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This is demonstrated via the so-called 3D printed spinning cup-based platform for immunoextraction of emerging contaminants using diclofenac as a model analyte. A new format of rotating cylindrical scaffold (containing a semispherical upper cavity) with enhanced coverage of biorecognition elements, and providing\u00a0elevated enhancement factors with no need of eluate processing as compared with other microextraction stirring units is proposed. Two distinct synthetic routes capitalized upon modification of the acrylate surface of stereolithographic 3D printed parts with hexamethylenediamine or branched polyethyleneimine chemistries were assayed for covalent binding of monoclonal diclofenac antibody.<\/jats:p><jats:p>Under the optimized experimental conditions, a LOD of 108\u00a0ng L<jats:sup>\u22121<\/jats:sup> diclofenac, dynamic linear range of 0.4\u20131,500\u00a0\u00b5g L<jats:sup>\u20131<\/jats:sup>, and enrichment factors\u2009&gt;\u200983 (for near-exhaustive extraction) were obtained using liquid chromatography coupled with UV\u2013Vis detection. The feasibility of the antibody-laden device for handling of complex samples was demonstrated with the analysis of raw influent wastewaters with relative recoveries ranging from 102 to 109%. By exploiting stereolithographic 3D printing, up to 36 midget devices were fabricated in a single run with an estimated cost of mere 0.68 euros per 3D print and up to 16 \u20ac\/device after the incorporation of the monoclonal antibody.<\/jats:p>\n                <jats:p><jats:bold>Graphical abstract<\/jats:bold><\/jats:p>","DOI":"10.1007\/s00604-022-05267-9","type":"journal-article","created":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T17:02:16Z","timestamp":1648918936000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["3D printed spinning cup-shaped device for immunoaffinity solid-phase extraction of diclofenac in wastewaters"],"prefix":"10.1007","volume":"189","author":[{"given":"Enrique Javier","family":"Carrasco-Correa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Herrero-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto Francisco","family":"Sim\u00f3-Alfonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Knopp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8413-3008","authenticated-orcid":false,"given":"Manuel","family":"Mir\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,2]]},"reference":[{"key":"5267_CR1","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1515\/pac-2020-0206","volume":"92","author":"PN Nesterenko","year":"2020","unstructured":"Nesterenko PN (2020) 3D printing in analytical chemistry: Current state and future. 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