{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T02:46:27Z","timestamp":1784429187158,"version":"3.55.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"MCIN\/AEI","award":["PID2021-124554NB-I00"],"award-info":[{"award-number":["PID2021-124554NB-I00"]}]},{"name":"EU \u201cERDF \u2013 A way of making Europe\u201d","award":["PID2021-124554NB-I00"],"award-info":[{"award-number":["PID2021-124554NB-I00"]}]},{"name":"Conselleria de Educaci\u00f3n, Universidades y Empleo \u2013 Generalitat Valenciana","award":["CIPROM\/2023\/46"],"award-info":[{"award-number":["CIPROM\/2023\/46"]}]},{"name":"EU FEDER \u2013 Generalitat Valenciana","award":["ID-FEDER\/2018\/049"],"award-info":[{"award-number":["ID-FEDER\/2018\/049"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Microchim Acta"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s00604-025-07774-x","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T03:45:17Z","timestamp":1767757517000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Confined plasmonic device for green and sustainable determination of endogenous H2S emitted by living cells: application to cardiomyocytes"],"prefix":"10.1007","volume":"193","author":[{"given":"Lusine","family":"Hakobyan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Carrero-Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Ballester-Caudet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"G\u00f3mez-Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imelda","family":"Ontoria-Oviedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akaitz","family":"Dorronsoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Tejedor-Gasc\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Sep\u00falveda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Molins-Legua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Camp\u00edns-Falc\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"7774_CR1","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1089\/ars.2009.2919","volume":"12","author":"H Kimura","year":"2010","unstructured":"Kimura H (2010) Hidrogen sulfide: from brain to gut. Antioxid Redox Signal 12:1111\u20131123. https:\/\/doi.org\/10.1089\/ars.2009.2919","journal-title":"Antioxid Redox Signal"},{"key":"7774_CR2","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1038\/ki.2009.221","volume":"76","author":"R Wang","year":"2009","unstructured":"Wang R (2009) Hydrogen sulphide: a new EDRF. Kidney Int 76:700\u2013704. https:\/\/doi.org\/10.1038\/ki.2009.221","journal-title":"Kidney Int"},{"key":"7774_CR3","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1089\/ars.2009.2900","volume":"12","author":"JL Walles","year":"2010","unstructured":"Walles JL (2010) Physiological and pathophysiological roles of hydrogen sulphide in the Gastrointestinal tract. Antiox Redox Signal 12:1125\u20131133. https:\/\/doi.org\/10.1089\/ars.2009.2900","journal-title":"Antiox Redox Signal"},{"issue":"1","key":"7774_CR4","doi-asserted-by":"publisher","first-page":"6","DOI":"10.4103\/2045-9912.324590","volume":"12","author":"W Peng","year":"2022","unstructured":"Peng W, Meng-Ling Z, Zhang J, Chen G (2022) Potential role of hydrogen sulfide in central nervous system tumors: A narrative review. Med Gas Res 12(1):6\u20139. https:\/\/doi.org\/10.4103\/2045-9912.324590","journal-title":"Med Gas Res"},{"key":"7774_CR5","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3390\/biom14091145","volume":"17","author":"A Martelli","year":"2012","unstructured":"MartelliA, Testai L, Marino A, Breschi C, Da Settimo M, Calderone F (2012) Hydrogen sulphide: biopharmacological roles in the hydrogen sufide: an endogenous mediator of resolution of inflammation and injury. Antiox Redox Signal 17:58\u201367 https:\/\/doi.org\/10.3390\/biom14091145","journal-title":"Antiox Redox Signal"},{"key":"7774_CR6","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1126\/science.1162667","volume":"322","author":"GD Yang","year":"2008","unstructured":"YangGD, Wu LY, Jiang W, Yang B, Qi W, Cao JS, Meng K, Mustafa QH, Mu AK, Zhang WT, Snyder SM, Wang SH (2008) H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma- lyase. Science 322:587\u2013590 https:\/\/doi.org\/10.1126\/science.1162667","journal-title":"Science"},{"key":"7774_CR7","doi-asserted-by":"publisher","first-page":"2943","DOI":"10.1073\/pnas.1115634109","volume":"109","author":"M Fu","year":"2012","unstructured":"Fu M, Zhang WH, Wu LY, Yang GD, Li HZ, Wang R (2012) Hydrogen sulfide H2S metabolism in mitochondria and its regulatory role in energy production. Proc Natl Acad Sci U S A 109:2943\u20132948. https:\/\/doi.org\/10.1073\/pnas.1115634109","journal-title":"Proc Natl Acad Sci U S A"},{"key":"7774_CR8","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1021\/tx300066z","volume":"25","author":"M Hoffman","year":"2012","unstructured":"Hoffman M, Rajapakse A, Shen X, Gates KS (2012) Generation of DNA-damaging reactive oxygen species via the autoxidation of hydrogen sulfide under physiologically relevant conditions: chemistry relevant to both the genotoxic and cell signaling properties of H2S. Chem Res Toxicol 25:1609\u20131615. https:\/\/doi.org\/10.1021\/tx300066z","journal-title":"Chem Res Toxicol"},{"key":"7774_CR9","doi-asserted-by":"publisher","unstructured":"Cirino G, Szabo C, Papapetropoulos A Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs. Physiol Rev 103: 31\u2013276. https:\/\/doi.org\/10.1152\/physrev.00028.2021","DOI":"10.1152\/physrev.00028.2021"},{"issue":"20","key":"7774_CR10","doi-asserted-by":"publisher","first-page":"3325","DOI":"10.1016\/j.jare.2020.05.015","volume":"19","author":"A Martelli","year":"2012","unstructured":"MartelliA, Testai L, Marino A, Breschi C, Da Settimo M, Calderone F, Sulphide VH (2012) Biopharmacological roles in the cardiovascular system and pharmaceutical perspectives. Curr Med Chem 19(20):3325\u20133336 https:\/\/doi.org\/10.1016\/j.jare.2020.05.015","journal-title":"Curr Med Chem"},{"key":"7774_CR11","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-16-0991-6_8","volume-title":"Advances in hydrogen sulfide biology. Advances in experimental medicine and biology","author":"Q Ding","year":"2021","unstructured":"Ding Q, Zhu YZ (2021) The cardiovascular effects of hydrogen sulfide: the epigenetic mechanisms. In: Zhu YC (ed) Advances in hydrogen sulfide biology. Advances in experimental medicine and biology, vol 1315. Springer, Singapore. https:\/\/doi.org\/10.1007\/978-981-16-0991-6_8."},{"issue":"9","key":"7774_CR12","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1253\/circj.cj-14-0728","volume":"78","author":"LA Barr","year":"2014","unstructured":"BarrLA, Calvert JW (2014) Discoveries of hydrogen sulfide as a novel cardiovascular therapeutic. Circ J 78(9):2111\u20132118 https:\/\/doi.org\/10.1253\/circj.cj-14-0728","journal-title":"Circ J"},{"key":"7774_CR13","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s00395-005-0569-9","volume":"101","author":"D Johansen","year":"2006","unstructured":"Johansen D, Ytrehus K, Baxter GF (2006) Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemia\u2013reperfusion injury. Basic Res Cardiol 101:53\u201360. https:\/\/doi.org\/10.1007\/s00395-005-0569-9","journal-title":"Basic Res Cardiol"},{"key":"7774_CR14","doi-asserted-by":"publisher","first-page":"285","DOI":"10.12659\/aot.901410","volume":"22","author":"NA Garcia","year":"2017","unstructured":"Garcia NA, Moncayo-Arlandi J, Vazquez A, Genov\u00e9s P, Calvo CJ, Millet J, Mart\u00ed N, Aguado C, Knecht E, Valiente-Alandi I, Montero JA, D\u00edez-Juan A, Sep\u00falveda P (2017) Hydrogen sulfide improves cardiomyocyte function in a cardiac arrest model. Ann Transpl 22:285\u2013295. https:\/\/doi.org\/10.12659\/aot.901410","journal-title":"Ann Transpl"},{"key":"7774_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jare.2019.11.010","volume":"27","author":"AK Alyan","year":"2021","unstructured":"AlyanAK, Hanafi RS, Gad MG (2021) Point-of-care testing and optimization of sample treatment for fluorometric determination of hydrogen sulphide in plasma of cardiovascular patients. J Adv Res 27:1\u201310 https:\/\/doi.org\/10.1016\/j.jare.2019.11.010","journal-title":"J Adv Res"},{"key":"7774_CR16","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.jare.2020.05.018","volume":"27","author":"H Ibrahim","year":"2021","unstructured":"Ibrahim H, Serag A, Farag MA (2021) Emerging analytical tools for the detection of the third Gasotransmitter H2S, a comprehensive review. J Adv Res V 27:137\u2013153. https:\/\/doi.org\/10.1016\/j.jare.2020.05.018","journal-title":"J Adv Res V"},{"key":"7774_CR17","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.jelechem.2007.09.019","volume":"612","author":"B Spilker","year":"2008","unstructured":"SpilkerB, Randhahn J, Grabow H, Beikirch H, Jeroschewski P (2008) New electrochemical sensor for the detection of hydrogen sulfide and other redox active species. J Electroanal Chem 612:121\u2013130 https:\/\/doi.org\/10.1016\/j.jelechem.2007.09.019","journal-title":"J Electroanal Chem"},{"key":"7774_CR18","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/bs.mie.2014.11.013","volume":"554","author":"V Vitvitsky","year":"2015","unstructured":"VitvitskyV, Banerjee R, Seven C (2015) H2S analysis in biological samples using gas chromatography with sulfur chemiluminescence detection. Methods Enzymol 554:111\u2013123 https:\/\/doi.org\/10.1016\/bs.mie.2014.11.013","journal-title":"Methods Enzymol"},{"issue":"6","key":"7774_CR19","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1002\/pi.3095","volume":"60","author":"ET Kato Jr","year":"2011","unstructured":"Kato ET Jr., Yoshida CM, Reis AB, Melo IS, Franco TT (2011) Fast detection of hydrogen sulfide using a biodegradable colorimetric indicator system. Polym Int 60(6):951\u2013956. https:\/\/doi.org\/10.1002\/pi.3095","journal-title":"Polym Int"},{"key":"7774_CR20","doi-asserted-by":"publisher","first-page":"104724","DOI":"10.1016\/j.microc.2020.104724","volume":"155","author":"YJ Ahn","year":"2020","unstructured":"Ahn YJ, Yeong-Gyu Gil YG, Young Ju Lee YJ, Jang H (2020) Gi-Ja Lee, GJ. A dual- mode colorimetric and SERS detection of hydrogen sulphide in live prostate cancer cells using a silver nanoplate-coated paper assay. Microchem J 155:104724. https:\/\/doi.org\/10.1016\/j.microc.2020.104724","journal-title":"Microchem J"},{"key":"7774_CR21","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.niox.2014.05.012","volume":"41","author":"KR Olson","year":"2014","unstructured":"Olson KR, DeLeon ER, Liu F (2014) Controversies and conundrums in hydrogen sulfide biology. Nitric Oxide 41:11\u201326. https:\/\/doi.org\/10.1016\/j.niox.2014.05.012","journal-title":"Nitric Oxide"},{"key":"7774_CR22","doi-asserted-by":"publisher","unstructured":"Hoebe RA, Van Oven CH, Gadella TWJ, Dhonukshe PB, Van Noorden CJF, Manders EMM (2007) Controlled light-exposure microscopy reduces photobleaching and phototoxicity in fluorescence live-cell imaging. 25(2):249\u2013253. https:\/\/doi.org\/10.1038\/nbt1278","DOI":"10.1038\/nbt1278"},{"key":"7774_CR23","doi-asserted-by":"publisher","first-page":"2597","DOI":"10.1007\/s00216-019-01697-2","volume":"411","author":"B Sinduja","year":"2019","unstructured":"Sinduja B, John SA (2019) Silver nanoparticles capped with carbon Dots as a fluorescent probe for the highly sensitive off\u2013on sensing of sulfide ions in water. Anal Bioanal Chem 411:2597\u20132605. https:\/\/doi.org\/10.1007\/s00216-019-01697-2","journal-title":"Anal Bioanal Chem"},{"key":"7774_CR24","doi-asserted-by":"publisher","first-page":"7443","DOI":"10.1039\/C5AN01665G","volume":"140","author":"X Zhang","year":"2015","unstructured":"Zhang X, Zhou W, Yuan Z, Lu C (2015) Colorimetric detection of biological hydrogen sulfide using fluorosurfactant functionalized gold nanorods. Analyst 140:7443\u20137450. https:\/\/doi.org\/10.1039\/C5AN01665G","journal-title":"Analyst"},{"key":"7774_CR25","doi-asserted-by":"publisher","first-page":"1800515","DOI":"10.1002\/adfm.201800515","volume":"28","author":"J Zeng","year":"2018","unstructured":"Zeng J, Li M, Liu A, Feng F, Zeng T, Duan W, Li M, Gong M, Wen C-Y, Yin Y (2018) Au\/AgI dimeric nanoparticles for highly selective and sensitive colorimetric detection of hydrogen sulfide. Adv Funct Mater 28:1800515. https:\/\/doi.org\/10.1002\/adfm.201800515","journal-title":"Adv Funct Mater"},{"issue":"7","key":"7774_CR26","doi-asserted-by":"publisher","first-page":"3638","DOI":"10.1021\/ac303543r","volume":"85","author":"AP Jarosz","year":"2013","unstructured":"Jarosz AP, Yep T, Mutus B (2013) Microplate\u2013based colorimetric detection of free hydrogen sulfide. Anal Chem 85(7):3638\u20133643. https:\/\/doi.org\/10.1021\/ac303543r","journal-title":"Anal Chem"},{"key":"7774_CR27","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.saa.2017.01.040","volume":"177","author":"YJ Ahn","year":"2017","unstructured":"Ahn YJ, Lee YJ, Lee J, Lee D, Park H-K, Lee G-J (2017) Colorimetric detection of endogenous hydrogen sulfide production in living cells utilizing silver-embedded polymer membrane. Spectrochim Acta Part A Mol Biomol Spectrosc 177:118\u2013124. https:\/\/doi.org\/10.1016\/j.saa.2017.01.040","journal-title":"Spectrochim Acta Part A Mol Biomol Spectrosc"},{"key":"7774_CR28","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.1021\/acssensors.9b01019","volume":"4","author":"N Jornet-Mart\u00ednez","year":"2019","unstructured":"Jornet-Mart\u00ednez N, Hakobyan L, Argente-Garc\u00eda AI, Molins-Legua C, Camp\u00edns-Falco P (2019) Nylon-Supported plasmonic assay based on the aggregation of silver nanoparticles: in situ determination of hydrogen Sulfide-like compounds in breath samples as a proof of concept. ACS Sens 4:2164\u20132172. https:\/\/doi.org\/10.1021\/acssensors.9b01019","journal-title":"ACS Sens"},{"key":"7774_CR29","unstructured":"Argente Garcia AI, Jornet Mart\u00ednez N, Campins Falc\u00f3 P, Herr\u00e1ez-Hern\u00e1ndez R, Moliner-Mart\u00ednez Y, Verd\u00fa Andres J (2018) Colorimetric sensor based on silver nanoparticles for the determination of volatile sulfur compounds; PCT\/ES2017\/070532, EP3467476A1, EPO."},{"key":"7774_CR30","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1023\/A:1021120723498","volume":"4","author":"j Li","year":"2002","unstructured":"Li j, Lin Y, Zhao B (2002) Spontaneous agglomeration of silver nanoparticles deposited on carbon film surface. J Nanopart Res 4:345\u2013349. https:\/\/doi.org\/10.1023\/A:1021120723498","journal-title":"J Nanopart Res"},{"issue":"9","key":"7774_CR31","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.3390\/nano10091802","volume":"10","author":"L Sanjuan \u2013 Navarro","year":"2020","unstructured":"Sanjuan\u2013 Navarro L, Boughbina-Portol\u00e9s A, Moliner - Martinez Y, Campins - Falc\u00f3 P (2020) Aqueous dilution of noble nps bulk dispersions: modeling instability due to dissolution by AF4 and stablishing considerations for plasmonic assays. Nanomaterials 10(9):1802 https:\/\/doi.org\/10.3390\/nano10091802","journal-title":"Nanomaterials"},{"key":"7774_CR32","doi-asserted-by":"publisher","unstructured":"Ballester-Caudet A, Camp\u00edns-Falc\u00f3 P, P\u00e9rez B, Sancho R, Lorente M, Sastre G, Gonz\u00e1lez C (2019) A new tool for evaluating and\/or selecting analytical methods: summarizing the information in a hexagon. TrAC Trends Anal Chem 118: 538\u2013547. https:\/\/doi.org\/10.1016\/j.trac.2019.06.015","DOI":"10.1016\/j.trac.2019.06.015"},{"key":"7774_CR33","doi-asserted-by":"publisher","first-page":"123449","DOI":"10.1016\/j.talanta.2022.123449","volume":"245","author":"I Carrero-Ferrer","year":"2022","unstructured":"Carrero-FerrerI,Molins-Legua C, Camp\u00edns-Falc\u00f3 P (2022) Plasmonic sensor for hydrogen sulphide in saliva: multisensor platform and bag format. Talanta 245:123449. https:\/\/doi.org\/10.1016\/j.talanta.2022.123449","journal-title":"Talanta"},{"key":"7774_CR34","doi-asserted-by":"publisher","first-page":"11459","DOI":"10.1021\/ac503622n","volume":"86","author":"Y Ma","year":"2014","unstructured":"Ma Y, Su H, Kuang K, Li X, Zhang T, Tang B (2014) Heterogeneous nano Metal\u2013Organic framework fluorescence probe for highly selective and sensitive detection of hydrogen sulfide in living cells. Anal Chem 86:11459\u201311463. https:\/\/doi.org\/10.1021\/ac503622n","journal-title":"Anal Chem"},{"key":"7774_CR35","doi-asserted-by":"publisher","unstructured":"Gomathi A, Viswanathamurthi P (2019) Hydrogen sulfide detection by ESIPT based fluorescent sensor: potential in living cells imagingjournal of photochemistry & photobiology a: chemistry. 369:97\u2013105. https:\/\/doi.org\/10.1016\/j.jphotochem.2018.10.013","DOI":"10.1016\/j.jphotochem.2018.10.013"}],"container-title":["Microchimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00604-025-07774-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00604-025-07774-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00604-025-07774-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T07:27:04Z","timestamp":1771054024000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00604-025-07774-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,7]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["7774"],"URL":"https:\/\/doi.org\/10.1007\/s00604-025-07774-x","relation":{},"ISSN":["0026-3672","1436-5073"],"issn-type":[{"value":"0026-3672","type":"print"},{"value":"1436-5073","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,7]]},"assertion":[{"value":"16 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"71"}}