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Since the 1980s, it has been regarded as a marker of brain tissue injury in both trauma and disease. There have been no recent reports regarding MBP in aneurysmal subarachnoid haemorrhage (SAH).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>One hundred four SAH patients with ruptured aneurysms underwent endovascular treatment within 24\u00a0h of rupture, and 156 blood samples were collected: 104 on days 0\u20133, 32 on days 4\u20136 and 20 on days 9\u201312 post-SAH. MBP levels were assayed using ELISA and compared with the clinical status on admission, laboratory results, imaging findings and treatment outcome at 3\u00a0months.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>MBP levels on days 0\u20133 post-SAH were significantly higher among poor outcome patients (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001), non-survivors (<jats:italic>p<\/jats:italic>\u00a0=\u20090.005), patients who underwent intracranial intervention (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001) and patients with intracerebral haemorrhage (ICH; <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001). On days 4\u20136 post-SAH, significantly higher levels were found following intracranial intervention (<jats:italic>p<\/jats:italic>\u00a0=\u20090.009) and ICH (<jats:italic>p<\/jats:italic>\u00a0=\u20090.039). There was clinically relevant correlation between MBP levels on days 0\u20133 post-SAH and 3-month Glasgow Outcome Scale (cc\u2009=\u2009\u2212\u20090.42) and also ICH volume (cc\u2009=\u20090.48). All patients who made a full recovery had MBP levels below detection limit on days 0\u20133 post-SAH. Following endovascular aneurysm occlusion, there was no increase in MBP in 86 of the 104 patients investigated (83%).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The concentration of MBP in peripheral blood after intracranial aneurysm rupture reflects the severity of the brain tissue injury (due to surgery or ICH) and correlates with the treatment outcome. Endovascular aneurysm occlusion was not followed by a rise in MBP in most cases, suggesting the safety of this technique.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00701-019-04185-9","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T07:02:51Z","timestamp":1578466971000},"page":"545-552","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Serum myelin basic protein as a marker of brain injury in aneurysmal subarachnoid haemorrhage"],"prefix":"10.1007","volume":"162","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4588-7787","authenticated-orcid":false,"given":"Norbert","family":"W\u0105sik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartosz","family":"Sok\u00f3\u0142","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Ho\u0142ysz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Witold","family":"Ma\u0144ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Juszkat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr Pawe\u0142","family":"Jagodzi\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Jankowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,8]]},"reference":[{"issue":"17","key":"4185_CR1","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1007\/s00018-006-6094-7","volume":"63","author":"JM Boggs","year":"2006","unstructured":"Boggs JM (2006) Myelin basic protein: a multifunctional protein. 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This article does not contain any studies with animals performed by any of the authors.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The sponsor had no role in the design or conduct of this research.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}}]}}