{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:15:58Z","timestamp":1773285358030,"version":"3.50.1"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T00:00:00Z","timestamp":1397779200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neurochir"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1007\/s00701-014-2089-6","type":"journal-article","created":{"date-parts":[[2014,4,17]],"date-time":"2014-04-17T02:20:14Z","timestamp":1397701214000},"page":"1409-1418","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Transplantation of neurotrophin-3-expressing bone mesenchymal stem cells improves recovery in a rat model of spinal cord injury"],"prefix":"10.1007","volume":"156","author":[{"given":"Ling-Jie","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui-Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Ding","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,4,18]]},"reference":[{"key":"2089_CR1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3171\/spi.2004.1.3.0330","volume":"1","author":"A Bakshi","year":"2004","unstructured":"Bakshi A, Hunter C, Swanger S, Lepore A, Fischer I (2004) Minimally invasive delivery of stem cells for spinal cord injury: advantages of the lumbar puncture technique. J Neurosurg Spine 1:330\u2013337","journal-title":"J Neurosurg Spine"},{"key":"2089_CR2","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1096\/fj.01-0467fje","volume":"16","author":"R Barouch","year":"2002","unstructured":"Barouch R, Schwartz M (2002) Autoreactive T cells induce neurotrophin production by immune and neural cells in injured rat optic nerve: implications for protective autoimmunity. FASEB J 16:1304\u20131306","journal-title":"FASEB J"},{"key":"2089_CR3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/neu.1995.12.1","volume":"12","author":"DM Basso","year":"1995","unstructured":"Basso DM, Beattie MS, Bresnahan JC (1995) A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 12:1\u201321","journal-title":"J Neurotrauma"},{"key":"2089_CR4","doi-asserted-by":"crossref","first-page":"6303","DOI":"10.4049\/jimmunol.162.11.6303","volume":"162","author":"M Besser","year":"1999","unstructured":"Besser M, Wank R (1999) Cutting edge: clonally restricted production of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3 mRNA by human immune cells and Th1\/Th2-polarized expression of their receptors. J Immunol 162:6303\u20136306","journal-title":"J Immunol"},{"key":"2089_CR5","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S1474-4422(02)00040-6","volume":"1","author":"M Chopp","year":"2002","unstructured":"Chopp M, Li Y (2002) Treatment of neural injury with marrow stromal cells. Lancet Neurol 1:92\u2013100","journal-title":"Lancet Neurol"},{"key":"2089_CR6","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3171\/jns.1994.80.1.0097","volume":"80","author":"S Constantini","year":"1994","unstructured":"Constantini S, Young W (1994) The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats. J Neurosurg 80:97\u2013111","journal-title":"J Neurosurg"},{"key":"2089_CR7","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.expneurol.2005.10.029","volume":"198","author":"L Crigler","year":"2006","unstructured":"Crigler L, Robey RC, Asawachaicharn A, Gaupp D, Phinney DG (2006) Human mesenchymal stem cell subpopulations express a variety of neuro-regulatory molecules and promote neuronal cell survival and neuritogenesis. Exp Neurol 198:54\u201364","journal-title":"Exp Neurol"},{"key":"2089_CR8","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1006\/nbdi.2000.0318","volume":"7","author":"KD Dougherty","year":"2000","unstructured":"Dougherty KD, Dreyfus CF, Black IB (2000) Brain-derived neurotrophic factor in astrocytes, oligodendrocytes, and microglia\/macrophages after spinal cord injury. Neurobiol Dis 7:574\u2013585","journal-title":"Neurobiol Dis"},{"key":"2089_CR9","doi-asserted-by":"crossref","first-page":"e51706","DOI":"10.1371\/journal.pone.0051706","volume":"7","author":"M Douglas-Escobar","year":"2012","unstructured":"Douglas-Escobar M, Rossignol C, Steindler D, Zheng T, Weiss MD (2012) Neurotrophin-induced migration and neuronal differentiation of multipotent astrocytic stem cells in vitro. PLoS ONE 7:e51706","journal-title":"PLoS ONE"},{"key":"2089_CR10","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1523\/JNEUROSCI.16-08-02508.1996","volume":"16","author":"S Elkabes","year":"1996","unstructured":"Elkabes S, DiCicco-Bloom EM, Black IB (1996) Brain microglia\/macrophages express neurotrophins that selectively regulate microglial proliferation and function. J Neurosci 16:2508\u20132521","journal-title":"J Neurosci"},{"key":"2089_CR11","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.neulet.2004.05.080","volume":"366","author":"Y Fujiwara","year":"2004","unstructured":"Fujiwara Y, Tanaka N, Ishida O, Fujimoto Y, Murakami T, Kajihara H, Yasunaga Y, Ochi M (2004) Intravenously injected neural progenitor cells of transgenic rats can migrate to the injured spinal cord and differentiate into neurons, astrocytes and oligodendrocytes. Neurosci Lett 366:287\u2013291","journal-title":"Neurosci Lett"},{"key":"2089_CR12","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1146\/annurev.neuro.23.1.579","volume":"23","author":"JL Goldberg","year":"2000","unstructured":"Goldberg JL, Barres BA (2000) The relationship between neuronal survival and regeneration. Annu Rev Neurosci 23:579\u2013612","journal-title":"Annu Rev Neurosci"},{"key":"2089_CR13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/sj.sc.3101943","volume":"45","author":"JS Guo","year":"2007","unstructured":"Guo JS, Zeng YS, Li HB, Huang WL, Liu RY, Li XB, Ding Y, Wu LZ, Cai DZ (2007) Cotransplant of neural stem cells and NT-3 gene modified Schwann cells promote the recovery of transected spinal cord injury. Spinal Cord 45:15\u201324","journal-title":"Spinal Cord"},{"key":"2089_CR14","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1089\/scd.2011.0596","volume":"21","author":"GW Hawryluk","year":"2012","unstructured":"Hawryluk GW, Mothe A, Wang J, Wang S, Tator C, Fehlings MG (2012) An in vivo characterization of trophic factor production following neural precursor cell or bone marrow stromal cell transplantation for spinal cord injury. Stem Cells Dev 21:2222\u20132238","journal-title":"Stem Cells Dev"},{"key":"2089_CR15","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1073\/pnas.042678299","volume":"99","author":"CP Hofstetter","year":"2002","unstructured":"Hofstetter CP, Schwarz EJ, Hess D, Widenfalk J, El Manira A, Prockop DJ, Olson L (2002) Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery. Proc Natl Acad Sci U S A 99:2199\u20132204","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2089_CR16","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1634\/stemcells.22-3-415","volume":"22","author":"JF Ji","year":"2004","unstructured":"Ji JF, He BP, Dheen ST, Tay SS (2004) Interactions of chemokines and chemokine receptors mediate the migration of mesenchymal stem cells to the impaired site in the brain after hypoglossal nerve injury. Stem Cells 22:415\u2013427","journal-title":"Stem Cells"},{"key":"2089_CR17","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1002\/bit.22476","volume":"104","author":"PJ Johnson","year":"2009","unstructured":"Johnson PJ, Parker SR, Sakiyama-Elbert SE (2009) Controlled release of neurotrophin-3 from fibrin-based tissue engineering scaffolds enhances neural fiber sprouting following subacute spinal cord injury. Biotechnol Bioeng 104:1207\u20131214","journal-title":"Biotechnol Bioeng"},{"key":"2089_CR18","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1097\/BRS.0b013e318059afab","volume":"32","author":"N Kamei","year":"2007","unstructured":"Kamei N, Tanaka N, Oishi Y, Hamasaki T, Nakanishi K, Sakai N, Ochi M (2007) BDNF, NT-3, and NGF released from transplanted neural progenitor cells promote corticospinal axon growth in organotypic cocultures. Spine (Phila Pa 1976) 32:1272\u20131278","journal-title":"Spine (Phila Pa 1976)"},{"key":"2089_CR19","doi-asserted-by":"crossref","first-page":"412","DOI":"10.3171\/spi.2007.6.5.412","volume":"6","author":"N Kamei","year":"2007","unstructured":"Kamei N, Tanaka N, Oishi Y, Ishikawa M, Hamasaki T, Nishida K, Nakanishi K, Sakai N, Ochi M (2007) Bone marrow stromal cells promoting corticospinal axon growth through the release of humoral factors in organotypic cocultures in neonatal rats. J Neurosurg Spine 6:412\u2013419","journal-title":"J Neurosurg Spine"},{"key":"2089_CR20","doi-asserted-by":"crossref","first-page":"4492","DOI":"10.2174\/092986710794182971","volume":"17","author":"EM Kan","year":"2010","unstructured":"Kan EM, Ling EA, Lu J (2010) Stem cell therapy for spinal cord injury. Curr Med Chem 17:4492\u20134510","journal-title":"Curr Med Chem"},{"key":"2089_CR21","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3346\/jkms.2012.27.6.586","volume":"27","author":"ES Kang","year":"2012","unstructured":"Kang ES, Ha KY, Kim YH (2012) Fate of transplanted bone marrow derived mesenchymal stem cells following spinal cord injury in rats by transplantation routes. J Korean Med Sci 27:586\u2013593","journal-title":"J Korean Med Sci"},{"key":"2089_CR22","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2217\/rme.11.121","volume":"7","author":"S Kubinova","year":"2012","unstructured":"Kubinova S, Sykova E (2012) Biomaterials combined with cell therapy for treatment of spinal cord injury. Regen Med 7:207\u2013224","journal-title":"Regen Med"},{"key":"2089_CR23","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1432-1033.1994.tb19047.x","volume":"223","author":"MA Laurenzi","year":"1994","unstructured":"Laurenzi MA, Barbany G, Timmusk T, Lindgren JA, Persson H (1994) Expression of mRNA encoding neurotrophins and neurotrophin receptors in rat thymus, spleen tissue and immunocompetent cells. Regulation of neurotrophin-4 mRNA expression by mitogens and leukotriene B4. Eur J Biochem 223:733\u2013741","journal-title":"Eur J Biochem"},{"key":"2089_CR24","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s10571-010-9633-6","volume":"31","author":"Y Li","year":"2011","unstructured":"Li Y, Zhang WM, Wang TH (2011) Optimal location and time for neural stem cell transplantation into transected rat spinal cord. Cell Mol Neurobiol 31:407\u2013414","journal-title":"Cell Mol Neurobiol"},{"key":"2089_CR25","doi-asserted-by":"crossref","first-page":"e63444","DOI":"10.1371\/journal.pone.0063444","volume":"8","author":"WP Lin","year":"2013","unstructured":"Lin WP, Chen XW, Zhang LQ, Wu CY, Huang ZD, Lin JH (2013) Effect of neuroglobin genetically modified bone marrow mesenchymal stem cells transplantation on spinal cord injury in rabbits. PLoS ONE 8:e63444","journal-title":"PLoS ONE"},{"key":"2089_CR26","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1179\/1743132810Y.0000000031","volume":"33","author":"WG Liu","year":"2011","unstructured":"Liu WG, Wang ZY, Huang ZS (2011) Bone marrow-derived mesenchymal stem cells expressing the bFGF transgene promote axon regeneration and functional recovery after spinal cord injury in rats. Neurol Res 33:686\u2013693","journal-title":"Neurol Res"},{"key":"2089_CR27","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.nurt.2010.07.002","volume":"7","author":"DJ Loane","year":"2010","unstructured":"Loane DJ, Byrnes KR (2010) Role of microglia in neurotrauma. Neurotherapeutics 7:366\u2013377","journal-title":"Neurotherapeutics"},{"key":"2089_CR28","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.expneurol.2007.03.029","volume":"209","author":"JM Massey","year":"2008","unstructured":"Massey JM, Amps J, Viapiano MS, Matthews RT, Wagoner MR, Whitaker CM, Alilain W, Yonkof AL, Khalyfa A, Cooper NG, Silver J, Onifer SM (2008) Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome by chondroitinase ABC and neurotrophin-3. Exp Neurol 209:426\u2013445","journal-title":"Exp Neurol"},{"key":"2089_CR29","first-page":"133","volume":"143","author":"M Murray","year":"2004","unstructured":"Murray M (2004) Cellular transplants: steps toward restoration of function in spinal injured animals. Prog Brain Res 143:133\u2013146","journal-title":"Prog Brain Res"},{"key":"2089_CR30","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.brainres.2004.11.055","volume":"1035","author":"B Neuhuber","year":"2005","unstructured":"Neuhuber B, Timothy Himes B, Shumsky JS, Gallo G, Fischer I (2005) Axon growth and recovery of function supported by human bone marrow stromal cells in the injured spinal cord exhibit donor variations. Brain Res 1035:73\u201385","journal-title":"Brain Res"},{"key":"2089_CR31","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1097\/01.wnr.0000227993.07799.a2","volume":"17","author":"K Nishida","year":"2006","unstructured":"Nishida K, Tanaka N, Nakanishi K, Kamei N, Hamasaki T, Yanada S, Mochizuki Y, Ochi M (2006) Magnetic targeting of bone marrow stromal cells into spinal cord: through cerebrospinal fluid. Neuroreport 17:1269\u20131272","journal-title":"Neuroreport"},{"key":"2089_CR32","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.expneurol.2004.01.021","volume":"187","author":"M Ohta","year":"2004","unstructured":"Ohta M, Suzuki Y, Noda T, Ejiri Y, Dezawa M, Kataoka K, Chou H, Ishikawa N, Matsumoto N, Iwashita Y, Mizuta E, Kuno S, Ide C (2004) Bone marrow stromal cells infused into the cerebrospinal fluid promote functional recovery of the injured rat spinal cord with reduced cavity formation. Exp Neurol 187:266\u2013278","journal-title":"Exp Neurol"},{"key":"2089_CR33","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S1084-9521(03)00011-9","volume":"14","author":"H Okano","year":"2003","unstructured":"Okano H, Ogawa Y, Nakamura M, Kaneko S, Iwanama A, Toyama Y (2003) Transplantation of neural stem cells into the spinal cord after injury. Semin Cell Dev Biol 14:191\u2013198","journal-title":"Semin Cell Dev Biol"},{"key":"2089_CR34","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.surneu.2007.09.043","volume":"70","author":"AM Parr","year":"2008","unstructured":"Parr AM, Kulbatski I, Wang XH, Keating A, Tator CH (2008) Fate of transplanted adult neural stem\/progenitor cells and bone marrow-derived mesenchymal stromal cells in the injured adult rat spinal cord and impact on functional recovery. Surg Neurol 70:600\u2013607, discussion 607","journal-title":"Surg Neurol"},{"key":"2089_CR35","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/sj.bmt.1705757","volume":"40","author":"AM Parr","year":"2007","unstructured":"Parr AM, Tator CH, Keating A (2007) Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury. Bone Marrow Transplant 40:609\u2013619","journal-title":"Bone Marrow Transplant"},{"key":"2089_CR36","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0959-4388(00)00208-7","volume":"11","author":"A Patapoutian","year":"2001","unstructured":"Patapoutian A, Reichardt LF (2001) Trk receptors: mediators of neurotrophin action. Curr Opin Neurobiol 11:272\u2013280","journal-title":"Curr Opin Neurobiol"},{"key":"2089_CR37","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nbt1189","volume":"24","author":"AD Pyle","year":"2006","unstructured":"Pyle AD, Lock LF, Donovan PJ (2006) Neurotrophins mediate human embryonic stem cell survival. Nat Biotechnol 24:344\u2013350","journal-title":"Nat Biotechnol"},{"key":"2089_CR38","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/(SICI)1098-2779(1998)4:3<187::AID-MRDD6>3.0.CO;2-L","volume":"4","author":"AG Rabchevsky","year":"1998","unstructured":"Rabchevsky AG, Streit WJ (1998) Role of microglia in post injury repair and regeneration of the CNS. Ment Retard Dev Disabil Res Rev 4:187\u2013192","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"2089_CR39","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.expneurol.2004.01.022","volume":"187","author":"JM Rosenstein","year":"2004","unstructured":"Rosenstein JM, Krum JM (2004) New roles for VEGF in nervous tissue\u2014beyond blood vessels. Exp Neurol 187:246\u2013253","journal-title":"Exp Neurol"},{"key":"2089_CR40","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nrneurol.2010.73","volume":"6","author":"V Sahni","year":"2010","unstructured":"Sahni V, Kessler JA (2010) Stem cell therapies for spinal cord injury. Nat Rev Neurol 6:363\u2013372","journal-title":"Nat Rev Neurol"},{"key":"2089_CR41","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1097\/BRS.0b013e3181eb9fb0","volume":"36","author":"H Sasaki","year":"2011","unstructured":"Sasaki H, Tanaka N, Nakanishi K, Nishida K, Hamasaki T, Yamada K, Ochi M (2011) Therapeutic effects with magnetic targeting of bone marrow stromal cells in a rat spinal cord injury model. Spine (Phila Pa 1976) 36:933\u2013938","journal-title":"Spine (Phila Pa 1976)"},{"key":"2089_CR42","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1097\/01.brs.0000138273.02820.0a","volume":"29","author":"K Satake","year":"2004","unstructured":"Satake K, Lou J, Lenke LG (2004) Migration of mesenchymal stem cells through cerebrospinal fluid into injured spinal cord tissue. Spine (Phila Pa 1976) 29:1971\u20131979","journal-title":"Spine (Phila Pa 1976)"},{"key":"2089_CR43","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.jocn.2012.03.002","volume":"19","author":"MD Schiller","year":"2012","unstructured":"Schiller MD, Mobbs RJ (2012) The historical evolution of the management of spinal cord injury. J Clin Neurosci 19:1348\u20131353","journal-title":"J Clin Neurosci"},{"key":"2089_CR44","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.brainres.2011.03.019","volume":"1391","author":"AJ Shang","year":"2011","unstructured":"Shang AJ, Hong SQ, Xu Q, Wang HY, Yang Y, Wang ZF, Xu BN, Jiang XD, Xu RX (2011) NT-3-secreting human umbilical cord mesenchymal stromal cell transplantation for the treatment of acute spinal cord injury in rats. Brain Res 1391:102\u2013113","journal-title":"Brain Res"},{"key":"2089_CR45","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.acra.2009.03.016","volume":"16","author":"J Shen","year":"2009","unstructured":"Shen J, Zhong XM, Duan XH, Cheng LN, Hong GB, Bi XB, Liu Y (2009) Magnetic resonance imaging of mesenchymal stem cells labeled with dual (MR and fluorescence) agents in rat spinal cord injury. Acad Radiol 16:1142\u20131154","journal-title":"Acad Radiol"},{"key":"2089_CR46","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.3727\/096368912X657495","volume":"22","author":"L Shen","year":"2013","unstructured":"Shen L, Zeng W, Wu YX, Hou CL, Chen W, Yang MC, Li L, Zhang YF, Zhu CH (2013) Neurotrophin-3 accelerates wound healing in diabetic mice by promoting a paracrine response in mesenchymal stem cells. Cell Transplant 22:1011\u20131021","journal-title":"Cell Transplant"},{"key":"2089_CR47","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0014-4886(03)00398-4","volume":"184","author":"JS Shumsky","year":"2003","unstructured":"Shumsky JS, Tobias CA, Tumolo M, Long WD, Giszter SF, Murray M (2003) Delayed transplantation of fibroblasts genetically modified to secrete BDNF and NT-3 into a spinal cord injury site is associated with limited recovery of function. Exp Neurol 184:114\u2013130","journal-title":"Exp Neurol"},{"key":"2089_CR48","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.resp.2009.08.008","volume":"169","author":"GC Sieck","year":"2009","unstructured":"Sieck GC, Mantilla CB (2009) Role of neurotrophins in recovery of phrenic motor function following spinal cord injury. Respir Physiol Neurobiol 169:218\u2013225","journal-title":"Respir Physiol Neurobiol"},{"key":"2089_CR49","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1634\/stemcells.2005-0271","volume":"24","author":"BR Son","year":"2006","unstructured":"Son BR, Marquez-Curtis LA, Kucia M, Wysoczynski M, Turner AR, Ratajczak J, Ratajczak MZ, Janowska-Wieczorek A (2006) Migration of bone marrow and cord blood mesenchymal stem cells in vitro is regulated by stromal-derived factor-1-CXCR4 and hepatocyte growth factor-c-met axes and involves matrix metalloproteinases. Stem Cells 24:1254\u20131264","journal-title":"Stem Cells"},{"key":"2089_CR50","doi-asserted-by":"crossref","first-page":"e1707","DOI":"10.1371\/journal.pone.0001707","volume":"3","author":"XY Song","year":"2008","unstructured":"Song XY, Li F, Zhang FH, Zhong JH, Zhou XF (2008) Peripherally-derived BDNF promotes regeneration of ascending sensory neurons after spinal cord injury. PLoS ONE 3:e1707","journal-title":"PLoS ONE"},{"key":"2089_CR51","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1196\/annals.1334.014","volume":"1049","author":"E Sykova","year":"2005","unstructured":"Sykova E, Jendelova P (2005) Magnetic resonance tracking of implanted adult and embryonic stem cells in injured brain and spinal cord. Ann N Y Acad Sci 1049:146\u2013160","journal-title":"Ann N Y Acad Sci"},{"key":"2089_CR52","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1089\/neu.2009.1177","volume":"28","author":"W Tetzlaff","year":"2011","unstructured":"Tetzlaff W, Okon EB, Karimi-Abdolrezaee S, Hill CE, Sparling JS, Plemel JR, Plunet WT, Tsai EC, Baptiste D, Smithson LJ, Kawaja MD, Fehlings MG, Kwon BK (2011) A systematic review of cellular transplantation therapies for spinal cord injury. J Neurotrauma 28:1611\u20131682","journal-title":"J Neurotrauma"},{"key":"2089_CR53","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nrn1955","volume":"7","author":"S Thuret","year":"2006","unstructured":"Thuret S, Moon LD, Gage FH (2006) Therapeutic interventions after spinal cord injury. Nat Rev Neurosci 7:628\u2013643","journal-title":"Nat Rev Neurosci"},{"key":"2089_CR54","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.neuint.2007.02.009","volume":"50","author":"GR Ullal","year":"2007","unstructured":"Ullal GR, Michalski B, Xu B, Racine RJ, Fahnestock M (2007) NT-3 modulates BDNF and proBDNF levels in naive and kindled rat hippocampus. Neurochem Int 50:866\u2013871","journal-title":"Neurochem Int"},{"key":"2089_CR55","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.2147\/IJN.S32824","volume":"7","author":"V Vanecek","year":"2012","unstructured":"Vanecek V, Zablotskii V, Forostyak S, R\u016f\u017ei\u010dka J, Herynek V, Babi\u010d M, Jendelov\u00e1 P, Kubinov\u00e1 S, Dejneka A, Sykov\u00e1 E (2012) Highly efficient magnetic targeting of mesenchymal stem cells in spinal cord injury. Int J Nanomedicine 7:3719\u20133730","journal-title":"Int J Nanomedicine"},{"key":"2089_CR56","first-page":"197","volume":"26","author":"RE White","year":"2008","unstructured":"White RE, Jakeman LB (2008) Don\u2019t fence me in: harnessing the beneficial roles of astrocytes for spinal cord repair. Restor Neurol Neurosci 26:197\u2013214","journal-title":"Restor Neurol Neurosci"},{"key":"2089_CR57","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0306-4522(03)00399-3","volume":"120","author":"J Widenfalk","year":"2003","unstructured":"Widenfalk J, Lipson A, Jubran M, Hofstetter C, Ebendal T, Cao Y, Olson L (2003) Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury. Neuroscience 120:951\u2013960","journal-title":"Neuroscience"},{"key":"2089_CR58","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/stem.570","volume":"29","author":"KT Wright","year":"2011","unstructured":"Wright KT, El Masri W, Osman A, Chowdhury J, Johnson WE (2011) Concise review: bone marrow for the treatment of spinal cord injury: mechanisms and clinical applications. Stem Cells 29:169\u2013178","journal-title":"Stem Cells"},{"key":"2089_CR59","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/jnr.10587","volume":"72","author":"S Wu","year":"2003","unstructured":"Wu S, Suzuki Y, Ejiri Y, Noda T, Bai H, Kitada M, Kataoka K, Ohta M, Chou H, Ide C (2003) Bone marrow stromal cells enhance differentiation of cocultured neurosphere cells and promote regeneration of injured spinal cord. J Neurosci Res 72:343\u2013351","journal-title":"J Neurosci Res"},{"key":"2089_CR60","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neulet.2005.12.009","volume":"397","author":"MM Yaghoobi","year":"2006","unstructured":"Yaghoobi MM, Mowla SJ (2006) Differential gene expression pattern of neurotrophins and their receptors during neuronal differentiation of rat bone marrow stromal cells. Neurosci Lett 397:149\u2013154","journal-title":"Neurosci Lett"},{"key":"2089_CR61","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.brainres.2010.08.072","volume":"1359","author":"W Zhang","year":"2010","unstructured":"Zhang W, Yan Q, Zeng YS, Zhang XB, Xiong Y, Wang JM, Chen SJ, Li Y, Bruce IC, Wu W (2010) Implantation of adult bone marrow-derived mesenchymal stem cells transfected with the neurotrophin-3 gene and pretreated with retinoic acid in completely transected spinal cord. Brain Res 1359:256\u2013271","journal-title":"Brain Res"},{"key":"2089_CR62","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.jcyt.2013.04.004","volume":"15","author":"T Zhao","year":"2013","unstructured":"Zhao T, Yan W, Xu K, Qi Y, Dai X, Shi Z (2013) Combined treatment with platelet-rich plasma and brain-derived neurotrophic factor-overexpressing bone marrow stromal cells supports axonal remyelination in a rat spinal cord hemi-section model. Cytotherapy 15:792\u2013804","journal-title":"Cytotherapy"}],"container-title":["Acta Neurochirurgica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00701-014-2089-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00701-014-2089-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00701-014-2089-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T05:46:15Z","timestamp":1689140775000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00701-014-2089-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,18]]},"references-count":62,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["2089"],"URL":"https:\/\/doi.org\/10.1007\/s00701-014-2089-6","relation":{},"ISSN":["0001-6268","0942-0940"],"issn-type":[{"value":"0001-6268","type":"print"},{"value":"0942-0940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,18]]}}}