{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:14:31Z","timestamp":1792782871512,"version":"4.5.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"SveaNor Fastigheter AB"},{"name":"Haugans Hus Invest AS"},{"name":"Hathon Holding AS"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neurochir"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fatigue is a common and disabling sequel after aneurysmal subarachnoid hemorrhage (aSAH). At present, prevalence estimates of post-aSAH fatigue in the chronic phase are scarce and vary greatly. Factors from the acute phase of aSAH have hitherto barely been associated with post-aSAH fatigue in the chronic phase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective study assessing prevalence of fatigue using the Fatigue Severity Scale (FSS) in patients who were living independently 1 to 7 years after aSAH. We compared demographic, medical, and radiological variables from the acute phase of aSAH between patients with and without fatigue (FSS \u2265 4 versus &lt; 4) and searched for predictors of fatigue among these variables applying univariable and multivariable regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 726 patients treated for aSAH in the period between January 2012 and December 2017, 356 patients completed the assessment. The mean FSS score was 4.7 \u00b1 1.7, and fatigue was present in 69.7%. The frequency of patients with fatigue did not decline significantly over time. Univariable analysis identified nicotine use, loss of consciousness at ictus (LOCi), rebleed prior to aneurysm repair, reduced consciousness to Glasgow Coma Scale (GCS) &lt; 14, large amounts of subarachnoid blood, the presence of acute hydrocephalus, and severe vasospasm as factors that were significantly associated with fatigue. In multivariable analysis, nicotine use, reduced GCS, and severe vasospasm were independent predictors that all more than doubled the risk to develop post-aSAH fatigue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Fatigue is a frequent sequel persisting several years after aSAH. Nicotine use, reduced consciousness at admission, and severe vasospasm are independent predictors of fatigue from the acute phase of aSAH. We propose inflammatory cytokines causing dopamine imbalance to be a common denominator for post-aSAH fatigue and the presently identified predictors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00701-020-04538-9","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T07:02:49Z","timestamp":1597734169000},"page":"3107-3116","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Prevalence and predictors of fatigue after aneurysmal subarachnoid hemorrhage"],"prefix":"10.1007","volume":"162","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3915-1960","authenticated-orcid":false,"given":"Elin","family":"Western","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Sorteberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathrine","family":"Brunborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonje Haug","family":"Nordenmark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,18]]},"reference":[{"key":"4538_CR1","doi-asserted-by":"publisher","unstructured":"Beeler JA, Mourra D (2018) To do or not to do: dopamine, affordability and the economics of opportunity:12. https:\/\/doi.org\/10.3389\/fnint.2018.00006","DOI":"10.3389\/fnint.2018.00006"},{"key":"4538_CR2","doi-asserted-by":"publisher","unstructured":"Biasi MD, Dani JA (2011) Reward, addiction, withdrawal to nicotine. 34:105\u2013130. https:\/\/doi.org\/10.1146\/annurev-neuro-061010-113734","DOI":"10.1146\/annurev-neuro-061010-113734"},{"key":"4538_CR3","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1097\/phm.0000000000000353","volume":"95","author":"W Boerboom","year":"2016","unstructured":"Boerboom W, Heijenbrok-Kal MH, Khajeh L, van Kooten F, Ribbers GM (2016) Long-term functioning of patients with aneurysmal subarachnoid hemorrhage: a 4-yr follow-up study. Am J Phy Med Rehabil 95:112\u2013120. https:\/\/doi.org\/10.1097\/phm.0000000000000353","journal-title":"Am J Phy Med Rehabil"},{"key":"4538_CR4","doi-asserted-by":"publisher","first-page":"5534","DOI":"10.1158\/1078-0432.CCR-08-2584","volume":"15","author":"JE Bower","year":"2009","unstructured":"Bower JE, Ganz PA, Tao ML, Hu W, Belin TR, Sepah S, Cole S, Aziz N (2009) Inflammatory biomarkers and fatigue during radiation therapy for breast and prostate cancer. Clin Cancer Res 15:5534\u20135540. https:\/\/doi.org\/10.1158\/1078-0432.CCR-08-2584","journal-title":"Clin Cancer Res"},{"key":"4538_CR5","doi-asserted-by":"publisher","first-page":"H1518","DOI":"10.1152\/ajpheart.00928.2010","volume":"300","author":"ST Bradford","year":"2011","unstructured":"Bradford ST, Stamatovic SM, Dondeti RS, Keep RF, Andjelkovic AV (2011) Nicotine aggravates the brain postischemic inflammatory response. Am J Physiol Heart Circ Physiol 300:H1518\u2013H1529. https:\/\/doi.org\/10.1152\/ajpheart.00928.2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"4538_CR6","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.3109\/02699052.2015.1073789","volume":"29","author":"AM Buunk","year":"2015","unstructured":"Buunk AM, Groen RJM, Veenstra WS, Spikman JM (2015) Leisure and social participation in patients 4\u201310 years after aneurysmal subarachnoid haemorrhage. Brain Inj 29:1589\u20131596. https:\/\/doi.org\/10.3109\/02699052.2015.1073789","journal-title":"Brain Inj"},{"key":"4538_CR7","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1111\/ene.13723","volume":"25","author":"AM Buunk","year":"2018","unstructured":"Buunk AM, Groen RJM, Wijbenga RA, Ziengs AL, Metzemaekers JDM, Dijk JMC, Spikman JM (2018) Mental versus physical fatigue after subarachnoid hemorrhage: differential associations with outcome. Eur J Neurol 25:1313\u2013e1113. https:\/\/doi.org\/10.1111\/ene.13723","journal-title":"Eur J Neurol"},{"key":"4538_CR8","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/S0022-510X(00)00411-1","volume":"179","author":"A Chaudhuri","year":"2000","unstructured":"Chaudhuri A, Behan PO (2000) Fatigue and basal ganglia. J Neurol Sci 179:34\u201342. https:\/\/doi.org\/10.1016\/S0022-510X(00)00411-1","journal-title":"J Neurol Sci"},{"key":"4538_CR9","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1016\/S0140-6736(04)15794-2","volume":"363","author":"A Chaudhuri","year":"2004","unstructured":"Chaudhuri A, Behan PO (2004) Fatigue in neurological disorders. Lancet 363:978\u2013988. https:\/\/doi.org\/10.1016\/S0140-6736(04)15794-2","journal-title":"Lancet"},{"key":"4538_CR10","doi-asserted-by":"publisher","unstructured":"Cumming TB, Packer M, Kramer SF, English C (2016) The prevalence of fatigue after stroke: a systematic review and meta-analysis. 11:968\u2013977. https:\/\/doi.org\/10.1177\/1747493016669861","DOI":"10.1177\/1747493016669861"},{"key":"4538_CR11","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1136\/jnnp-2017-316007","volume":"89","author":"W De Doncker","year":"2018","unstructured":"De Doncker W, Dantzer R, Ormstad H, Kuppuswamy A (2018) Mechanisms of poststroke fatigue. J Neurol Neurosurg Psychiatry 89:287\u2013293. https:\/\/doi.org\/10.1136\/jnnp-2017-316007","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"4538_CR12","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1161\/STROKEAHA.112.674291","volume":"44","author":"NK de Rooij","year":"2013","unstructured":"de Rooij NK, Rinkel GJ, Dankbaar JW, Frijns CJM (2013) Delayed cerebral ischemia after subarachnoid hemorrhage: a systematic review of clinical, laboratory, and radiological predictors. Stroke 44:43\u201354. https:\/\/doi.org\/10.1161\/STROKEAHA.112.674291","journal-title":"Stroke"},{"key":"4538_CR13","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/s0022-3999(03)00371-4","volume":"56","author":"AJ Dittner","year":"2004","unstructured":"Dittner AJ, Wessely SC, Brown RG (2004) The assessment of fatigue: a practical guide for clinicians and researchers. J Psychosom Res 56:157\u2013170. https:\/\/doi.org\/10.1016\/s0022-3999(03)00371-4","journal-title":"J Psychosom Res"},{"key":"4538_CR14","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3389\/fneur.2015.00052","volume":"6","author":"E Dobryakova","year":"2015","unstructured":"Dobryakova E, Genova HM, DeLuca J, Wylie GR (2015) The dopamine imbalance hypothesis of fatigue in multiple sclerosis and other neurological disorders. Front Neurol 6:52. https:\/\/doi.org\/10.3389\/fneur.2015.00052","journal-title":"Front Neurol"},{"key":"4538_CR15","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1227\/01.NEU.0000068863.37133.9E","volume":"53","author":"AS Dumont","year":"2003","unstructured":"Dumont AS, Dumont RJ, Chow MM, Lin C-l, Calisaneller T, Ley KF, Kassell NF, Lee KS (2003) Cerebral vasospasm after subarachnoid hemorrhage: putative role of inflammation. Neurosurgery 53:123\u2013135. https:\/\/doi.org\/10.1227\/01.NEU.0000068863.37133.9E","journal-title":"Neurosurgery"},{"key":"4538_CR16","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1002\/brb3.181","volume":"3","author":"M Engstr\u00f6m","year":"2013","unstructured":"Engstr\u00f6m M, Flensner G, Landtblom A-M, Ek A-C, Karlsson T (2013) Thalamo-striato-cortical determinants to fatigue in multiple sclerosis. Brain Behav 3:715\u2013728. https:\/\/doi.org\/10.1002\/brb3.181","journal-title":"Brain Behav"},{"key":"4538_CR17","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.yfrne.2012.09.003","volume":"33","author":"JC Felger","year":"2012","unstructured":"Felger JC, Miller AH (2012) Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise. Front Neuroendocrinol 33:315\u2013327. https:\/\/doi.org\/10.1016\/j.yfrne.2012.09.003","journal-title":"Front Neuroendocrinol"},{"key":"4538_CR18","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1227\/01.neu.0000243277.86222.6c","volume":"59","author":"JA Frontera","year":"2006","unstructured":"Frontera JA, Claassen J, Schmidt JM, Wartenberg KE, Temes R, Connolly ES, Macdonald RL, Mayer SA (2006) Prediction of symptomatic vasospasm after subarachnoid hemorrhage: the modified Fisher scale. Neurosurgery 59:21\u201327. https:\/\/doi.org\/10.1227\/01.neu.0000243277.86222.6c","journal-title":"Neurosurgery"},{"key":"4538_CR19","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1191\/026921599669500092","volume":"13","author":"DJ Hellawell","year":"1999","unstructured":"Hellawell DJ, Taylor R, Pentland B (1999) Persisting symptoms and carers\u2019 views of outcome after subarachnoid haemorrhage. Clin Rehabil 13:333\u2013340. https:\/\/doi.org\/10.1191\/026921599669500092","journal-title":"Clin Rehabil"},{"key":"4538_CR20","doi-asserted-by":"publisher","first-page":"2268","DOI":"10.1161\/01.str.30.11.2268","volume":"30","author":"JW Hop","year":"1999","unstructured":"Hop JW, Rinkel GJ, Algra A, van Gijn J (1999) Initial loss of consciousness and risk of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Stroke 30:2268\u20132271. https:\/\/doi.org\/10.1161\/01.str.30.11.2268","journal-title":"Stroke"},{"key":"4538_CR21","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3171\/jns.1968.28.1.0014","volume":"28","author":"WE Hunt","year":"1968","unstructured":"Hunt WE, Hess RM (1968) Surgical risk as related to time of intervention in the repair of intracranial aneurysms. J Neurosurg 28:14\u201320. https:\/\/doi.org\/10.3171\/jns.1968.28.1.0014","journal-title":"J Neurosurg"},{"key":"4538_CR22","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.wneu.2015.08.052","volume":"85","author":"T Inagawa","year":"2016","unstructured":"Inagawa T (2016) Risk factors for cerebral vasospasm following aneurysmal subarachnoid hemorrhage: a review of the literature. World Neurosurg 85:56\u201376. https:\/\/doi.org\/10.1016\/j.wneu.2015.08.052","journal-title":"World Neurosurg"},{"key":"4538_CR23","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/S0140-6736(75)92830-5","volume":"305","author":"B Jennett","year":"1975","unstructured":"Jennett B, Bond M (1975) Assessment of outcome after severe brain damage: a practical scale. Lancet 305:480\u2013484. https:\/\/doi.org\/10.1016\/S0140-6736(75)92830-5","journal-title":"Lancet"},{"key":"4538_CR24","doi-asserted-by":"publisher","DOI":"10.5772\/57311","volume-title":"Traumatic brain injury","author":"B Johansson","year":"2014","unstructured":"Johansson B, R\u00f6nnb\u00e4ck L (2014) Long-lasting mental fatigue after traumatic brain injury \u2013 a major problem most often neglected diagnostic criteria, assessment, relation to emotional and cognitive problems, cellular background, and aspects on treatment. In: Sadaka F (ed) Traumatic brain injury. INTECH, Rijeka. https:\/\/doi.org\/10.5772\/57311"},{"key":"4538_CR25","doi-asserted-by":"publisher","unstructured":"Karshikoff B, Sundelin T, Lasselin J (2017) Role of inflammation in human fatigue: relevance of multidimensional assessments and potential neuronal mechanisms. 8. https:\/\/doi.org\/10.3389\/fimmu.2017.00021","DOI":"10.3389\/fimmu.2017.00021"},{"key":"4538_CR26","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1111\/ene.13014","volume":"23","author":"L Khajeh","year":"2016","unstructured":"Khajeh L, Ribbers GM, Heijenbrok-Kal MH, Blijdorp K, Dippel DW, Sneekes EM, van den Berg-Emons HJ, van der Lely AJ, Neggers SJ, van Kooten F (2016) The effect of hypopituitarism on fatigue after subarachnoid hemorrhage. Eur J Neurol 23:1269\u20131274. https:\/\/doi.org\/10.1111\/ene.13014","journal-title":"Eur J Neurol"},{"key":"4538_CR27","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1001\/archneur.1989.00520460115022","volume":"46","author":"LB Krupp","year":"1989","unstructured":"Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD (1989) The fatigue severity scale: application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol 46:1121\u20131123. https:\/\/doi.org\/10.1001\/archneur.1989.00520460115022","journal-title":"Arch Neurol"},{"key":"4538_CR28","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.jpsychores.2011.12.008","volume":"72","author":"MA Kutlubaev","year":"2012","unstructured":"Kutlubaev MA, Barugh AJ, Mead GE (2012) Fatigue after subarachnoid haemorrhage: a systematic review. J Psychosom Res 72:305\u2013310. https:\/\/doi.org\/10.1016\/j.jpsychores.2011.12.008","journal-title":"J Psychosom Res"},{"key":"4538_CR29","doi-asserted-by":"crossref","unstructured":"Le Roux PD, Winn HR (1999) Intracranial aneurysms and subarachnoid hemorrhage management of the poor grade patient. In: Acta Neurochir Suppl, vol 72. 1999\/05\/25 edn., pp 7-26","DOI":"10.1007\/978-3-7091-6377-1_2"},{"key":"4538_CR30","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1080\/14034940410028406","volume":"33","author":"A Lerdal","year":"2005","unstructured":"Lerdal A, Wahl AK, Rustoen T, Hanestad BR, Moum T (2005) Fatigue in the general population: a translation and test of the psychometric properties of the Norwegian version of the fatigue severity scale. Scand J Public Health 33:123\u2013130. https:\/\/doi.org\/10.1080\/14034940410028406","journal-title":"Scand J Public Health"},{"key":"4538_CR31","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/978-3-7091-8975-7_16","volume":"42","author":"KF Lindegaard","year":"1988","unstructured":"Lindegaard KF, Nornes H, Bakke SJ, Sorteberg W, Nakstad P (1988) Cerebral vasospasm after subarachnoid haemorrhage investigated by means of transcranial Doppler ultrasound. Acta Neurochir Suppl 42:81\u201384. https:\/\/doi.org\/10.1007\/978-3-7091-8975-7_16","journal-title":"Acta Neurochir Suppl"},{"key":"4538_CR32","doi-asserted-by":"publisher","first-page":"2090","DOI":"10.1161\/STROKEAHA.106.478941","volume":"38","author":"G Mead","year":"2007","unstructured":"Mead G, Lynch J, Greig C, Young A, Lewis S, Sharpe M (2007) Evaluation of fatigue scales in stroke patients. Stroke 38:2090\u20132095. https:\/\/doi.org\/10.1161\/STROKEAHA.106.478941","journal-title":"Stroke"},{"key":"4538_CR33","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1097\/00000542-197010000-00013","volume":"33","author":"J Michenfelder","year":"1970","unstructured":"Michenfelder J, Theye RJ (1970) The effects of anesthesia and hypothermia on canine cerebral ATP and lactate during anoxia produced by decapitation. Anesthesiology 33:430\u2013439. https:\/\/doi.org\/10.1097\/00000542-197010000-00013","journal-title":"Anesthesiology"},{"key":"4538_CR34","doi-asserted-by":"publisher","unstructured":"Nordenmark TH, Karic T, R\u00f8e C, Sorteberg W, Sorteberg A (2019) The post-aSAH syndrome: a self-reported cluster of symptoms in patients with aneurysmal subarachnoid hemorrhage. J Neurosurg:1\u201310. https:\/\/doi.org\/10.3171\/2019.1.JNS183168","DOI":"10.3171\/2019.1.JNS183168"},{"key":"4538_CR35","doi-asserted-by":"publisher","unstructured":"Nornes H (1973) The role of intracranial pressure in the arrest of hemorrhage in patients with ruptured intracranial aneurysm. 39:226. https:\/\/doi.org\/10.3171\/jns.1973.39.2.0226","DOI":"10.3171\/jns.1973.39.2.0226"},{"key":"4538_CR36","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1159\/000306642","volume":"29","author":"PE Passier","year":"2010","unstructured":"Passier PE, Visser-Meily JM, van Zandvoort MJ, Post MW, Rinkel GJ, van Heugten C (2010) Prevalence and determinants of cognitive complaints after aneurysmal subarachnoid hemorrhage. Cerebrovasc Dis (Basel, Switzerland) 29:557\u2013563. https:\/\/doi.org\/10.1159\/000306642","journal-title":"Cerebrovasc Dis (Basel, Switzerland)"},{"key":"4538_CR37","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1007\/s00415-010-5891-y","volume":"258","author":"PE Passier","year":"2011","unstructured":"Passier PE, Post MWM, van Zandvoort MJE, Rinkel GJE, Lindeman E, Visser-Meily JMA (2011) Predicting fatigue 1 year after aneurysmal subarachnoid hemorrhage. J Neurol 258:1091\u20131097. https:\/\/doi.org\/10.1007\/s00415-010-5891-y","journal-title":"J Neurol"},{"key":"4538_CR38","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.jstrokecerebrovasdis.2010.02.001","volume":"20","author":"PE Passier","year":"2011","unstructured":"Passier PE, Visser-Meily JM, Rinkel GJ, Lindeman E, Post MW (2011) Life satisfaction and return to work after aneurysmal subarachnoid hemorrhage. J Stroke Cerebrovasc Dis 20:324\u2013329. https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2010.02.001","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"4538_CR39","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1136\/jnnp.2002.000414","volume":"75","author":"J Powell","year":"2004","unstructured":"Powell J, Kitchen N, Heslin J, Greenwood R (2004) Psychosocial outcomes at 18 months after good neurological recovery from aneurysmal subarachnoid haemorrhage. J Neurol Neurosurg Psychiatry 75:1119\u20131124. https:\/\/doi.org\/10.1136\/jnnp.2002.000414","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"4538_CR40","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.bbi.2008.11.005","volume":"23","author":"CL Raison","year":"2009","unstructured":"Raison CL, Lin J-MS, Reeves WC (2009) Association of peripheral inflammatory markers with chronic fatigue in a population-based sample. Brain Behav Immun 23:327\u2013337. https:\/\/doi.org\/10.1016\/j.bbi.2008.11.005","journal-title":"Brain Behav Immun"},{"key":"4538_CR41","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1034\/j.1600-0404.2002.01128.x","volume":"106","author":"M R\u00f6dholm","year":"2002","unstructured":"R\u00f6dholm M, Starmark JE, Ekholm S, Von Essen C (2002) Organic psychiatric disorders after aneurysmal SAH: outcome and associations with age, bleeding severity, and arterial hypertension. Acta Neurol Scand 106:8\u201318. https:\/\/doi.org\/10.1034\/j.1600-0404.2002.01128.x","journal-title":"Acta Neurol Scand"},{"key":"4538_CR42","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s11010-016-2885-9","volume":"426","author":"SK Sanganalmath","year":"2017","unstructured":"Sanganalmath SK, Gopal P, Parker JR, Downs RK, Parker JC, Dawn B (2017) Global cerebral ischemia due to circulatory arrest: insights into cellular pathophysiology and diagnostic modalities. Mol Cell Biochem 426:111\u2013127. https:\/\/doi.org\/10.1007\/s11010-016-2885-9","journal-title":"Mol Cell Biochem"},{"key":"4538_CR43","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1007\/s00701-013-1683-3","volume":"155","author":"A Vetkas","year":"2013","unstructured":"Vetkas A, Lepik T, Eilat T, R\u00e4tsep T, Asser T (2013) Emotional health and quality of life after aneurysmal subarachnoid hemorrhage. Acta Neurochir 155:1107\u20131114. https:\/\/doi.org\/10.1007\/s00701-013-1683-3","journal-title":"Acta Neurochir"},{"key":"4538_CR44","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1161\/strokeaha.108.531277","volume":"40","author":"JM Visser-Meily","year":"2009","unstructured":"Visser-Meily JM, Rhebergen ML, Rinkel GJ, van Zandvoort MJ, Post MW (2009) Long-term health-related quality of life after aneurysmal subarachnoid hemorrhage: relationship with psychological symptoms and personality characteristics. Stroke 40:1526\u20131529. https:\/\/doi.org\/10.1161\/strokeaha.108.531277","journal-title":"Stroke"}],"container-title":["Acta Neurochirurgica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00701-020-04538-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00701-020-04538-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00701-020-04538-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T19:56:24Z","timestamp":1629230184000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00701-020-04538-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,18]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["4538"],"URL":"https:\/\/doi.org\/10.1007\/s00701-020-04538-9","relation":{},"ISSN":["0001-6268","0942-0940"],"issn-type":[{"value":"0001-6268","type":"print"},{"value":"0942-0940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,18]]},"assertion":[{"value":"5 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}