004","journal-title":"Chemom Intell Lab Syst"},{"key":"4984_CR21","doi-asserted-by":"publisher","first-page":"119016","DOI":"10.1016\/j.saa.2020.119016","volume":"246","author":"M Razavi","year":"2021","unstructured":"Razavi M, Kompany-Zareh M, Khoshkam M (2021) PARAFAC study of L-cys@CdTe QDs interaction to BSA, cytochrome c and trypsin: an approach through electrostatic and covalent bonds. Spectrochim Acta - Part A Mol Biomol Spectrosc 246:119016. https:\/\/doi.org\/10.1016\/j.saa.2020.119016","journal-title":"Spectrochim Acta - Part A Mol Biomol Spectrosc"},{"key":"4984_CR22","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1039\/c5an02457a","volume":"141","author":"J Hu","year":"2016","unstructured":"Hu J, Zhuang Q, Wang Y, Ni Y (2016) Label-free fluorescent catalytic biosensor for highly sensitive and selective detection of the ferrous ion in water samples using a layered molybdenum disulfide nanozyme coupled with an advanced chemometric model. Analyst 141:1822\u20131829. https:\/\/doi.org\/10.1039\/c5an02457a","journal-title":"Analyst"},{"key":"4984_CR23","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s10895-008-0395-1","volume":"19","author":"H Gon\u00e7alves","year":"2009","unstructured":"Gon\u00e7alves H, Mendon\u00e7a C, Esteves Da Silva JCG (2009) PARAFAC analysis of the quenching of EEM of fluorescence of glutathione capped CdTe quantum dots by Pb (II). J Fluoresc 19:141\u2013149. https:\/\/doi.org\/10.1007\/s10895-008-0395-1","journal-title":"J Fluoresc"},{"key":"4984_CR24","doi-asserted-by":"publisher","first-page":"14530","DOI":"10.1021\/ja073790m","volume":"129","author":"W Liu","year":"2007","unstructured":"Liu W, Hak SC, Zimmer JP et al (2007) Compact cysteine-coated CdSe(ZnCdS) quantum dots for in vivo applications. J Am Chem Soc 129:14530\u201314531. https:\/\/doi.org\/10.1021\/ja073790m","journal-title":"J Am Chem Soc"},{"key":"4984_CR25","doi-asserted-by":"publisher","first-page":"9392","DOI":"10.1021\/nn203598c","volume":"5","author":"S Tamang","year":"2011","unstructured":"Tamang S, Beaune G, Texier I, Reiss P (2011) Aqueous phase transfer of InP\/ZnS nanocrystals conserving fluorescence and high colloidal stability. ACS Nano 5:9392\u20139402. https:\/\/doi.org\/10.1021\/nn203598c","journal-title":"ACS Nano"},{"key":"4984_CR26","doi-asserted-by":"publisher","first-page":"2854","DOI":"10.1021\/cm034081k","volume":"15","author":"WW Yu","year":"2003","unstructured":"Yu WW, Qu L, Guo W, Peng X (2003) Experimental determination of the extinction coefficient of CdTe, CdSe, and CdS nanocrystals. Chem Mater 15:2854\u20132860. https:\/\/doi.org\/10.1021\/cm034081k","journal-title":"Chem Mater"},{"key":"4984_CR27","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.colsurfa.2010.01.059","volume":"359","author":"M Noh","year":"2010","unstructured":"Noh M, Kim T, Lee H, Kim CK, Joo SW, Lee K (2010) Fluorescence quenching caused by aggregation of water-soluble CdSe quantum dots. Colloids Surfaces A Physicochem Eng Asp 359:39\u201344. https:\/\/doi.org\/10.1016\/j.colsurfa.2010.01.059","journal-title":"Colloids Surfaces A Physicochem Eng Asp"},{"key":"4984_CR28","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1007\/s12274-019-2283-1","volume":"12","author":"G Chen","year":"2019","unstructured":"Chen G, Zhang Y, Peng Z, Huang D, Li C, Wang Q (2019) Glutathione-capped quantum dots for plasma membrane labeling and membrane potential imaging. Nano Res 12:1321\u20131326. https:\/\/doi.org\/10.1007\/s12274-019-2283-1","journal-title":"Nano Res"},{"key":"4984_CR29","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/0307-4412(83)90048-1","volume":"11","author":"R Stevens","year":"1983","unstructured":"Stevens R, Stevens L, Price NC (1983) The stabilities of various thiol compounds used in protein purifications. Biochamical Educ 11:70. https:\/\/doi.org\/10.1016\/0307-4412(83)90048-1","journal-title":"Biochamical Educ"},{"key":"4984_CR30","doi-asserted-by":"publisher","first-page":"395501","DOI":"10.1088\/1361-6528\/ab9c58","volume":"31","author":"S Parani","year":"2020","unstructured":"Parani S, Oluwafemi OS (2020) Selective and sensitive fluorescent nanoprobe based on AgInS2-ZnS quantum dots for the rapid detection of Cr (III) ions in the midst of interfering ions. Nanotechnology 31:395501. https:\/\/doi.org\/10.1088\/1361-6528\/ab9c58","journal-title":"Nanotechnology"},{"key":"4984_CR31","doi-asserted-by":"publisher","first-page":"640","DOI":"10.3390\/jcm8050640","volume":"8","author":"A Plenis","year":"2019","unstructured":"Plenis A, Ol\u0119dzka I, Kowalski P, Mi\u0119kus N, B\u0105czek T (2019) Recent trends in the quantification of biogenic amines in biofluids as biomarkers of various disorders: a review. J Clin Med 8:640. https:\/\/doi.org\/10.3390\/jcm8050640","journal-title":"J Clin Med"},{"key":"4984_CR32","doi-asserted-by":"publisher","first-page":"15244","DOI":"10.1039\/c7nj03170j","volume":"41","author":"R Rajamanikandan","year":"2017","unstructured":"Rajamanikandan R, Ilanchelian M (2017) Highly selective and sensitive biosensing of dopamine based on glutathione coated silver nanoclusters enhanced fluorescence. New J Chem 41:15244\u201315250. https:\/\/doi.org\/10.1039\/c7nj03170j","journal-title":"New J Chem"},{"key":"4984_CR33","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/NMAT2811","volume":"9","author":"IL Medintz","year":"2010","unstructured":"Medintz IL, Stewart MH, Trammell SA, Susumu K, Delehanty JB, Mei BC, Melinger JS, Blanco-Canosa JB, Dawson PE, Mattoussi H (2010) Quantum-dot\/dopamine bioconjugates function as redox coupled assemblies for in vitro and intracellular pH sensing. Nat Mater 9:676\u2013684. https:\/\/doi.org\/10.1038\/NMAT2811","journal-title":"Nat Mater"},{"key":"4984_CR34","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1039\/C3AN01592K","volume":"139","author":"Q Mu","year":"2014","unstructured":"Mu Q, Xu H, Li Y, Ma S, Zhong X (2014) Adenosine capped QDs based fluorescent sensor for detection of dopamine with high selectivity and sensitivity. Analyst 139:93\u201398. https:\/\/doi.org\/10.1039\/C3AN01592K","journal-title":"Analyst"},{"key":"4984_CR35","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s00604-012-0925-z","volume":"180","author":"A Xiangzhao","year":"2013","unstructured":"Xiangzhao A, Qiang M, Xingguang S (2013) Nanosensor for dopamine and glutathione based on the quenching and recovery of the fluorescence of silica-coated quantum dots. Microchim Acta 180:269\u2013277. https:\/\/doi.org\/10.1007\/s00604-012-0925-z","journal-title":"Microchim Acta"},{"key":"4984_CR36","doi-asserted-by":"publisher","first-page":"129354","DOI":"10.1016\/j.snb.2020.129354","volume":"331","author":"K G\u0142owacz","year":"2021","unstructured":"G\u0142owacz K, Wawrzyniak UE, Ciosek-Skibi\u0144ska P (2021) Comparison of various data analysis techniques applied for the classification of oligopeptides and amino acids by voltammetric electronic tongue. Sensors Actuators B Chem 331:129354. https:\/\/doi.org\/10.1016\/j.snb.2020.129354","journal-title":"Sensors Actuators B Chem"},{"key":"4984_CR37","doi-asserted-by":"publisher","first-page":"116128","DOI":"10.1016\/j.trac.2020.116128","volume":"134","author":"MB Anzardi","year":"2021","unstructured":"Anzardi MB, Arancibia JA, Olivieri AC (2021) Processing multi-way chromatographic data for analytical calibration, classification and discrimination: a successful marriage between separation science and chemometrics. TrAC - Trends Anal Chem 134:116128. https:\/\/doi.org\/10.1016\/j.trac.2020.116128","journal-title":"TrAC - Trends Anal Chem"},{"key":"4984_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.chemolab.2017.09.001","volume":"170","author":"CLM Morais","year":"2017","unstructured":"Morais CLM, Lima KMG (2017) Comparing unfolded and two-dimensional discriminant analysis and support vector machines for classification of EEM data. Chemom Intell Lab Syst 170:1\u201312. https:\/\/doi.org\/10.1016\/j.chemolab.2017.09.001","journal-title":"Chemom Intell Lab Syst"}],"container-title":["Microchimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00604-021-04984-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00604-021-04984-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00604-021-04984-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T02:19:36Z","timestamp":1634091576000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00604-021-04984-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,15]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["4984"],"URL":"https:\/\/doi.org\/10.1007\/s00604-021-04984-x","relation":{},"ISSN":["0026-3672","1436-5073"],"issn-type":[{"value":"0026-3672","type":"print"},{"value":"1436-5073","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,15]]},"assertion":[{"value":"20 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"343"}}