{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:03:02Z","timestamp":1777471382619,"version":"3.51.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T00:00:00Z","timestamp":1579046400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T00:00:00Z","timestamp":1579046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neurochir"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1007\/s00701-019-04132-8","type":"journal-article","created":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T07:02:41Z","timestamp":1579071761000},"page":"581-592","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Detection of spreading depolarizations in a middle cerebral artery occlusion model in swine"],"prefix":"10.1007","volume":"162","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2756-7731","authenticated-orcid":false,"given":"Modar","family":"Kentar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Mann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Sahm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Olivares-Rivera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renan","family":"Sanchez-Porras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Zerelles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver W.","family":"Sakowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas W.","family":"Unterberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8976-5549","authenticated-orcid":false,"given":"Edgar","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,1,15]]},"reference":[{"issue":"2","key":"4132_CR1","doi-asserted-by":"publisher","first-page":"e0172637","DOI":"10.1371\/journal.pone.0172637","volume":"12","author":"F Arikan","year":"2017","unstructured":"Arikan F, Mart\u00ednez-Valverde T, S\u00e1nchez-Guerrero \u00c1 et al (2017) Malignant infarction of the middle cerebral artery in a porcine model. A pilot study. PLoS One 12(2):e0172637","journal-title":"PLoS One"},{"issue":"6 Suppl 1","key":"4132_CR2","doi-asserted-by":"publisher","first-page":"S87","DOI":"10.1161\/STROKEAHA.112.680264","volume":"44","author":"C Ayata","year":"2013","unstructured":"Ayata C (2013) Spreading depression and neurovascular coupling. Stroke J Cereb Circ 44(6 Suppl 1):S87\u2013S89","journal-title":"Stroke J Cereb Circ"},{"issue":"6","key":"4132_CR3","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1523\/JNEUROSCI.5137-07.2008","volume":"28","author":"S Baltan","year":"2008","unstructured":"Baltan S, Besancon EF, Mbow B, Ye Z, Hamner MA, Ransom BR (2008) White matter vulnerability to ischemic injury increases with age because of enhanced excitotoxicity. J Neurosci 28(6):1479\u20131489","journal-title":"J Neurosci"},{"key":"4132_CR4","unstructured":"Carlson AP, Abbas M, Alunday RL, Qeadan F, Shuttleworth CW (2018) Spreading depolarization in acute brain injury inhibited by ketamine: a prospective, randomized, multiple crossover trial. J Neurosurg:1\u20137"},{"issue":"1","key":"4132_CR5","first-page":"36","volume":"1","author":"YD Cheng","year":"2004","unstructured":"Cheng YD, Al-Khoury L, Zivin JA (2004) Neuroprotection for ischemic stroke: two decades of success and failure. NeuroRx J Am Soc Exp Neurother 1(1):36\u201345","journal-title":"NeuroRx J Am Soc Exp Neurother"},{"issue":"4","key":"4132_CR6","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/nm.2333","volume":"17","author":"JP Dreier","year":"2011","unstructured":"Dreier JP (2011) The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease. Nat Med 17(4):439\u2013447","journal-title":"Nat Med"},{"issue":"5","key":"4132_CR7","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1177\/0271678X16654496","volume":"37","author":"JP Dreier","year":"2017","unstructured":"Dreier JP, Fabricius M, Ayata C et al (2017) Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: review and recommendations of the COSBID research group. J Cereb Blood Flow Metab 37(5):1595\u20131625","journal-title":"J Cereb Blood Flow Metab"},{"key":"4132_CR8","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.physbeh.2013.11.004","volume":"125","author":"KJ Duberstein","year":"2014","unstructured":"Duberstein KJ, Platt SR, Holmes SP, Dove CR, Howerth EW, Kent M, Stice SL, Hill WD, Hess DC, West FD (2014) Gait analysis in a pre- and post-ischemic stroke biomedical pig model. Physiol Behav 125:8\u201316","journal-title":"Physiol Behav"},{"issue":"4","key":"4132_CR9","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/0013-4694(87)90213-6","volume":"66","author":"NA Gorelova","year":"1987","unstructured":"Gorelova NA, Koroleva VI, Amemori T, Pavl\u00edk V, Bur\u0115s J (1987) Ketamine blockade of cortical spreading depression in rats. Electroencephalogr Clin Neurophysiol 66(4):440\u2013447","journal-title":"Electroencephalogr Clin Neurophysiol"},{"issue":"5","key":"4132_CR10","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1177\/0271678X16654495","volume":"37","author":"Jed A Hartings","year":"2016","unstructured":"Hartings JA, Shuttleworth CW, Kirov SA et al (2016) The continuum of spreading depolarizations in acute cortical lesion development: Examining Le\u00e3o\u2019s legacy. J Cereb Blood Flow Metab. https:\/\/doi.org\/10.1177\/0271678X16654495","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"issue":"2 Suppl","key":"4132_CR11","first-page":"123","volume":"104","author":"H Imai","year":"2006","unstructured":"Imai H, Konno K, Nakamura M et al (2006) A new model of focal cerebral ischemia in the miniature pig. J Neurosurg 104(2 Suppl):123\u2013132","journal-title":"J Neurosurg"},{"issue":"7","key":"4132_CR12","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1177\/0271678X18771440","volume":"38","author":"Anna Klass","year":"2018","unstructured":"Klass A, S\u00e1nchez-Porras R, Santos E (2018) Systematic review of the pharmacological agents that have been tested against spreading depolarizations. J Cereb Blood Flow Metab. https:\/\/doi.org\/10.1177\/0271678X18771440","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"issue":"6","key":"4132_CR13","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1152\/jn.1947.10.6.409","volume":"10","author":"AAP Leao","year":"1947","unstructured":"Leao AAP (1947) Further observations on the spreading depression of activity in the cerebral cortex. J Neurophysiol 10(6):409\u2013414","journal-title":"J Neurophysiol"},{"issue":"6","key":"4132_CR14","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1152\/jn.1944.7.6.359","volume":"7","author":"AAP Leo","year":"1944","unstructured":"Leo AAP (1944) Spreading depression of activity in the cerebral cortex. J Neurophysiol 7(6):359\u2013390","journal-title":"J Neurophysiol"},{"issue":"6","key":"4132_CR15","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1093\/brain\/awy102","volume":"141","author":"Janos L\u00fcckl","year":"2018","unstructured":"L\u00fcckl J, Lemale CL, Kola V et al (2018) The negative ultraslow potential, electrophysiological correlate of infarction in the human cortex. Brain J Neurol. https:\/\/doi.org\/10.1093\/brain\/awy102","journal-title":"Brain"},{"key":"4132_CR16","doi-asserted-by":"publisher","unstructured":"Mangla S, Choi JH, Barone FC, Novotney C, Libien J, Lin E, Pile-Spellman J (2015) Endovascular external carotid artery occlusion for brain selective targeting: a cerebrovascular swine model. BMC Res Notes. https:\/\/doi.org\/10.1186\/s13104-015-1714-7","DOI":"10.1186\/s13104-015-1714-7"},{"issue":"Pt 7","key":"4132_CR17","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1093\/brain\/awq117","volume":"133","author":"H Nakamura","year":"2010","unstructured":"Nakamura H, Strong AJ, Dohmen C et al (2010) Spreading depolarizations cycle around and enlarge focal ischaemic brain lesions. Brain J Neurol 133(Pt 7):1994\u20132006","journal-title":"Brain J Neurol"},{"issue":"1","key":"4132_CR18","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.neuroimage.2008.11.025","volume":"45","author":"TP Obrenovitch","year":"2009","unstructured":"Obrenovitch TP, Chen S, Farkas E (2009) Simultaneous, live imaging of cortical spreading depression and associated cerebral blood flow changes, by combining voltage-sensitive dye and laser speckle contrast methods. NeuroImage 45(1):68\u201374","journal-title":"NeuroImage"},{"issue":"8","key":"4132_CR19","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1038\/jcbfm.2010.40","volume":"30","author":"AI Oliveira-Ferreira","year":"2010","unstructured":"Oliveira-Ferreira AI, Milakara D, Alam M et al (2010) Experimental and preliminary clinical evidence of an ischemic zone with prolonged negative DC shifts surrounded by a normally perfused tissue belt with persistent electrocorticographic depression. J Cereb Blood Flow Metab 30(8):1504\u20131519","journal-title":"J Cereb Blood Flow Metab"},{"issue":"1","key":"4132_CR20","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/2040-7378-6-5","volume":"6","author":"SR Platt","year":"2014","unstructured":"Platt SR, Holmes SP, Howerth EW et al (2014) Development and characterization of a Yucatan miniature biomedical pig permanent middle cerebral artery occlusion stroke model. Exp Transl Stroke Med 6(1):5","journal-title":"Exp Transl Stroke Med"},{"issue":"5","key":"4132_CR21","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1177\/0271678X16646586","volume":"37","author":"R S\u00e1nchez-Porras","year":"2017","unstructured":"S\u00e1nchez-Porras R, Santos E, Sch\u00f6ll M, Kunzmann K, Stock C, Silos H, Unterberg AW, Sakowitz OW (2017) Ketamine modulation of the haemodynamic response to spreading depolarization in the gyrencephalic swine brain. J Cereb Blood Flow Metab 37(5):1720\u20131734","journal-title":"J Cereb Blood Flow Metab"},{"key":"4132_CR22","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.neuropharm.2014.04.018","volume":"84","author":"Ren\u00e1n S\u00e1nchez-Porras","year":"2014","unstructured":"S\u00e1nchez-Porras R, Santos E, Sch\u00f6ll M, Stock C, Zheng Z, Schiebel P, Orakcioglu B, Unterberg AW, Sakowitz OW (2014) The effect of ketamine on optical and electrical characteristics of spreading depolarizations in gyrencephalic swine cortex. Neuropharmacology. https:\/\/doi.org\/10.1016\/j.neuropharm.2014.04.018","journal-title":"Neuropharmacology"},{"issue":"12","key":"4132_CR23","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1177\/0271678X16671317","volume":"36","author":"E Santos","year":"2016","unstructured":"Santos E, Le\u00f3n F, Silos H, Sanchez-Porras R, Shuttleworth CW, Unterberg A, Sakowitz OW (2016) Incidence, hemodynamic, and electrical characteristics of spreading depolarization in a swine model are affected by local but not by intravenous application of magnesium. J Cereb Blood Flow Metab 36(12):2051\u20132057","journal-title":"J Cereb Blood Flow Metab"},{"key":"4132_CR24","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.neuroimage.2014.05.021","volume":"99","author":"E Santos","year":"2014","unstructured":"Santos E, Sch\u00f6ll M, S\u00e1nchez-Porras R, Dahlem MA, Silos H, Unterberg A, Dickhaus H, Sakowitz OW (2014) Radial, spiral and reverberating waves of spreading depolarization occur in the gyrencephalic brain. NeuroImage 99:244\u2013255","journal-title":"NeuroImage"},{"key":"4132_CR25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/978-3-7091-1434-6_16","volume":"118","author":"E Santos","year":"2013","unstructured":"Santos E, Sch\u00f6ll M, Sanchez-Porras R, Kentar M, Orakcioglu B, Unterberg A, Dickhaus H, Sakowitz OW (2013) Cortical spreading depression dynamics can be studied using intrinsic optical signal imaging in gyrencephalic animal cortex. Acta Neurochir Suppl 118:93\u201397","journal-title":"Acta Neurochir Suppl"},{"issue":"5","key":"4132_CR26","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1177\/0271678X16668988","volume":"37","author":"Michael Johannes Sch\u00f6ll","year":"2016","unstructured":"Sch\u00f6ll MJ, Santos E, Sanchez-Porras R et al (2016) Large field-of-view movement-compensated intrinsic optical signal imaging for the characterization of the haemodynamic response to spreading depolarizations in large gyrencephalic brains. J Cereb Blood Flow Metab. https:\/\/doi.org\/10.1177\/0271678X16668988","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"issue":"3","key":"4132_CR27","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.neuroimage.2011.05.040","volume":"57","author":"X Sun","year":"2011","unstructured":"Sun X, Wang Y, Chen S, Luo W, Li P, Luo Q (2011) Simultaneous monitoring of intracellular pH changes and hemodynamic response during cortical spreading depression by fluorescence-corrected multimodal optical imaging. NeuroImage 57(3):873\u2013884","journal-title":"NeuroImage"},{"issue":"1","key":"4132_CR28","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1161\/STROKEAHA.107.489906","volume":"39","author":"Y Tanaka","year":"2008","unstructured":"Tanaka Y, Imai H, Konno K et al (2008) Experimental model of lacunar infarction in the gyrencephalic brain of the miniature pig: neurological assessment and histological, immunohistochemical, and physiological evaluation of dynamic corticospinal tract deformation. Stroke J Cereb Circ 39(1):205\u2013212","journal-title":"Stroke J Cereb Circ"},{"issue":"4","key":"4132_CR29","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1152\/ajplegacy.1946.147.4.669","volume":"147","author":"A Van Harreveld","year":"1946","unstructured":"Van Harreveld A, Hawes RC (1946) Asphyxial depolarisation in the spinal cord. Am J Phys 147(4):669\u2013684","journal-title":"Am J Phys"},{"issue":"5","key":"4132_CR30","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1177\/0271678X16641424","volume":"37","author":"MK Winkler","year":"2017","unstructured":"Winkler MK, Dengler N, Hecht N, Hartings JA, Kang EJ, Major S, Martus P, Vajkoczy P, Woitzik J, Dreier JP (2017) Oxygen availability and spreading depolarizations provide complementary prognostic information in neuromonitoring of aneurysmal subarachnoid hemorrhage patients. J Cereb Blood Flow Metab 37(5):1841\u20131856","journal-title":"J Cereb Blood Flow Metab"},{"issue":"6","key":"4132_CR31","doi-asserted-by":"publisher","first-page":"e0158157","DOI":"10.1371\/journal.pone.0158157","volume":"11","author":"EA Wright","year":"2016","unstructured":"Wright EA, d\u2019Esterre CD, Morrison LB, Cockburn N, Kovacs M, Lee T-Y (2016) Absolute cerebral blood flow infarction threshold for 3-hour ischemia time determined with CT perfusion and 18F-FFMZ-PET imaging in a porcine model of cerebral ischemia. PLoS ONE 11(6):e0158157","journal-title":"PLoS ONE"},{"issue":"6","key":"4132_CR32","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1007\/s12264-015-1567-z","volume":"31","author":"T Yan","year":"2015","unstructured":"Yan T, Chopp M, Chen J (2015) Experimental animal models and inflammatory cellular changes in cerebral ischemic and hemorrhagic stroke. Neurosci Bull 31(6):717\u2013734","journal-title":"Neurosci Bull"},{"key":"4132_CR33","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.neuroimage.2013.02.079","volume":"76","author":"C Yin","year":"2013","unstructured":"Yin C, Zhou F, Wang Y, Luo W, Luo Q, Li P (2013) Simultaneous detection of hemodynamics, mitochondrial metabolism and light scattering changes during cortical spreading depression in rats based on multi-spectral optical imaging. NeuroImage 76:70\u201380","journal-title":"NeuroImage"}],"container-title":["Acta Neurochirurgica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00701-019-04132-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00701-019-04132-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00701-019-04132-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T03:54:36Z","timestamp":1695614076000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00701-019-04132-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,15]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["4132"],"URL":"https:\/\/doi.org\/10.1007\/s00701-019-04132-8","relation":{},"ISSN":["0001-6268","0942-0940"],"issn-type":[{"value":"0001-6268","type":"print"},{"value":"0942-0940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,15]]},"assertion":[{"value":"29 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers\u2019 bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony, or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed in accordance with the Institutional Animal Care and Use Committee in Karlsruhe, Baden W\u00fcrttemberg, Germany (Protocols No. G-13\/15, G-148-15, G-69\/16).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All procedures performed in studies involving animals were in accordance with the University of Heidelberg Animal Ethics Policy.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Animal Experiments"}}]}}