{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:14:01Z","timestamp":1787868841942,"version":"build-2784847793"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2010,4,16]],"date-time":"2010-04-16T00:00:00Z","timestamp":1271376000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neurochir"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1007\/s00701-010-0644-3","type":"journal-article","created":{"date-parts":[[2010,4,15]],"date-time":"2010-04-15T16:56:34Z","timestamp":1271350594000},"page":"1129-1137","source":"Crossref","is-referenced-by-count":37,"title":["Eosinophilic granuloma of spine in adults: a report of 30 cases and outcome"],"prefix":"10.1007","volume":"152","author":[{"given":"Wending","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianru","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mosong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapeng","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianshun","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujia","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,4,16]]},"reference":[{"key":"644_CR1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00247-004-1262-0","volume":"35","author":"EM Azouz","year":"2005","unstructured":"Azouz EM, Saigal G, Rodriguez MM, Podda A (2005) Langerhans\u2019 cell histiocytosis: pathology, imaging and treatment of skeletal involvement. Pediatr Radiol 35:103\u2013115","journal-title":"Pediatr Radiol"},{"key":"644_CR2","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1097\/00007632-200207010-00007","volume":"27","author":"C Bertram","year":"2002","unstructured":"Bertram C, Madert J, Eggers C (2002) Eosinophilic granuloma of the cervical spine. Spine 27:1408\u20131413","journal-title":"Spine"},{"key":"644_CR3","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1007\/s00247-003-0943-4","volume":"33","author":"LA Binkovitz","year":"2003","unstructured":"Binkovitz LA, Olshefski RS, Adler BH (2003) Coincidence FDG-PET in the evaluation of Langerhans\u2019 cell histiocytosis: preliminary findings. Pediatr Radiol 33:598\u2013602","journal-title":"Pediatr Radiol"},{"key":"644_CR4","first-page":"230","volume":"48","author":"CW Brown","year":"2005","unstructured":"Brown CW, Jarvis JG, Letts M, Carpenter B (2005) Treatment and outcome of vertebral Langerhans cell histiocytosis at the Children\u2019s Hospital of Eastern Ontario. Can J Surg 48:230\u2013236","journal-title":"Can J Surg"},{"key":"644_CR5","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/01241398-198505000-00016","volume":"5","author":"R Capanna","year":"1985","unstructured":"Capanna R, Springfield DS, Ruggieri P, Biaqini R, Picci P, Bacci G, Giunti A, Lorenzi EG, Campanacci M (1985) Direct cortisone injection in eosinophilic granuloma of bone. A preliminary report on 11 patients. J Pediatr Orthop 5:339\u2013342","journal-title":"J Pediatr Orthop"},{"key":"644_CR6","first-page":"208","volume":"1","author":"T Chu","year":"1987","unstructured":"Chu T, D\u2019Angio GJ, Favara B, Ladisch S, Nesbit M, Pritchard J (1987) The writing group of the histiocyte society. Histiocytic syndromes in children. Lancet 1:208\u2013209","journal-title":"Lancet"},{"key":"644_CR7","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1148\/radiology.136.2.7403498","volume":"136","author":"M Cohen","year":"1980","unstructured":"Cohen M, Zornoza J, Cangir A, Murray JA, Wallace S (1980) Direct injection of methylprednisolone sodium succinate in the treatment of solitary eosinophilic granuloma of bone. A report of 9 cases. Radiology 136:289\u2013293","journal-title":"Radiology"},{"key":"644_CR8","doi-asserted-by":"crossref","first-page":"E936","DOI":"10.1097\/BRS.0b013e3181859aab","volume":"33","author":"L Denaro","year":"2008","unstructured":"Denaro L, Longo UG, Papalia R, Di Martino A, Maffulli N, Denaro V (2008) Eosinophilic granuloma of the pediatric cervical spine. Spine 33:E936\u2013941","journal-title":"Spine"},{"key":"644_CR9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-3476(95)70248-2","volume":"127","author":"RM Egeler","year":"1995","unstructured":"Egeler RM, D\u2019Angio GJ (1995) Langerhans cell histiocytosis. J Pediatr 127:1\u201311","journal-title":"J Pediatr"},{"key":"644_CR10","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1097\/01241398-199211000-00021","volume":"12","author":"RM Egeler","year":"1992","unstructured":"Egeler RM, Thompson RC Jr, Voute PA, Nesbit ME Jr (1992) Intralesional infiltration of corticosteroids in localized Langerhans\u2019 cell histiocytosis. J Pediatr Orthop 12:811\u2013814","journal-title":"J Pediatr Orthop"},{"key":"644_CR11","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/(SICI)1096-911X(199709)29:3<157::AID-MPO1>3.0.CO;2-C","volume":"29","author":"BE Favara","year":"1997","unstructured":"Favara BE, Feller AC, Pauli M, Jaffe ES, Weiss LM, Arico M, Bucsky P, Egeler RM, Elinder G, Gadner H, Henter JI, Imashuku S, Janka-schaub G, Jaffe R, Ladisch S, Nezelof C, Pritchard J (1997) Contemporary classification of histiocytic disorders. The WHO Committee on Histiocytic\/Reticulum Cell Proliferations. Reclassification Working Group of the Histiocyte Society. Med Pediatr Oncol 29:157\u2013166","journal-title":"Med Pediatr Oncol"},{"issue":"suppl 4","key":"644_CR12","first-page":"252","volume":"105","author":"AJ Fenoy","year":"2006","unstructured":"Fenoy AJ, Greenlee JD, Menezes AH, Donovan KA, Sato Y, Hitchon PW, Chaloupka JC (2006) Primary bone tumors of the spine in children. J Neurosurg 105(suppl 4):252\u2013260","journal-title":"J Neurosurg"},{"key":"644_CR13","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/01202412-199710000-00008","volume":"6","author":"Y Floman","year":"1997","unstructured":"Floman Y, Bar-On E, Mosheiff R, Mirovsky Y, Robin GC, Ramu N (1997) Eosinophilic granuloma of the spine. J Pediatr Orthop B 6:260\u2013265","journal-title":"J Pediatr Orthop B"},{"key":"644_CR14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1177\/230949900601400118","volume":"14","author":"B Garg","year":"2006","unstructured":"Garg B, Sharma V, Eachempati KK, Malhotra R, Bhan S (2006) An unusual presentation of eosinophilic granuloma in an adult: a case report. J Orthop Surg 14:81\u201383","journal-title":"J Orthop Surg"},{"key":"644_CR15","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.2106\/00004623-200408000-00019","volume":"86A","author":"S Garg","year":"2004","unstructured":"Garg S, Mehta S, Dormans JP (2004) Langerhans cell histiocytosis of the spine in children. Long-term follow-up. J Bone Joint Surg Am 86A:1740\u20131750","journal-title":"J Bone Joint Surg Am"},{"key":"644_CR16","doi-asserted-by":"crossref","first-page":"E445","DOI":"10.1097\/01.BRS.0000096462.51682.0F","volume":"28","author":"S Garg","year":"2003","unstructured":"Garg S, Mehta S, Dormans JP (2003) An atypical presentation of Langerhans cell histiocytosis of the cervical spine in a child. Spine 28:E445\u2013E448","journal-title":"Spine"},{"key":"644_CR17","first-page":"124","volume":"23","author":"I Ghanem","year":"2003","unstructured":"Ghanem I, Tolo VT, D\u2019Ambra P, Malogalowkin MH (2003) Langerhans cell histiocytosis of bone in children and adolescents. J Pediatr Orthop 23:124\u2013130","journal-title":"J Pediatr Orthop"},{"key":"644_CR18","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1159\/000103308","volume":"43","author":"JD Greenlee","year":"2007","unstructured":"Greenlee JD, Fenoy AJ, Donovan KA, Menezes AH (2007) Eosinophilic granuloma in the pediatric spine. Pediatr Neurosurg 43:285\u2013292","journal-title":"Pediatr Neurosurg"},{"key":"644_CR19","first-page":"499","volume":"24","author":"WT Green","year":"1942","unstructured":"Green WT, Farber S, McDermott LJ (1942) Eosinophilic or solitary Granuloma of bone. J Bone Jt Surg 24:499\u2013526","journal-title":"J Bone Jt Surg"},{"key":"644_CR20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s002560050361","volume":"27","author":"BW Hindman","year":"1998","unstructured":"Hindman BW, Thomas RD, Young LW, Yu L (1998) Langerhans cell histiocytosis: unusual skeletal manifestations observed in thirty four cases. Skeletal Radiol 27:177\u2013181","journal-title":"Skeletal Radiol"},{"key":"644_CR21","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.jocn.2007.05.032","volume":"15","author":"H Nakamura","year":"2008","unstructured":"Nakamura H, Nagayama R (2008) Eosinophilic granuloma present with local osteolysis in an adult lumbar spine. J Clin Nureosci 15:1398\u20131400","journal-title":"J Clin Nureosci"},{"key":"644_CR22","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1002\/(SICI)1097-0142(19990515)85:10<2278::AID-CNCR25>3.0.CO;2-U","volume":"85","author":"DM Howarth","year":"1999","unstructured":"Howarth DM, Gilchrist GS, Mullan BP, Wiseman GA, Edmonson JH, Schomberg PJ (1999) Langerhans cell histiocytosis: diagnosis, natural history, management, and outcome. Cancer 85:2278\u20132290","journal-title":"Cancer"},{"key":"644_CR23","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.2106\/00004623-198466090-00006","volume":"66","author":"E Ippolito","year":"1984","unstructured":"Ippolito E, Farsetti P, Tudisco C (1984) Vertebra plana. Long-term follow-up in five patients. J Bone Jt Surg Am 66:1364\u20131368","journal-title":"J Bone Jt Surg Am"},{"key":"644_CR24","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/00003086-200010000-00027","volume":"379","author":"RB Islinger","year":"2000","unstructured":"Islinger RB, Kuklo TR, Owens BD, Horan PJ, Choma TJ, Murphey MD, Temple HT (2000) Langerhans\u2019 cell histiocytosis in patients older than 21\u00a0years. Clin Orthop Relat Res 379:231\u2013235","journal-title":"Clin Orthop Relat Res"},{"key":"644_CR25","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00247-007-0467-4","volume":"37","author":"SC Kaste","year":"2007","unstructured":"Kaste SC, Rodriguex-Galindo C, McCarville ME, Shulkin BL (2007) PET-CT in pediatric Langerhans\u2019s cell histiocytosis. Pediatr Radiol 37:615\u2013622","journal-title":"Pediatr Radiol"},{"key":"644_CR26","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1002\/1097-0142(19951215)76:12<2471::AID-CNCR2820761211>3.0.CO;2-Z","volume":"76","author":"SE Kilpatrick","year":"1995","unstructured":"Kilpatrick SE, Wenger DE, Gilchrist GS, Shives TC, Wollan PC, Unni KK (1995) Langerhans\u2019 cell histiocytosis (histiocytosis X) of bone. A clinicopathologic analysis of 263 pediatric and adult cases. Cancer 76:2471\u20132484","journal-title":"Cancer"},{"key":"644_CR27","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/00002517-199506000-00013","volume":"8","author":"MD Lauffenburger","year":"1995","unstructured":"Lauffenburger MD, Dull ST, Toselli R (1995) Eosinophilic granuloma of the adult spine: a case report and review of the literature. J Spinal Disord 8:243\u2013248","journal-title":"J Spinal Disord"},{"key":"644_CR28","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/00000478-199605000-00001","volume":"20","author":"PH Leiberman","year":"1996","unstructured":"Leiberman PH, Jones CR, Steinman RM, Erlandson RA, Smith J, Gee T, Huvos A, Garin-Chesa P, Filippa DA, Urmacher C, Ganqi MD, Sperber M (1996) Langerhans cell (eosinophilic) granulomatosis. A clinicopathologic study encompassing 50\u00a0years. Am J Surg Pathol 20:519\u2013552","journal-title":"Am J Surg Pathol"},{"key":"644_CR29","first-page":"84","volume":"56","author":"L Lichtenstein","year":"1953","unstructured":"Lichtenstein L (1953) Histiocytosis X. Integration of eosinophilicgranuloma of bone, \u201cLetterer-Siwe disease\u201d, and \u201cSchiiller-Christian disease\u201d as related manifestations of a single nosologic entity. Arch Pathol 56:84\u2013102","journal-title":"Arch Pathol"},{"key":"644_CR30","first-page":"595","volume":"16","author":"L Lichtenstein","year":"1940","unstructured":"Lichtenstein L, Jaffe ML (1940) Eosinophilic granuloma of bone, with a report of a case. Am J Pathol 16:595\u2013604","journal-title":"Am J Pathol"},{"key":"644_CR31","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/(SICI)1096-911X(199612)27:6<540::AID-MPO6>3.0.CO;2-L","volume":"27","author":"JS Malpas","year":"1996","unstructured":"Malpas JS, Norton AJ (1996) Langerhans cell histiocytosis in the adult. Med Pediatr Oncol 27:540\u2013546","journal-title":"Med Pediatr Oncol"},{"key":"644_CR32","first-page":"821","volume":"17","author":"S Mammano","year":"1997","unstructured":"Mammano S, Candiotto S, Balsano M (1997) Cast and brace treatment of eosinophilic granuloma of the spine: long-term follow-up. J Pediatr Orthop 17:821\u2013827","journal-title":"J Pediatr Orthop"},{"key":"644_CR33","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/BF00263187","volume":"7","author":"JF Martinez-Lage","year":"1991","unstructured":"Martinez-Lage JF, Poza M, Cartagena J, Vicente JP, Biec F, De Las HM (1991) Solitary eosinophilic granuloma of the pediatric skull and spine. The role of surgery. Child Nerv Syst 7:448\u2013451","journal-title":"Child Nerv Syst"},{"key":"644_CR34","first-page":"479","volume":"16","author":"S Otani","year":"1940","unstructured":"Otani S, Ehrlich JC (1940) Solitary granuloma of bone simulating primary neoplasm. Am J Pathol 16:479\u2013490","journal-title":"Am J Pathol"},{"key":"644_CR35","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s00264-008-0529-8","volume":"33","author":"XS Peng","year":"2009","unstructured":"Peng XS, Pan T, Chen LY, Huang G, Wang J (2009) Langerhans\u2019 cell histiocytosis of the spine in children with soft tissue extension and chemotherapy. Int Orthop 33:731\u2013736","journal-title":"Int Orthop"},{"key":"644_CR36","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1302\/0301-620X.84B6.0840870","volume":"84-B","author":"F Plasschaert","year":"2002","unstructured":"Plasschaert F, Craig C, Bell R, Cole WG, Wunder JS, Alman BA (2002) Eosinophilic granuloma. A Different behaviour in children than in adults. J Bone Jt Surg Br 84-B:870\u2013872","journal-title":"J Bone Jt Surg Br"},{"key":"644_CR37","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3109\/17453677508989210","volume":"46","author":"JO Poulsen","year":"1975","unstructured":"Poulsen JO, Jensen JT, Nixon JE (1975) Ewing\u2019s sarcoma simulating vertebra plana. Acta Orthop Scand 46:211\u2013215","journal-title":"Acta Orthop Scand"},{"key":"644_CR38","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1097\/00007632-199806150-00011","volume":"23","author":"P Raab","year":"1998","unstructured":"Raab P, Hohmann F, Kuhl J, Krauspe R (1998) Vertebral remodeling in eosinophilic granuloma of the spine. A long-term follow-up. Spine 23:1351\u20131354","journal-title":"Spine"},{"key":"644_CR39","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/00043426-198100320-00008","volume":"3","author":"MP Richter","year":"1981","unstructured":"Richter MP, D\u2019Angio GJ (1981) The role of radiation therapy in the management of children with histiocytosis X. Am J Pediatr Hematol Oncol 3:161\u2013163","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"644_CR40","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/mpo.2950180203","volume":"18","author":"MT Selch","year":"1990","unstructured":"Selch MT, Parker RG (1990) Radiation therapy in the management of Langerhans cell histiocytosis. Med Pediatr Oncol 18:97\u2013102","journal-title":"Med Pediatr Oncol"},{"key":"644_CR41","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.2106\/00004623-199410000-00011","volume":"76","author":"S Sessa","year":"1994","unstructured":"Sessa S, Sommelet D, Lascombes P, Prevot J (1994) Treatment of Langerhans-cell histiocytosis in children: experience at the Children\u2019s Hospital of Nancy. J Bone Jt Surg Am 76:1513\u20131525","journal-title":"J Bone Jt Surg Am"},{"key":"644_CR42","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/mpo.2950080208","volume":"8","author":"JM Slater","year":"1980","unstructured":"Slater JM, Swarm OJ (1980) Eosinophilic granuloma of bone. Med Pediatr Oncol 8:151\u2013164","journal-title":"Med Pediatr Oncol"},{"key":"644_CR43","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1148\/radiographics.12.4.1636041","volume":"12","author":"MA Stull","year":"1992","unstructured":"Stull MA, Kransdorf MJ, Devaney KO (1992) Langerhans cell histiocytosis of bone. Radiographics 12:801\u2013823","journal-title":"Radiographics"},{"key":"644_CR44","first-page":"123","volume":"13","author":"G Tan","year":"2004","unstructured":"Tan G, Samson I, De Wever I, Goffin J, Demaerel P, Van Gool SW (2004) Langerhans cell histiocytosis of the cervical spine: a single institution experience in four patients. J Pediatr Orthop 13:123\u2013126","journal-title":"J Pediatr Orthop"},{"key":"644_CR45","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1200\/JCO.1996.14.7.2073","volume":"14","author":"B Willis","year":"1996","unstructured":"Willis B, Ablin A, Weinberg V, Zoger S, Wara WM, Matthay KK (1996) Disease course and late sequelae of Langerhans\u2019 cell histiocytosis: 25\u00a0year experience at the University of California, San Francisco. J Clin Oncol 14:2073\u20132082","journal-title":"J Clin Oncol"},{"key":"644_CR46","doi-asserted-by":"crossref","first-page":"219","DOI":"10.2106\/00004623-199802000-00009","volume":"80","author":"AW Yasko","year":"1998","unstructured":"Yasko AW, Fanning CV, Ayala AG, Carrasco CH, Murray JA (1998) Percutaneous techniques for the diagnosis and treatment of localized Lanerhans-cell histiocytosis (eosinophilic granuloma of bone). J Bone Jt Surg Am 80:219\u2013228","journal-title":"J Bone Jt Surg Am"},{"key":"644_CR47","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1097\/00007632-199908150-00016","volume":"24","author":"JS Yeom","year":"1999","unstructured":"Yeom JS, Lee CK, Shin HY, Lee CS, Chang H (1999) Langerhans\u2019 cell histiocytosis of the spine. Analysis of twenty-three cases. Spine 24:1740\u20131749","journal-title":"Spine"}],"container-title":["Acta Neurochirurgica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00701-010-0644-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00701-010-0644-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00701-010-0644-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T04:16:26Z","timestamp":1559103386000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00701-010-0644-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,16]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["644"],"URL":"https:\/\/doi.org\/10.1007\/s00701-010-0644-3","relation":{},"ISSN":["0001-6268","0942-0940"],"issn-type":[{"value":"0001-6268","type":"print"},{"value":"0942-0940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,16]]}}}