{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:51:55Z","timestamp":1790880715776,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21574070"],"award-info":[{"award-number":["21574070"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22071121"],"award-info":[{"award-number":["22071121"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NCC","award":["NCC2020PY12"],"award-info":[{"award-number":["NCC2020PY12"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Microchim Acta"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s00604-022-05551-8","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T15:49:04Z","timestamp":1669304944000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Preparation of complex biological sample-compatible \u201cturn-on\u201d-type ratiometric fluorescent molecularly imprinted polymer microspheres via one-pot surface-initiated ATRP"],"prefix":"10.1007","volume":"189","author":[{"given":"Qun","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanlan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinru","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8430-691X","authenticated-orcid":false,"given":"Huiqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,23]]},"reference":[{"key":"5551_CR1","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1002\/jmr.793","volume":"19","author":"H Zhang","year":"2006","unstructured":"Zhang H, Ye L, Mosbach K (2006) Non-covalent molecular imprinting with emphasis on its application in separation and drug development. J Mol Recognit 19:248\u2013259","journal-title":"J Mol Recognit"},{"key":"5551_CR2","doi-asserted-by":"publisher","first-page":"3517","DOI":"10.1039\/C0JM03122D","volume":"21","author":"Y Hoshino","year":"2011","unstructured":"Hoshino Y, Shea KJ (2011) The evolution of plastic antibodies. J Mater Chem 21:3517\u20133521","journal-title":"J Mater Chem"},{"key":"5551_CR3","doi-asserted-by":"publisher","first-page":"6243","DOI":"10.1039\/C8CC02923G","volume":"54","author":"T Takeuchi","year":"2018","unstructured":"Takeuchi T, Sunayama H (2018) Beyond natural antibodies-a new generation of synthetic antibodies created by post-imprinting modification of molecularly imprinted polymers. Chem Commun 54:6243\u20136251","journal-title":"Chem Commun"},{"key":"5551_CR4","doi-asserted-by":"publisher","first-page":"1806328","DOI":"10.1002\/adma.201806328","volume":"32","author":"H Zhang","year":"2020","unstructured":"Zhang H (2020) Molecularly imprinted nanoparticles for biomedical applications. Adv Mater 32:1806328","journal-title":"Adv Mater"},{"key":"5551_CR5","doi-asserted-by":"publisher","first-page":"3858","DOI":"10.1002\/anie.202005309","volume":"60","author":"S Xu","year":"2020","unstructured":"Xu S, Wang L, Liu Z (2020) Molecularly imprinted polymer nanoparticles: an emerging versatile platform for cancer therapy. Angew Chem Int Ed 60:3858\u20133869","journal-title":"Angew Chem Int Ed"},{"key":"5551_CR6","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202106493","volume":"61","author":"B Tse Sum Bui","year":"2022","unstructured":"Tse Sum Bui B, Auroy T, Haupt K (2022) Fighting antibiotic-resistant bacteria: promising strategies orchestrated by molecularly imprinted polymers. Angew Chem Int Ed 61:e202106493","journal-title":"Angew Chem Int Ed"},{"key":"5551_CR7","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1039\/b609548h","volume":"36","author":"L Basabe-Desmonts","year":"2007","unstructured":"Basabe-Desmonts L, Reinhoudt DN, Crego-Calama M (2007) Design of fluorescent materials for chemical sensing. Chem Soc Rev 36:993\u20131017","journal-title":"Chem Soc Rev"},{"key":"5551_CR8","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1021\/cr990099w","volume":"100","author":"K Haupt","year":"2000","unstructured":"Haupt K, Mosbach K (2000) Molecularly imprinted polymers and their use in biomimetic sensors. Chem Rev 100:2495\u20132504","journal-title":"Chem Rev"},{"key":"5551_CR9","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1016\/j.biotechadv.2013.08.010","volume":"31","author":"F Canfarotta","year":"2013","unstructured":"Canfarotta F, Whitcombe MJ, Piletsky SA (2013) Polymeric nanoparticles for optical sensing. Biotechnol Adv 31:1585\u20131599","journal-title":"Biotechnol Adv"},{"key":"5551_CR10","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.snb.2014.09.094","volume":"207","author":"J Wackerlig","year":"2015","unstructured":"Wackerlig J, Lieberzeit PA (2015) Molecularly imprinted polymer nanoparticles in chemical sensing-synthesis, characterisation and application. Sensor Actuat B-Chem 207:144\u2013157","journal-title":"Sensor Actuat B-Chem"},{"key":"5551_CR11","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1007\/s00216-015-9174-4","volume":"408","author":"W Wan","year":"2016","unstructured":"Wan W, Wagner S, Rurack K (2016) Fluorescent monomers: \u201cbricks\u201d that make a molecularly imprinted polymer \u201cbright.\u201d Anal Bioanal Chem 408:1753\u20131771","journal-title":"Anal Bioanal Chem"},{"key":"5551_CR12","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.bios.2018.04.028","volume":"112","author":"Q Yang","year":"2018","unstructured":"Yang Q, Li J, Wang X, Peng H, Xiong H, Chen L (2018) Strategies of molecular imprinting-based fluorescence sensors for chemical and biological analysis. Biosens Bioelectron 112:54\u201371","journal-title":"Biosens Bioelectron"},{"key":"5551_CR13","first-page":"97","volume-title":"Methods in molecular biology 2359: Molecularly Imprinted Polymers-Methods and Protocols","author":"H Zhang","year":"2021","unstructured":"Zhang H (2021) Water-compatible fluorescent molecularly imprinted polymers. In: Mart\u00edn-Esteban A (ed) Methods in molecular biology 2359: Molecularly Imprinted Polymers-Methods and Protocols. Humana Press (Springer Nature), New York, pp 97\u2013108"},{"key":"5551_CR14","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.bios.2016.03.031","volume":"81","author":"X Wang","year":"2016","unstructured":"Wang X, Yu J, Wu X, Fu J, Kang Q, Shen D, Li J, Chen L (2016) A molecular imprinting-based turn-on ratiometric fluorescence sensor for highly selective and sensitive detection of 2,4-dichlorophenoxyacetic acid (2,4-D). Biosens Bioelectron 81:438\u2013444","journal-title":"Biosens Bioelectron"},{"key":"5551_CR15","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.bios.2017.02.013","volume":"92","author":"H Lu","year":"2017","unstructured":"Lu H, Xu S (2017) Visualizing BPA by molecularly imprinted ratiometric fluorescence sensor based on dual emission nanoparticles. Biosens Bioelectron 92:147\u2013153","journal-title":"Biosens Bioelectron"},{"key":"5551_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2021.130465","volume":"346","author":"Z Lian","year":"2021","unstructured":"Lian Z, Zhao M, Wang J, Yu RC (2021) Dual-emission ratiometric sensor based molecularly imprinted nanoparticles for visual detection of okadaic acid in seawater and sediment. Sensor Actuat B-Chem 346:130465","journal-title":"Sensor Actuat B-Chem"},{"key":"5551_CR17","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s00604-021-04929-4","volume":"188","author":"X Sun","year":"2021","unstructured":"Sun X, Jiang M, Chen L, Niu N (2021) Construction of ratiometric fluorescence MIPs probe for selective detection of tetracycline based on passion fruit peel-carbon dots and europium. Microchim Acta 188:297","journal-title":"Microchim Acta"},{"key":"5551_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.134499","volume":"433","author":"X Hu","year":"2022","unstructured":"Hu X, Guo Y, Zhang J, Wang X, Fang G, Wang S (2022) A signal-amplified ratiometric fluorescence biomimetic sensor based on the synergistic effect of IFE and AE for the visual smart monitoring of oxytetracycline. Chem Eng J 433:134499","journal-title":"Chem Eng J"},{"key":"5551_CR19","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.bios.2016.07.034","volume":"86","author":"W Li","year":"2016","unstructured":"Li W, Zhang H, Chen S, Liu Y, Zhuang J, Lei B (2016) Synthesis of molecularly imprinted carbon dot grafted YVO4:Eu3+ for the ratiometric fluorescent determination of paranitrophenol. Biosens Bioelectron 86:706\u2013713","journal-title":"Biosens Bioelectron"},{"key":"5551_CR20","doi-asserted-by":"publisher","first-page":"6529","DOI":"10.1039\/D0NR00765J","volume":"12","author":"Q Yang","year":"2020","unstructured":"Yang Q, Li C, Li J, Wang X, Arabi M, Peng H, Xiong H, Chen L (2020) Rational construction of a triple emission molecular imprinting sensor for accurate naked-eye detection of folic acid. Nanoscale 12:6529\u20136536","journal-title":"Nanoscale"},{"key":"5551_CR21","doi-asserted-by":"publisher","first-page":"12403","DOI":"10.1021\/acs.langmuir.9b03851","volume":"36","author":"Y Hou","year":"2020","unstructured":"Hou Y, Zou Y, Zhou Y, Zhang H (2020) Biological sample-compatible ratiometric fluorescent molecularly imprinted polymer microspheres by RAFT coupling chemistry. Langmuir 36:12403\u201312413","journal-title":"Langmuir"},{"key":"5551_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2020.120711","volume":"211","author":"S Xu","year":"2020","unstructured":"Xu S, Zou Y, Zhang H (2020) Well-defined hydrophilic \u201cturn-on\u201d-type ratiometric fluorescent molecularly imprinted polymer microspheres for direct and highly selective herbicide optosensing in the undiluted pure milks. Talanta 211:120711","journal-title":"Talanta"},{"key":"5551_CR23","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.eurpolymj.2012.12.016","volume":"49","author":"H Zhang","year":"2013","unstructured":"Zhang H (2013) Controlled\/\u201cliving\u201d radical precipitation polymerization: a versatile polymerization technique for advanced functional polymers. Eur Polym J 49:579\u2013600","journal-title":"Eur Polym J"},{"key":"5551_CR24","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1021\/bm500086e","volume":"15","author":"M Zhao","year":"2014","unstructured":"Zhao M, Chen X, Zhang HT, Yan H, Zhang H (2014) Well-defined hydrophilic molecularly imprinted polymer microspheres for efficient molecular recognition in real biological samples by facile RAFT coupling chemistry. Biomacromolecules 15:1663\u20131675","journal-title":"Biomacromolecules"},{"key":"5551_CR25","doi-asserted-by":"publisher","first-page":"8317","DOI":"10.1002\/anie.201301045","volume":"52","author":"XA Ton","year":"2013","unstructured":"Ton XA, Tse Sum Bui B, Resmini M, Bonomi P, Dika I, Soppera O, Haupt K (2013) Versatile fiber-optic fluorescence sensor based on molecularly imprinted microstructures polymerized in situ. Angew Chem Int Ed 52:8317\u20138321","journal-title":"Angew Chem Int Ed"},{"key":"5551_CR26","doi-asserted-by":"publisher","first-page":"15741","DOI":"10.1021\/acsami.6b04176","volume":"8","author":"Y Yang","year":"2016","unstructured":"Yang Y, Niu H, Zhang H (2016) Direct and highly selective drug optosensing in real, undiluted biological samples with quantum-dot-labeled hydrophilic molecularly imprinted polymer microparticles. ACS Appl Mater Interfaces 8:15741\u201315749","journal-title":"ACS Appl Mater Interfaces"},{"key":"5551_CR27","doi-asserted-by":"publisher","first-page":"5666","DOI":"10.1021\/ma970535l","volume":"30","author":"H Fischer","year":"1997","unstructured":"Fischer H (1997) The persistent radical effect in \u201cliving\u201d radical polymerization. Macromolecules 30:5666\u20135672","journal-title":"Macromolecules"},{"key":"5551_CR28","doi-asserted-by":"publisher","first-page":"6169","DOI":"10.1021\/ma0104736","volume":"34","author":"H Zhang","year":"2001","unstructured":"Zhang H, Klumperman B, Ming W, Fischer H, van der Linde R (2001) Effect of Cu(II) on the kinetics of the homogeneous atom transfer radical polymerization of methyl methacrylate. Macromolecules 34:6169\u20136173","journal-title":"Macromolecules"},{"key":"5551_CR29","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1002\/anie.201206514","volume":"52","author":"Y Ma","year":"2013","unstructured":"Ma Y, Pan G, Zhang Y, Guo X, Zhang H (2013) Narrowly dispersed hydrophilic molecularly imprinted polymer nanoparticles for efficient molecular recognition in real aqueous samples including river water, milk, and bovine serum. Angew Chem Int Ed 52:1511\u20131514","journal-title":"Angew Chem Int Ed"},{"key":"5551_CR30","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.bios.2006.04.014","volume":"22","author":"S Boonpangrak","year":"2006","unstructured":"Boonpangrak S, Whitcombe MJ, Prachayasittikul V, Mosbach K, Ye L (2006) Preparation of molecularly imprinted polymers using nitroxide-mediated living radical polymerization. Biosens Bioelectron 22:349\u2013354","journal-title":"Biosens Bioelectron"},{"key":"5551_CR31","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.polymer.2013.12.064","volume":"55","author":"H Zhang","year":"2014","unstructured":"Zhang H (2014) Water-compatible molecularly imprinted polymers: promising synthetic substitutes for biological receptors. Polymer 55:699\u2013714","journal-title":"Polymer"},{"key":"5551_CR32","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1021\/am100805y","volume":"3","author":"DC Apodaca","year":"2011","unstructured":"Apodaca DC, Pernites RB, Ponnapati RR, Del Mundo FR, Advincula RC (2011) Electro polymerized molecularly imprinted polymer films of a bis-terthiophene dendron: folic acid quartz crystal microbalance sensing. ACS Appl Mater Interfaces 3:191\u2013203","journal-title":"ACS Appl Mater Interfaces"},{"key":"5551_CR33","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1351\/pac200375081123","volume":"75","author":"D Hamilton","year":"2003","unstructured":"Hamilton D, Ambrus A, Dieterle R, Felsot A, Harris C, Holland P, Katayama A, Kurihara N, Linders J, Unsworth J, Wong S (2003) Regulatory limits for pesticide residues in water (IUPAC technical report). Pure Appl Chem 75:1123\u20131155","journal-title":"Pure Appl Chem"},{"key":"5551_CR34","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S1001-0742(09)60099-1","volume":"22","author":"DM Han","year":"2010","unstructured":"Han DM, Jia WP, Liang HD (2010) Selective removal of 2,4-dichlorophenoxyacetic acid from water by molecularly-imprinted amino-functionalized silica gel sorbent. J Environ Sci 22:237\u2013241","journal-title":"J Environ Sci"},{"key":"5551_CR35","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1021\/ma0522716","volume":"39","author":"W Jakubowski","year":"2006","unstructured":"Jakubowski W, Min K, Matyjaszewski K (2006) Activators regenerated by electron transfer for atom transfer radical polymerization of styrene. Macromolecules 39:39\u201345","journal-title":"Macromolecules"}],"container-title":["Microchimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00604-022-05551-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00604-022-05551-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00604-022-05551-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T12:16:23Z","timestamp":1670415383000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00604-022-05551-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,23]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["5551"],"URL":"https:\/\/doi.org\/10.1007\/s00604-022-05551-8","relation":{},"ISSN":["0026-3672","1436-5073"],"issn-type":[{"value":"0026-3672","type":"print"},{"value":"1436-5073","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,23]]},"assertion":[{"value":"5 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"464"}}