{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T21:59:23Z","timestamp":1784671163814,"version":"3.55.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T00:00:00Z","timestamp":1542758400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neurochir"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1007\/s00701-018-3736-0","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T09:37:23Z","timestamp":1542793043000},"page":"119-127","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Long-term outcome of trans-sphenoidal surgery for Cushing\u2019s disease in Indian patients"],"prefix":"10.1007","volume":"161","author":[{"given":"S.","family":"Saini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kanwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Behari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3275-6673","authenticated-orcid":false,"given":"Subhash","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,11,21]]},"reference":[{"issue":"5","key":"3736_CR1","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s00701-007-1133-1","volume":"149","author":"JJ Acebes","year":"2007","unstructured":"Acebes JJ, Martino J, Masuet C, Montanya E, Soler J (2007) Early post-operative ACTH and cortisol as predictors of remission in Cushing\u2019s disease. Acta Neurochir 149(5):471\u2013477 discussion 477-9","journal-title":"Acta Neurochir"},{"issue":"4","key":"3736_CR2","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1530\/EJE-12-0921","volume":"168","author":"KI Alexandraki","year":"2013","unstructured":"Alexandraki KI, Kaltsas GA, Isidori AM et al (2013) Long-term remission and recurrence rates in Cushing\u2019s disease: predictive factors in a single-centre study. Eur J Endocrinol 168(4):639\u2013648","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"3736_CR3","doi-asserted-by":"publisher","first-page":"222","DOI":"10.14310\/horm.2002.1312","volume":"10","author":"AC Ammini","year":"2011","unstructured":"Ammini AC, Bhattacharya S, Sahoo JP et al (2011) Cushing\u2019s disease: results of treatment and factors affecting outcome. Hormones (Athens) 10(3):222\u2013229","journal-title":"Hormones (Athens)"},{"issue":"5","key":"3736_CR4","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1111\/j.1365-2265.2005.02380.x","volume":"63","author":"AB Atkinson","year":"2005","unstructured":"Atkinson AB, Kennedy A, Wiggam MI, McCance DR, Sheridan B (2005) Long-term remission rates after pituitary surgery for Cushing\u2019s disease: the need for long-term surveillance. Clin Endocrinol 63(5):549\u2013559","journal-title":"Clin Endocrinol"},{"issue":"11","key":"3736_CR5","first-page":"3114","volume":"80","author":"D Bochicchio","year":"1995","unstructured":"Bochicchio D, Losa M, Buchfelder M (1995) Factors influencing the immediate and late outcome of Cushing\u2019s disease treated by transsphenoidal surgery: a retrospective study by the European Cushing\u2019s Disease Survey Group. J Clin Endocrinol Metab 80(11):3114\u20133120","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"3736_CR6","first-page":"168","volume":"62","author":"F Cavagnini","year":"2001","unstructured":"Cavagnini F, Pecori Giraldi F (2001) Epidemiology and follow-up of Cushing\u2019s disease. Ann Endocrinol (Paris) 62(2):168\u2013172","journal-title":"Ann Endocrinol (Paris)"},{"issue":"1","key":"3736_CR7","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1227\/NEU.0b013e31822dda2c","volume":"70","author":"I Ciric","year":"2012","unstructured":"Ciric I, Zhao J-C, Du H, Findling JW, Molitch ME, Weiss RE, Refetoff S, Kerr WD, Meyer J (2012) Transsphenoidal surgery for Cushing disease: experience with 136 patients. Neurosurgery 70(1):70\u201380 discussion 80\u20131","journal-title":"Neurosurgery"},{"issue":"1","key":"3736_CR8","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.ecl.2014.10.010","volume":"44","author":"RF Dallapiazza","year":"2015","unstructured":"Dallapiazza RF, Jane JA (2015) Outcomes of endoscopic transsphenoidal pituitary surgery. Endocrinol Metab Clin N Am 44(1):105\u2013115","journal-title":"Endocrinol Metab Clin N Am"},{"issue":"2","key":"3736_CR9","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s11102-015-0646-5","volume":"18","author":"RF Dallapiazza","year":"2015","unstructured":"Dallapiazza RF, Oldfield EH, Jane JA (2015) Surgical management of Cushing\u2019s disease. Pituitary 18(2):211\u2013216","journal-title":"Pituitary"},{"issue":"2","key":"3736_CR10","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1530\/EJE-13-0634","volume":"170","author":"C Dimopoulou","year":"2014","unstructured":"Dimopoulou C, Schopohl J, Rachinger W, Buchfelder M, Honegger J, Reincke M, Stalla GK (2014) Long-term remission and recurrence rates after first and second transsphenoidal surgery for Cushing\u2019s disease: care reality in the Munich metropolitan region. Eur J Endocrinol 170(2):283\u2013292","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"3736_CR11","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1210\/jc.2005-1204","volume":"91","author":"F Esposito","year":"2006","unstructured":"Esposito F, Dusick JR, Cohan P, Moftakhar P, McArthur D, Wang C, Swerdloff RS, Kelly DF (2006) Clinical review: early morning cortisol levels as a predictor of remission after transsphenoidal surgery for Cushing\u2019s disease. J Clin Endocrinol Metab 91(1):7\u201313","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"3736_CR12","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.clineuro.2008.12.011","volume":"111","author":"E Fomekong","year":"2009","unstructured":"Fomekong E, Maiter D, Grandin C, Raftopoulos C (2009) Outcome of transsphenoidal surgery for Cushing\u2019s disease: a high remission rate in ACTH-secreting macroadenomas. Clin Neurol Neurosurg 111(5):442\u2013449","journal-title":"Clin Neurol Neurosurg"},{"issue":"8","key":"3736_CR13","doi-asserted-by":"publisher","first-page":"962","DOI":"10.4158\/EP171787.OR","volume":"23","author":"EB Geer","year":"2017","unstructured":"Geer EB, Shafiq I, Gordon MB et al (2017) Biochemical control during long-term follow-up of 230 adult patients with Cushing disease: a multicenter retrospective study. Endocr Pract 23(8):962\u2013970","journal-title":"Endocr Pract"},{"issue":"12","key":"3736_CR14","doi-asserted-by":"publisher","first-page":"6348","DOI":"10.1210\/jc.2003-032180","volume":"89","author":"GD Hammer","year":"2004","unstructured":"Hammer GD, Tyrrell JB, Lamborn KR, Applebury CB, Hannegan ET, Bell S, Rahl R, Lu A, Wilson CB (2004) Transsphenoidal microsurgery for Cushing\u2019s disease: initial outcome and long-term results. J Clin Endocrinol Metab 89(12):6348\u20136357","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"3736_CR15","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1210\/jc.2011-2957","volume":"97","author":"ZK Hassan-Smith","year":"2012","unstructured":"Hassan-Smith ZK, Sherlock M, Reulen RC, Arlt W, Ayuk J, Toogood AA, Cooper MS, Johnson AP, Stewart PM (2012) Outcome of Cushing\u2019s disease following transsphenoidal surgery in a single center over 20\u00a0years. J Clin Endocrinol Metab 97(4):1194\u20131201","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"3736_CR16","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3171\/JNS\/2008\/108\/01\/0009","volume":"108","author":"BM Hofmann","year":"2008","unstructured":"Hofmann BM, Hlavac M, Martinez R, Buchfelder M, M\u00fcller OA, Fahlbusch R (2008) Long-term results after microsurgery for Cushing disease: experience with 426 primary operations over 35\u00a0years. J Neurosurg 108(1):9\u201318","journal-title":"J Neurosurg"},{"issue":"4","key":"3736_CR17","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1111\/j.1365-2265.2011.04268.x","volume":"76","author":"J Honegger","year":"2012","unstructured":"Honegger J, Schmalisch K, Beuschlein F, Kaufmann S, Schnauder G, Naegele T, Psaras T (2012) Contemporary microsurgical concept for the treatment of Cushing\u2019s disease: endocrine outcome in 83 consecutive patients. Clin Endocrinol 76(4):560\u2013567","journal-title":"Clin Endocrinol"},{"issue":"2","key":"3736_CR18","first-page":"440","volume":"84","author":"C Invitti","year":"1999","unstructured":"Invitti C, Pecori Giraldi F, de Martin M, Cavagnini F (1999) Diagnosis and management of Cushing\u2019s syndrome: results of an Italian multicentre study. Study Group of the Italian Society of endocrinology on the pathophysiology of the hypothalamic-pituitary-adrenal axis. J Clin Endocrinol Metab 84(2):440\u2013448","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"3736_CR19","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1007\/s11102-017-0802-1","volume":"20","author":"PC Johnston","year":"2017","unstructured":"Johnston PC, Kennedy L, Hamrahian AH, Sandouk Z, Bena J, Hatipoglu B, Weil RJ (2017) Surgical outcomes in patients with Cushing\u2019s disease: the Cleveland clinic experience. Pituitary 20(4):430\u2013440","journal-title":"Pituitary"},{"issue":"9996","key":"3736_CR20","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/S0140-6736(14)61375-1","volume":"386","author":"A Lacroix","year":"2015","unstructured":"Lacroix A, Feelders RA, Stratakis CA, Nieman LK (2015) Cushing\u2019s syndrome. Lancet (London, England) 386(9996):913\u2013927","journal-title":"Lancet (London, England)"},{"issue":"3","key":"3736_CR21","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1210\/jc.2012-2893","volume":"98","author":"JK Lambert","year":"2013","unstructured":"Lambert JK, Goldberg L, Fayngold S, Kostadinov J, Post KD, Geer EB (2013) Predictors of mortality and long-term outcomes in treated Cushing\u2019s disease: a study of 346 patients. J Clin Endocrinol Metab 98(3):1022\u20131030","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"3736_CR22","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.1210\/jc.2011-0456","volume":"96","author":"JR Lindsay","year":"2011","unstructured":"Lindsay JR, Oldfield EH, Stratakis CA, Nieman LK (2011) The postoperative basal cortisol and CRH tests for prediction of long-term remission from Cushing\u2019s disease after transsphenoidal surgery. J Clin Endocrinol Metab 96(7):2057\u20132064","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"3736_CR23","doi-asserted-by":"publisher","first-page":"M33","DOI":"10.1530\/EJE-15-0464","volume":"173","author":"LK Nieman","year":"2015","unstructured":"Nieman LK (2015) Cushing\u2019s syndrome: update on signs, symptoms and biochemical screening. Eur J Endocrinol 173(4):M33\u2013M38","journal-title":"Eur J Endocrinol"},{"issue":"8","key":"3736_CR24","doi-asserted-by":"publisher","first-page":"2807","DOI":"10.1210\/jc.2015-1818","volume":"100","author":"LK Nieman","year":"2015","unstructured":"Nieman LK, BMK B, Findling JW, Murad MH, Newell-Price J, Savage MO, Tabarin A, Endocrine Society (2015) Treatment of Cushing\u2019s syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 100(8):2807\u20132831","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"3736_CR25","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1210\/jc.2007-2013","volume":"93","author":"CG Patil","year":"2008","unstructured":"Patil CG, Prevedello DM, Lad SP, Vance ML, Thorner MO, Katznelson L, Laws ER (2008) Late recurrences of Cushing\u2019s disease after initial successful transsphenoidal surgery. J Clin Endocrinol Metab 93(2):358\u2013362","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"3736_CR26","doi-asserted-by":"publisher","first-page":"5858","DOI":"10.1210\/jc.2003-030751","volume":"88","author":"AM Pereira","year":"2003","unstructured":"Pereira AM, van Aken MO, van Dulken H, Schutte PJ, Biermasz NR, Smit JWA, Roelfsema F, Romijn JA (2003) Long-term predictive value of postsurgical cortisol concentrations for cure and risk of recurrence in Cushing\u2019s disease. J Clin Endocrinol Metab 88(12):5858\u20135864","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"3736_CR27","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1210\/er.2013-1048","volume":"36","author":"R Pivonello","year":"2015","unstructured":"Pivonello R, De Leo M, Cozzolino A, Colao A (2015) The treatment of Cushing\u2019s disease. Endocr Rev 36(4):385\u2013486","journal-title":"Endocr Rev"},{"issue":"4","key":"3736_CR28","doi-asserted-by":"publisher","first-page":"751","DOI":"10.3171\/JNS\/2008\/109\/10\/0751","volume":"109","author":"DM Prevedello","year":"2008","unstructured":"Prevedello DM, Pouratian N, Sherman J, Jane JA, Vance ML, Lopes MB, Laws ER (2008) Management of Cushing\u2019s disease: outcome in patients with microadenoma detected on pituitary magnetic resonance imaging. J Neurosurg 109(4):751\u2013759","journal-title":"J Neurosurg"},{"issue":"4","key":"3736_CR29","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1046\/j.1365-2265.2002.01511.x","volume":"56","author":"DA Rees","year":"2002","unstructured":"Rees DA, Hanna FWF, Davies JS, Mills RG, Vafidis J, Scanlon MF (2002) Long-term follow-up results of transsphenoidal surgery for Cushing\u2019s disease in a single centre using strict criteria for remission. Clin Endocrinol 56(4):541\u2013551","journal-title":"Clin Endocrinol"},{"issue":"1","key":"3736_CR30","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s00701-015-2638-7","volume":"158","author":"S Sarkar","year":"2016","unstructured":"Sarkar S, Rajaratnam S, Chacko G, Mani S, Hesargatta AS, Chacko AG (2016) Pure endoscopic transsphenoidal surgery for functional pituitary adenomas: outcomes with Cushing\u2019s disease. Acta Neurochir 158(1):77\u201386 discussion 86","journal-title":"Acta Neurochir"},{"key":"3736_CR31","first-page":"919","volume":"54","author":"NS Shah","year":"2006","unstructured":"Shah NS, Goel AH, Nagpal RD, Menon PS (2006) Cushing\u2019s disease: management outcome in a tertiary care centre. J Assoc Physicians India 54:919\u2013922","journal-title":"J Assoc Physicians India"},{"issue":"1","key":"3736_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3171\/jns.2001.95.1.0001","volume":"95","author":"NE Simmons","year":"2001","unstructured":"Simmons NE, Alden TD, Thorner MO, Laws ER (2001) Serum cortisol response to transsphenoidal surgery for Cushing disease. J Neurosurg 95(1):1\u20138","journal-title":"J Neurosurg"},{"issue":"2","key":"3736_CR33","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1227\/NEU.0b013e31827b966a","volume":"72","author":"RM Starke","year":"2013","unstructured":"Starke RM, Reames DL, Chen C-J, Laws ER, Jane JA (2013) Endoscopic transsphenoidal surgery for Cushing disease: techniques, outcomes, and predictors of remission. Neurosurgery 72(2):240\u2013247 discussion 247","journal-title":"Neurosurgery"},{"issue":"2","key":"3736_CR34","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1210\/jc.2009-1672","volume":"95","author":"E Valassi","year":"2010","unstructured":"Valassi E, Biller BMK, Swearingen B, Pecori Giraldi F, Losa M, Mortini P, Hayden D, Cavagnini F, Klibanski A (2010) Delayed remission after transsphenoidal surgery in patients with Cushing\u2019s disease. J Clin Endocrinol Metab 95(2):601\u2013610","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"3736_CR35","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1530\/EJE-11-0272","volume":"165","author":"E Valassi","year":"2011","unstructured":"Valassi E, Santos A, Yaneva M et al (2011) The European registry on Cushing\u2019s syndrome: 2-year experience. Baseline demographic and clinical characteristics. Eur J Endocrinol 165(3):383\u2013392","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"3736_CR36","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1530\/EJE-13-0325","volume":"169","author":"MAEM Wagenmakers","year":"2013","unstructured":"Wagenmakers MAEM, Boogaarts HD, Roerink SHPP, Timmers HJLM, Stikkelbroeck NMML, Smit JWA, van Lindert EJ, Netea-Maier RT, Grotenhuis JA, Hermus ARMM (2013) Endoscopic transsphenoidal pituitary surgery: a good and safe primary treatment option for Cushing\u2019s disease, even in case of macroadenomas or invasive adenomas. Eur J Endocrinol 169(3):329\u2013337","journal-title":"Eur J Endocrinol"},{"issue":"8","key":"3736_CR37","doi-asserted-by":"publisher","first-page":"4963","DOI":"10.1210\/jc.2005-0070","volume":"90","author":"YS Woo","year":"2005","unstructured":"Woo YS, Isidori AM, Wat WZ, Kaltsas GA, Afshar F, Sabin I, Jenkins PJ, Monson JP, Besser GM, Grossman AB (2005) Clinical and biochemical characteristics of adrenocorticotropin-secreting macroadenomas. J Clin Endocrinol Metab 90(8):4963\u20134969","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Acta Neurochirurgica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00701-018-3736-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00701-018-3736-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00701-018-3736-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T19:38:37Z","timestamp":1574278717000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00701-018-3736-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,21]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["3736"],"URL":"https:\/\/doi.org\/10.1007\/s00701-018-3736-0","relation":{},"ISSN":["0001-6268","0942-0940"],"issn-type":[{"value":"0001-6268","type":"print"},{"value":"0942-0940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,21]]},"assertion":[{"value":"13 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}