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Periodic massive proliferations of the ovatoxin-producing organism (<jats:italic>Ostreopsis<\/jats:italic> cf. <jats:italic>ovata<\/jats:italic>) worldwide, particularly in the Mediterranean, have caused severe toxic outbreaks, drawing the attention of health authorities. At present, an efficient and sustainable sampling system for monitoring ovatoxins in seawater remains unavailable. Herein, different cyclodextrin (CD) polymers were investigated as a green and effective alternative to conventional and low-performing resins to detect ovatoxins in seawater. Spiking experiments using different concentrations of palytoxin or ovatoxins (namely 200 and 3.3\u00a0ng PLTX\/mL or 200\u00a0ng OVTX-a\/mL) were conducted and LC-HRMS was used to evaluate the suitability of CD polymers in capturing palytoxin-like compounds. Several conditions were tested for extracting polymer materials, including different extraction times (1.5 to 4\u00a0h), various solvent mixtures (acidic or alkaline), and organic modifiers (methanol or acetonitrile) at different ratios. Among the tested polymers, \u03b3-CD-hexamethylene diisocyanate (HDI) resulted to be the most promising one, providing ovatoxin recoveries in the range 82\u2013108% at a\u00a0spiking level of\u00a0200\u00a0ng OVTX-a per mL. The best extracting condition was alkaline pH methanol:water 8:2 mixture, which showed the best palytoxin recovery  in both high and low concentration spiking experiments. Finally, a time-dependent increase in the amount of ovatoxins captured by \u03b3-CD-HDI disks deployed in <jats:italic>O<\/jats:italic>. cf. <jats:italic>ovata<\/jats:italic> cultures was observed. These findings provide valuable insights on the efficiency of passive sampling using CD polymers for capturing ovatoxins during <jats:italic>O<\/jats:italic>. cf. <jats:italic>ovata<\/jats:italic> bloom events.<\/jats:p>\n          <jats:p>\n            <jats:bold>Graphical Abstract<\/jats:bold>\n          <\/jats:p>","DOI":"10.1007\/s00604-025-07507-0","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T19:17:27Z","timestamp":1757531847000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the efficiency of cyclodextrin polymers as sustainable sampling material for catching palytoxin-like compounds in seawater"],"prefix":"10.1007","volume":"192","author":[{"given":"Antonella","family":"Miglione","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Melchiorre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuela","family":"Capellacci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana","family":"Tartaglione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Varra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Fragoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Casabianca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mabel","family":"Torr\u00e9ns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Diog\u00e8ne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Penna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmela","family":"Dell\u2019Aversano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f2nica","family":"Camp\u00e0s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"key":"7507_CR1","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1126\/science.172.3982.495","volume":"172","author":"RE Moore","year":"1971","unstructured":"Moore RE, Scheuer PJ (1971) Palytoxin: a new marine toxin from a coelenterate. 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