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Identifying as many FCCs as possible is imperative for evaluating their impact on human health. Supramolecular solvent (SUPRAS)-based all-in-one extractions are proposed for the first time for sample treatment of FCMs and combined with liquid chromatography high-resolution mass spectrometry for developing comprehensive suspect screening  of FCCs. SUPRASs featuring inverted hexagonal and sponge-like nanostructures were investigated for this purpose. Those produced from 1-decanol in ethanol\u2013water media, behaving as restricted access materials for macromolecules, showed excellent performance in terms of interference removal, reproducibility and number of features detected. Sample treatment was simple (only  vortex-shaking and centrifugation\u00a0is required), fast (FCC extraction and FCM cleanup were integrated in a single step) and sustainable (only  100 \u00b5L of SUPRAS per sample\u00a0is required). An in-house suspect list containing 1389 chemicals was developed for FCCs identification. The approach developed was applied to determine\u00a0 18 plastic- and Tetra-Brik-based FCMs. Twenty-nine FCCs (9 intentionally and 20 non-intentionally added substances; IAS\/NIAS) belonging to eight chemical classes were identified. These FCCs featured a wide polarity range (log P\u2009\u2212\u20095.2 to 9.8), thus proving the ability of SUPRASs to develop comprehensive extraction of FCCs and increase the chance of raising the number of FCCs identified (e.g., 18 out of the 29 FCCs found in this study have not been previously reported in FCMs).<\/jats:p>","DOI":"10.1007\/s00604-025-07216-8","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T13:51:20Z","timestamp":1748958680000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Supramolecular solvent-based all-in-one extractions for comprehensive suspect screening of chemicals in food contact materials"],"prefix":"10.1007","volume":"192","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2531-1967","authenticated-orcid":false,"given":"Laura","family":"Garc\u00eda-Cansino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0662-1815","authenticated-orcid":false,"given":"Noelia","family":"Caballero-Casero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6292-8232","authenticated-orcid":false,"given":"Mar\u00eda \u00c1ngeles","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5583-1624","authenticated-orcid":false,"given":"Mar\u00eda Luisa","family":"Marina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9128-4787","authenticated-orcid":false,"given":"Soledad","family":"Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"7216_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/s41370-024-00718-2","author":"B Geueke","year":"2024","unstructured":"Geueke B, Parkinson LV, Groh KJ, Kassotis CD, Maffin MV, Martin OV, Zimmermann L, Scheringer M, Muncke J (2024) Evidence for widespread human exposure to food contact chemicals. 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