{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:44:23Z","timestamp":1790909063156,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"faculty of science research fund 2021, prince of songkla university, hat yai, thailand","award":["264003"],"award-info":[{"award-number":["264003"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Microchim Acta"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s00604-021-05067-7","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T22:02:16Z","timestamp":1636495336000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Cavitas electrochemical sensors for the direct determination of salivary thiocyanate levels"],"prefix":"10.1007","volume":"188","author":[{"given":"Rachanon","family":"Sangsawang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongdee","family":"Buranachai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panote","family":"Thavarungkul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Proespichaya","family":"Kanatharana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8016-6411","authenticated-orcid":false,"given":"Itthipon","family":"Jeerapan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,9]]},"reference":[{"key":"5067_CR1","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1021\/acs.analchem.9b04668","volume":"92","author":"JR Sempionatto","year":"2020","unstructured":"Sempionatto JR, Jeerapan I, Krishnan S, Wang J (2020) Wearable chemical sensors: emerging systems for on-body analytical chemistry. Anal Chem 92:378\u2013396. https:\/\/doi.org\/10.1021\/acs.analchem.9b04668","journal-title":"Anal Chem"},{"key":"5067_CR2","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1007\/s00604-021-04793-2","volume":"188","author":"K Pungjunun","year":"2021","unstructured":"Pungjunun K, Yakoh A, Chaiyo S, Praphairaksit N, Siangproh W, Kalcher K, Chailapakul O (2021) Laser engraved microapillary pump paper-based microfluidic device for colorimetric and electrochemical detection of salivary thiocyanate. Microchim Acta 188:140. https:\/\/doi.org\/10.1007\/s00604-021-04793-2","journal-title":"Microchim Acta"},{"key":"5067_CR3","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/j.electacta.2018.07.012","volume":"283","author":"SK Ponnaiah","year":"2018","unstructured":"Ponnaiah SK, Prakash P, Vellaichamy B, Paulmony T, Selvanathan R (2018) Picomolar-level electrochemical detection of thiocyanate in the saliva samples of smokers and non-smokers of tobacco using carbon dots doped Fe3O4 nanocomposite embedded on g-C3N4 nanosheets. Electrochim Acta 283:914\u2013921. https:\/\/doi.org\/10.1016\/j.electacta.2018.07.012","journal-title":"Electrochim Acta"},{"key":"5067_CR4","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/s41587-019-0321-x","volume":"38","author":"Y Yang","year":"2020","unstructured":"Yang Y, Song Y, Bo X, Min J, Pak OS, Zhu L, Wang M, Tu J, Kogan A, Zhang H, Hsiai TK, Li Z, Gao W (2020) A laser-engraved wearable sensor for sensitive detection of uric acid and tyrosine in sweat. Nat Biotechnol 38:217\u2013224. https:\/\/doi.org\/10.1038\/s41587-019-0321-x","journal-title":"Nat Biotechnol"},{"key":"5067_CR5","doi-asserted-by":"publisher","first-page":"116164","DOI":"10.1016\/j.trac.2020.116164","volume":"135","author":"V Mani","year":"2021","unstructured":"Mani V, Beduk T, Khushaim W, Ceylan AE, Timur S, Wolfbeis OS, Salama KN (2021) Electrochemical sensors targeting salivary biomarkers: a comprehensive review. TrAC Trends Anal Chem 135:116164. https:\/\/doi.org\/10.1016\/j.trac.2020.116164","journal-title":"TrAC Trends Anal Chem"},{"key":"5067_CR6","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1039\/C7AN01571B","volume":"143","author":"K Ngamchuea","year":"2018","unstructured":"Ngamchuea K, Chaisiwamongkhol K, Batchelor-McAuley C, Compton RG (2018) Chemical analysis in saliva and the search for salivary biomarkers \u2013 a tutorial review. Analyst 143:81\u201399. https:\/\/doi.org\/10.1039\/C7AN01571B","journal-title":"Analyst"},{"key":"5067_CR7","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/978-3-319-47319-2_3","volume-title":"Sensors for everyday life: healthcare settings","author":"T Arakawa","year":"2017","unstructured":"Arakawa T, Mitsubayashi K (2017) Cavitas sensors (soft contact lens type biosensor, mouth-guard type sensor, etc.) for daily medicine. In: Postolache OA, Mukhopadhyay SC, Jayasundera KP, Swain AK (eds) Sensors for everyday life: healthcare settings. Springer International Publishing, Cham, pp 45\u201365"},{"key":"5067_CR8","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/j.bios.2015.07.039","volume":"74","author":"J Kim","year":"2015","unstructured":"Kim J, Imani S, de Araujo WR, Warchall J, Vald\u00e9s-Ram\u00edrez G, Paix\u00e3o TRLC, Mercier PP, Wang J (2015) Wearable salivary uric acid mouthguard biosensor with integrated wireless electronics. Biosens Bioelectron 74:1061\u20131068. https:\/\/doi.org\/10.1016\/j.bios.2015.07.039","journal-title":"Biosens Bioelectron"},{"key":"5067_CR9","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1039\/C3AN02359A","volume":"139","author":"J Kim","year":"2014","unstructured":"Kim J, Vald\u00e9s-Ram\u00edrez G, Bandodkar AJ, Jia W, Martinez AG, Ram\u00edrez J, Mercier P, Wang J (2014) Non-invasive mouthguard biosensor for continuous salivary monitoring of metabolites. Analyst 139:1632\u20131636. https:\/\/doi.org\/10.1039\/C3AN02359A","journal-title":"Analyst"},{"key":"5067_CR10","doi-asserted-by":"publisher","first-page":"5377","DOI":"10.1073\/pnas.1719573115","volume":"115","author":"Y Lee","year":"2018","unstructured":"Lee Y, Howe C, Mishra S, Lee DS, Mahmood M, Piper M, Kim Y, Tieu K, Byun H-S, Coffey JP, Shayan M, Chun Y, Costanzo RM, Yeo W-H (2018) Wireless, intraoral hybrid electronics for real-time quantification of sodium intake toward hypertension management. Proc Natl Acad Sci 115:5377. https:\/\/doi.org\/10.1073\/pnas.1719573115","journal-title":"Proc Natl Acad Sci"},{"key":"5067_CR11","doi-asserted-by":"publisher","first-page":"12201","DOI":"10.1021\/acs.analchem.0c01201","volume":"92","author":"T Arakawa","year":"2020","unstructured":"Arakawa T, Tomoto K, Nitta H, Toma K, Takeuchi S, Sekita T, Minakuchi S, Mitsubayashi K (2020) A wearable cellulose acetate-coated mouthguard biosensor for in vivo salivary glucose measurement. Anal Chem 92:12201\u201312207. https:\/\/doi.org\/10.1021\/acs.analchem.0c01201","journal-title":"Anal Chem"},{"key":"5067_CR12","doi-asserted-by":"publisher","first-page":"4919","DOI":"10.1007\/s00216-019-01788-0","volume":"411","author":"LF de Castro","year":"2019","unstructured":"de Castro LF, de Freitas SV, Duarte LC, de Souza JAC, Paix\u00e3o TRLC, Coltro WKT (2019) Salivary diagnostics on paper microfluidic devices and their use as wearable sensors for glucose monitoring. Anal Bioanal Chem 411:4919\u20134928. https:\/\/doi.org\/10.1007\/s00216-019-01788-0","journal-title":"Anal Bioanal Chem"},{"key":"5067_CR13","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.snb.2018.10.096","volume":"281","author":"B Ciui","year":"2019","unstructured":"Ciui B, Tertis M, Feurdean CN, Ilea A, Sandulescu R, Wang J, Cristea C (2019) Cavitas electrochemical sensor toward detection of N-epsilon (carboxymethyl)lysine in oral cavity. Sens Actuators B Chem 281:399\u2013407. https:\/\/doi.org\/10.1016\/j.snb.2018.10.096","journal-title":"Sens Actuators B Chem"},{"key":"5067_CR14","doi-asserted-by":"publisher","unstructured":"Riedel K, Hagedorn HW, Scherer G (2013) Thiocyanate in plasma and saliva [Biomonitoring Methods, 2013]. In: The MAK-Collection for Occupational Health and Safety. Wiley, Chichester, pp 277-292. https:\/\/doi.org\/10.1002\/3527600418.bi5712sale0013","DOI":"10.1002\/3527600418.bi5712sale0013"},{"key":"5067_CR15","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/0021-9681(81)90068-0","volume":"34","author":"M Heli\u00f6vaara","year":"1981","unstructured":"Heli\u00f6vaara M, Karvonen MJ, Punsar S, Rautanen Y, Haapakoski J (1981) Serum thiocyanate concentration and cigarette smoking in relation to overall mortality and to deaths from coronary heart disease and lung cancer. J Chronic Dis 34:305\u2013311. https:\/\/doi.org\/10.1016\/0021-9681(81)90068-0","journal-title":"J Chronic Dis"},{"key":"5067_CR16","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.3109\/10715762.2014.947286","volume":"48","author":"PE Nedoboy","year":"2014","unstructured":"Nedoboy PE, Morgan PE, Mocatta TJ, Richards AM, Winterbourn CC, Davies MJ (2014) High plasma thiocyanate levels are associated with enhanced myeloperoxidase-induced thiol oxidation and long-term survival in subjects following a first myocardial infarction. Free Radical Res 48:1256\u20131266. https:\/\/doi.org\/10.3109\/10715762.2014.947286","journal-title":"Free Radical Res"},{"key":"5067_CR17","doi-asserted-by":"publisher","first-page":"727","DOI":"10.4314\/ahs.v18i3.31","volume":"18","author":"A Madiyal","year":"2018","unstructured":"Madiyal A, Ajila V, Babu SG, Hegde S, Kumari S, Madi M, Achalli S, Alva P, Ullal H (2018) Status of thiocyanate levels in the serum and saliva of non-smokers, ex-smokers and smokers. Afr Health Sci 18:727\u2013736. https:\/\/doi.org\/10.4314\/ahs.v18i3.31\u00a0","journal-title":"Afr Health Sci"},{"issue":"20","key":"5067_CR18","doi-asserted-by":"publisher","first-page":"3790","DOI":"10.3390\/molecules24203790","volume":"24","author":"J Flieger","year":"2019","unstructured":"Flieger J, Kawka J, Tatarczak-Michalewska M (2019) Levels of the thiocyanate in the saliva of tobacco smokers in comparison to e-cigarette smokers and nonsmokers measured by HPLC on a phosphatidylcholine column. Molecules 24(20):3790. https:\/\/doi.org\/10.3390\/molecules24203790","journal-title":"Molecules"},{"key":"5067_CR19","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1248\/jhs.46.343","volume":"46","author":"K Tsuge","year":"2000","unstructured":"Tsuge K, Kataoka M, Seto Y (2000) Cyanide and thiocyanate levels in blood and saliva of healthy adult volunteers. J Health Sci 46:343\u2013350. https:\/\/doi.org\/10.1248\/jhs.46.343","journal-title":"J Health Sci"},{"key":"5067_CR20","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1080\/10408340490273726","volume":"34","author":"M Vald\u00e9s","year":"2004","unstructured":"Vald\u00e9s M, D\u00edaz-Garc\u00eda M (2004) Determination of thiocyanate within physiological fluids and environmental samples: current practice and future trends. Crit Rev Anal Chem 34:9\u201323. https:\/\/doi.org\/10.1080\/10408340490273726","journal-title":"Crit Rev Anal Chem"},{"key":"5067_CR21","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/B0-12-369397-7\/00077-7","volume-title":"Encyclopedia of Analytical Science","author":"G Hanrahan","year":"2005","unstructured":"Hanrahan G, Udeh F, Patil DG (2005) CHEMOMETRICS AND STATISTICS | Multivariate Calibration Techniques. In: Worsfold P, Townshend A, Poole C (eds) Encyclopedia of Analytical Science, 2nd edn. Elsevier, Oxford, pp 27\u201332","edition":"2"},{"key":"5067_CR22","doi-asserted-by":"publisher","first-page":"037573","DOI":"10.1149\/1945-7111\/ab7117","volume":"167","author":"I Jeerapan","year":"2020","unstructured":"Jeerapan I, Poorahong S (2020) Review\u2014flexible and stretchable electrochemical sensing systems: materials, energy sources, and integrations. J Electrochem Soc 167:037573. https:\/\/doi.org\/10.1149\/1945-7111\/ab7117","journal-title":"J Electrochem Soc"},{"key":"5067_CR23","doi-asserted-by":"publisher","unstructured":"Kim J, Jeerapan I, Ciui B, Hartel MC, Martin A, Wang J (2017) Edible electrochemistry: food materials based electrochemical sensors. Adv Healthcare Mater. 6:1700770. https:\/\/doi.org\/10.1002\/adhm.201700770","DOI":"10.1002\/adhm.201700770"},{"key":"5067_CR24","doi-asserted-by":"publisher","first-page":"3852","DOI":"10.1021\/acs.chemrev.9b00739","volume":"120","author":"C Jiang","year":"2020","unstructured":"Jiang C, Wang G, Hein R, Liu N, Luo X, Davis JJ (2020) Antifouling strategies for selective in vitro and in vivo sensing. Chem Rev 120:3852\u20133889. https:\/\/doi.org\/10.1021\/acs.chemrev.9b00739","journal-title":"Chem Rev"},{"key":"5067_CR25","doi-asserted-by":"publisher","unstructured":"Morgan AJ, Wynn PC, Sheehy PA (2016) Milk proteins: minor proteins, bovine serum albumin, and vitamin-binding proteins and their biological properties. In: Reference Module in Food Science. Elsevier. https:\/\/doi.org\/10.1016\/B978-0-08-100596-5.00947-1","DOI":"10.1016\/B978-0-08-100596-5.00947-1"},{"key":"5067_CR26","doi-asserted-by":"publisher","first-page":"11610","DOI":"10.1021\/ac403013r","volume":"85","author":"J Patel","year":"2013","unstructured":"Patel J, Radhakrishnan L, Zhao B, Uppalapati B, Daniels RC, Ward KR, Collinson MM (2013) Electrochemical properties of nanostructured porous gold electrodes in biofouling solutions. Anal Chem 85:11610\u201311618. https:\/\/doi.org\/10.1021\/ac403013r","journal-title":"Anal Chem"},{"key":"5067_CR27","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1007\/s10008-007-0295-3","volume":"11","author":"P Krishnan","year":"2007","unstructured":"Krishnan P (2007) The effect of concentration in electrochemical oxidation of thiocyanate on platinum electrode. J Solid State Electrochem 11:1327\u20131334. https:\/\/doi.org\/10.1007\/s10008-007-0295-3","journal-title":"J Solid State Electrochem"},{"key":"5067_CR28","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1021\/ac051635p","volume":"78","author":"ML Griffiths","year":"2006","unstructured":"Griffiths ML, Barbagallo RP, Keer JT (2006) Multiple and simultaneous fluorophore detection using fluorescence spectrometry and partial least-squares regression with sample-specific confidence intervals. Anal Chem 78:513\u2013523. https:\/\/doi.org\/10.1021\/ac051635p","journal-title":"Anal Chem"},{"key":"5067_CR29","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0039-9140(97)00269-5","volume":"46","author":"A Herrero","year":"1998","unstructured":"Herrero A, Ortiz MC (1998) Modelling the background current with partial least squares regression and transference of the calibration models in the simultaneous determination of Tl and Pb by stripping voltammetry. Talanta 46:129\u2013138. https:\/\/doi.org\/10.1016\/S0039-9140(97)00269-5","journal-title":"Talanta"},{"key":"5067_CR30","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.talanta.2017.02.034","volume":"167","author":"M Sisouane","year":"2017","unstructured":"Sisouane M, Cascant MM, Tahiri S, Garrigues S, El Krati M, Boutchich GELK, Cervera ML, de la Guardia M (2017) Prediction of organic carbon and total nitrogen contents in organic wastes and their composts by infrared spectroscopy and partial least square regression. Talanta 167:352\u2013358. https:\/\/doi.org\/10.1016\/j.talanta.2017.02.034","journal-title":"Talanta"},{"key":"5067_CR31","unstructured":"Wold S (1994) PLS for multivariate linear modeling. QSAR: chemometric methods in molecular design Methods and principles in medicinal chemistry. Weinheim, Germany: Verlag-Chemie"},{"key":"5067_CR32","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.sbsr.2015.02.002","volume":"4","author":"W Zhang","year":"2015","unstructured":"Zhang W, Du Y, Wang ML (2015) Noninvasive glucose monitoring using saliva nano-biosensor. Sens Bio-Sensing Res 4:23\u201329. https:\/\/doi.org\/10.1016\/j.sbsr.2015.02.002","journal-title":"Sens Bio-Sensing Res"},{"key":"5067_CR33","doi-asserted-by":"publisher","unstructured":"Kumar B, Kashyap N, Avinash A, Chevvuri R, Sagar MK, Kumar S (2017) The composition, function and role of saliva in maintaining oral health: a review. Int J Contemp Dent Med Rev.  https:\/\/doi.org\/10.15713\/ins.ijcdmr.121","DOI":"10.15713\/ins.ijcdmr.121"},{"key":"5067_CR34","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1758-5996-4-14","volume":"4","author":"M Soukup","year":"2012","unstructured":"Soukup M, Biesiada I, Henderson A, Idowu B, Rodeback D, Ridpath L, Bridges EG, Nazar AM, Bridges KG (2012) Salivary uric acid as a noninvasive biomarker of metabolic syndrome. Diabetol Metab Syndr 4:14. https:\/\/doi.org\/10.1186\/1758-5996-4-14","journal-title":"Diabetol Metab Syndr"},{"key":"5067_CR35","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1080\/0886022X.2017.1308256","volume":"39","author":"R Renda","year":"2017","unstructured":"Renda R (2017) Can salivary creatinine and urea levels be used to diagnose chronic kidney disease in children as accurately as serum creatinine and urea levels? A case\u2013control study. Ren Fail 39:452\u2013457. https:\/\/doi.org\/10.1080\/0886022X.2017.1308256","journal-title":"Ren Fail"},{"key":"5067_CR36","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1556\/ABiol.63.2012.Suppl.1.9","volume":"63","author":"\u00c9 T\u00e9kus","year":"2012","unstructured":"T\u00e9kus \u00c9, Kaj M, Szab\u00f3 E, Sz\u00e9n\u00e1si NL, Kerepesi I, Figler M, G\u00e1briel R, Wilhelm M (2012) Comparison of blood and saliva lactate level after maximum intensity exercise. Acta Biol Hung 63:89\u201398. https:\/\/doi.org\/10.1556\/ABiol.63.2012.Suppl.1.9","journal-title":"Acta Biol Hung"},{"key":"5067_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.aca.2018.05.051","volume":"1033","author":"D-W Hwang","year":"2018","unstructured":"Hwang D-W, Lee S, Seo M, Chung TD (2018) Recent advances in electrochemical non-enzymatic glucose sensors \u2013 a review. Anal Chim Acta 1033:1\u201334. https:\/\/doi.org\/10.1016\/j.aca.2018.05.051","journal-title":"Anal Chim Acta"},{"key":"5067_CR38","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1093\/clinchem\/43.1.184","volume":"43","author":"LM Galanti","year":"1997","unstructured":"Galanti LM (1997) Specificity of salivary thiocyanate as marker of cigarette smoking is not affected by alimentary sources. Clin Chem 43:184\u2013185. https:\/\/doi.org\/10.1093\/clinchem\/43.1.184","journal-title":"Clin Chem"}],"container-title":["Microchimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00604-021-05067-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00604-021-05067-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00604-021-05067-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T11:30:15Z","timestamp":1639049415000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00604-021-05067-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,9]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["5067"],"URL":"https:\/\/doi.org\/10.1007\/s00604-021-05067-7","relation":{},"ISSN":["0026-3672","1436-5073"],"issn-type":[{"value":"0026-3672","type":"print"},{"value":"1436-5073","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,9]]},"assertion":[{"value":"1 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"415"}}