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The portable two-electrode cell comprises carbon black (CB)-filled polylactic acid (PLA) electrodes sealed within insulating poly(lactic acid) walls, constituting an integrated multi-material system. Joint tensile and electrical tests, as well as tomography analyses, enabled the optimisation of 3DPEC dimensions and printing parameters. A practical and straightforward route for 3DPEC post-processing activation was proposed to enhance the electrochemically active surface area (ESA). Finally, we present the\u00a0(sensitive determination of nimesulide, an anti-inflammatory drug, in industrial sewage after a 1:10 (v\/v) dilution in phosphate buffer solution (PBS). The detection platform demonstrated high competitive performance in electroanalysis, with excellent reproducibility (RSD\u2009=\u20096.8% by CV, 3.4% by DPV), a recovery of 90\u2009\u00b1\u20095%, a detection limit of 0.19\u00a0\u03bcM, and selectivity against most studied interferents. The presented approach serves as a proof-of-concept for a customisable, multi-material integrated 3D-printed electrochemical detection platform that prioritises reproducibility, low cost, and applicability in complex environmental matrices, highlighting its practical potential for sustainable wastewater monitoring.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s00604-025-07634-8","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:22:19Z","timestamp":1761596539000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Multi-material integrated 3D-printed electrochemical detection platform for rapid on-site screening of nimesulide in industrial sewage"],"prefix":"10.1007","volume":"192","author":[{"given":"Mateusz","family":"Cie\u015blik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Rucka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilvana P.","family":"Siqueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Koterwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Rycewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo A. 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