{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T23:18:29Z","timestamp":1768087109395,"version":"3.49.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T00:00:00Z","timestamp":1691107200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T00:00:00Z","timestamp":1691107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21964023"],"award-info":[{"award-number":["21964023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Microchim Acta"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1007\/s00604-023-05917-6","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T12:02:10Z","timestamp":1691150530000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Fluorescent immunochromatographic test strip for therapeutic drug monitoring of methotrexate with high sensitivity and wide dynamic range"],"prefix":"10.1007","volume":"190","author":[{"given":"Zhongjie","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinxia","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhifeng","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1741-5363","authenticated-orcid":false,"given":"Yong","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,8,4]]},"reference":[{"key":"5917_CR1","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1056\/NEJM198311033091805","volume":"309","author":"J Jolivet","year":"1983","unstructured":"Jolivet J, Cowan KH, Curt GA et al (1983) The pharmacology and clinical use of methotrexate. N Engl J Med 309:1094\u20131104","journal-title":"N Engl J Med"},{"key":"5917_CR2","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1016\/S0140-6736(19)33018-1","volume":"395","author":"F Malard","year":"2020","unstructured":"Malard F, Mohty M (2020) Acute lymphoblastic leukaemia. Lancet 395:1146\u20131162","journal-title":"Lancet"},{"key":"5917_CR3","doi-asserted-by":"publisher","first-page":"2380","DOI":"10.1200\/JCO.2015.62.4544","volume":"34","author":"EC Larsen","year":"2016","unstructured":"Larsen EC, Devidas M, Chen S et al (2016) Dexamethasone and high-dose methotrexate improve outcome for children and young adults with high-risk B-acute lymphoblastic leukemia: a report from children\u2019s oncology group study AALL0232. J Clin Oncol 34:2380\u20132388","journal-title":"J Clin Oncol"},{"key":"5917_CR4","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1002\/jcph.1349","volume":"59","author":"KH Hui","year":"2019","unstructured":"Hui KH, Chu HM, Fong PS et al (2019) Population pharmacokinetic study and individual dose adjustments of high-dose methotrexate in Chinese pediatric patients with acute lymphoblastic leukemia or osteosarcoma. J Clin Pharmacol 59:566\u2013577","journal-title":"J Clin Pharmacol"},{"key":"5917_CR5","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1634\/theoncologist.2015-0164","volume":"21","author":"SC Howard","year":"2016","unstructured":"Howard SC, McCormick J, Pui C-H et al (2016) Preventing and managing toxicities of high-dose methotrexate. Oncologist 21:1471\u20131482","journal-title":"Oncologist"},{"key":"5917_CR6","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.1021\/acssensors.1c00749","volume":"6","author":"JQ He","year":"2021","unstructured":"He JQ, Wang JY, Zhang M et al (2021) Selection of a structure-switching aptamer for the specific methotrexate detection. ACS Sens 6:2436\u20132441","journal-title":"ACS Sens"},{"key":"5917_CR7","doi-asserted-by":"publisher","first-page":"e231","DOI":"10.1016\/S1470-2045(16)30035-3","volume":"17","author":"K Schmiegelow","year":"2016","unstructured":"Schmiegelow K, Attarbaschi A, Barzilai S et al (2016) Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus. Lancet Oncol 17:e231\u2013e239","journal-title":"Lancet Oncol"},{"key":"5917_CR8","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1016\/j.ejca.2014.04.014","volume":"50","author":"A Paci","year":"2014","unstructured":"Paci A, Veal G, Bardin C et al (2014) Review of therapeutic drug monitoring of anticancer drugs part 1 \u2013 cytotoxics. Eur J Cancer 50:2010\u20132019","journal-title":"Eur J Cancer"},{"key":"5917_CR9","doi-asserted-by":"publisher","first-page":"2664","DOI":"10.1021\/acssensors.1c00643","volume":"6","author":"Y Goksel","year":"2021","unstructured":"Goksel Y, Zor K, Rind T et al (2021) Quantification of methotrexate in human serum using surface-enhanced raman scattering-toward therapeutic drug monitoring. ACS Sens 6:2664\u20132673","journal-title":"ACS Sens"},{"key":"5917_CR10","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.trac.2015.11.016","volume":"79","author":"K Freudenberger","year":"2016","unstructured":"Freudenberger K, Hilbig U, Gauglitz G (2016) Recent advances in therapeutic drug monitoring of immunosuppressive drugs. TrAC Trends Anal Chem 79:257\u2013268","journal-title":"TrAC Trends Anal Chem"},{"key":"5917_CR11","doi-asserted-by":"publisher","first-page":"475","DOI":"10.5582\/bst.2017.01121","volume":"11","author":"WL Li","year":"2017","unstructured":"Li WL, Li R, Liu HJ et al (2017) A comparison of liquid chromatography-tandem mass spectrometry (LC-MS\/MS) and enzyme-multiplied immunoassay technique (EMIT) for the determination of the cyclosporin A concentration in whole blood from Chinese patients. Biosci Trends 11:475\u2013482","journal-title":"Biosci Trends"},{"key":"5917_CR12","doi-asserted-by":"publisher","first-page":"340240","DOI":"10.1016\/j.aca.2022.340240","volume":"1225","author":"E-D Bojescu","year":"2022","unstructured":"Bojescu E-D, Prim D, Pfeifer ME et al (2022) Fluorescence-polarization immunoassays within glass fiber micro-chambers enable tobramycin quantification in whole blood for therapeutic drug monitoring at the point of care. Anal Chim Acta 1225:340240","journal-title":"Anal Chim Acta"},{"key":"5917_CR13","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jpha.2018.09.002","volume":"9","author":"R Sogawa","year":"2019","unstructured":"Sogawa R, Saita T, Yamamoto Y et al (2019) Development of a competitive enzyme-linked immunosorbent assay for therapeutic drug monitoring of afatinib. J Pharm Anal 9:49\u201354","journal-title":"J Pharm Anal"},{"key":"5917_CR14","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1016\/j.tibtech.2020.03.001","volume":"38","author":"HC Ates","year":"2020","unstructured":"Ates HC, Roberts JA, Lipman J et al (2020) On-site therapeutic drug monitoring. Trends Biotechnol 38:1262\u20131277","journal-title":"Trends Biotechnol"},{"key":"5917_CR15","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S2468-1253(21)00223-5","volume":"7","author":"K Papamichael","year":"2022","unstructured":"Papamichael K, Afif W, Drobne D et al (2022) Therapeutic drug monitoring of biologics in inflammatory bowel disease: unmet needs and future perspectives. Lancet Gastroenterol Hepatol 7:171\u2013185","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"5917_CR16","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s00604-022-05186-9","volume":"189","author":"DC Robert","year":"2022","unstructured":"Robert DC, Nina CD, Evelyn S et al (2022) Electroanalytical point-of-care detection of gold standard and emerging cardiac biomarkers for stratification and monitoring in intensive care medicine- a review. Microchim Acta 189:142","journal-title":"Microchim Acta"},{"key":"5917_CR17","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1042\/EBC20150012","volume":"60","author":"KM Koczula","year":"2016","unstructured":"Koczula KM, Gallotta A (2016) Lateral flow assays. Essays Biochem 60:111\u2013120","journal-title":"Essays Biochem"},{"key":"5917_CR18","doi-asserted-by":"publisher","first-page":"3421","DOI":"10.1016\/j.cclet.2021.05.019","volume":"32","author":"JZ Liu","year":"2021","unstructured":"Liu JZ, Meng HM, Zhang L et al (2021) Dual-readout test strips platform for portable and highly sensitive detection of alkaline phosphatase in human serum samples. Chin Chem Lett 32:3421\u20133425","journal-title":"Chin Chem Lett"},{"key":"5917_CR19","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/j.snb.2018.02.040","volume":"262","author":"JZ Liu","year":"2018","unstructured":"Liu JZ, Ji DY, Meng HM et al (2018) A portable fluorescence biosensor for rapid and sensitive glutathione detection by using quantum dots-based lateral flow test strip. Sens Actuators B 262:486\u2013492","journal-title":"Sens Actuators B"},{"key":"5917_CR20","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1007\/s00216-019-02343-7","volume":"412","author":"J Chen","year":"2020","unstructured":"Chen J, Meng H-M, An Y et al (2020) A fluorescent nanosphere-based immunochromatography test strip for ultrasensitive and point-of-care detection of tetanus antibody in human serum. Anal Bioanal Chem 412:1151\u20131158","journal-title":"Anal Bioanal Chem"},{"key":"5917_CR21","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s00604-022-05167-y","volume":"189","author":"M Fariba","year":"2022","unstructured":"Fariba M, Nader Z-S, Mehrorang G (2022) A review on corona virus disease 2019 (COVID-19): current progress, clinical features and bioanalytical diagnostic methods. Microchim Acta 189:103","journal-title":"Microchim Acta"},{"key":"5917_CR22","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1111\/bcp.15134","volume":"88","author":"ZW Song","year":"2022","unstructured":"Song ZW, Hu Y, Liu S et al (2022) Medication therapy of high-dose methotrexate: an evidence-based practice guideline of the Division of Therapeutic Drug Monitoring, Chinese Pharmacological Society. Br J Clin Pharmacol 88:2456\u20132472","journal-title":"Br J Clin Pharmacol"},{"key":"5917_CR23","unstructured":"(2019) Expert consensus on high-dose methotrexate calcium folinate rescue therapy for malignant tumors. Chin J Clin Oneol 46:761\u2013767"},{"key":"5917_CR24","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1039\/D2AN01658C","volume":"148","author":"JQ He","year":"2023","unstructured":"He JQ, Wang JY, Zhang M et al (2023) Ultrasensitive therapeutic drug monitoring of methotrexate by a structure-switching aptamer with cascade primer exchange reaction. Analyst 148:222\u2013226","journal-title":"Analyst"},{"key":"5917_CR25","doi-asserted-by":"publisher","first-page":"3457","DOI":"10.1021\/acssensors.0c01404","volume":"5","author":"A Inoue","year":"2020","unstructured":"Inoue A, Ohmuro-Matsuyama Y, Kitaguchi T et al (2020) (2020) Creation of a nanobody-based fluorescent immunosensor Mini Q-body for rapid signal-On detection of small hapten methotrexate. ACS Sens 5:3457\u20133464","journal-title":"ACS Sens"},{"key":"5917_CR26","doi-asserted-by":"publisher","first-page":"4742","DOI":"10.1039\/c2an35839e","volume":"137","author":"SS Zhao","year":"2012","unstructured":"Zhao SS, Bichelberger MA, Colin DY et al (2012) Monitoring methotrexate in clinical samples from cancer patients during chemotherapy with a LSPR-based competitive sensor. Analyst 137:4742\u20134750","journal-title":"Analyst"},{"key":"5917_CR27","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1039\/C5AY02270C","volume":"8","author":"ZR Song","year":"2016","unstructured":"Song ZR, Wang YF, Dong YQ et al (2016) A validated chemiluminescence immunoassay for methotrexate (MTX) and its application in a pharmacokinetic study. Anal Methods 8:162\u2013170","journal-title":"Anal Methods"},{"key":"5917_CR28","doi-asserted-by":"publisher","first-page":"42156","DOI":"10.1021\/acsami.7b16618","volume":"9","author":"M Chen","year":"2017","unstructured":"Chen M, Luo W, Zhang ZM et al (2017) Synthesis of multi-Au nanoparticles-embedded mesoporous silica microspheres as self-filtering and reusable substrates for SERS detection. ACS Appl Mater Interfaces 9:42156\u201342166","journal-title":"ACS Appl Mater Interfaces"},{"key":"5917_CR29","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s10544-014-9871-3","volume":"16","author":"J Yang","year":"2014","unstructured":"Yang J, Tan XB, Shih W-C et al (2014) A sandwich substrate for ultrasensitive and label-free SERS spectroscopic detection of folic acid \/ methotrexate. Biomed Microdevices 16:673\u2013679","journal-title":"Biomed Microdevices"},{"key":"5917_CR30","doi-asserted-by":"publisher","first-page":"6702","DOI":"10.1021\/acs.analchem.7b00916","volume":"89","author":"A Subaihi","year":"2017","unstructured":"Subaihi A, Trivedi DK, Hollywood KA et al (2017) Quantitative online liquid chromatography-surface-enhanced Raman scattering (LC-SERS) of methotrexate and its major metabolites. Anal Chem 89:6702\u20136709","journal-title":"Anal Chem"},{"key":"5917_CR31","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s00604-019-4016-2","volume":"187","author":"N Jandagh","year":"2020","unstructured":"Jandagh N, Jahani S, Foroughi MM et al (2020) Cerium-doped flower-shaped ZnO nano-crystallites as a sensing component for simultaneous electrochemical determination of epirubicin and methotrexate. Microchim Acta 187:24","journal-title":"Microchim Acta"},{"key":"5917_CR32","doi-asserted-by":"publisher","first-page":"2358","DOI":"10.1021\/acssensors.2c01022","volume":"7","author":"Y Goksel","year":"2022","unstructured":"Goksel Y, Dumont E, Slipets R et al (2022) Methotrexate detection in serum at clinically relevant levels with electrochemically assisted SERS on a benchtop, custom built Raman spectrometer. ACS Sens 7:2358\u20132369","journal-title":"ACS Sens"}],"container-title":["Microchimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00604-023-05917-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00604-023-05917-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00604-023-05917-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T13:03:42Z","timestamp":1693919022000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00604-023-05917-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,4]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["5917"],"URL":"https:\/\/doi.org\/10.1007\/s00604-023-05917-6","relation":{},"ISSN":["0026-3672","1436-5073"],"issn-type":[{"value":"0026-3672","type":"print"},{"value":"1436-5073","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,4]]},"assertion":[{"value":"26 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"342"}}