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Excellent discrimination is obtained by principal component analysis (PCA) for seven derivatives: A\u03b2<jats:sub>1-16<\/jats:sub>, A\u03b2<jats:sub>4-16<\/jats:sub>, A\u03b2<jats:sub>4-9<\/jats:sub>, A\u03b2<jats:sub>5-16<\/jats:sub>, A\u03b2<jats:sub>5-12<\/jats:sub>, A\u03b2<jats:sub>5-9<\/jats:sub>, A\u03b2<jats:sub>12-16<\/jats:sub>. Detection of A\u03b2<jats:sub>4-16<\/jats:sub>, A\u03b2<jats:sub>4-16<\/jats:sub>, and A\u03b2<jats:sub>5-9<\/jats:sub> in binary and ternary mixtures performed by QDs-based chemical tongue using partial least squares-discriminant analysis (PLS-DA) provided perfect 100% accuracy for the two studied peptides (A\u03b2<jats:sub>4-16<\/jats:sub> and A\u03b2<jats:sub>4-16<\/jats:sub>), while for the third one (A\u03b2<jats:sub>5-9<\/jats:sub>) it was slightly lower (97.9%). Successful detection of A\u03b2<jats:sub>4-16<\/jats:sub> at 1\u00a0pmol\/mL (1.6\u00a0ng\/mL) suggests that the detection limit of the proposed method for short-length A\u03b2 peptides can span nanomolar concentrations. This result is highly promising for the development of simple and efficient methods for sequence recognition in short-length peptides and better understanding of mechanisms at the QD-analyte interface.<\/jats:p>\n                <jats:p><jats:bold>Graphical Abstract<\/jats:bold><\/jats:p>","DOI":"10.1007\/s00604-023-06115-0","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T09:02:53Z","timestamp":1705309373000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Quantum dots-based \u201cchemical tongue\u201d for the discrimination of short-length A\u03b2 peptides"],"prefix":"10.1007","volume":"191","author":[{"given":"Klaudia","family":"G\u0142owacz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Drozd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weronika","family":"Tokarska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina E.","family":"Wezynfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8265-1039","authenticated-orcid":false,"given":"Patrycja","family":"Ciosek-Skibi\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,15]]},"reference":[{"issue":"15","key":"6115_CR1","doi-asserted-by":"publisher","first-page":"7840","DOI":"10.1021\/cr5005524","volume":"115","author":"L You","year":"2015","unstructured":"You L, Zha D, Anslyn EV (2015) Recent advances in supramolecular analytical chemistry using optical sensing. 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