{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:26:47Z","timestamp":1761823607891},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T00:00:00Z","timestamp":1393372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neurochir"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1007\/s00701-014-2032-x","type":"journal-article","created":{"date-parts":[[2014,2,25]],"date-time":"2014-02-25T09:23:34Z","timestamp":1393320214000},"page":"741-747","source":"Crossref","is-referenced-by-count":10,"title":["Prothrombin complex concentrate facilitates emergency spinal surgery in anticoagulated patients"],"prefix":"10.1007","volume":"156","author":[{"given":"Christopher","family":"Beynon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Potzy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas W.","family":"Unterberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver W.","family":"Sakowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,2,26]]},"reference":[{"issue":"3","key":"2032_CR1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1093\/icvts\/ivs224","volume":"15","author":"V Arn\u00e9kian","year":"2012","unstructured":"Arn\u00e9kian V, Camous J, Fattal S, R\u00e9zaiguia-Delclaux S, Nottin R, St\u00e9phan F (2012) Use of prothrombin complex concentrate for excessive bleeding after cardiac surgery. Interact Cardiovasc Thorac Surg 15(3):382\u2013389","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"4","key":"2032_CR2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3109\/02688697.2011.650736","volume":"26","author":"JS Batchelor","year":"2012","unstructured":"Batchelor JS, Grayson A (2012) A meta-analysis to determine the effect of anticoagulation on mortality in patients with blunt head trauma. Br J Neurosurg 26(4):525\u2013530","journal-title":"Br J Neurosurg"},{"issue":"1","key":"2032_CR3","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1865-1380-4-40","volume":"4","author":"BF Bechtel","year":"2011","unstructured":"Bechtel BF, Nunez TC, Lyon JA, Cotton BA, Barrett TW (2011) Treatments for reversing warfarin anticoagulation in patients with acute intracranial hemorrhage: a structured literature review. Int J Emerg Med 4(1):40","journal-title":"Int J Emerg Med"},{"key":"2032_CR4","doi-asserted-by":"crossref","unstructured":"Beynon C, Jakobs M, Rizos T, Unterberg AW, Sakowitz OW (2013) Rapid bedside coagulometry prior to urgent neurosurgical procedures in anticoagulated patients. Br J Neurosurg 28(1):29\u201333. doi: 10.3109\/02688697.2013.869549","DOI":"10.3109\/02688697.2013.869549"},{"key":"2032_CR5","doi-asserted-by":"crossref","unstructured":"Bourassa-Moreau E, Mac-Thiong J-M, Feldman DE, Thompson C, Parent S (2013) Non-neurological outcomes following complete traumatic spinal cord injury: The impact of surgical timing. J Neurotrauma 30(18):1596\u2013601. doi: 10.1089\/neu.2013.2957","DOI":"10.1089\/neu.2013.2957"},{"issue":"6","key":"2032_CR6","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.clineuro.2012.07.006","volume":"115","author":"KP Cabral","year":"2013","unstructured":"Cabral KP, Fraser GL, Duprey J, Gibbons BA, Hayes T, Florman JE, Seder DB (2013) Prothrombin complex concentrates to reverse warfarin-induced coagulopathy in patients with intracranial bleeding. Clin Neurol Neurosurg 115(6):770\u2013774","journal-title":"Clin Neurol Neurosurg"},{"issue":"5","key":"2032_CR7","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/BRS.0b013e318193a25b","volume":"34","author":"JH Chi","year":"2009","unstructured":"Chi JH, Gokaslan Z, McCormick P, Tibbs PA, Kryscio RJ, Patchell RA (2009) Selecting treatment for patients with malignant epidural spinal cord compression-does age matter?: results from a randomized clinical trial. Spine 34(5):431\u2013435","journal-title":"Spine"},{"issue":"4","key":"2032_CR8","doi-asserted-by":"crossref","first-page":"809","DOI":"10.3109\/0284186X.2012.705437","volume":"52","author":"S Crnalic","year":"2013","unstructured":"Crnalic S, Hildingsson C, Bergh A, Widmark A, Svensson O, L\u00f6fvenberg R (2013) Early diagnosis and treatment is crucial for neurological recovery after surgery for metastatic spinal cord compression in prostate cancer. Acta Oncol 52(4):809\u2013815","journal-title":"Acta Oncol"},{"issue":"3","key":"2032_CR9","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1160\/TH11-01-0052","volume":"106","author":"F Dentali","year":"2011","unstructured":"Dentali F, Marchesi C, Pierfranceschi MG, Crowther M, Garcia D, Hylek E, Witt DM, Clark NP, Squizzato A, Imberti D, Ageno W (2011) Safety of prothrombin complex concentrates for rapid anticoagulation reversal of vitamin K antagonists. A meta-analysis. Thromb Haemost 106(3):429\u2013438","journal-title":"Thromb Haemost"},{"issue":"3","key":"2032_CR10","doi-asserted-by":"crossref","first-page":"e178","DOI":"10.1016\/j.thromres.2012.05.029","volume":"130","author":"T Desmettre","year":"2012","unstructured":"Desmettre T, Dubart A-E, Capellier G, Fanara B, Puyraveau M, Kepka S, Coquart J, Sheppard F, Tazarourte K (2012) Emergency reversal of anticoagulation: the real use of prothrombin complex concentrates: a prospective multicenter two year French study from 2006 to 2008. Thromb Res 130(3):e178\u2013e183","journal-title":"Thromb Res"},{"issue":"2","key":"2032_CR11","doi-asserted-by":"crossref","first-page":"e32037","DOI":"10.1371\/journal.pone.0032037","volume":"7","author":"MG Fehlings","year":"2012","unstructured":"Fehlings MG, Vaccaro A, Wilson JR, Singh A, WCadotte D, Harrop JS, Aarabi B, Shaffrey C, Dvorak M, Fisher C, Arnold P, Massicotte EM, Lewis S, Rampersaud R (2012) Early versus delayed decompression for traumatic cervical spinal cord injury: results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS). PLoS ONE 7(2):e32037","journal-title":"PLoS ONE"},{"issue":"13","key":"2032_CR12","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1097\/BRS.0b013e318286b7c0","volume":"38","author":"SJ Fineberg","year":"2013","unstructured":"Fineberg SJ, Oglesby M, Patel AA, Pelton MA, Singh K (2013) The incidence and mortality of thromboembolic events in lumbar spine surgery. Spine 38(13):1154\u20131159","journal-title":"Spine"},{"issue":"4","key":"2032_CR13","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1161\/CIRCULATIONAHA.113.001875","volume":"128","author":"M Hickey","year":"2013","unstructured":"Hickey M, Gatien M, Taljaard M, Aujnarain A, Giulivi A, Perry JJ (2013) Outcomes of urgent warfarin reversal with frozen plasma versus prothrombin complex concentrate in the emergency department. Circulation 128(4):360\u2013364","journal-title":"Circulation"},{"issue":"5","key":"2032_CR14","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1111\/j.1538-7836.2006.01815.x","volume":"4","author":"MW Lankiewicz","year":"2006","unstructured":"Lankiewicz MW, Hays J, Friedman KD, Tinkoff G, Blatt PM (2006) Urgent reversal of warfarin with prothrombin complex concentrate. J Thromb Haemost 4(5):967\u2013970","journal-title":"J Thromb Haemost"},{"issue":"1","key":"2032_CR15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/jns.1995.83.1.0001","volume":"83","author":"MT Lawton","year":"1995","unstructured":"Lawton MT, Porter RW, Heiserman JE, Jacobowitz R, Sonntag VK, Dickman CA (1995) Surgical management of spinal epidural hematoma: relationship between surgical timing and neurological outcome. J Neurosurg 83(1):1\u20137","journal-title":"J Neurosurg"},{"issue":"7","key":"2032_CR16","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1002\/ccd.22167","volume":"74","author":"ID Moussa","year":"2009","unstructured":"Moussa ID, Colombo A (2009) Antiplatelet therapy discontinuation following drug-eluting stent placement: dangers, reasons, and management recommendations. Catheter Cardiovasc Interv 74(7):1047\u20131054","journal-title":"Catheter Cardiovasc Interv"},{"key":"2032_CR17","doi-asserted-by":"crossref","unstructured":"Mukerji N, Todd N (2013) Spinal epidural haematoma; factors influencing outcome. Br J Neurosurg 27(6):712\u2013717. doi: 10.3109\/02688697.2013.793289","DOI":"10.3109\/02688697.2013.793289"},{"issue":"3","key":"2032_CR18","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1001\/jama.295.3.293","volume":"295","author":"KA O\u2019Connell","year":"2006","unstructured":"O\u2019Connell KA, Wood JJ, Wise RP, Lozier JN, Braun MM (2006) Thromboembolic adverse events after use of recombinant human coagulation factor VIIa. JAMA 295(3):293\u2013298","journal-title":"JAMA"},{"key":"2032_CR19","doi-asserted-by":"crossref","unstructured":"Oglesby M, Fineberg SJ, Patel AA, Pelton MA, Singh K (2013) The incidence and mortality of thromboembolic events in cervical spine surgery. Spine. doi: 10.1097\/BRS.0b013e3182897839","DOI":"10.1097\/BRS.0b013e3182897839"},{"issue":"3","key":"2032_CR20","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00277-009-0830-7","volume":"89","author":"Pabinger I, Tiede A, Kalina U, Knaub S, Germann R, Ostermann H, Beriplex P\/N Anticoagulation Reversal Study Group","year":"2010","unstructured":"Pabinger I, Tiede A, Kalina U, Knaub S, Germann R, Ostermann H, Beriplex P\/N Anticoagulation Reversal Study Group (2010) Impact of infusion speed on the safety and effectiveness of prothrombin complex concentrate: a prospective clinical trial of emergency anticoagulation reversal. Ann Hematol 89(3):309\u2013316","journal-title":"Ann Hematol"},{"issue":"Suppl 2","key":"2032_CR21","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1016\/S0049-3848(08)70005-7","volume":"122","author":"I Pabinger-Fasching","year":"2008","unstructured":"Pabinger-Fasching I (2008) Warfarin-reversal: results of a phase III study with pasteurised, nanofiltrated prothrombin complex concentrate. Thromb Res 122(Suppl 2):S19\u2013S22","journal-title":"Thromb Res"},{"issue":"5","key":"2032_CR22","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1365-2141.2010.08223.x","volume":"150","author":"DJ Perry","year":"2010","unstructured":"Perry DJ, Fitzmaurice DA, Kitchen S, Mackie IJ, Mallett S (2010) Point-of-care testing in haemostasis. Br J Haematol 150(5):501\u2013514","journal-title":"Br J Haematol"},{"issue":"5\u20136","key":"2032_CR23","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1159\/000343655","volume":"34","author":"T Rizos","year":"2012","unstructured":"Rizos T, Horstmann S, Jenetzky E, Spindler M, Gumbinger C, M\u00f6hlenbruch M, Ringleb P, Hacke W, Veltkamp R (2012) Oral anticoagulants\u2013a frequent challenge for the emergency management of acute ischemic stroke. Cerebrovasc Dis 34(5\u20136):411\u2013418","journal-title":"Cerebrovasc Dis"},{"issue":"2","key":"2032_CR24","doi-asserted-by":"crossref","first-page":"R76","DOI":"10.1186\/cc12685","volume":"17","author":"DR Spahn","year":"2013","unstructured":"Spahn DR, Bouillon B, Cerny V, Coats TJ, Duranteau J, Fernandez-Mondejar E, Filipescu D, Hunt BJ, Komadina R, Nardi G, Neugebauer E, Ozier Y, Riddez L, Schultz A, Vincent JL, Rossaint R (2013) Management of bleeding and coagulopathy following major trauma: an updated European guideline. Crit Care 17(2):R76","journal-title":"Crit Care"},{"issue":"4","key":"2032_CR25","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1538-7836.2012.04630.x","volume":"10","author":"AC Spyropoulos","year":"2012","unstructured":"Spyropoulos AC, Douketis JD, Gerotziafas G, Kaatz S, Ortel TL, Schulman S (2012) Periprocedural antithrombotic and bridging therapy: recommendations for standardized reporting in patients with arterial indications for chronic oral anticoagulant therapy. J Thromb Haemost 10(4):692\u2013694","journal-title":"J Thromb Haemost"},{"issue":"12","key":"2032_CR26","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1345\/aph.1R497","volume":"46","author":"LV Tsu","year":"2012","unstructured":"Tsu LV, Dienes JE, Dager WE (2012) Vitamin K dosing to reverse warfarin based on INR, route of administration, and home warfarin dose in the acute\/critical care setting. Ann Pharmacother 46(12):1617\u20131626","journal-title":"Ann Pharmacother"},{"issue":"4","key":"2032_CR27","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1177\/2151458511417434","volume":"2","author":"MA Vitale","year":"2011","unstructured":"Vitale MA, Vanbeek C, Spivack JH, Cheng B, Geller JA (2011) Pharmacologic reversal of warfarin-associated coagulopathy in geriatric patients with hip fractures: a retrospective study of thromboembolic events, postoperative complications, and time to surgery. Geriatr Orthop Surg Rehabil 2(4):128\u2013134","journal-title":"Geriatr Orthop Surg Rehabil"},{"issue":"1","key":"2032_CR28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.7326\/0003-4819-122-1-199501010-00006","volume":"122","author":"RH White","year":"1995","unstructured":"White RH, McKittrick T, Hutchinson R, Twitchell J (1995) Temporary discontinuation of warfarin therapy: changes in the international normalized ratio. Ann Intern Med 122(1):40\u201342","journal-title":"Ann Intern Med"},{"issue":"5","key":"2032_CR29","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2169\/internalmedicine.50.4239","volume":"50","author":"S Yamashita","year":"2011","unstructured":"Yamashita S, Kimura K, Iguchi Y, Shibazaki K (2011) Prior oral antithrombotic therapy is associated with early death in patients with supratentorial intracerebral hemorrhage. Intern Med 50(5):413\u2013419","journal-title":"Intern Med"}],"container-title":["Acta Neurochirurgica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00701-014-2032-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00701-014-2032-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00701-014-2032-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T04:16:08Z","timestamp":1559103368000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00701-014-2032-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,26]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["2032"],"URL":"https:\/\/doi.org\/10.1007\/s00701-014-2032-x","relation":{},"ISSN":["0001-6268","0942-0940"],"issn-type":[{"value":"0001-6268","type":"print"},{"value":"0942-0940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,26]]}}}