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Four half hour long periods were studied: before bolus injection and at 5, 10, and 24 hours thereafter, respectively, and a fifth tapering period with S-thiopental between &lt; 100 and &lt; 30 \u03bcmol\/L. S-thiopental concentrations and administered doses were registered.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Seventeen children treated with BCT 2007\u20132017 with high-resolution data were included; median age 15 (range 6\u201317) and median Glasgow coma score 7 (range 3\u20138). Median time from trauma to start of BCT was 44.5 h (range 2.5\u2013197.5) and from start to stop 99.0 h (range 21.0\u2013329.0). Median ICP was 22 (IQR 20\u201325) in the half hour period before onset of BCT and 16 (IQR 11\u201320) in the half hour period 5 h later (<jats:italic>p<\/jats:italic> = 0.011). The corresponding figures for CPP were 65 (IQR 62\u201371) and 63 (57\u201371) (<jats:italic>p<\/jats:italic> &gt; 0.05). The RAP index was in the half hour period before onset of BCT 0.6 (IQR 0.1\u20130.7), in the half hour period 5 h later 0.3 (IQR 0.1\u20130.7) (<jats:italic>p<\/jats:italic> = 0.331), and in the whole BCT period 0.3 (IQR 0.2\u20130.4) (<jats:italic>p<\/jats:italic> = 0.004). Eighty-two percent (14\/17) had favorable outcome (good recovery = 8 patients and moderate disability = 6 patients).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>BCT significantly reduced ICP and RAP index with preserved CPP. BCT should be considered in case of RICH.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00701-020-04677-z","type":"journal-article","created":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T23:03:11Z","timestamp":1608418991000},"page":"489-498","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Temporal effects of barbiturate coma on intracranial pressure and compensatory reserve in children with traumatic brain injury"],"prefix":"10.1007","volume":"163","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2928-7132","authenticated-orcid":false,"given":"Fartein","family":"Velle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Lew\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Howells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pelle","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Enblad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,12,19]]},"reference":[{"key":"4677_CR1","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s00701-003-0187-y","volume":"146","author":"M Balestreri","year":"2004","unstructured":"Balestreri M, Czosnyka M, Steiner LA, Schmidt E, Smielewski P, Matta B, Pickard JD (2004) Intracranial hypertension: what additional information can be derived from ICP waveform after head injury? 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