{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:38:19Z","timestamp":1789616299912,"version":"build-2803163510"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102516"],"award-info":[{"award-number":["82102516"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Disciplinary Construction Innovation Team Foundation of Chengdu Medical College","award":["CMC-XK-2103"],"award-info":[{"award-number":["CMC-XK-2103"]}]},{"name":"the Science and Technology Project of Chengdu","award":["2021-YF05-01475-SN"],"award-info":[{"award-number":["2021-YF05-01475-SN"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Microchim Acta"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1007\/s00604-023-05674-6","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T07:29:12Z","timestamp":1676618952000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["An electrochemical immunosensor based on polyaniline microtubules and zinc gallinate for detection of human growth differentiation factor-15"],"prefix":"10.1007","volume":"190","author":[{"given":"Cizhi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,15]]},"reference":[{"issue":"11","key":"5674_CR1","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1038\/s41569-022-00700-1","volume":"19","author":"N Chapman","year":"2022","unstructured":"Chapman N, Thomas EE, Tan JTM et al (2022) A road map of strategies to support cardiovascular researchers: from policy to practice. Nat Rev Cardiol 19(11):765\u2013777. https:\/\/doi.org\/10.1038\/s41569-022-00700-1","journal-title":"Nat Rev Cardiol"},{"key":"5674_CR2","unstructured":"WHO Cardiovascular diseases (CVDs). https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cardiovascular-diseases-(cvds). Accessed 29 Sep 2022. World Health, (Organ)"},{"issue":"25","key":"5674_CR3","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","volume":"76","author":"GA Roth","year":"2020","unstructured":"Roth GA, Mensah GA, Johnson CO et al (2020) Global burden of cardiovascular diseases and risk factors, 1990\u20132019: update from the GBD 2019 study. J Am Coll Cardiol 76(25):2982\u20133021. https:\/\/doi.org\/10.1016\/j.jacc.2020.11.010","journal-title":"J Am Coll Cardiol"},{"issue":"16","key":"5674_CR4","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1182\/blood.2019004572","volume":"136","author":"ES Hansen","year":"2020","unstructured":"Hansen ES, Hindberg K, Latysheva N et al (2020) Plasma levels of growth differentiation factor 15 are associated with future risk of venous thromboembolism. Blood 136(16):1863\u20131870. https:\/\/doi.org\/10.1182\/blood.2019004572","journal-title":"Blood"},{"key":"5674_CR5","doi-asserted-by":"publisher","unstructured":"Myrmel GMS, Steiro OT, Tjora HL et al (2021) Growth differentiation factor 15-a strong prognostic marker in patients presenting with acute chest pain without acute myocardial infarction. Eur Heart J 42(Supplement_1). https:\/\/doi.org\/10.1093\/eurheartj\/ehab724.1380","DOI":"10.1093\/eurheartj\/ehab724.1380"},{"issue":"3","key":"5674_CR6","doi-asserted-by":"publisher","first-page":"494","DOI":"10.36660\/abc.20200426","volume":"116","author":"BM May","year":"2021","unstructured":"May BM, Pimentel M, Zimerman LI, Rohde LE (2021) GDF-15 como Biomarcador em Doen\u00e7as Cardiovasculares. Arq Bras Cardiol 116(3):494\u2013500. https:\/\/doi.org\/10.36660\/abc.20200426","journal-title":"Arq Bras Cardiol"},{"issue":"22","key":"5674_CR7","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.1161\/CIRCULATIONAHA.120.050360","volume":"142","author":"PL Myhre","year":"2020","unstructured":"Myhre PL, Prebensen C, Strand H et al (2020) Growth differentiation Factor 15 provides prognostic information superior to established cardiovascular and inflammatory biomarkers in unselected patients hospitalized with COVID-19. Circulation 142(22):2128\u20132137. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.120.050360","journal-title":"Circulation"},{"issue":"Suppl 1","key":"5674_CR8","doi-asserted-by":"publisher","first-page":"714.2","DOI":"10.1136\/annrheumdis-2020-eular.2841","volume":"79","author":"M Qiu","year":"2020","unstructured":"Qiu M, Sun X, Lu F, Wang Q, Zhou L (2020) The clinical value of Gdf-15 in assessing myocardial involvement of idiopathic inflammatory myopathy. Ann Rheum Dis 79(Suppl 1):714.2-71714. https:\/\/doi.org\/10.1136\/annrheumdis-2020-eular.2841","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"5674_CR9","doi-asserted-by":"publisher","first-page":"e0133362","DOI":"10.1371\/journal.pone.0133362","volume":"10","author":"VW Tsai","year":"2015","unstructured":"Tsai VW, Macia L, Feinle-Bisset C et al (2015) Serum levels of human MIC-1\/GDF15 vary in a diurnal pattern, do not display a profile suggestive of a satiety factor and are related to BMI. PLOS ONE 10(7):e0133362. https:\/\/doi.org\/10.1371\/journal.pone.0133362","journal-title":"PLOS ONE"},{"key":"5674_CR10","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.jcis.2019.08.012","volume":"555","author":"Y Chen","year":"2019","unstructured":"Chen Y, Feng JJ, Mei LP, Shi CG, Wang AJ (2019) Dendritic core-shell rhodium@platinum-cobalt nanocrystals for ultrasensitive electrochemical immunoassay of squamous cell carcinoma antigen. J Colloid Interface Sci 555:647\u2013654. https:\/\/doi.org\/10.1016\/j.jcis.2019.08.012","journal-title":"J Colloid Interface Sci"},{"key":"5674_CR11","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.bios.2017.11.029","volume":"102","author":"FS Felix","year":"2018","unstructured":"Felix FS, Angnes L (2018) Electrochemical immunosensors \u2013 a powerful tool for analytical applications. Biosens Bioelectron 102:470\u2013478. https:\/\/doi.org\/10.1016\/j.bios.2017.11.029","journal-title":"Biosens Bioelectron"},{"key":"5674_CR12","doi-asserted-by":"publisher","unstructured":"Zhang Z, Cong Y, Huang Y, Du X (2019) Nanomaterials-based electrochemical immunosensors. Micromachines (Basel) 10(6). https:\/\/doi.org\/10.3390\/mi10060397","DOI":"10.3390\/mi10060397"},{"key":"5674_CR13","doi-asserted-by":"publisher","unstructured":"Kim J, Park M (2021) Recent progress in electrochemical immunosensors. Biosensors (Basel) 11(10). https:\/\/doi.org\/10.3390\/bios11100360","DOI":"10.3390\/bios11100360"},{"key":"5674_CR14","doi-asserted-by":"publisher","first-page":"122521","DOI":"10.1016\/j.talanta.2021.122521","volume":"233","author":"L Cao","year":"2021","unstructured":"Cao L, Tan Y, Deng W, Xie Q (2021) MWCNTs-CoP hybrids for dual-signal electrochemical immunosensing of carcinoembryonic antigen based on overall water splitting. Talanta 233:122521. https:\/\/doi.org\/10.1016\/j.talanta.2021.122521","journal-title":"Talanta"},{"issue":"9","key":"5674_CR15","doi-asserted-by":"publisher","first-page":"8945","DOI":"10.1021\/acsami.9b01779","volume":"11","author":"F Li","year":"2019","unstructured":"Li F, Feng J, Gao Z et al (2019) Facile synthesis of Cu2O@TiO2-PtCu nanocomposites as a signal amplification strategy for the insulin detection. ACS Appl Mater Interfaces 11(9):8945\u20138953. https:\/\/doi.org\/10.1021\/acsami.9b01779","journal-title":"ACS Appl Mater Interfaces"},{"key":"5674_CR16","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.bios.2019.01.054","volume":"130","author":"J Li","year":"2019","unstructured":"Li J, He J, Zhang C et al (2019) Dual-type responsive electrochemical biosensor for the detection of \u03b12,6-sialylated glycans based on AuNRs-SA coupled with c-SWCNHs\/S-PtNC nanocomposites signal amplification. Biosens Bioelectron 130:166\u2013173. https:\/\/doi.org\/10.1016\/j.bios.2019.01.054","journal-title":"Biosens Bioelectron"},{"key":"5674_CR17","doi-asserted-by":"publisher","first-page":"113779","DOI":"10.1016\/j.bios.2021.113779","volume":"197","author":"C Tang","year":"2022","unstructured":"Tang C, Wang P, Zhou K et al (2022) Electrochemical immunosensor based on hollow porous Pt skin AgPt alloy\/NGR as a dual signal amplification strategy for sensitive detection of neuron-specific enolase. Biosens Bioelectron 197:113779. https:\/\/doi.org\/10.1016\/j.bios.2021.113779","journal-title":"Biosens Bioelectron"},{"key":"5674_CR18","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.apmt.2017.09.001","volume":"9","author":"MH Naveen","year":"2017","unstructured":"Naveen MH, Gurudatt NG, Shim Y-B (2017) Applications of conducting polymer composites to electrochemical sensors: a review. Appl Mater Today 9:419\u2013433. https:\/\/doi.org\/10.1016\/j.apmt.2017.09.001","journal-title":"Appl Mater Today"},{"issue":"9","key":"5674_CR19","doi-asserted-by":"publisher","first-page":"2868","DOI":"10.1021\/jacs.5b12474","volume":"138","author":"Q Zhou","year":"2016","unstructured":"Zhou Q, Shi G (2016) Conducting polymer-based catalysts. J Am Chem Soc 138(9):2868\u20132876. https:\/\/doi.org\/10.1021\/jacs.5b12474","journal-title":"J Am Chem Soc"},{"issue":"3","key":"5674_CR20","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1080\/15583724.2020.1858871","volume":"61","author":"F Kazemi","year":"2021","unstructured":"Kazemi F, Naghib SM, Zare Y, Rhee KY (2021) Biosensing applications of polyaniline (PANI)-based nanocomposites: a review. Polym Rev 61(3):553\u2013597. https:\/\/doi.org\/10.1080\/15583724.2020.1858871","journal-title":"Polym Rev"},{"key":"5674_CR21","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.apsusc.2019.03.321","volume":"483","author":"W Jin","year":"2019","unstructured":"Jin W, Huang X, Cheng H et al (2019) Polyaniline hollow tubes loading tiny platinum nanoparticles for boosting methanol oxidation. Appl Surf Sci 483:489\u2013495. https:\/\/doi.org\/10.1016\/j.apsusc.2019.03.321","journal-title":"Appl Surf Sci"},{"key":"5674_CR22","doi-asserted-by":"publisher","first-page":"114220","DOI":"10.1016\/j.bios.2022.114220","volume":"208","author":"J Wang","year":"2022","unstructured":"Wang J, Bei J, Guo X et al (2022) Ultrasensitive photoelectrochemical immunosensor for carcinoembryonic antigen detection based on pillar[5]arene-functionalized au nanoparticles and hollow PANI hybrid BiOBr heterojunction. Biosens Bioelectron 208:114220. https:\/\/doi.org\/10.1016\/j.bios.2022.114220","journal-title":"Biosens Bioelectron"},{"key":"5674_CR23","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.bios.2019.02.007","volume":"131","author":"Y Li","year":"2019","unstructured":"Li Y, Wang Y, Zhang N et al (2019) Magnetic electrode-based electrochemical immunosensor using amorphous bimetallic sulfides of CoSnSx as signal amplifier for the NTpro BNP detection. Biosens Bioelectron 131:250\u2013256. https:\/\/doi.org\/10.1016\/j.bios.2019.02.007","journal-title":"Biosens Bioelectron"},{"key":"5674_CR24","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.bios.2017.11.032","volume":"102","author":"Z Gao","year":"2018","unstructured":"Gao Z, Li Y, Zhang X et al (2018) Ultrasensitive electrochemical immunosensor for quantitative detection of HBeAg using Au@Pd\/MoS2@MWCNTs nanocomposite as enzyme-mimetic labels. Biosens Bioelectron 102:189\u2013195. https:\/\/doi.org\/10.1016\/j.bios.2017.11.032","journal-title":"Biosens Bioelectron"},{"key":"5674_CR25","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.jallcom.2018.01.035","volume":"740","author":"TA Safeera","year":"2018","unstructured":"Safeera TA, Khanal R, Medvedeva JE et al (2018) Low temperature synthesis and characterization of zinc gallate quantum dots for optoelectronic applications. J Alloys Compd 740:567\u2013573. https:\/\/doi.org\/10.1016\/j.jallcom.2018.01.035","journal-title":"J Alloys Compd"},{"key":"5674_CR26","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.matchemphys.2016.06.029","volume":"181","author":"TA Safeera","year":"2016","unstructured":"Safeera TA, Johns N, Krishna KM et al (2016) Zinc gallate and its starting materials in solid state reaction route- a comparative study. Mater Chem Phys 181:21\u201325. https:\/\/doi.org\/10.1016\/j.matchemphys.2016.06.029","journal-title":"Mater Chem Phys"},{"issue":"A","key":"5674_CR27","doi-asserted-by":"publisher","first-page":"124069","DOI":"10.1016\/j.jhazmat.2020.124069","volume":"404","author":"EB Kim","year":"2021","unstructured":"Kim EB, Imran M, Akhtar MS, Shin HS, Ameen S (2021) Enticing 3D peony-like ZnGa2O4 microstructures for electrochemical detection of N,N-dimethylmethanamide chemical. J Hazard Mater 404(A):124069. https:\/\/doi.org\/10.1016\/j.jhazmat.2020.124069","journal-title":"J Hazard Mater"},{"issue":"29","key":"5674_CR28","doi-asserted-by":"publisher","first-page":"9438","DOI":"10.1002\/slct.201701343","volume":"2","author":"X Guo","year":"2017","unstructured":"Guo X, Qian C, Yang H, Lin S, Fan T (2017) Silver nanograins with pore-array architecture for the electrochemical detection of hydrogen peroxide. ChemistrySelect 2(29):9438\u20139442. https:\/\/doi.org\/10.1002\/slct.201701343","journal-title":"ChemistrySelect"},{"key":"5674_CR29","doi-asserted-by":"publisher","unstructured":"Kong F, He X, Chen J etal (2019) Hierarchal Ni(HCO3)2 nanosheets anchored on carbon nanofibers as binder-free anodes for lithium-ion batteries. Energy Technol 7(6). https:\/\/doi.org\/10.1002\/ente.201900094","DOI":"10.1002\/ente.201900094"},{"key":"5674_CR30","doi-asserted-by":"publisher","unstructured":"Pu H, Dai H, Zhang T et al (2022) Metal nanoparticles with clean surface: the importance and progress. Curr Opin Electrochem 32. https:\/\/doi.org\/10.1016\/j.coelec.2021.100927","DOI":"10.1016\/j.coelec.2021.100927"},{"issue":"12","key":"5674_CR31","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1007\/s10800-020-01487-0","volume":"50","author":"MR Mahmoudian","year":"2020","unstructured":"Mahmoudian MR, Basirun WJ, Woi PM, Alias Y (2020) Synthesis of polyaniline microtubes\/Pt reduced N-graphene oxide in the presence of L-glutamine for the detection of Hg2+. J Appl Electrochem 50(12):1269\u20131280. https:\/\/doi.org\/10.1007\/s10800-020-01487-0","journal-title":"J Appl Electrochem"},{"key":"5674_CR32","doi-asserted-by":"publisher","unstructured":"Feng Y-G, He J-W, Jiang L-Y et al (2022) Novel sandwich-typed electrochemical immunosensing of C-reactive protein using multiply twinned AuPtRh nanobead chains and nitrogen-rich porous carbon nanospheres decorated with Au nanoparticles. Sens Actuators B 358. https:\/\/doi.org\/10.1016\/j.snb.2022.131518","DOI":"10.1016\/j.snb.2022.131518"},{"key":"5674_CR33","doi-asserted-by":"publisher","first-page":"112713","DOI":"10.1016\/j.bios.2020.112713","volume":"171","author":"J Miao","year":"2021","unstructured":"Miao J, Du K, Li X et al (2021) Ratiometric electrochemical immunosensor for the detection of procalcitonin based on the ratios of SiO2-Fc-COOH-Au and UiO-66-TB complexes. Biosens Bioelectron 171:112713. https:\/\/doi.org\/10.1016\/j.bios.2020.112713","journal-title":"Biosens Bioelectron"},{"issue":"4","key":"5674_CR34","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s00604-021-04763-8","volume":"188","author":"L Jiang","year":"2021","unstructured":"Jiang L, Li Y, Xu Z et al (2021) Simultaneous electrochemical determination of two hepatitis B antigens using graphene-SnO2 hybridized with sea urchin-like bimetallic nanoparticles. Mikrochim Acta 188(4):109. https:\/\/doi.org\/10.1007\/s00604-021-04763-8","journal-title":"Mikrochim Acta"},{"key":"5674_CR35","doi-asserted-by":"publisher","unstructured":"Liu C, Yang W, Min X et al (2021) An enzyme-free electrochemical immunosensor based on quaternary metallic\/nonmetallic PdPtBP alloy mesoporous nanoparticles\/MXene and conductive CuCl2 nanowires for ultrasensitive assay of kidney injury molecule-1 (J). Sens Actuators B 334. https:\/\/doi.org\/10.1016\/j.snb.2021.129585","DOI":"10.1016\/j.snb.2021.129585"},{"key":"5674_CR36","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.snb.2019.04.128","volume":"292","author":"A-J Wang","year":"2019","unstructured":"Wang A-J, Zhu X-Y, Chen Y et al (2019) Ultrasensitive label-free electrochemical immunoassay of carbohydrate antigen 15\u20133 using dendritic Au@Pt nanocrystals\/ferrocene-grafted-chitosan for efficient signal amplification. Sens Actuators B 292:164\u2013177. https:\/\/doi.org\/10.1016\/j.snb.2019.04.128","journal-title":"Sens Actuators B"}],"container-title":["Microchimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00604-023-05674-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00604-023-05674-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00604-023-05674-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T20:30:10Z","timestamp":1679862610000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00604-023-05674-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,15]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["5674"],"URL":"https:\/\/doi.org\/10.1007\/s00604-023-05674-6","relation":{},"ISSN":["0026-3672","1436-5073"],"issn-type":[{"value":"0026-3672","type":"print"},{"value":"1436-5073","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,15]]},"assertion":[{"value":"6 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"92"}}