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Studies reporting a high frequency of the latter raise the question about the clinical relevance (i.e., the incidence of tension pneumocephalus) and the efficacy of a treatment by an air replacement procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective study enrolled 540 patients harboring vestibular schwannomas who underwent posterior fossa surgery in a supine (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009111) or semi-sitting (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009429) position. The extent of the PP was evaluated by voxel-based volumetry (VBV) and related to clinical predictive factors (i.e., age, gender, position, duration of surgery, and tumor size).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PP with a mean volume of 32\u2009\u00b1\u200933\u00a0ml (range: 0\u2013179.1\u00a0ml) was detected in 517\/540 (96%) patients. The semi-sitting position was associated with a significantly higher PP volume than the supine position (40.3\u2009\u00b1\u200933.0\u00a0ml [0\u2013179.1] and 0.8\u2009\u00b1\u20091.4 [0\u201310.2],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Tension pneumocephalus was observed in only 14\/429 (3.3%) of the semi-sitting cases, while no tension pneumocephalus occurred in the supine position. Positive predictors for PP were higher age, male gender, and longer surgery duration, while large (T4) tumor size was established as a negative predictor. Air exchange via a twist-drill was only necessary in 14 cases with an intracranial air volume &gt;\u200960\u00a0ml. Air replacement procedures did not add any complications or prolong the ICU stay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although pneumocephalus is frequently observed following posterior fossa surgery in semi-sitting position, relevant clinical symptoms (i.e., a tension pneumocephalus) occur in only very few cases. These cases are well-treated by an air evacuation procedure. This study indicates that the risk of postoperative pneumocephalus is not a contraindication for semi-sitting positioning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00701-020-04504-5","type":"journal-article","created":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T03:02:51Z","timestamp":1595646171000},"page":"2629-2636","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Occurrence and management of postoperative pneumocephalus using the semi-sitting position in vestibular schwannoma surgery"],"prefix":"10.1007","volume":"162","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5350-4574","authenticated-orcid":false,"given":"Kathrin","family":"Machetanz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Leuze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Mounts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonidas","family":"Trakolis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Gugel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Grimm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Tatagiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4807-6234","authenticated-orcid":false,"given":"Georgios","family":"Naros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,25]]},"reference":[{"key":"4504_CR1","doi-asserted-by":"publisher","unstructured":"Bithal PK, Pandia MP, Dash HH, Chouhan RS, Mohanty B, Padhy N (2004) Comparative incidence of venous air embolism and associated hypotension in adults and children operated for neurosurgery in the sitting position. 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