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Scientific advances in nanomaterials have led to the construction of new generations of enzymatic-free GLU sensors. In this work, an innovative 3D-printed device modified with a water-stable and non-toxic metal\u2013organic framework of iron (Fe(II)-MOF), which serves as a nanozyme, has been developed for the voltammetric determination of GLU in artificial sweat. In contrast to existing MOF-based GLU sensors which exhibit electrocatalytic activity for the oxidation of GLU in alkaline media, the nanozyme Fe(II)-MOF\/3D-printed device can operate in the acidic epidermal sweat environment. The enzymatic-free GLU sensor is composed of a 3-electrode 3D-printed device with the MOF nanozyme immobilized on the surface of the working electrode. GLU sensing is conducted by differential pulse voltammetry without interference from other co-existing metabolites in artificial sweat. The response is based on the oxidation of glucose\u00a0to gluconolactone, induced by the redox activity of the Fe-centers of the MOF. GLU gives rise to an easily detectable and well-defined voltammetric peak at about \u2212 1.2 V and the limit of detection is 17.6 \u03bcmol L<jats:sup>-1<\/jats:sup>. The synergy of a nanozyme with 3D printing technology results in an advanced, sensitive, and low-cost sensor, paving the way for on-skin applications.<\/jats:p>\n                <jats:p><jats:bold>Graphical abstract<\/jats:bold><\/jats:p>","DOI":"10.1007\/s00604-023-05860-6","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T11:39:02Z","timestamp":1687606742000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["3D-printed electrochemical glucose device with integrated Fe(II)-MOF nanozyme"],"prefix":"10.1007","volume":"190","author":[{"given":"Eleni","family":"Koukouviti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexios K.","family":"Plessas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varvara","family":"Pagkali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasios","family":"Economou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giannis S.","family":"Papaefstathiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4696-0245","authenticated-orcid":false,"given":"Christos","family":"Kokkinos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,24]]},"reference":[{"issue":"17","key":"5860_CR1","doi-asserted-by":"publisher","first-page":"4891","DOI":"10.3390\/s20174891","volume":"20","author":"SA Abrori","year":"2020","unstructured":"Abrori SA, Septiani NLW, Nugraha AI, Suyatman SV, Yuliarto B (2020) Metal-organic-framework FeBDC-derived Fe3O4 for non-enzymatic electrochemical detection of glucose. 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