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The biosensors based on Arg-selective enzymes are the most promising devices for Arg assay. In this research, three types of amperometric biosensors have been fabricated. They exploit arginine oxidase (ArgO), recombinant arginase I (ARG)\/urease, and arginine deiminase (ADI) coupled with the ammonium-chelating redox-active nanoparticles. Cadmium-copper nanoparticles (nCdCu) as the most effective nanochelators were used for the development of ammonium chemosensors and enzyme-coupled Arg biosensors. The fabricated enzyme\/nCdCu-containing bioelectrodes show wide linear ranges (up to 200\u00a0\u00b5M), satisfactory storage stabilities (14\u00a0days), and high sensitivities (A\u22c5M<jats:sup>\u22121<\/jats:sup>\u22c5m<jats:sup>\u22122<\/jats:sup>) to Arg: 1650, 1700, and 4500 for ADI-, ArgO- and ARG\/urease-based sensors, respectively. All biosensors have been exploited to estimate Arg content in commercial juices. The obtained data correlate well with the values obtained by the reference method. A hypothetic scheme for mechanism of action of ammonium nanochelators in electron transfer reaction on the arginine-sensing electrodes has been proposed.<\/jats:p>\n                <jats:p><jats:bold>Graphical abstract<\/jats:bold><\/jats:p>","DOI":"10.1007\/s00604-023-06114-1","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T10:02:04Z","timestamp":1703239324000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ammonium nanochelators in conjunction with arginine-specific enzymes in amperometric biosensors for arginine assay"],"prefix":"10.1007","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6550-8145","authenticated-orcid":false,"given":"Nataliya","family":"Stasyuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina","family":"Gayda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Nogala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Holdynski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olha","family":"Demkiv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyubov","family":"Fayura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andriy","family":"Sibirny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mykhailo","family":"Gonchar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,22]]},"reference":[{"key":"6114_CR1","doi-asserted-by":"publisher","first-page":"961","DOI":"10.3390\/nu14050961","volume":"24","author":"A Szlas","year":"2022","unstructured":"Szlas A, Kurek JM, Krejpcio Z (2022) The potential of L-arginine in prevention and treatment of disturbed carbohydrate and lipid metabolism A review. 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