{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T01:26:39Z","timestamp":1787966799118,"version":"build-2784847793"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Microchim Acta"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00604-025-07642-8","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T18:59:17Z","timestamp":1763146757000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["CRISPR\/Cas12a-SERS biosensor based on sea urchin-like AuNPs for the detection of \u03b2-thalassemia mutant gene CD31"],"prefix":"10.1007","volume":"192","author":[{"given":"Huaqiu","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huagan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingsha","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delan","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"7642_CR1","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3390\/thalassrep14040010","volume":"14","author":"IZ Sadiq","year":"2024","unstructured":"Sadiq IZ, Abubakar FS, Usman HS, Abdullahi AD, Ibrahim B, Kastayal BS, Ibrahim M, Hassan HA (2024) Thalassemia: pathophysiology, diagnosis, and advances in treatment. Thalassemia Rep 14:81\u2013102. https:\/\/doi.org\/10.3390\/thalassrep14040010","journal-title":"Thalassemia Rep"},{"key":"7642_CR2","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.1016\/s0140-6736(22)00536-0","volume":"399","author":"A Kattamis","year":"2022","unstructured":"Kattamis A, Kwiatkowski JL, Aydinok Y (2022) Thalassaemia. Lancet 399:2310\u20132324. https:\/\/doi.org\/10.1016\/s0140-6736(22)00536-0","journal-title":"Lancet"},{"key":"7642_CR3","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1111\/ejh.13512","volume":"105","author":"A Kattamis","year":"2020","unstructured":"Kattamis A, Forni GL, Aydinok Y, Viprakasit V (2020) Changing patterns in the epidemiology of \u03b2-thalassemia. Eur J Haematol 105:692\u2013703. https:\/\/doi.org\/10.1111\/ejh.13512","journal-title":"Eur J Haematol"},{"key":"7642_CR4","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1007\/s00256-021-03732-9","volume":"50","author":"M Hajimoradi","year":"2021","unstructured":"Hajimoradi M, Haseli S, Abadi A, Chalian M (2021) Musculoskeletal imaging manifestations of beta-thalassemia. Skeletal Radiol 50:1749\u20131762. https:\/\/doi.org\/10.1007\/s00256-021-03732-9","journal-title":"Skeletal Radiol"},{"issue":"10","key":"7642_CR5","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.3390\/medicina60101571","volume":"60","author":"C Savvidis","year":"2024","unstructured":"Savvidis C, Ragia D, Delicou S, Xydaki A, Rizzo A, Ilias I (2024) Adrenal insufficiency in patients with beta thalassemia: a meta-analysis. Medicina (Kaunas) 60(10):1571. https:\/\/doi.org\/10.3390\/medicina60101571","journal-title":"Medicina (Kaunas)"},{"key":"7642_CR6","doi-asserted-by":"publisher","unstructured":"Fabella TDF, Silao CLT, Naranjo MLT, Padilla CD, Yuson EDJ (2020) High Performance Liquid Chromatography (HPLC) screening among Filipinos with suspected Thalassemia. Acta Med Phil 54(4). https:\/\/doi.org\/10.47895\/amp.v54i4.1900","DOI":"10.47895\/amp.v54i4.1900"},{"key":"7642_CR7","doi-asserted-by":"publisher","first-page":"3277","DOI":"10.1039\/d0ay00384k","volume":"12","author":"C Guo","year":"2020","unstructured":"Guo C, Zhang Q, Bao L, Li H, Zheng Q, Guo Z, Chen Y (2020) A stable version of capillary electrophoresis for determining human hemoglobin chains aiming at the screening and diagnosis of thalassemia. Anal Methods 12:3277\u20133284. https:\/\/doi.org\/10.1039\/d0ay00384k","journal-title":"Anal Methods"},{"key":"7642_CR8","doi-asserted-by":"publisher","first-page":"19999","DOI":"10.1038\/s41598-022-22011-8","volume":"12","author":"F Rustam","year":"2022","unstructured":"Rustam F, Ashraf I, Jabbr S, Tutusaus K, Mazas C, Pascual Barrera AE, de la Torre I, Diez I (2022) Prediction of \\beta -Thalassemia carriers using complete blood count features. Sci Rep 12:19999. https:\/\/doi.org\/10.1038\/s41598-022-22011-8","journal-title":"Sci Rep"},{"key":"7642_CR9","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1093\/clinchem\/hvac200","volume":"69","author":"Q Liang","year":"2023","unstructured":"Liang Q, He J, Li Q, Zhou Y, Liu Y, Li Y, Tang L, Huang S, Li R, Zeng F, Mao A, Liu Y, Liang D, Wu L (2023) Evaluating the clinical utility of a long-read sequencing-based approach in prenatal diagnosis of thalassemia. Clin Chem 69:239\u2013250. https:\/\/doi.org\/10.1093\/clinchem\/hvac200","journal-title":"Clin Chem"},{"key":"7642_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2020.00074","volume":"7","author":"T Munkongdee","year":"2020","unstructured":"Munkongdee T, Chen P, Winichagoon P, Fucharoen S, Paiboonsukwong K (2020) Update in laboratory diagnosis of thalassemia. Front Mol Biosci 7:74. https:\/\/doi.org\/10.3389\/fmolb.2020.00074","journal-title":"Front Mol Biosci"},{"key":"7642_CR11","doi-asserted-by":"publisher","first-page":"e636","DOI":"10.1002\/agt2.636","volume":"5","author":"Y Yang","year":"2024","unstructured":"Yang Y, Lu H, Fang D, Zhang Y, Tang Y, Zhao S, Yan J, Qin X, Shen J, Yang F (2024) DNA-encoded plasmonic bubbles aggregating dual-microRNA SERS signals for cancer diagnosis. Aggregate 5:e636. https:\/\/doi.org\/10.1002\/agt2.636","journal-title":"Aggregate"},{"key":"7642_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2025.117583","volume":"285","author":"B Ji","year":"2025","unstructured":"Ji B, Liu Z, Lv Z, Yang Q, Sun J, Su G, Xia Y, Yan X, Hu J, Hu P, Yi W, Jia C, Wu J, Zhan P, Tan P, Wu W, Liu F (2025) Targeted molecular rapid SERS diagnosis in clinical human serum through aptamer origami-collapsed nanofingers chip. Biosens Bioelectron 285:117583. https:\/\/doi.org\/10.1016\/j.bios.2025.117583","journal-title":"Biosens Bioelectron"},{"key":"7642_CR13","doi-asserted-by":"publisher","first-page":"11966","DOI":"10.1021\/acsanm.3c01793","volume":"6","author":"KM Arun Kumar","year":"2023","unstructured":"Arun Kumar KM, Ashok Kumar E, Wang TJ, Kokulnathan T, Chang YH (2023) SERS-active silver nanoprisms deposited on cuprous oxide microspheres for detection of nitrofurazone. ACS Appl Nano Mater 6:11966\u201311975. https:\/\/doi.org\/10.1021\/acsanm.3c01793","journal-title":"ACS Appl Nano Mater"},{"key":"7642_CR14","doi-asserted-by":"publisher","first-page":"19813","DOI":"10.1039\/d1ra03223b","volume":"11","author":"Y Qin","year":"2021","unstructured":"Qin Y, Wu Y, Wang B, Wang J, Zong X, Yao W (2021) Controllable preparation of sea urchin-like Au NPs as a SERS substrate for highly sensitive detection of the toxic atropine. RSC Adv 11:19813\u201319818. https:\/\/doi.org\/10.1039\/d1ra03223b","journal-title":"RSC Adv"},{"key":"7642_CR15","doi-asserted-by":"publisher","first-page":"10558","DOI":"10.1021\/acsnano.5c01675","volume":"19","author":"Y Zhang","year":"2025","unstructured":"Zhang Y, Niu D, Zhang L, Zhang E, Shen J (2025) Modulating the structural complexity of AuNCs aggregates for generation of bright luminescence. ACS Nano 19:10558\u201310567. https:\/\/doi.org\/10.1021\/acsnano.5c01675","journal-title":"ACS Nano"},{"key":"7642_CR16","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1039\/d3an01678a","volume":"149","author":"Y Zhou","year":"2023","unstructured":"Zhou Y, Yu Z, Zhou Q, Chen J, Cai M, Wang Y, Zhang L (2023) Design and performance of pH-responsive cyano-Raman label SERS probes based on single urchin Au nanoparticles. Analyst 149:76\u201381. https:\/\/doi.org\/10.1039\/d3an01678a","journal-title":"Analyst"},{"issue":"18","key":"7642_CR17","doi-asserted-by":"publisher","first-page":"18332","DOI":"10.1021\/acsnano.3c05633","volume":"17","author":"MG Kim","year":"2023","unstructured":"Kim MG, Jue M, Lee KH, Lee EY, Roh Y, Lee M, Lee HJ, Lee S, Liu H, Koo B, Jang YO, Kim EY, Zhen Q, Kim SH, Kim JK, Shin Y (2023) Deep learning assisted surface-enhanced Raman spectroscopy (SERS) for rapid and direct nucleic acid amplification and detection: toward enhanced molecular diagnostics. ACS Nano 17(18):18332\u201318345. https:\/\/doi.org\/10.1021\/acsnano.3c05633","journal-title":"ACS Nano"},{"key":"7642_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2022.340221","volume":"1224","author":"W Luo","year":"2022","unstructured":"Luo W, Hu Y, Zhang H, Yuan R, Yang X (2022) Oriented interfacial self-assembled SERS platform with dual nucleic acid amplification for detection of MiRNA 21. Anal Chim Acta 1224:340221. https:\/\/doi.org\/10.1016\/j.aca.2022.340221","journal-title":"Anal Chim Acta"},{"key":"7642_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2025.128289","volume":"294","author":"Q Wang","year":"2025","unstructured":"Wang Q, Wu Y, Wang Y, Mei R, Zhao R, Wang X, Chen L (2025) Surface enhanced Raman scattering tag enabled ultrasensitive molecular identification of Hippocampus trimaculatus based on DNA barcoding. Talanta 294:128289. https:\/\/doi.org\/10.1016\/j.talanta.2025.128289","journal-title":"Talanta"},{"key":"7642_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2021.116401","volume":"143","author":"C Yuan","year":"2021","unstructured":"Yuan C, Fang J, Chapelle MLDL, Zhang Y, Zeng X, Huang G, Yang X, Fu W (2021) Surface-enhanced Raman scattering inspired by programmable nucleic acid isothermal amplification technology. Trac-Trend Anal Chem 143:116401. https:\/\/doi.org\/10.1016\/j.trac.2021.116401","journal-title":"Trac-Trend Anal Chem"},{"issue":"31","key":"7642_CR21","doi-asserted-by":"publisher","first-page":"12684","DOI":"10.1021\/acs.analchem.4c01474","volume":"96","author":"H Jiang","year":"2024","unstructured":"Jiang H, Chang W, Zhu X, Liu G, Liu K, Chen W, Wang H, Qin P (2024) Development of a colorimetric and SERS dual-signal platform via dCas9-mediated chain assembly of bifunctional Au@Pt nanozymes for ultrasensitive and robust Salmonella assay. Anal Chem 96(31):12684\u201312691. https:\/\/doi.org\/10.1021\/acs.analchem.4c01474","journal-title":"Anal Chem"},{"key":"7642_CR22","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s00604-024-06899-9","volume":"192","author":"Z Chen","year":"2025","unstructured":"Chen Z, Mao K, Chen Z, Feng R, Du W, Zhang H, Tu C (2025) Isothermal nucleic acid amplification for monitoring hand-foot-and-mouth disease: current status and future implications. Microchim Acta 192:31. https:\/\/doi.org\/10.1007\/s00604-024-06899-9","journal-title":"Microchim Acta"},{"key":"7642_CR23","doi-asserted-by":"publisher","first-page":"2303398","DOI":"10.1002\/smll.202303398","volume":"19","author":"W Yin","year":"2023","unstructured":"Yin W, Zhuang J, Li J, Xia L, Hu K, Yin J, Mu Y (2023) Digital recombinase polymerase amplification, digital loop-mediated isothermal amplification, and digital CRISPR-Cas assisted assay: current status, challenges, and perspectives. Small 19:2303398. https:\/\/doi.org\/10.1002\/smll.202303398","journal-title":"Small"},{"issue":"44","key":"7642_CR24","doi-asserted-by":"publisher","first-page":"16305","DOI":"10.1021\/acs.analchem.3c03481","volume":"95","author":"T Liang","year":"2023","unstructured":"Liang T, Qin X, Zhang Y, Yang Y, Chen Y, Yuan L, Liu F, Chen Z, Li X, Yang F (2023) CRISPR\/dCas9-mediated specific molecular assembly facilitates genotyping of mutant circulating tumor DNA. Anal Chem 95(44):16305\u201316314. https:\/\/doi.org\/10.1021\/acs.analchem.3c03481","journal-title":"Anal Chem"},{"key":"7642_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2022.114836","volume":"219","author":"JJ Zhang","year":"2023","unstructured":"Zhang JJ, Song C, Zhu Y, Gan H, Fang X, Peng Q, Xiong J, Dong C, Han C, Wang L (2023) A novel cascade signal amplification strategy integrating CRISPR\/Cas13a and branched hybridization chain reaction for ultra-sensitive and specific SERS detection of disease-related nucleic acids. Biosens Bioelectron 219:114836. https:\/\/doi.org\/10.1016\/j.bios.2022.114836","journal-title":"Biosens Bioelectron"},{"key":"7642_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2024.116046","volume":"249","author":"J Wang","year":"2024","unstructured":"Wang J, Jiang H, Chen Y, Zhu X, Wu Q, Chen W, Zhao Q, Wang J, Qin P (2024) CRISPR\/ Cas9-mediated SERS\/colorimetric dual-mode lateral flow platform combined with smartphone for rapid and sensitive detection of Staphylococcus aureus. Biosens Bioelectron 249:116046. https:\/\/doi.org\/10.1016\/j.bios.2024.116046","journal-title":"Biosens Bioelectron"},{"key":"7642_CR27","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1021\/acssensors.0c02365","volume":"6","author":"Y Jiang","year":"2021","unstructured":"Jiang Y, Hu M, Liu A, Lin Y, Liu L, Yu B, Zhou X, Pang DW (2021) Detection of SARS-CoV-2 by CRISPR\/Cas12a-enhanced colorimetry. ACS Sens 6:1086\u20131093. https:\/\/doi.org\/10.1021\/acssensors.0c02365","journal-title":"ACS Sens"},{"key":"7642_CR28","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.omtn.2021.02.012","volume":"24","author":"MH Tran","year":"2021","unstructured":"Tran MH, Park H, Nobles CL, Karunadharma P, Pan L, Zhong G, Wang H, He W, Ou T, Crynen G, Sheptack K, Stiskin I, Mou H, Farzan M (2021) A more efficient CRISPR-Cas12a variant derived from Lachnospiraceae bacterium MA2020. Mol Ther Nucleic Acids 24:40\u201353. https:\/\/doi.org\/10.1016\/j.omtn.2021.02.012","journal-title":"Mol Ther Nucleic Acids"},{"key":"7642_CR29","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41538-025-00401-2","volume":"9","author":"L Zhang","year":"2025","unstructured":"Zhang L, Zhang M, Liu X, Wei J, Yin C, Wang N, Fan B, Fu Y, Liu Y, Bu L, Su Z, Pang B, Li J, Song X (2025) Portable DNA extraction integrated with LAMP-CRISPR\/Cas12a technology for on-site detection of Salmonella Typhimurium. NPJ Sci Food 9:39. https:\/\/doi.org\/10.1038\/s41538-025-00401-2","journal-title":"NPJ Sci Food"},{"key":"7642_CR30","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s11658-024-00548-y","volume":"29","author":"Y Liu","year":"2024","unstructured":"Liu Y, Chao Z, Ding W, Fang T, Gu X, Xue M, Wang W, Han R, Sun W (2024) A multiplex RPA-CRISPR\/Cas12a-based POCT technique and its application in human papillomavirus (HPV) typing assay. Cell Mol Biol Lett 29:34. https:\/\/doi.org\/10.1186\/s11658-024-00548-y","journal-title":"Cell Mol Biol Lett"},{"key":"7642_CR31","doi-asserted-by":"publisher","first-page":"137293","DOI":"10.1016\/j.snb.2025.137293","volume":"429","author":"A Su","year":"2025","unstructured":"Su A, Chen Z, Xu W, Liang C, Liu X, Xu S (2025) CRISPR\/dCas9-assisted SERS sensing for transgenic crops based on two-factor verification of 35S promoter and Nos terminator. Sensor Actuat B-Chem 429:137293. https:\/\/doi.org\/10.1016\/j.snb.2025.137293","journal-title":"Sensor Actuat B-Chem"},{"key":"7642_CR32","doi-asserted-by":"publisher","first-page":"137120","DOI":"10.1016\/j.snb.2024.137120","volume":"427","author":"H Wu","year":"2025","unstructured":"Wu H, Zhang R, Lai H, Lai L, Liu Y, Fan Y, Zhang Y, Shi J, Yang M (2025) A MXene-Au nanosheets-based fluorescent-SERS dual-mode biosensor integrated with CRISPR\/Cas12a system for endotoxin detection. Sens Actuat B-Chem 427:137120. https:\/\/doi.org\/10.1016\/j.snb.2024.137120","journal-title":"Sens Actuat B-Chem"},{"key":"7642_CR33","doi-asserted-by":"publisher","first-page":"4286","DOI":"10.1021\/acssensors.5c00547","volume":"10","author":"J Ye","year":"2025","unstructured":"Ye J, Shen Y, Lin Z, Xu L, Wang L, Lin X, Huang B, Ma Z, Yu Z, Lin D, Chen W, Feng S (2025) A crispr\/Cas12a-assisted SERS nanosensor for highly sensitive detection of HPV DNA. ACS Sens 10:4286\u20134296. https:\/\/doi.org\/10.1021\/acssensors.5c00547","journal-title":"ACS Sens"},{"key":"7642_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2023.123464","volume":"305","author":"X Lin","year":"2024","unstructured":"Lin X, Li LJ, Guo HYX, Li R, Feng J (2024) Preparation of 3D nano silver trees\/sea urchin-like gold and SERS detection of uric acid. Spectrochim Acta A Mol Biomol Spectrosc 305:123464. https:\/\/doi.org\/10.1016\/j.saa.2023.123464","journal-title":"Spectrochim Acta A Mol Biomol Spectrosc"},{"key":"7642_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2022.132295","volume":"369","author":"A Su","year":"2022","unstructured":"Su A, Liu Y, Cao X, Xu W, Liang C, Xu S (2022) A universal CRISPR\/Cas12a-mediated AuNPs aggregation-based surface-enhanced raman scattering (CRISPR\/Cas-SERS) platform for virus gene detection. Sensor Actuat B-Chem 369:132295. https:\/\/doi.org\/10.1016\/j.snb.2022.132295","journal-title":"Sensor Actuat B-Chem"}],"container-title":["Microchimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00604-025-07642-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00604-025-07642-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00604-025-07642-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T18:11:29Z","timestamp":1765822289000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00604-025-07642-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,14]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["7642"],"URL":"https:\/\/doi.org\/10.1007\/s00604-025-07642-8","relation":{},"ISSN":["0026-3672","1436-5073"],"issn-type":[{"value":"0026-3672","type":"print"},{"value":"1436-5073","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,14]]},"assertion":[{"value":"7 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}],"article-number":"810"}}